KEGG   ENZYME: 1.1.1.414Help
Entry
EC 1.1.1.414                Enzyme                                 

Name
L-galactonate 5-dehydrogenase;
lgoD (gene name);
lgaC (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-galactonate:NAD+ 5-oxidoreductase
Reaction(IUBMB)
L-galactonate + NAD+ = D-tagaturonate + NADH + H+ [RN:R12146]
Reaction(KEGG)
Substrate
L-galactonate [CPD:C15930];
NAD+ [CPD:C00003]
Product
D-tagaturonate [CPD:C00558];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, reported from the human gut bacteria Escherichia coli and Bacteroides vulgatus, participates in an L-galactonate degradation pathway.
History
EC 1.1.1.414 created 2018
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K23005  L-galactonate 5-dehydrogenase
K23007  L-galactonate 5-dehydrogenase
Genes
ECO: b4358(lgoD)
ECJ: JW5793(yjjN)
EBW: BWG_4051(yjjN)
ECE: Z5958(yjjN)
ECS: ECs5318
ECF: ECH74115_5871
ETW: ECSP_5441(yjjN)
ELX: CDCO157_5004
EOJ: ECO26_5565(yjjN)
EOI: ECO111_5219(yjjN)
EOH: ECO103_5142(yjjN)
ECOO: ECRM13514_5617(yjjN)
ECOH: ECRM13516_5331(yjjN)
ECG: E2348C_4657(yjjN)
EOK: G2583_5160(yjjN)
ESO: O3O_03630
ESM: O3M_21650
ESL: O3K_21750
ELH: ETEC_4660
ECC: c5437
ECP: ECP_4689
ECV: APECO1_2066(yjjN)
ECY: ECSE_4634
ECR: ECIAI1_4580(yjjN)
ECQ: ECED1_5226(yjjN)
ECK: EC55989_5020(yjjN)
EOC: CE10_5102
EUM: ECUMN_4981(yjjN)
ECZ: ECS88_4979(yjjN)
ESE: ECSF_4292
EBR: ECB_04235(yjjN)
EBD: ECBD_3661
EKF: KO11_23430(yjjN)
EAB: ECABU_c49910(yjjN)
EDJ: ECDH1ME8569_4215(yjjN)
ENA: ECNA114_4600(yjjN)
ELW: ECW_m4718(yjjN)
ELL: WFL_22985(yjjN)
ELC: i14_4953
ELD: i02_4953
ELP: P12B_c4436(yjjN)
EBL: ECD_04235(lgoD)
EBE: B21_04201(yjjN)
ELF: LF82_3500(yjjN)
ECOI: ECOPMV1_04815(tdh_5)
ECOJ: P423_24755
ECOS: EC958_0088
SFV: SFV_4389(yjjN)
SFE: SFxv_4783
SFN: SFy_6301
SFS: SFyv_6371
SFT: NCTC1_04766(tdh_3)
SSN: SSON_4504(yjjN)
SBO: SBO_4418(yjjN)
KPE: KPK_4815
KPJ: N559_4490
KPNU: LI86_23075
KVA: Kvar_4448
KOX: KOX_10125
CRO: ROD_48491
CAMA: F384_16240
SPE: Spro_1409
SRL: SOD_c12980(yjjN)
SPLY: Q5A_007080(lgoD)
SMAF: D781_1318
ECA: ECA4382
PATR: EV46_21815
PATO: GZ59_44780
PCT: PC1_0059
PEC: W5S_0066
EBI: EbC_43440
EGE: EM595_0166(yjjN)
PAM: PANA_3799(yjjN)
PLF: PANA5342_0239(yjjN)
PAJ: PAJ_3018(yjjN)
PVA: Pvag_3084(yjjN)
PSTW: DSJ_01705
PRG: RB151_028060(yjjN)
PHEI: NCTC12003_02862(tdh_1)
LRI: NCTC12151_02880(tdh)
MSU: MS0525(tdh)
ASU: Asuc_0159
BTH: BT_3617
BTHO: Btheta7330_04668(yjmD_2)
BVU: BVU_0222
BXY: BXY_29160
BOA: Bovatus_03714(yjmD_1)
BCEL: BcellWH2_04739(yjmD_2)
PSAC: PSM36_2676
PRU: PRU_2840
 » show all
Taxonomy
Reference
1  [PMID:381020]
  Authors
Cooper RA
  Title
The pathway for L-galactonate catabolism in Escherichia coli K-12.
  Journal
FEBS Lett 103:216-20 (1979)
Reference
2  [PMID:24861318]
  Authors
Kuivanen J, Richard P
  Title
The yjjN of E. coli codes for an L-galactonate dehydrogenase and can be used for  quantification of L-galactonate and L-gulonate.
  Journal
Appl Biochem Biotechnol 173:1829-35 (2014)
DOI:10.1007/s12010-014-0969-0
  Sequence
[ecs:ECs5318]
Reference
3  [PMID:24963813]
  Authors
Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM
  Title
l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota.
  Journal
Biochemistry 53:4661-70 (2014)
DOI:10.1021/bi500656m
  Sequence
[bvu:BVU_0222]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.414
IUBMB Enzyme Nomenclature: 1.1.1.414
ExPASy - ENZYME nomenclature database: 1.1.1.414
BRENDA, the Enzyme Database: 1.1.1.414

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