Entry |
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Name |
4-phospho-D-threonate 3-dehydrogenase;
pdxA2 (gene name) (ambiguous)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
4-phospho-D-threonate:NAD+ 3-oxidoreductase
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Reaction(IUBMB) |
4-phospho-D-threonate + NAD+ = glycerone phosphate + CO2 + NADH + H+ (overall reaction) [RN: R11724];
(1a) 4-phospho-D-threonate + NAD+ = 3-dehydro-4-phospho-D-erythronate + NADH + H+;
(1b) 3-dehydro-4-phospho-D-erythronate = glycerone phosphate + CO2 (spontaneous)
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Reaction(KEGG) |
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Substrate |
4-phospho-D-threonate [CPD: C21585];
NAD+ [CPD: C00003];
3-dehydro-4-phospho-D-erythronate [CPD: C21610]
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Product |
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Comment |
The enzyme, characterized from bacteria, is involved in a pathway for D-threonate catabolism.
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History |
EC 1.1.1.408 created 2017
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Orthology |
K22024 | 4-phospho-D-threonate 3-dehydrogenase / 4-phospho-D-erythronate 3-dehydrogenase |
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Genes |
ECOI: | ECOPMV1_00694(pdxA2) |
SEM: | STMDT12_C01640(pdxA2) |
SETC: | CFSAN001921_16595(pdxA) |
SEEN: | SE451236_06835(pdxA) |
SENH: | CFSAN002069_08365(pdxA) |
SEEH: | SEEH1578_09895(pdxA) |
SENJ: | CFSAN001992_10180(pdxA) |
SEEC: | CFSAN002050_07310(pdxA) |
SEEB: | SEEB0189_018525(pdxA) |
SENC: | SEET0819_07710(pdxA) |
KPU: | KP1_2115 KP1_2670(pdxA) |
KPZ: | KPNIH27_09455(pdxA) KPNIH27_12435(pdxA) |
KPY: | KPNIH31_09905(pdxA) KPNIH31_12315(pdxA) |
KPT: | VK055_0860(pdxA) VK055_1342(pdxA3) |
KPO: | KPN2242_08670(pdxA) KPN2242_11020(pdxA) |
KPR: | KPR_2164 KPR_2528(pdxA2) |
KPI: | D364_05815(pdxA) D364_08330(pdxA) |
KPX: | PMK1_03460(pdxA2_1) PMK1_03959(pdxA2_2) |
KPNK: | BN49_2208 BN49_2734(pdxA2) |
KVQ: | SP68_01640 SP68_24145 |
KOX: | KOX_11095(pdxA) KOX_17445(pdxA) |
KOE: | A225_0928 A225_2342 A225_3116 |
KOY: | J415_20095(pdxA) J415_26615(pdxA) |
KOM: | HR38_09825(pdxA) HR38_15980(pdxA) |
KOK: | KONIH1_04830(pdxA) KONIH1_11465(pdxA) |
KQV: | B8P98_14300(pdxA) B8P98_17625 |
KLL: | BJF97_05370 BJF97_11735 |
KLW: | DA718_13835 DA718_17065(pdxA) |
KAR: | LGL98_13030 LGL98_15615(pdxA) |
REE: | electrica_03132(pdxA2_1) electrica_03426(pdxA2_2) electrica_04211(pdxA2_3) |
RPLN: | B1209_18255 B1209_22535 |
RTG: | NCTC13098_06158(pdxA2) |
PGE: | LG71_03885(pdxA) LG71_22075(pdxA) |
KOU: | C0557_09380 C0557_11295(pdxA) |
AHN: | NCTC12129_00915(pdxA_1) |
KIN: | AB182_11690(pdxA) AB182_28825(pdxA) |
METY: | MRY16398_27450(pdxA) |
IZH: | FEM41_08400(pdxA) FEM41_09750 |
PSGC: | G163CM_12470(pdxA2) |
SOF: | NCTC11214_02615(pdxA2) |
GQU: | AWC35_13995(pdxA) AWC35_18690(pdxA) |
SERA: | Ser39006_006345(pdxA) |
PWA: | Pecwa_0987 Pecwa_3706 |
PPAR: | A8F97_00135 A8F97_14000 |
PBRA: | B5S52_03825 B5S52_17810 |
PPOO: | LW347_04105(pdxA) LW347_17935 |
CED: | LH89_02195(pdxA) LH89_16275(pdxA) |
DFN: | CVE23_10575 CVE23_18650(pdxA) |
DDA: | Dd703_0692 Dd703_2154 |
SLIG: | GTU79_04320 GTU79_10210 GTU79_13070 |
PLF: | PANA5342_p10089(pdxA2) |
PAGG: | AL522_00720 AL522_07760 |
MTHI: | C7M52_01832(pdxA2_1) C7M52_02633(pdxA2_2) |
PMAK: | PMPD1_2703 PMPD1_2804 |
PFQ: | QQ39_07690(pdxA) QQ39_15125(pdxA) |
LRI: | NCTC12151_01094(pdxA2_1) NCTC12151_03011(pdxA2_3) NCTC12151_03394(pdxA2_4) |
LGB: | V8L73_15850(pdxA) V8L73_18010(pdxA) |
MSU: | MS0066(pdxA) MS0381(pdxA) |
BSUN: | A4G13_09130 A4G13_10295 |
VIB: | VspSTUT11_30610(pdxA_2) |
HAAH: | HALA3H3_510100(pdxA) HALA3H3_790076(pdxA) |
HTT: | HZS52_09005(pdxA) HZS52_13685(pdxA) |
GAQ: | RAM11_05265(pdxA) RAM11_08260(pdxA) |
ORB: | IPMB12_05480(pdxA) IPMB12_07400(pdxA) |
BUE: | BRPE67_DCDS02110(pdxA) |
PLAD: | PPGU16_67290(pdxA_2) |
PANN: | PanNE5_00740(pdxA_1) |
BTRM: | SAMEA390648701898(pdxA1) |
AXX: | ERS451415_04387(pdxA2_3) |
SMEL: | SM2011_b20146(pdxA2) |
SFD: | USDA257_c12620(pdxA3) |
SAME: | SAMCFNEI73_pC1136(pdxA) |
ALF: | CFBP5473_19950(pdxA) |
ASAL: | CFBP5507_18975(pdxA) |
RPUS: | CFBP5875_19040(pdxA) |
ALEG: | CFBP4996_19150(pdxA) |
REC: | RHECIAT_PC0000324(pdxAc) |
REL: | REMIM1_PA00031(pdxA-2) |
REP: | IE4803_PD00338(pdxA-2) |
REI: | IE4771_PE00353(pdxA-2) |
RGA: | RGR602_PC02257(pdxA-4) |
RHN: | AMJ98_PE00140(pdxA-2) |
RPHA: | AMC79_PD00347(pdxA-2) |
RHX: | AMK02_PA00027(pdxA-2) |
RHK: | Kim5_PD00314(pdxA-3) |
REZ: | AMJ99_PD00141(pdxA-2) |
RLW: | RlegWSM1455_31875(pdxA) |
RBW: | RLCC275e_31560(pdxA) |
NEN: | NCHU2750_32640(pdxA) |
MNO: | Mnod_1465 Mnod_8127 Mnod_8220 |
MAQU: | Maq22A_1p33465(pdxA) Maq22A_1p37920(pdxA) |
MMES: | MMSR116_09930(pdxA) |
MIND: | mvi_35260(pdxA_1) mvi_57090(pdxA1) |
MMED: | Mame_01849(pdxA2_2) |
SALO: | EF888_12915(pdxA) EF888_15830(pdxA) |
RAP: | RHOA_2658(pdxA) RHOA_4449(pdxA) |
AZZ: | DEW08_19515(pdxA) DEW08_27560(pdxA) |
BSON: | S101395_01353(pdxA) |
BGY: | BGLY_3555 BGLY_4093(pdxA) |
BLE: | BleG1_0287 BleG1_2822 |
SHUA: | PQ477_02165(pdxA) PQ477_09860(pdxA) |
OJD: | NP439_11215(pdxA) NP439_23565(pdxA) |
PCAL: | BV455_00367(pdxA2_1) BV455_02003(pdxA2_2) |
PARG: | PspKH34_23790(pdxA_1) PspKH34_36340(pdxA_2) |
HSAN: | MUN89_03235(pdxA) MUN89_06045(pdxA) |
HAMY: | MUO15_17925(pdxA) MUO15_18315(pdxA) |
TAP: | GZ22_12740(pdxA) GZ22_16805 |
BMUR: | ABE28_001640 ABE28_017150 |
SCIB: | HUG20_02465(pdxA) HUG20_02580(pdxA) |
BLEN: | NCTC4824_01890(pdxA) |
LGZ: | NCTC10812_01011(pdxA2) |
BAYD: | BSPP4475_15635(pdxA) |
ADAU: | NZD86_18740(pdxA) NZD86_19320(pdxA) NZD86_23280(pdxA) NZD86_23745(pdxA) |
ACYC: | JI721_04965(pdxA) JI721_10495(pdxA) |
SPOR: | SporoP33_06890(pdxA) |
KEB: | GXN75_03575(pdxA) GXN75_10350(pdxA) |
SURN: | NCTC13766_01484(pdxA2) |
CLJ: | CLJU_c03850(pdxA) CLJU_c38400 |
CACE: | CACET_c08840(pdxA1) CACET_c19140(pdxA2) |
CFM: | BJL90_04885 BJL90_10465 |
OVA: | OBV_34520(pdxA) OBV_43810(pdxA) |
PFAA: | MM59RIKEN_13140(pdxA) |
VFA: | MM35RIKEN_03490(pdxA) |
PETR: | QKW49_13070(pdxA) QKW49_19570(pdxA) |
AACX: | DEACI_3880 DEACI_3881 |
EMT: | CPZ25_000950 CPZ25_002740(pdxA) |
ELIM: | B2M23_14775 B2M23_16950 |
THEF: | E1B22_01420(pdxA) E1B22_01575(pdxA) |
BPRO: | PMF13cell1_02617(pdxA2) |
LACY: | A4V08_10345 A4V08_22385 A4V08_24335 |
CSCI: | HDCHBGLK_03263(pdxA2) |
CHYL: | CE91St63_12990(pdxA_1) CE91St63_30710(pdxA_2) |
ANR: | Ana3638_13990(pdxA) Ana3638_22700(pdxA) |
ACHT: | bsdcttw_01070(pdxA) |
CBOL: | CGC65_04980(pdxA) CGC65_09955(pdxA) |
CASP: | NQ535_02270(pdxA) NQ535_11980(pdxA) NQ535_20360(pdxA) |
HHJ: | NQ487_22420(pdxA) NQ487_25390(pdxA) |
VGU: | HYG85_03630(pdxA) HYG85_04345(pdxA) |
MTHO: | MOTHE_c06670(pdxA2) |
MTHZ: | MOTHA_c07620(pdxA2) |
HALS: | D7D81_02110(pdxA) D7D81_02310(pdxA) |
STED: | SPTER_35230(pdxA2_2) |
SSPH: | SPSPH_035950(pdxA2_1) |
SSID: | SPSIL_004990(pdxA2) |
RQI: | C1M55_02950(pdxA) C1M55_03020(pdxA) |
RANT: | RHODO2019_18495(pdxA) |
SMAL: | SMALA_6924 SMALA_7856 |
SSOI: | I1A49_38395(pdxA) I1A49_43120(pdxA) |
STRC: | AA958_02460(pdxA) AA958_27200 |
SBAT: | G4Z16_01765 G4Z16_01770(pdxA) G4Z16_07470(pdxA) |
SARM: | DVA86_16665(pdxA) DVA86_22890(pdxA) |
BLIN: | BLSMQ_0740 BLSMQ_1374 |
BSPO: | L1F31_04015(pdxA) L1F31_06705(pdxA) |
BREB: | PGC08_03975(pdxA) PGC08_07060(pdxA) |
PAUS: | NCTC13651_02085(pdxA2) |
RAIN: | Rai3103_05845(pdxA) |
NRO: | K8W59_01020(pdxA) K8W59_06645(pdxA) |
NAKE: | KGD83_12545(pdxA) KGD83_13270(pdxA) |
SEN: | SACE_3460(pdxA) SACE_4548(pdxA3) |
AHM: | TL08_00895 TL08_04475 TL08_08630 |
ACTI: | UA75_00915 UA75_04520 UA75_08665 |
ACAD: | UA74_00915 UA74_04415 UA74_08695 |
AHG: | AHOG_00885(pdxA1) AHOG_04275(pdxA2) AHOG_08155(pdxA3) |
PMAD: | BAY61_14555 BAY61_25040 |
BALA: | DSM104299_03617(pdxA2) |
LMAJ: | GKN94_04240(pdxA) GKN94_08830(pdxA) |
PBP: | STSP1_01118(pdxA2_2) |
TSK: | HRI97_00600(pdxA) HRI97_08970(pdxA) |
TAZ: | TREAZ_1188(pdxA_1) TREAZ_3636(pdxA_2) |
TALB: | FTW19_07875(pdxA) FTW19_15085(pdxA) |
LUB: | TBR22_A22020(pdxA_1) |
FVA: | FV113G1_29370(pdxA2) |
PSPC: | Strain318_001995(pdxA) |
CPO: | COPRO5265_0183(pdxA) |
SRUB: | C2R22_00765(pdxA) C2R22_15145(pdxA) |
» show all
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Reference |
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Authors |
Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crecy-Lagard V, Jacobson MP, Almo SC, Gerlt JA |
Title |
Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.408 |
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