KEGG   ENZYME: 1.1.1.413
Entry
EC 1.1.1.413                Enzyme                                 
Name
A-factor type gamma-butyrolactone 1'-reductase (1S-forming);
barS1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one:NADP+ 1'-oxidoreductase
Reaction(IUBMB)
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP+ = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H+ [RN:R11776]
Reaction(KEGG)
R11776
Substrate
(3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one [CPD:C21666];
NADP+ [CPD:C00006]
Product
(3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one [CPD:C21668];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which is found in bacteria that produce virginiae-butanolide (VB) type gamma-butyrolactone autoregulators, reduces its substrate stereospecifically, forming a hydroxyl group in the (S) configuration.
History
EC 1.1.1.413 created 2017
Orthology
K22322  A-factor type gamma-butyrolactone 1'-reductase (1S-forming)
Genes
VOGLCH97_14275
ERAFJ9537_10520
SCBSCAB_12071
SSXSACTE_3174
SHYSHJG_4001 SHJG_8653
SHOSHJGH_3766 SHJGH_8413
SFASfla_3301 Sfla_6321
SDVBN159_4441
STRPF750_0226 F750_3442
SALUDC74_7609
SALLSAZ_39260
SGUSGLAU_25510
STREGZL_00105
SCWTU94_11470
SLDT261_2142
STRMM444_36570
SCZABE83_19735
SCXAS200_24420
SRWTUE45_pSRc_0612(linC)
SLEsle_45930(sle_45930)
SRNA4G23_05427(linC_2)
SCLFBB341_16840
SVUB1H20_15520
SGVB1H19_37525
SLAUSLA_3027
SALJSMD11_6028
SRJSRO_3380
SCYAEJ357_35235
SNQCP978_34570
STIRDDW44_31510
SNKCP967_09555 CP967_17820 CP967_30570
SRKFGW37_31680
SFICEIZ62_19140
SSPODDQ41_04305 DDQ41_08115 DDQ41_31050
SGFHEP81_03592
SCAVCVT27_14850
SSUBCP968_00755 CP968_02875 CP968_15820
SCINCP977_28700
SSPBCP982_00425 CP982_41465
SHUNDWB77_04715(linC)
SLIAHA039_29940
SCALI6J39_15535
SFBCP974_28890
SANUK7396_07605
SDDD9753_04940 D9753_06790 D9753_09120
 » show all
Reference
1  [PMID:12193632]
  Authors
Shikura N, Yamamura J, Nihira T
  Title
barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species.
  Journal
J Bacteriol 184:5151-7 (2002)
DOI:10.1128/JB.184.18.5151-5157.2002
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.413
IUBMB Enzyme Nomenclature: 1.1.1.413
ExPASy - ENZYME nomenclature database: 1.1.1.413
BRENDA, the Enzyme Database: 1.1.1.413

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