KEGG   ENZYME: 1.1.1.406Help
Entry
EC 1.1.1.406                Enzyme                                 

Name
galactitol 2-dehydrogenase (L-tagatose-forming);
GatDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
galactitol:NAD+ 2-oxidoreductase (L-tagatose-forming)
Reaction(IUBMB)
galactitol + NAD+ = L-tagatose + NADH + H+ [RN:R11637]
Reaction(KEGG)
Substrate
galactitol [CPD:C01697];
NAD+ [CPD:C00003]
Product
L-tagatose [CPD:C21523];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized in the bacterium Rhodobacter sphaeroides, has a wide subtrate specificity. In addition to galactitol, it primarily oxidizes D-threitol and xylitol, and in addition to L-tagatose, it primarily reduces L-erythrulose, D-ribulose and L-glyceraldehyde. It is specific for NAD+. The enzyme also shows activity with D-tagatose (cf. EC 1.1.1.16, galactitol 2-dehydrogenase).
History
EC 1.1.1.406 created 2017
Orthology
K21702  galactitol 2-dehydrogenase (L-tagatose-forming)
Genes
RSP: RSP_2363
RSH: Rsph17029_1024
RSK: RSKD131_0675
Taxonomy
Reference
1  [PMID:7551050]
  Authors
Schneider KH, Jakel G, Hoffmann R, Giffhorn F
  Title
Enzyme evolution in Rhodobacter sphaeroides: selection of a mutant expressing a new galactitol dehydrogenase and biochemical characterization of the enzyme.
  Journal
Microbiology 141 ( Pt 8):1865-73 (1995)
DOI:10.1099/13500872-141-8-1865
Reference
2  [PMID:20410293]
  Authors
Carius Y, Christian H, Faust A, Zander U, Klink BU, Kornberger P, Kohring GW, Giffhorn F, Scheidig AJ
  Title
Structural insight into substrate differentiation of the sugar-metabolizing enzyme galactitol dehydrogenase from Rhodobacter sphaeroides D.
  Journal
J Biol Chem 285:20006-14 (2010)
DOI:10.1074/jbc.M110.113738
  Sequence
[rsp:RSP_2363]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.406
IUBMB Enzyme Nomenclature: 1.1.1.406
ExPASy - ENZYME nomenclature database: 1.1.1.406
BRENDA, the Enzyme Database: 1.1.1.406

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