KEGG   ENZYME: 1.1.1.39
Entry
EC 1.1.1.39                 Enzyme                                 
Name
malate dehydrogenase (decarboxylating);
'malic' enzyme (ambiguous);
pyruvic-malic carboxylase (ambiguous);
NAD-specific malic enzyme (ambiguous);
NAD-malic enzyme (ambiguous);
malate dehydrogenase (decarboxylating) (ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(S)-malate + NAD+ = pyruvate + CO2 + NADH [RN:R00214]
Reaction(KEGG)
R00214
Substrate
(S)-malate [CPD:C00149];
NAD+ [CPD:C00003]
Product
pyruvate [CPD:C00022];
CO2 [CPD:C00011];
NADH [CPD:C00004]
Comment
There are several forms of malate dehydrogenases that differ in their use of substrates and cofactors. This particular form is found only in the plant kingdom. Unlike EC 1.1.1.38, which catalyses a similar reaction, this enzyme can not bind oxaloacetate, and thus does not decarboxylate exogeneously-added oxaloacetate. cf. EC 1.1.1.37, malate dehydrogenase; EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating); and EC 1.1.1.83, D-malate dehydrogenase (decarboxylating).
History
EC 1.1.1.39 created 1961
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation by Calvin cycle
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00028  malate dehydrogenase (decarboxylating)
Genes
EAF: 111714933 111716746
LSM: 121127274
TCF: 131891736
ATH: AT2G13560(NAD-ME1) AT4G00570(NAD-ME2)
ALY: 9309009 9319868
CRB: 17882677 17890615
CSAT: 104705320 104712096 104737720 104748683 104766630 104793732
EUS: EUTSA_v10022600mg EUTSA_v10028520mg
BRP: 103836911 103837635 103858863
BNA: 106365524 106366363 106388718 106410651 106434956 106438600
BOE: 106318356 106318857 106328013
RSZ: 108827160 108828697 108847837
THJ: 104801455 104817017 104821820
CPAP: 110814719 110819439
CIT: 102578068 102613192 127901471
CIC: CICLE_v10019380mg CICLE_v10024268mg
PVY: 116135872 116135999
MINC: 123215684 123217445
TCC: 18585720 18614193
GRA: 105779788 105797262 105802672
GHI: 107911964 107948661 107952931 107954551 107957250 107960344
GAB: 108460249 108473639 108489905
HSYR: 120119776 120126166 120135979 120187763 120189144
DZI: 111287834 111294958 111296010 111304697 111313837
EGR: 104442071 104444509
GMX: 100775394 100795823 100799344 100806545 100811081
GSJ: 114366896 114394531 114405779 114406445 114418473
PVU: PHAVU_008G068700g PHAVU_010G041000g PHAVU_010G094700g
VRA: 106759136 106774063 106774244
VAR: 108327762 108347668 108347684
VUN: 114166768 114167293 114183224
VUM: 124820019 124828028 124828184
CCAJ: 109797379 109803053 109808017
APRC: 113848983 113849288 113863262
MTR: 11420682 11433166 11446923
TPRA: 123883315 123883456 123888227 123894345
CAM: 101495744 101498557 101512359
PSAT: 127075910 127076653 127127125
VVO: 131616139 131616664 131638323
LJA: 130746056 130749286
ADU: 107463422 107472570 107473149 107485621
AIP: 107617619 107624845 107634962
AHF: 112702894 112726786 112730723 112736379 112744045 112775467 112797403
LANG: 109340825 109356956 109362754
PCIN: 129290321 129290957
QSA: O6P43_017142 O6P43_017582 O6P43_027202
FVE: 101311315 101311414
RCN: 112181173 112195955
PPER: 18784996 18787040
PMUM: 103331446 103331878
PAVI: 110759261 110771802
PDUL: 117617475 117617700 117617857
MDM: 103406865 103410089 103420647 103426311
MSYL: 126613974 126623689 126627818 126629316
PXB: 103929748 103932045 103935555 103935560 103941811 103965503
ZJU: 107421706 107434740
MNT: 21389976 21399476 21406650
CSAV: 115706551 115709889 115709970 115710857
CSV: 101204181 101212275 116403313 116406292
CMO: 103483428 103499065
BHJ: 120067607 120071054
MCHA: 111016110 111023088
CMAX: 111473484 111479676 111494177
CMOS: 111432147 111454410 111464523
CPEP: 111779018 111791420 111799614
RCU: 8258537 8266672
MEAN: 126654144 126686764
JCU: 105643023 105643271
HBR: 110656650 110663918 110669466
MESC: 110614540 110615698 110615778 110617007
POP: 18105029 7483786 7494056 7496944
PEU: 105120704 105124900 105133444 105138021
PALZ: 118034113 118041498 118042322 118057732
JRE: 108989611 108999352 109008031
CILL: 122292440 122294846 122309577
CAVE: 132176656 132186269
QSU: 111987655 112009249
QLO: 115958301 115986477
TWL: 119982702 120003883 120004431
VVI: 100241371 100261633
VRI: 117931764 117932479
SLY: 101246159 101246962
SPEN: 107008018 107028553
SOT: 102581802(NAD-ME) 102598070(NAD-ME)
SSTN: 125842143 125868755
SDUL: 129886596 129888952
CANN: 107839152 107848011
LBB: 132609358 132645613
NTA: 107775826 107796436 107805341 107806354 107810978
NSY: 104210631 104224059 104242848
NTO: 104093154 104093687 104111265
NAU: 109229152 109237538
INI: 109155626 109182296 109184308
ITR: 115995687 116016970 116016997
SIND: 105172150 105173441
OEU: 111373253 111410770
EGT: 105952445 105963770
SSPL: 121752213 121752219 121784963 121792605 121794541 121795196 121798772
SMIL: 130999140 131015839
SHIS: 125205586 125218283 125223056
APAN: 127255177 127261055
HAN: 110864621 110873556 110931063 110937673
ECAD: 122581759 122593445 122593711 122599291
LSV: 111906043 111912885 111916924 111921407
CCAV: 112519078 112526692 112526699 112529260
DCR: 108218849 108218977
CSIN: 114262846 114272458 114285273 114299972 114311305 114319956
RVL: 131332264 131333297
AEW: 130773632 130783323 130791683 130795065
BVG: 104888560 104905215
SOE: 110777831 110789122
CQI: 110685325 110685327 110713881 110720454 110721588 110725120
ATRI: 130809856 130810412 130810413
MOF: 131165368 131165901
NNU: 104590669 104596127 104606431
MING: 122081858 122082471 122086646 122086919
TSS: 122664431 122664589 122668195 122669090
PSOM: 113274902 113304446 113322204 113326677 113332529 113332530 113345817
OSA: 4343294 4349051
OBR: 102709210 102715868
OGL: 127779981 127786234
BDI: 100838567 100844092
ATS: 109740058 109765298
TDC: 119271014 119335465 119354435 119363581
TAES: 123044809 123048050 123052611 123123205 123181203 123188587
TUA: 125509222 125509229 125537282
LPER: 127302967 127333761
LRD: 124678239 124681455 124708745
SBI: 8067080 8077468
ZMA: 100191942 100501486
MFLO: 136535171 136535695 136542340
SITA: 101754809 101758088
SVS: 117836304 117844898
PVIR: 120644448 120650587 120661403 120685343 120688565 120692869
PHAI: 112874454 112883548
PDA: 103704635 103712115
EGU: 105042873 105053894
MUS: 103989605 103990429
ZOF: 121968283 121989327 121998276 122041362 122045865 122050446
DCT: 110104377 110105405
PEQ: 110020669 110024664
AOF: 109825172 109836847
MSIN: 131231906 131232705
NCOL: 116265575 116265638
ATR: 18423085 18429109
SMO: SELMODRAFT_110809 SELMODRAFT_176472
PPP: 112288778
CRE: CHLRE_06g268750v5
MNG: MNEG_12178 MNEG_2849
CSL: COCSUDRAFT_54433
CVR: CHLNCDRAFT_136414
OLU: OSTLU_26919
OTA: OT_ostta12g02650
BPG: Bathy07g01650
MIS: MICPUN_55180(NAD-ME)
MPP: MICPUCDRAFT_43783(NADP-ME_2)
CCP: CHC_T00008878001
NGR: NAEGRDRAFT_76270 NAEGRDRAFT_81494
 » show all
Reference
1  [PMID:4399380]
  Authors
Macrae AR
  Title
Isolation and properties of a 'malic' enzyme from cauliflower bud mitochondria.
  Journal
Biochem J 122:495-501 (1971)
DOI:10.1042/bj1220495
Reference
2  [PMID:7294802]
  Authors
Grover SD, Canellas PF, Wedding RT
  Title
Purification of NAD malic enzyme from potato and investigation of some physical and kinetic properties.
  Journal
Arch Biochem Biophys 209:396-407 (1981)
DOI:10.1016/0003-9861(81)90297-6
Reference
3  [PMID:16663114]
  Authors
Wedding RT, Black MK
  Title
Physical and Kinetic Properties and Regulation of the NAD Malic Enzyme Purified from Leaves of Crassula argentea.
  Journal
Plant Physiol 72:1021-8 (1983)
DOI:10.1104/pp.72.4.1021
Reference
4  [PMID:16666776]
  Authors
Wedding RT
  Title
Malic enzymes of higher plants: characteristics, regulation, and physiological function.
  Journal
Plant Physiol 90:367-71 (1989)
DOI:10.1104/pp.90.2.367
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.39
IUBMB Enzyme Nomenclature: 1.1.1.39
ExPASy - ENZYME nomenclature database: 1.1.1.39
BRENDA, the Enzyme Database: 1.1.1.39
CAS: 9028-46-0

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