KEGG   ENZYME: 1.1.1.419Help
Entry
EC 1.1.1.419                Enzyme                                 

Name
nepetalactol dehydrogenase;
NEPS1 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
nepetalactol:NAD+ 1-oxidoreductase
Reaction(IUBMB)
(1) (+)-cis,cis-nepetalactol + NAD+ = (+)-cis,cis-nepetalactone + NADH + H+ [RN:R12483];
(2) (+)-cis,trans-nepetalactol + NAD+ = (+)-cis,trans-nepetalactone + NADH + H+ [RN:R12484]
Reaction(KEGG)
Substrate
(+)-cis,cis-nepetalactol [CPD:C22200];
NAD+ [CPD:C00003];
(+)-cis,trans-nepetalactol [CPD:C09804]
Product
(+)-cis,cis-nepetalactone [CPD:C22201];
NADH [CPD:C00004];
H+ [CPD:C00080];
(+)-cis,trans-nepetalactone [CPD:C09791]
Comment
The enzyme, characterized from the plant Nepeta mussinii, binds an NAD+ cofactor. It also catalyses the activity of EC 5.5.1.34, (+)-cis,trans-nepetalactol synthase.
History
EC 1.1.1.419 created 2019
Orthology
K23862  nepetalactol dehydrogenase
Reference
1  [PMID:30531909]
  Authors
Lichman BR, Kamileen MO, Titchiner GR, Saalbach G, Stevenson CEM, Lawson DM, O'Connor SE
  Title
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.
  Journal
Nat Chem Biol 15:71-79 (2019)
DOI:10.1038/s41589-018-0185-2
  Sequence
Reference
2  [PMID:30664302]
  Authors
Lichman BR, O'Connor SE, Kries H
  Title
Biocatalytic Strategies towards [4+2] Cycloadditions.
  Journal
Chemistry 25:6864-6877 (2019)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.419
IUBMB Enzyme Nomenclature: 1.1.1.419
ExPASy - ENZYME nomenclature database: 1.1.1.419
BRENDA, the Enzyme Database: 1.1.1.419

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