KEGG   ENZYME: 1.1.1.421
Entry
EC 1.1.1.421                Enzyme                                 
Name
D-apionate oxidoisomerase;
apnO (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-apionate:NAD+ oxidoreductase (isomerizing)
Reaction(IUBMB)
D-apionate + NAD+ = 3-oxoisoapionate + NADH + H+ [RN:R12503]
Reaction(KEGG)
R12503
Substrate
D-apionate [CPD:C22219];
NAD+ [CPD:C00003]
Product
3-oxoisoapionate [CPD:C22220];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group. Stereospecificity of the product, 3-oxoisoapionate, has not been determined.
History
EC 1.1.1.421 created 2019
Orthology
K23245  D-apionate oxidoisomerase
Genes
EFEEFER_0433
SYMK6K13_04240
AHNNCTC12129_01617
IZHFEM41_02315
RBADH2866_02220
ECAECA0869
PATREV46_03995
PATOGZ59_08050
PCCPCC21_007740
PCVBCS7_03830
PAQUDMB82_0016425
PVZOA04_08720
EBIEbC_33080
EPECI789_01900
PAOPat9b_4284
KLNLH22_13015
PANSFCN45_09510
LRINCTC12151_01557
HHUAR456_16015
HSVHNO53_09520
HAAA5892_08225
KMAB9H00_09310
MMWMmwyl1_3119
MMEMarme_1594
MPRIMP3633_1136
MARDIBG28_06430
MARSA8C75_12425
LLPGH975_02705
CNCCNE_BB1p11570
BYIBYI23_D003660
BUEBRPE67_DCDS05380
BCAIK788_0005389
PSPWBJG93_30095
PHSC2L64_29630
PTERC2L65_18750
PGPCUJ91_23790
PTSCUJ90_28690
PACPFAZ97_28265
PEWKZJ38_24880
BUOBRPE64_DCDS09230
ODIODI_R0403
PACRFXN63_20020
POLBpro_0087
AMONH9L24_19530
VPDVAPA_2c01350
HYLLPB072_19445
HHTF506_07870
HFRG5S34_07105
MLOmll7016
MLNA9174_13175
MCIMesci_5306
MOPMesop_5762 Mesop_5767
MAMMesau_05256 Mesau_05262
MAMOA6B35_09550
MESWA9K65_029010
MESMEJ066_15555
MHUAMCHK_0239
MJREB229_13310
MERDEB233_28435
PHTBLM14_21740
ORMHTY61_08785
KMNHW532_08970
SMESM_b20348
SMKSinme_3830
SMQSinmeB_4326
SMXSM11_pD1266
SMIBN406_06324
SMEGC770_GR4pD1254
SMELSM2011_b20348
SMERDU99_31555
SMDSmed_3771
RHINGR_b22080 NGR_c06730
SFHSFHH103_05023
SFDUSDA257_c23040
SIXBSY16_3618
SAMESAMCFNEI73_pC0426
SINOSS05631_b62760
EADOV14_b0214
ARAArad_9232
RETRHE_PF00038
RECRHECIAT_PC0000968
RELREMIM1_PF00042
RLEpRL120394
RLTRleg2_4653
RLGRleg_4760
RLBRLEG3_07485
RTRRTCIAT899_PC04835
RHLLPU83_pLPU83c0535
RGARGR602_PC01943
RHNAMJ98_PE00041
RPHAAMC79_PD00975
RHXAMK02_PD00044
REZAMJ99_PD00041
RJGCCGE525_32350
RHRCKA34_20625
RGRFZ934_27715
RADCO657_28365
RIIFFM53_024630
RBANJ2J98_22045
RRGJ3P73_25295
RLSHB780_06770
RFVRFYW14_03816
SHZshn_27355
SZOK8M09_21765
SOJK6301_18815
ABAWD5400_10070
OINIAR37_15435
OANOant_3065
OAHDR92_3438
OPSA8A54_12350
OCHCES85_5835
OCRHGK82_18450
OCLGTN27_19415
BOPAXW83_16405
BOSBSY19_3215
BVVBHK69_00380
BOIBLM15_08495
XAUXaut_2925
SNOSnov_3663
STARG3545_23095
LNEFZC33_05855
APOLK9D25_01040
MNOMnod_2421
MEEDA075_21765
MTEADK419_14945
MINDmvi_46790
MOCBB934_35060
MMEDMame_04744
AUAM673_08900
AALAIGS74_19115
AALMLUX29_21305
LABTFIU93_28780
LAGGB0E33_28820
SIWGH266_14660
LIZLGH83_09570
ACUTMRB58_21490
JANJann_3066
OATOAN307_c00670
CMARIMCC12053_1017
TPROGa0080559_TMP295
SMEDJNX03_08295
SPSESULPSESMR1_01384
OCDFHY55_18960
MARUFIU81_13305
MALUKU6B_32130
PALXGQA70_00790
PARREOJ32_13845
PLIAE4191_04060 E4191_17665
PMAUCP157_00835
PTPRCA23_c02800
TECAKL02_017800
LVSLOKVESSMR4R_01067
GEHHYN69_13925
FAQG5B39_17445
GOYGLS_c05840
ACRAcry_1069
AMVACMV_08220
LCKHN018_21585
SKTIGS68_04930
SMUCJL100_022810
SROEJL101_021500
PSWUSY83_22155
PPSCEHS13_08895
PALBEJC50_24830
PRZGZH47_24965
PLYCGXP70_27325
AFXJZ786_23515
BYLA4V09_12480
BPROPMF13cell1_02749
IFNGM661_15975
SELTBCS37_00455
SCOSCO0576(SC5G5.08c)
SMALSMALA_4776
SSOII1A49_27990
SFASfla_3625
SBHSBI_04326
STRPF750_3092
SLVSLIV_35065
SXISXIM_40220
SCZABE83_02045
SGMGCM10017557_02940
STRDNI25_01435
SAUOBV401_27740
SGDELQ87_37485
SPADDVK44_35090
SFUGCNQ36_25915
SHARHUT13_20070
MTSMTES_2012
MIPAXH82_06840
MPALBO218_08380
MHOSCXR34_02895
MLVCVS47_02893
MICSC1N74_02580
RFSC1I64_09305
CUBBJK06_01745
CQFGBG65_13560
AMAUDSM26151_02430(apnO)
CPHYB5808_01905
PSAIC3B54_111591
MSPOKXZ72_12085
HUMDVJ78_00755
LYDD7I47_03120
PLAPEAO79_04825
HEAHL652_16140
FRNF1C15_12640
ARRARUE_c18600
ARHAHiyo8_31000
ARQBWQ92_12040
ARNCGK93_09900
BRXBH708_13640
BGGCFK41_17140
BSAUDWV08_14425
GYUFE374_03555
HALTIM660_18430
PACDEGX94_08900
PAUSNCTC13651_02079
MIKFOE78_11435
APRECNX65_13450
AMIAmir_2651
ACTIUA75_20490
ACADUA74_19990
ACTAC1701_04365
PMADBAY61_13405
PLANA1s21148_07065
RMARGBA65_17545
BSOLFSW04_03585
TROtrd_0130
AGVOJF2_37220
ABASACPOL_4618
PMUCING2E5A_0783
HHYHalhy_1310
SMONAWR27_07850
RHOZGXP67_19790
RSIRunsl_3636
FBTD770_14530 D770_14630
HALJG9465_24130
HALGHUG10_07080
HSALJMJ58_22915
 » show all
Reference
1  [PMID:29867142]
  Authors
Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA
  Title
Functional assignment of multiple catabolic pathways for D-apiose.
  Journal
Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7
  Sequence
[ara:Arad_9232]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.421
IUBMB Enzyme Nomenclature: 1.1.1.421
ExPASy - ENZYME nomenclature database: 1.1.1.421
BRENDA, the Enzyme Database: 1.1.1.421

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