KEGG ENZYME: 1.1.1.392

ENZYME: 1.1.1.392

Entry

EC 1.1.1.392                Enzyme

Name

3alpha-hydroxycholanate dehydrogenase (NADP+);
alpha-hydroxy-cholanate dehydrogenase (ambiguous)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

lithocholate:NADP+ 3-oxidoreductase

Reaction(IUBMB)

lithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ [RN:R11145]

Reaction(KEGG)

R11145

Substrate

lithocholate [CPD:C03990];
NADP+ [CPD:C00006]

Product

3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

This bacterial enzyme is involved in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids) via a 3-oxo intermediate. The enzyme catalyses a reversible reaction in vitro. Also acts on related bile acids. cf. EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+).

History

EC 1.1.1.392 created 2016

Pathway

ec00121

Secondary bile acid biosynthesis

Orthology

K22605

3alpha-hydroxycholanate dehydrogenase (NADP+)

Genes

PLEI:

Q9312_09915

CPF: