KEGG   ENZYME: 1.1.1.412Help
Entry
EC 1.1.1.412                Enzyme                                 

Name
2-alkyl-3-oxoalkanoate reductase;
oleD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(2R,3S)-2-alkyl-3-hydroxyalkanoate:NADP+ oxidoreductase
Reaction(IUBMB)
a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+ = an (R)-2-alkyl-3-oxoalkanoate + NADPH + H+ [RN:R11774]
Reaction(KEGG)
Substrate
(2R,3S)-2-alkyl-3-hydroxyalkanoate [CPD:C21645];
NADP+ [CPD:C00006]
Product
(R)-2-alkyl-3-oxoalkanoate [CPD:C21651];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, found in certain bacterial species, is part of a pathway for the production of olefins.
History
EC 1.1.1.412 created 2017
Orthology
K22320  2-alkyl-3-oxoalkanoate reductase
Genes
XFA: XF_1825
XFT: PD_1041(wcaG)
XFM: Xfasm12_1198
XFN: XfasM23_1105
XFF: XFLM_10955
XFL: P303_09120
XFS: D934_07450
XFH: XFHB_06190
XTW: AB672_05980
XCC: XCC0219(cdh)
XCB: XC_0229
XCP: XCR_4304
XCV: XCV0244(cdh1)
XAX: XACM_0224(cdh)
XAC: XAC0238(cdh)
XCI: XCAW_00636(wcaG)
XOO: XOO4216(cdh)
XOM: XOO3985(XOO3985)
XOP: PXO_03949
XOR: XOC_0334
XAL: XALC_3068
XPH: XppCFBP6546_10725(XppCFBP6546P_10725)
SML: Smlt0209
SMT: Smal_0171
SMZ: SMD_0179
PSUW: WQ53_07280
PSD: DSC_15425
LEZ: GLE_0204
LEM: LEN_4732
DKO: I596_3755
PPR: PBPRA1465(PD1041)
SON: SO_1745(oleD)
SDN: Sden_1372
SFR: Sfri_1368
SAZ: Sama_1185
SBL: Sbal_1553
SLO: Shew_1716
SSE: Ssed_1513
SPL: Spea_2733
SHL: Shal_2817
SWD: Swoo_3156
SWP: swp_3333
SVO: SVI_3042
SPSW: Sps_01974
CPS: CPS_2156
PIN: Ping_2000
MYA: MORIYA_1233(oleD)
MMAI: sS8_0068
GUR: Gura_2007
GLO: Glov_2272
GBM: Gbem_2099
GEO: Geob_3152
GEM: GM21_2119
GEB: GM18_2133
PPD: Ppro_3118
DES: DSOUD_2643(hpnA)
DPS: DP2630
DSF: UWK_02994
DOL: Dole_2011
BMX: BMS_1438
SCT: SCAT_2186
SVE: SVEN_5970
STRM: M444_36345
STRD: NI25_18845
KSK: KSE_01040t(ksbS1L) KSE_44610(ksbS5) KSE_75700t(ksbS1R)
CMI: CMM_2153
CMS: CMS1846
CMC: CMN_02120
MTS: MTES_0537
ARM: ART_1190
AAU: AAur_2000
ACH: Achl_0448
KRH: KRH_10500
IDO: I598_2612
SERJ: SGUI_1321
BLIN: BLSMQ_3615
MPH: MLP_50970
NDK: I601_0264
NML: Namu_4242
GOB: Gobs_2461
MMAR: MODMU_2227
KRA: Krad_1680
ASE: ACPL_1982(cdh2)
ACTS: ACWT_1860
CAU: Caur_3530
CAG: Cagg_0549
OTE: Oter_0857
CAA: Caka_2479
RBA: RB993
PSL: Psta_4275
PLM: Plim_1635
RUL: UC8_57180
IPA: Isop_1049
SACI: Sinac_3643
 » show all
Taxonomy
Reference
1  [PMID:21958090]
  Authors
Bonnett SA, Papireddy K, Higgins S, del Cardayre S, Reynolds KA
  Title
Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia.
  Journal
Biochemistry 50:9633-40 (2011)
DOI:10.1021/bi201096w
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.412
IUBMB Enzyme Nomenclature: 1.1.1.412
ExPASy - ENZYME nomenclature database: 1.1.1.412
BRENDA, the Enzyme Database: 1.1.1.412

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