| Entry |
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| Name |
3beta-hydroxycholanate 3-dehydrogenase (NADP+);
3beta-hydroxysteroid dehydrogenase (ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
isolithocholate:NADP+ 3-oxidoreductase
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| Reaction(IUBMB) |
isolithocholate + NADP+ = 3-oxo-5beta-cholan-24-oate + NADPH + H+ [RN: R11146]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This bacterial enzyme is involved, along with EC 1.1.1.52, 3alpha-hydroxycholanate dehydrogenase (NAD+), or EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+), in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids). The enzyme catalyses the reaction in the reduction direction in vivo. Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391, 3beta-hydroxycholanate 3-dehydrogenase (NAD+).
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| History |
EC 1.1.1.393 created 2016
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| Pathway |
| ec00121 | Secondary bile acid biosynthesis |
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| Orthology |
| K22607 | 3beta-hydroxycholanate 3-dehydrogenase (NADP+) |
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| Reference |
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| Authors |
Akao T, Akao T, Hattori M, Namba T, Kobashi K |
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| Title |
3 beta-Hydroxysteroid dehydrogenase of Ruminococcus sp. from human intestinal bacteria. |
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| Journal |
J Biochem 99:1425-31 (1986) |
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| Reference |
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| Authors |
Devlin AS, Fischbach MA |
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| Title |
A biosynthetic pathway for a prominent class of microbiota-derived bile acids. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.393 |
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