KEGG   ENZYME: 1.1.1.414
Entry
EC 1.1.1.414                Enzyme                                 
Name
L-galactonate 5-dehydrogenase;
lgoD (gene name);
lgaC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-galactonate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
L-galactonate + NAD+ = D-tagaturonate + NADH + H+ [RN:R12146]
Reaction(KEGG)
R12146
Substrate
L-galactonate [CPD:C15930];
NAD+ [CPD:C00003]
Product
D-tagaturonate [CPD:C00558];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, reported from the human gut bacteria Escherichia coli and Bacteroides vulgatus, participates in an L-galactonate degradation pathway.
History
EC 1.1.1.414 created 2018
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K23005  L-galactonate 5-dehydrogenase
K23007  L-galactonate 5-dehydrogenase
Genes
ECOb4358(lgoD)
ECJJW5793(yjjN)
EBWBWG_4051(yjjN)
ECEZ5958(yjjN)
ECSECs_5318(lgoD)
ECFECH74115_5871
ETWECSP_5441(yjjN)
ELXCDCO157_5004
EOIECO111_5219(yjjN)
EOJECO26_5565(yjjN)
EOHECO103_5142(yjjN)
ECOOECRM13514_5617(yjjN)
ECOHECRM13516_5331(yjjN)
ESLO3K_21750
ESOO3O_03630
ESMO3M_21650
ECKEC55989_5020(yjjN)
ECGE2348C_4657(yjjN)
EOKG2583_5160(yjjN)
ELRECO55CA74_24875
ELHETEC_4660
ECWEcE24377A_4951
EUNUMNK88_5273
ECPECP_4689
ENAECNA114_4600(yjjN)
ECOSEC958_0088
ECVAPECO1_2066(yjjN)
ECOAAPECO78_02945
ECXEcHS_A4590
ECMEcSMS35_4903
ECYECSE_4634
ECRECIAI1_4580(yjjN)
ECQECED1_5226(yjjN)
EUMECUMN_4981(yjjN)
EOCCE10_5102
EBRECB_04235(yjjN)
EBLECD_04235(lgoD)
EBEB21_04201(yjjN)
EBDECBD_3661
ECIUTI89_C5064
EIHECOK1_4867
ECZECS88_4979(yjjN)
ECCc5437
ELOEC042_4855
ELNNRG857_22035
ESEECSF_4292
ECLEcolC_3697
EKOEKO11_3955
EKFKO11_23430(yjjN)
EABECABU_c49910(yjjN)
EDHEcDH1_3639
EDJECDH1ME8569_4215(yjjN)
ELUUM146_22545
ELWECW_m4718(yjjN)
ELLWFL_22985(yjjN)
ELCi14_4953
ELDi02_4953
ELPP12B_c4436(yjjN)
ELFLF82_3500(yjjN)
ECOLLY180_22865
ECOIECOPMV1_04815(tdh_5)
ECOJP423_24755
EALEAKF1_ch1490c
EMAC1192_13195
ESZFEM44_14285
SFVSFV_4389(yjjN)
SFESFxv_4783
SFNSFy_6301
SFSSFyv_6371
SFTNCTC1_04766(tdh_3)
SSNSSON_4504(yjjN)
SBOSBO_4418(yjjN)
SBCSbBS512_E4898
SHQA0259_03570
EASEntas_0551
EHUD5067_0019970
KPMKPHS_06530
KPHKPNIH24_03350
KPZKPNIH27_03225
KPVKPNIH29_03550
KPWKPNIH30_03510
KPGKPNIH32_03515
KPCKPNIH10_03330
KPQKPR0928_03340
KPTVK055_2634
KPJN559_4490
KPAKPNJ1_04806
KPSKPNJ2_04755
KPNEKU54_023235
KPNULI86_23075
KVAKvar_4448
KPEKPK_4815
KPKA593_14075
KVDKR75_11525
KVQSP68_18160
KOXKOX_10125
KOYJ415_27610
KOMHR38_08850
KOKKONIH1_03850
KOCAB185_32340
KQVB8P98_24080
KLLBJF97_04400
KLWDA718_24680
KARLGL98_21680
KGRJJJ10_24140
RTGNCTC13098_06016(tdh_3)
CROROD_48491
CFDCFNIH1_09440
CBRAA6J81_13705
CWECO701_18655
CYOCD187_20790
CPOTFOB25_07880
CFQC2U38_03065
CSEDJY391_03505
CAMAF384_16240
CAFAL524_06760
CIFAL515_04575
CFARCI104_21335
CIRC2U53_13665
CIEAN232_00465
CPARCUC49_22680
CTELGBC03_08485
CITZE4Z61_13800
CARSE1B03_04280
KIENCTC12125_03110(tdh_1)
LERGNG29_03285
LPNUKQ929_17840
SYMK6K13_17335
METYMRY16398_48760
KINAB182_21985
PDZHHA33_24590
EBCC2U52_03730
YELLC20_03197
YEFFORC2_1728
YEEYE5303_15381
YMADA391_09900
YHID5F51_06765
SPESpro_1409
SRRSerAS9_1388
SRLSOD_c12980(yjjN)
SRYM621_07220
SPLYQ5A_007080(lgoD)
SRSSerAS12_1388
SRASerAS13_1389
SMAFD781_1318
SLQM495_06510
SFWWN53_16450
SFGAV650_11905
SRZAXX16_3773
SERASer39006_005275
SERQCWC46_05270
SERMCLM71_06460
SQUE4343_09110
SFJSAMEA4384070_1461(tdh_1)
SOFNCTC11214_05521(tdh_2)
SRHZFO014_03395
SFOZ042_20495
ECAECA4382
PATREV46_21815
PATOGZ59_44780
PCTPC1_0059
PWAPecwa_0065
PPARA8F97_18040
PECW5S_0066
PWSA7983_07110
PPUJE2566_00270
PARII2D83_00355
PAQUDMB82_0000300
BNGEH206_22130
EBIEbC_43440
EGEEM595_0166(yjjN)
PAMPANA_3799(yjjN)
PLFPANA5342_0239(yjjN)
PAJPAJ_3018(yjjN)
PAQPAGR_g0234
PVAPvag_3084(yjjN)
PAOPat9b_3800
KLNLH22_03340
PAGCBEE12_05865
PSTWDSJ_01705
PANSFCN45_18450
PEYEE896_01160
PDISD8B20_16485
PRGRB151_028060(yjjN)
PHEINCTC12003_02862(tdh_1)
PRQCYG50_02035
LRINCTC12151_02880(tdh)
MSUMS0525(tdh)
ASUAsuc_0159
GANUMN179_00482
PAETNCTC13378_01838(idnD_3)
VSRVspart_00851(yjjN)
PMAICF386_06500
PFAAMM59RIKEN_10640
ACOLK5I23_03160
ACACEYQ97_00600 EYQ97_13960
WHJH9Q79_12035
MTYMTOK_24930
SPHVF9278_27470
TPAVHRQ91_02975
SASSMUG09_13600
BTHBT_3617
BTHOBtheta7330_04668(yjmD_2)
BXYBXY_29160
BOABovatus_03714(yjmD_1)
BCELBcellWH2_04739(yjmD_2)
BISDXK01_012985
BEGINE88_01175
BFEK6V30_06575
BVUBVU_0222
BDOEL88_17225
BDHGV66_01265
PSACPSM36_2676
DYSG7050_15210
PGOLK6V26_20650
PRUPRU_2840
PHERprwr041_22380
MCOSGM418_23520
ATEEK9M52_11740
STHANCTC11429_02082(gutB_1)
SMUII6J00_09360
SSIYJVX97_10705
ASWUHUW51_09620
 » show all
Reference
1  [PMID:381020]
  Authors
Cooper RA
  Title
The pathway for L-galactonate catabolism in Escherichia coli K-12.
  Journal
FEBS Lett 103:216-20 (1979)
DOI:10.1016/0014-5793(79)81330-7
Reference
2  [PMID:24861318]
  Authors
Kuivanen J, Richard P
  Title
The yjjN of E. coli codes for an L-galactonate dehydrogenase and can be used for quantification of L-galactonate and L-gulonate.
  Journal
Appl Biochem Biotechnol 173:1829-35 (2014)
DOI:10.1007/s12010-014-0969-0
  Sequence
[ecs:ECs_5318]
Reference
3  [PMID:24963813]
  Authors
Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM
  Title
l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota.
  Journal
Biochemistry 53:4661-70 (2014)
DOI:10.1021/bi500656m
  Sequence
[bvu:BVU_0222]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.414
IUBMB Enzyme Nomenclature: 1.1.1.414
ExPASy - ENZYME nomenclature database: 1.1.1.414
BRENDA, the Enzyme Database: 1.1.1.414

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