KEGG   ENZYME: 1.1.1.400Help
Entry
EC 1.1.1.400                Enzyme                                 

Name
2-methyl-1,2-propanediol dehydrogenase;
mpdB (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2-methylpropane-1,2-diol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
2-methylpropane-1,2-diol + NAD+ = 2-hydroxy-2-methylpropanal + NADH + H+ [RN:R11338]
Reaction(KEGG)
Substrate
2-methylpropane-1,2-diol [CPD:C21290];
NAD+ [CPD:C00003]
Product
2-hydroxy-2-methylpropanal [CPD:C21291];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This bacterial enzyme is involved in the degradation pathways of the alkene 2-methylpropene and the fuel additive tert-butyl methyl ether (MTBE), a widely occurring groundwater contaminant.
History
EC 1.1.1.400 created 2016
Orthology
K20927  2-methyl-1,2-propanediol dehydrogenase
Genes
AHT: ANTHELSMS3_05160
PNP: IJ22_15610
MVQ: MYVA_3535
BSD: BLASA_1405(mpdB)
PSEA: WY02_10395
PSEE: FRP1_03830
PSEQ: AD006_11490
PECQ: AD017_19320
PHH: AFB00_04315
RRD: RradSPS_2609
Taxonomy
Reference
1  [PMID:16622053]
  Authors
Lopes Ferreira N, Labbe D, Monot F, Fayolle-Guichard F, Greer CW
  Title
Genes involved in the methyl tert-butyl ether (MTBE) metabolic pathway of Mycobacterium austroafricanum IFP 2012.
  Journal
Microbiology 152:1361-74 (2006)
DOI:10.1099/mic.0.28585-0
  Sequence
Reference
2  [PMID:25576605]
  Authors
Kottegoda S, Waligora E, Hyman M
  Title
Metabolism of 2-methylpropene (isobutylene) by the aerobic bacterium Mycobacterium sp. strain ELW1.
  Journal
Appl Environ Microbiol 81:1966-76 (2015)
DOI:10.1128/AEM.03103-14
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.400
IUBMB Enzyme Nomenclature: 1.1.1.400
ExPASy - ENZYME nomenclature database: 1.1.1.400
BRENDA, the Enzyme Database: 1.1.1.400

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