KEGG   ENZYME: 1.1.1.387Help
Entry
EC 1.1.1.387                Enzyme                                 

Name
L-serine 3-dehydrogenase (NAD+);
NAD+-dependent L-serine dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-serine:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-serine + NAD+ = 2-aminoacetaldehyde + CO2 + NADH + H+ (overall reaction) [RN:R10986];
(1a) L-serine + NAD+ = 2-aminomalonate semialdehyde + NADH + H+ [RN:R10985];
(1b) 2-aminomalonate semialdehyde = 2-aminoacetaldehyde + CO2 (spontaneous) [RN:R06830]
Reaction(KEGG)
Substrate
L-serine [CPD:C00065];
NAD+ [CPD:C00003];
2-aminomalonate semialdehyde [CPD:C11822]
Product
2-aminoacetaldehyde [CPD:C06735];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080];
2-aminomalonate semialdehyde [CPD:C11822]
Comment
The enzyme, purified from the bacterium Pseudomonas aeruginosa, also shows activity with L-threonine (cf. EC 1.1.1.103, L-threonine 3-dehydrogenase). The enzyme has only very low activity with NADP+ [cf. EC 1.1.1.276, serine 3-dehydrogenase (NADP+)].
History
EC 1.1.1.387 created 2015
Orthology
K19711  L-serine 3-dehydrogenase (NAD+)
Genes
PAE: PA0743
PAEV: N297_768(mmsB)
PAEI: N296_768(mmsB)
PAU: PA14_54670
PAP: PSPA7_4777(mmsB1)
PAG: PLES_46001
PAF: PAM18_4296
PNC: NCGM2_1469
PAEB: NCGM1900_2036
PDK: PADK2_21985
PAEP: PA1S_22945
PAEM: U769_22455
PAEL: T223_23470
PAEG: AI22_11210
PAEC: M802_765(mmsB)
PAEO: M801_767(mmsB)
PMY: Pmen_1371
PMK: MDS_1428
PRE: PCA10_42930(mmsB)
PPSE: BN5_3001(mmsB)
PKC: PKB_4189(mmsb3)
 » show all
Taxonomy
Reference
1  [PMID:22128181]
  Authors
Tchigvintsev A, Singer A, Brown G, Flick R, Evdokimova E, Tan K, Gonzalez CF, Savchenko A, Yakunin AF
  Title
Biochemical and structural studies of uncharacterized protein PA0743 from Pseudomonas aeruginosa revealed NAD+-dependent L-serine dehydrogenase.
  Journal
J Biol Chem 287:1874-83 (2012)
DOI:10.1074/jbc.M111.294561
  Sequence
[pae:PA0743]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.387
IUBMB Enzyme Nomenclature: 1.1.1.387
ExPASy - ENZYME nomenclature database: 1.1.1.387
BRENDA, the Enzyme Database: 1.1.1.387

DBGET integrated database retrieval system