KEGG   ENZYME: 1.1.1.412
Entry
EC 1.1.1.412                Enzyme                                 
Name
2-alkyl-3-oxoalkanoate reductase;
oleD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2R,3S)-2-alkyl-3-hydroxyalkanoate:NADP+ oxidoreductase
Reaction(IUBMB)
a (2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+ = an (R)-2-alkyl-3-oxoalkanoate + NADPH + H+ [RN:R11774]
Reaction(KEGG)
R11774
Substrate
(2R,3S)-2-alkyl-3-hydroxyalkanoate [CPD:C21645];
NADP+ [CPD:C00006]
Product
(R)-2-alkyl-3-oxoalkanoate [CPD:C21651];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, found in certain bacterial species, is part of a pathway for the production of olefins.
History
EC 1.1.1.412 created 2017
Orthology
K22320  2-alkyl-3-oxoalkanoate reductase
Genes
XFAXF_1825
XFTPD_1041(wcaG)
XFMXfasm12_1198
XFNXfasM23_1105
XFFXFLM_10955
XFLP303_09120
XFSD934_07450
XFHXFHB_06190
XTWAB672_05980
XCCXCC0219(cdh)
XCBXC_0229
XCAxcc-b100_0241
XCPXCR_4304
XCVXCV0244(cdh1)
XAXXACM_0224(cdh)
XACXAC0238(cdh)
XCIXCAW_00636(wcaG)
XCTJ151_00356
XCJJ158_00354
XCUJ159_00354
XCNJ169_00352
XCWJ162_00353
XCRJ163_00353
XCMJ164_00353
XCFJ172_00347
XFUXFF4834R_chr02110
XAOXAC29_01225
XOMXOO3985(XOO3985)
XOOXOO4216(cdh)
XOPPXO_03949
XOYAZ54_02860
XORXOC_0334
XOZBE73_22740
XALXALC_3068
XSASB85_13825
XTNFD63_01135
XFRBER92_17845
XVEBJD12_13765
XPEBJD13_15860
XHRXJ27_16885
XGABI317_23575
XPHXppCFBP6546_10725(XppCFBP6546P_10725)
XVAC7V42_01025
XANAC801_01015
XARXB05_17885
XHYFZ025_08630
XCZEBN15_19060
XTHG4Q83_18980
XEUXSP_000240
XHDLMG31886_02600(oleD_1)
XPRMUG10_09130
SMLSmlt0209
SMTSmal_0171
BUJBurJV3_0163
SMZSMD_0179
SACZAOT14_35090
STEKAXG53_15305
SRHBAY15_0302
SLMBIZ42_10305
STENCCR98_00920
STEMCLM74_00930
STESMG068_00785
SINCDAIF1_01830(oleD)
SPAQSTNY_R02130
PSUPsesu_0126
PSUWWQ53_07280
PSDDSC_15425
PMEXH4W19_13915
PJPLAG73_18685
PDDMNQ95_05835
LABLA76x_4681
LAQGLA29479_4478
LCPLC55x_0361
LGULG3211_0385
LEZGLE_0204
LEMLEN_4732
LMBC9I47_0308
LYTDWG18_14365
LYJFKV23_00860
LSOLGOY17_18035
LSXH8B22_06700
LAREHIV01_014690
LHXLYSHEL_13670(cdh)
LCASLYSCAS_13670(cdh)
LCICINQ41_12555
LAVIINQ42_12185
LLZLYB30171_00153(oleD)
LUMCNR27_02285
LUSE5843_01185
LUGFPZ22_06715
THESFHQ07_09330
THEHG7079_01945
TBVH9L17_09855
DKOI596_3755
XBAC7S18_19050
PPRPBPRA1465(PD1041)
SONSO_1745(oleD)
SDNSden_1372
SFRSfri_1368
SAZSama_1185
SBLSbal_1553
SBMShew185_1549
SBNSbal195_1583
SBPSbal223_2797
SBTSbal678_1620
SBSSbal117_1660
SBBSbal175_2779
SLOShew_1716
SPCSputcn32_1448
SHPSput200_1461
SSESsed_1513
SPLSpea_2733
SHEShewmr4_2545
SHMShewmr7_2612
SHNShewana3_2712
SHWSputw3181_2651
SHLShal_2817
SWDSwoo_3156
SWPswp_3333
SVOSVI_3042
SHFCEQ32_07530
SJASJ2017_1518
SPSWSps_01974
SBJCF168_07320
SMAVCFF01_10780
SHEWCKQ84_00020
SALGBS332_15310
SLJEGC82_14485
SMAIEXU30_02215
SPOLFH971_12830
SBKSHEWBE_2084(oleD)
SKHSTH12_00744
SAESHBH39_06155
SLITJQC75_05810
SCAATUM17387_25550(oleD)
SPSHFM037_19435
SEURFM038_007260
SCYPJYB88_06045
SSEMJYB85_06340
SGLAFJ709_06005
SINVK8B83_10020
SXMMKD32_13210
SVMKDH10_001504
CPSCPS_2156
COMCMT41_10370
PINPing_2000
PSYPCNPT3_05855
MYAMORIYA_1233(oleD)
WMAWM2015_505
WEZIC757_02575
GAIIMCC3135_24170
KAKKalk_10390
OAIOLEAN_C17430
GEMGM21_2119
GEBGM18_2133
GURGura_2007
GEOGeob_3152
GLOGlov_2272
GBMGbem_2099
GBNGEOBRER4_19290(cdh)
GERKP004_09500
GSUBKP001_05695
GNTKP003_08905
GPLM1B72_11270
PPDPpro_3118
DESDSOUD_2643(hpnA)
DPSDP2630
DSFUWK_02994
DPRDespr_2658
DEOCAY53_08370
DOGHP555_05665
DBKDGMP_15660
DOLDole_2011 Dole_2608
DMLDmul_23330
DATHRM2_32770
DTOTOL2_C30090
DOVDSCO28_06010(oleD)
DWDDSCW_10500(oleD)
DALKDSCA_08760(oleD)
DLIdnl_18040
DMMdnm_089060
VINAKJ08_2417
SAMYDB32_000492 DB32_004413
BBAEFRD01_11225
BMXBMS_1438
HAXBALOs_1697
BSTOC0V70_08405
NFANFA_34580
NFRERS450000_00591
NCYNOCYR_2358
NBRO3I_027210
NNONONO_c19410
NSLBOX37_16885
NSRNS506_01609 NS506_05576
NTPCRH09_11575 CRH09_29065
NOZDMB37_06265
NODFOH10_01635 FOH10_07000
NAHF5544_27080
NADNCTC11293_03165 NCTC11293_05892
NIEKV110_26600
NTCKHQ06_10835 KHQ06_28985
NHUH0264_10040 H0264_35195
NYALTV02_22800
NGPLTT66_26460
RHWBFN03_19160
RTMG4H71_11415
GITC6V83_16550
SAMBSAM23877_7349
SGVB1H19_06245
SLKSLUN_02585
STIRDDW44_00200
SGZC0216_32120
SHAWCEB94_37335
SSPODDQ41_00080
SPADDVK44_04255
SPACB1H29_01565
SCOECP976_38580
SVDCP969_29060
KITCFP65_7007
STRIC7M71_028205
LXLKDY119_02265
PSICJ4E96_06845
CMICMM_2153
CMSCMS1846
CMCCMN_02120
CMHVO01_10015
CCAPAES38_10515
CZHH9X71_10910
CPHAFGI33_02340
MTSMTES_0537
MCWA8L33_02700
MPALBO218_00775
MIHBJP65_04550
MLVCVS47_00574
MWAE4K62_15625
MLZF6J85_14995
MCHNHCR76_03800
MICSC1N74_10470
RTXTI83_10135
RTCAPU90_06925
RTNA6122_2396
RRYC1O28_10930
RIAC7V51_14970
RFSC1I64_12800
RTEGSU10_02660
CUMNI26_13030
CUBBJK06_11655
CUGC1N91_13445
CQFGBG65_03445
FRPAX769_07000
CARTPA27867_0154
CRYB7495_00680
MALKMalAC0309_0665
MYLC3E77_02035
SALAESZ53_01595
SALDFVA74_09110
PLAPEAO79_05145
AGGC1N71_09010
MANTBHD05_11885
FRNF1C15_06380
AGXAGREI_0632(oleD)
SUBTKPL76_12530
SUBALQ955_04755
ARRARUE_c21530
ARMART_1190
ARLAFL94_04860
AREAL755_14785
AAQAOC05_09360
ARWMB46_09745
ARYATC04_12990
ACRYAC20117_20165
ARTPE5206_10065
AAGINCTC2676_1_01689
AJGKKR91_11280
ASUNKG104_12085
ASUFMNQ99_08595
AAUAAur_2000
PNVJMY29_09455
ACHAchl_0448
PSNINIBR502771_13165
AAIAARI_10550
GARAOZ07_05525
GCRGcLGCM259_0858
GLUF0M17_05200
GPRJQN66_05300
GMINMP99_05685
KRHKRH_10500
KPLKPaMU14_04545
KFVAS188_12310
KIIKocCE7_05285
KRSEQG70_07610
KODHBK84_05445
KVRCIB50_0002124
MLUMlut_13250
MICKB1A86_00006580
MYUM8233_06350
RMURMDY18_08240
RDNHMPREF0733_12129
RAJRA11412_2079
RTERIDM49_05040
RAMAIDM48_05215
RKRI6G21_10210
SATKSA2016_3973
NAEBHE16_01720
AULDCC27_004465
PAEYKUF55_10285
BFABfae_17440
BRXBH708_04340
BRVCFK39_01155
BGGCFK41_08050
BRZCFK38_10150
BSAUDWV08_06120
BRRC1N80_10330
DVADAD186_09760
DJJCOP05_06020
KSEKsed_07140
IVAIsova_0151
IDOI598_2612
SKESked_36590
CELZE5225_13965
CEJGC089_14705
SERJSGUI_1321
SERWFY030_02620
ORNDV701_15450
ORZFNH13_16515
BLYA2T55_16620
BLINBLSMQ_3615
BRIFDF13_04810
BLUTEW640_09560
BCAUI6G59_02575
DCOSAMEA4475696_0222
GEZFE251_10280
GYUFE374_10100
RHALLQF10_10375
RSUALQF12_09170
MPHMLP_50970
MIKFOE78_05615
NMESH9L09_18020
NAQUENKNEFLB_01766(oleD_1)
ACTWF7P10_02420
NOABKM31_45970
NOWGBF35_34580
NCXNocox_12440
NGNLCN96_30345
NMLNamu_4242
NAKEH165_06750
GOBGobs_2461
MMARMODMU_2227
KRAKrad_1680
SSYIEKG83_13720
MCRAID554_00405
VERHUT12_12055
AYMYM304_23890
CAUCaur_3530
CHLChy400_3807
CAGCagg_0549
OTEOter_0857
OBGVerru16b_01070
VBHCMV30_08435
OLEK0B96_17290
OBTOPIT5_14965
CAACaka_2479
RUFIK0V07_03235
VBAIMCC26134_13700
RBARB993
PSLPsta_4275
PIRVN12_21925
RULUC8_57180
RMLFF011L_06520
MFFMFFC18_28900
ROLCA51_14280
AHELQ31a_02890
LCREPla8534_57740
AAGGETAA8_54930
BVOPan97_33050
RLCK227x_52910
LPAVPLANPX_1006
AMUCPan181_45060
PNDPla175_41190
AMOBHG15A2_09780
PLMPlim_1635
PEHSpb1_24870
PBSPlabr_4646
PLSVT03_24205
PLHVT85_06215
FMRFuma_02449
GMRGmarT_20660
GIMF1728_04055
GPNPan110_20030
MRIMal4_13120
SDYNMal52_34850
PLONPla110_31370
GESVT84_31310
GOGC1280_33745
GMSSOIL9_84930
TIMGMBLW1_07530
LRSPX52LOC_02052
FTJFTUN_1522
ULIETAA1_49630
TSPHKIH39_05435
IPAIsop_1049
SACISinac_3643
PBORBSF38_04649
AGVOJF2_56810
UAMUABAM_06730
SCORJ3U87_03675
NLIG3M70_16670
 » show all
Reference
1  [PMID:21958090]
  Authors
Bonnett SA, Papireddy K, Higgins S, del Cardayre S, Reynolds KA
  Title
Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia.
  Journal
Biochemistry 50:9633-40 (2011)
DOI:10.1021/bi201096w
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.412
IUBMB Enzyme Nomenclature: 1.1.1.412
ExPASy - ENZYME nomenclature database: 1.1.1.412
BRENDA, the Enzyme Database: 1.1.1.412

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