KEGG   ENZYME: 1.1.1.413Help
Entry
EC 1.1.1.413                Enzyme                                 

Name
A-factor type gamma-butyrolactone 1'-reductase (1S-forming);
barS1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase
Reaction(IUBMB)
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ [RN:R11776]
Reaction(KEGG)
Substrate
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one [CPD:C21666];
NADP+ [CPD:C00006]
Product
(3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one [CPD:C21668];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.
History
EC 1.1.1.413 created 2017
Orthology
K22322  A-factor type gamma-butyrolactone 1'-reductase (1S-forming)
Genes
SCB: SCAB_12071
SSX: SACTE_3174
SFA: Sfla_3301
SHY: SHJG_8653
SHO: SHJGH_8413
SDV: BN159_4441
STRP: F750_3442
SALU: DC74_7609
SALL: SAZ_39260
SGU: SGLAU_25510
STRE: GZL_00105
SLD: T261_2142
STRM: M444_36570
SRW: TUE45_pSRc_0612(linC)
SLE: sle_45930(sle_45930)
SRN: A4G23_05427(linC_2)
SLAU: SLA_3027
SALJ: SMD11_6028
 » show all
Taxonomy
Reference
1  [PMID:12193632]
  Authors
Shikura N, Yamamura J, Nihira T
  Title
barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species.
  Journal
J Bacteriol 184:5151-7 (2002)
DOI:10.1128/JB.184.18.5151-5157.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.413
IUBMB Enzyme Nomenclature: 1.1.1.413
ExPASy - ENZYME nomenclature database: 1.1.1.413
BRENDA, the Enzyme Database: 1.1.1.413

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