KEGG   ENZYME: 1.1.1.416Help
Entry
EC 1.1.1.416                Enzyme                                 

Name
isopyridoxal dehydrogenase (5-pyridoxolactone-forming)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
isopyridoxal:NAD+ oxidoreductase (5-pyridoxolactone-forming)
Reaction(IUBMB)
isopyridoxal + NAD+ = 5-pyridoxolactone + NADH + H+ [RN:R05084]
Reaction(KEGG)
Substrate
isopyridoxal [CPD:C06051];
NAD+ [CPD:C00003]
Product
5-pyridoxolactone [CPD:C06052];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Arthrobacter sp. Cr-7, participates in the degradation of pyridoxine. The enzyme also catalyses the activity of EC 1.2.1.102, isopyridoxal dehydrogenase (5-pyridoxate-forming).
History
EC 1.1.1.416 created 2018
Pathway
ec00750  Vitamin B6 metabolism
Reference
1  [PMID:3533936]
  Authors
Lee YC, Nelson MJ, Snell EE.
  Title
Enzymes of vitamin B6 degradation. Purification and properties of isopyridoxal dehydrogenase and 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylic-acid dehydrogenase.
  Journal
J Biol Chem 261:15106-11 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.416
IUBMB Enzyme Nomenclature: 1.1.1.416
ExPASy - ENZYME nomenclature database: 1.1.1.416
BRENDA, the Enzyme Database: 1.1.1.416

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