KEGG   ENZYME: 1.1.1.415Help
Entry
EC 1.1.1.415                Enzyme                                 

Name
noscapine synthase;
NOS (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
narcotine hemiacetal:NAD+ 1-oxidoreductase
Reaction(IUBMB)
narcotine hemiacetal + NAD+ = noscapine + NADH + H+ [RN:R10020]
Reaction(KEGG)
R10020;
(other) R11696
Show
Substrate
narcotine hemiacetal [CPD:C20297];
NAD+ [CPD:C00003]
Product
noscapine [CPD:C09592];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the plant Papaver somniferum (opium poppy), catalyses the last step in the biosynthesis of the isoquinoline alkaloid noscapine.
History
EC 1.1.1.415 created 2018
Pathway
ec00950  Isoquinoline alkaloid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K22098  noscapine synthase
Reference
1  [PMID:24708518]
  Authors
Chen X, Facchini PJ.
  Title
Short-chain dehydrogenase/reductase catalyzing the final step of noscapine biosynthesis is localized to laticifers in opium poppy.
  Journal
Plant J 77:173-84 (2014)
DOI:10.1111/tpj.12379
Reference
2  [PMID:29610307]
  Authors
Li Y, Li S, Thodey K, Trenchard I, Cravens A, Smolke CD
  Title
Complete biosynthesis of noscapine and halogenated alkaloids in yeast.
  Journal
Proc Natl Acad Sci U S A 115:E3922-E3931 (2018)
DOI:10.1073/pnas.1721469115
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.415
IUBMB Enzyme Nomenclature: 1.1.1.415
ExPASy - ENZYME nomenclature database: 1.1.1.415
BRENDA, the Enzyme Database: 1.1.1.415

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