KEGG   ENZYME: 1.1.1.404Help
Entry
EC 1.1.1.404                Enzyme                                 

Name
tetrachlorobenzoquinone reductase;
pcpD (gene name);
TCBQ reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase
Reaction(IUBMB)
2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ [RN:R11585]
Reaction(KEGG)
Substrate
2,3,5,6-tetrachlorohydroquinone [CPD:C03434];
NAD+ [CPD:C00003]
Product
2,3,5,6-tetrachloro-1,4-benzoquinone [CPD:C18933];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol.
History
EC 1.1.1.404 created 2017
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21607  tetrachlorobenzoquinone reductase
Genes
SOD: Sant_1981
PAO: Pat9b_4735
TCI: A7K98_17460
PAE: PA3498
PAEV: N297_3621
PAEI: N296_3621
PNC: NCGM2_5295
PAEB: NCGM1900_0866
PAEM: U769_04370
PAEL: T223_04310
PAEC: M802_3620
PAEO: M801_3486
PCQ: PcP3B5_07920(pobB_1) PcP3B5_28850(pobB_3)
PFC: PflA506_5354(vanB)
PSIL: PMA3_18885
AAUS: EP12_19110
AXE: P40_21510
RPI: Rpic_4500
REH: H16_B0739(h16_B0739)
RME: Rmet_5549(pobB)
BCEN: DM39_1986
BXE: Bxe_B2369
BXB: DR64_4701
PPNO: DA70_10510
PPNM: LV28_20550
PPUL: RO07_06165
PAPI: SG18_14725
BAV: BAV0615
BHZ: ACR54_03867(pobB)
POL: Bpro_3680
VEI: Veis_2771
DAC: Daci_0965
MMS: mma_2506
CARE: LT85_0544
AOL: S58_21520
HMC: HYPMC_3536(pobB)
CID: P73_2874
SMAZ: LH19_26280
SPHI: TS85_13180
SSAN: NX02_22630
SPHR: BSY17_2022
SPHT: K426_02680
AAY: WYH_01862(pobB_1) WYH_03339(pobB_2)
GOR: KTR9_4397
GOM: D7316_03931(pobB_3)
SBH: SBI_09770
 » show all
Taxonomy
Reference
1  [PMID:19325743]
  Authors
Chen L, Yang J
  Title
Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.
  Journal
Int J Mol Sci 9:198-212 (2008)
Reference
2  [PMID:23676275]
  Authors
Yadid I, Rudolph J, Hlouchova K, Copley SD
  Title
Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.
  Journal
Proc Natl Acad Sci U S A 110:E2182-90 (2013)
DOI:10.1073/pnas.1214052110
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.404
IUBMB Enzyme Nomenclature: 1.1.1.404
ExPASy - ENZYME nomenclature database: 1.1.1.404
BRENDA, the Enzyme Database: 1.1.1.404

DBGET integrated database retrieval system