KEGG   ENZYME: 1.1.1.397Help
Entry
EC 1.1.1.397                Enzyme                                 

Name
beta-methylindole-3-pyruvate reductase;
ind2 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate:NAD+ oxidoreductase
Reaction(IUBMB)
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate + NAD+ = (R)-3-(indol-3-yl)-2-oxobutanoate + NADH + H+ [RN:R11336]
Reaction(KEGG)
Substrate
(2S,3R)-2-hydroxy-3-(indol-3-yl)butanoate [CPD:C21288];
NAD+ [CPD:C00003]
Product
(R)-3-(indol-3-yl)-2-oxobutanoate [CPD:C21289];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Streptomyces griseus, participates in the biosynthesis of indolmycin, an antibacterial drug that inhibits the bacterial tryptophan---tRNA ligase (EC 6.1.1.2).
History
EC 1.1.1.397 created 2016
Orthology
K20939  beta-methylindole-3-pyruvate reductase
Reference
1  [PMID:25730866]
  Authors
Du YL, Alkhalaf LM, Ryan KS
  Title
In vitro reconstitution of indolmycin biosynthesis reveals the molecular basis of oxazolinone assembly.
  Journal
Proc Natl Acad Sci U S A 112:2717-22 (2015)
DOI:10.1073/pnas.1419964112
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.397
IUBMB Enzyme Nomenclature: 1.1.1.397
ExPASy - ENZYME nomenclature database: 1.1.1.397
BRENDA, the Enzyme Database: 1.1.1.397

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