KEGG   ENZYME: 1.1.1.396Help
Entry
EC 1.1.1.396                Enzyme                                 

Name
bacteriochlorophyllide a dehydrogenase;
bchC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide-a:NAD+ oxidoreductase (bacteriochlorophyllide a-forming)
Reaction(IUBMB)
(1) 3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD+ = bacteriochlorophyllide a + NADH + H+ [RN:R09055];
(2) 3-devinyl-3-(1-hydroxyethyl)chlorophyllide a + NAD+ = 3-acetyl-3-devinylchlorophyllide a + NADH + H+
Reaction(KEGG)
Substrate
3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a [CPD:C18153];
NAD+ [CPD:C00003];
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a [CPD:C18154]
Product
bacteriochlorophyllide a [CPD:C18155];
NADH [CPD:C00004];
H+ [CPD:C00080];
3-acetyl-3-devinylchlorophyllide a
Comment
The enzyme, together with EC 1.3.7.15, chlorophyllide-a reductase, and EC 4.2.1.165, chlorophyllide-a 31-hydratase, is involved in the conversion of chlorophyllide a to bacteriochlorophyllide a. The enzymes can act in multiple orders, resulting in the formation of different intermediates, but the final product of the cumulative action of the three enzymes is always bacteriochlorophyllide a. The enzyme oxidizes a hydroxyl group on ring A, converting it to an oxo group.
History
EC 1.1.1.396 created 2016
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01110  Biosynthesis of secondary metabolites
Orthology
K11337  bacteriochlorophyllide a dehydrogenase
Genes
ALV: Alvin_2563
TVI: Thivi_2012
TMB: Thimo_3006
MPUR: MARPU_13280
TSY: THSYN_31090
HHA: Hhal_1611
HHC: M911_10355
EBS: ECTOBSL9_3047
PDQ: CL55_00013600
RAC: RA876_05995
LIM: L103DPR2_00971(yjjN)
LIH: L63ED372_00627(yjjN)
HYR: BSY239_1382(bchC)
METP: C1M51_03580(bchC)
RGE: RGE_33710(bchC)
METR: BSY238_2447(bchC)
RPOD: E0E05_11785(bchC)
AGC: BSY240_3669(bchC)
BRA: BRADO1617(bchC)
BBT: BBta_6438(bchC)
BRS: S23_19170(bchC)
AOL: S58_59190
BRO: BRAD285_5782(bchC)
BRQ: CIT40_23945(bchC)
RPA: RPA1521(bchC)
RPB: RPB_4002
RPC: RPC_1292
RPD: RPD_3757
RPE: RPE_1326
RPT: Rpal_1709
BOS: BSY19_4056(bchC)
MEX: Mext_2729
MEA: Mex_1p2926(bchC)
MDI: METDI3495(bchC)
MCH: Mchl_2956
MPO: Mpop_2851
MET: M446_3696
MOR: MOC_3184(bchC)
META: Y590_13135
MEE: DA075_03955(bchC)
METD: C0214_15300(bchC)
METS: DK389_31440(bchC)
METI: DK427_17900(bchC)
MSL: Msil_2051
RVA: Rvan_0209
BVR: BVIR_598
BLAG: BLTE_02340
MROS: EHO51_17030(bchC)
RSP: RSP_0263(bchC)
RCP: RCAP_rcc00686(bchC)
JAN: Jann_0180(bchC)
RDE: RD1_0112(bchC)
RLI: RLO149_p940150(bchC)
DSH: Dshi_3516(bchC)
PTP: RCA23_c29610(bchC)
RSU: NHU_04286(bchC)
RHC: RGUI_1962
LVS: LOKVESSMR4R_03678(lgoD)
RBG: BG454_03030(bchC)
THAA: CFI11_23545(bchC)
GEH: HYN69_05520(bchC)
TAW: EI545_18940(bchC)
NOT: C7W88_00475(bchC)
SPHI: TS85_22900
SSAN: NX02_18455
BLAS: BSY18_3554(bchC)
ERK: CD351_13865(bchC)
PHZ: CHX26_14495(bchC)
AMV: ACMV_18800(bchC)
RRU: Rru_A2981
RRF: F11_15270
RCE: RC1_2093(bchC)
RPM: RSPPHO_01501(bchC)
NCB: C0V82_18170(bchC)
ABAW: D5400_04835(bchC)
RCA: Rcas_3747
CAU: Caur_0416
CAG: Cagg_3128
CTE: CT1422(bchC)
CPC: Cpar_0742
CCH: Cag_0401
CLI: Clim_0898
PVI: Cvib_1240
PLT: Plut_1422
PPH: Ppha_0980
PAA: Paes_1534
PROC: Ptc2401_00668(yjjN)
PROS: CHL67_03605(bchC)
CTS: Ctha_2719
 » show all
Taxonomy
Reference
1  [PMID:2555268]
  Authors
Wellington CL, Beatty JT
  Title
Promoter mapping and nucleotide sequence of the bchC bacteriochlorophyll biosynthesis gene from Rhodobacter capsulatus.
  Journal
Gene 83:251-61 (1989)
DOI:10.1016/0378-1119(89)90111-X
  Sequence
Reference
2  [PMID:8437569]
  Authors
McGlynn P, Hunter CN
  Title
Genetic analysis of the bchC and bchA genes of Rhodobacter sphaeroides.
  Journal
Mol Gen Genet 236:227-34 (1993)
DOI:10.1007/BF00277117
  Sequence
[rsp:RSP_0263]
Reference
3  [PMID:26088139]
  Authors
Lange C, Kiesel S, Peters S, Virus S, Scheer H, Jahn D, Moser J
  Title
Broadened Substrate Specificity of 3-Hydroxyethyl Bacteriochlorophyllide a Dehydrogenase (BchC) Indicates a New Route for the Biosynthesis of Bacteriochlorophyll a.
  Journal
J Biol Chem 290:19697-709 (2015)
DOI:10.1074/jbc.M115.660555
  Sequence
[cte:CT1422]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.396
IUBMB Enzyme Nomenclature: 1.1.1.396
ExPASy - ENZYME nomenclature database: 1.1.1.396
BRENDA, the Enzyme Database: 1.1.1.396

DBGET integrated database retrieval system