KEGG   ENZYME: 1.1.1.424
Entry
EC 1.1.1.424                Enzyme                                 

Name
D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming);
xacA (gene name);
xdh (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-xylose:NADP+ 1-oxidoreductase (D-xylono-1,4-lactone-forming)
Reaction(IUBMB)
D-xylose + NADP+ = D-xylono-1,4-lactone + NADPH + H+ [RN:R12643]
Reaction(KEGG)
R12643
Substrate
D-xylose [CPD:C00181];
NADP+ [CPD:C00006]
Product
D-xylono-1,4-lactone [CPD:C02753];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, which participates in the degradation of D-xylose, has been characterized from several halophilic archaeal species. cf. EC 1.1.1.179, D-xylose 1-dehydrogenase (NADP+, D-xylono-1,5-lactone-forming).
History
EC 1.1.1.424 created 2020
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K24442  D-xylose 1-dehydrogenase (NADP+, D-xylono-1,4-lactone-forming)
Genes
NANO: G5V58_11635
NMES: H9L09_09865
HHB: Hhub_4012 Hhub_4091
HJE: HacjB3_02295 HacjB3_03200 HacjB3_05780
HALR: EFA46_009975 EFA46_010985 EFA46_011180
HMA: pNG7191(gfo2) rrnAC3034(gfo6)
HHI: HAH_0291 HAH_5355(gfo4)
HHN: HISP_01540 HISP_19955
HAB: SG26_09370 SG26_18100
HTA: BVU17_01425 BVU17_16040
HALJ: G9465_01150 G9465_11050
HUT: Huta_2274
HTI: HTIA_1971
HALA: Hrd1104_00795
HMU: Hmuk_2533
HALZ: E5139_15810
HALL: LC1Hm_1813(xdh)
HALI: BV210_12335
HRR: HZS55_09950 HZS55_16380 HZS55_21940
HPEL: HZS54_15205 HZS54_19155 HZS54_25430
HLT: I7X12_14445 I7X12_19035 I7X12_19515
HWA: HQ_3202A
HWC: Hqrw_3764
HVO: HVO_A0330 HVO_B0028(xacA)
HGI: ABY42_15585
HALE: G3A49_05315 G3A49_07045
HALM: FCF25_13805
HLA: Hlac_1560 Hlac_2241
HALP: DOS48_12410
HALB: EKH57_12905
HEZZ: EO776_13375
HALQ: Hrr1229_008625
SRUB: C2R22_01265 C2R22_14900
HALN: B4589_002340 B4589_002525
HALG: HUG10_06145 HUG10_08065 HUG10_16045
HALU: HUG12_08080
HDF: AArcSl_0519
HAH: Halar_3506
HTU: Htur_0531 Htur_4116 Htur_4497
HDA: BB347_11275
HJT: DVR14_07440
HALY: HYG82_17880
HXA: Halxa_0582 Halxa_1863 Halxa_3767 Halxa_3993
NAT: NJ7G_0683
NPE: Natpe_3458
NVR: FEJ81_08200 FEJ81_16840
NPL: FGF80_15705
NOU: Natoc_1104 Natoc_3157
SALI: L593_08020
HLR: HALLA_04515 HALLA_06500
NAS: GCU68_19960
 » show all
Reference
1  [PMID:15342590]
  Authors
Johnsen U, Schonheit P
  Title
Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.
  Journal
J Bacteriol 186:6198-207 (2004)
DOI:10.1128/JB.186.18.6198-6207.2004
  Sequence
[hma:rrnAC3034]
Reference
2  [PMID:19584053]
  Authors
Johnsen U, Dambeck M, Zaiss H, Fuhrer T, Soppa J, Sauer U, Schonheit P
  Title
D-xylose degradation pathway in the halophilic archaeon Haloferax volcanii.
  Journal
J Biol Chem 284:27290-303 (2009)
DOI:10.1074/jbc.M109.003814
  Sequence
[hvo:HVO_B0028]
Reference
3  [PMID:28854683]
  Authors
Sutter JM, Johnsen U, Schonheit P
  Title
Characterization of a pentonolactonase involved in D-xylose and L-arabinose catabolism in the haloarchaeon Haloferax volcanii.
  Journal
FEMS Microbiol Lett 364:3898818 (2017)
DOI:10.1093/femsle/fnx140
  Sequence
[hvo:HVO_B0028]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.424
IUBMB Enzyme Nomenclature: 1.1.1.424
ExPASy - ENZYME nomenclature database: 1.1.1.424
BRENDA, the Enzyme Database: 1.1.1.424

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (1)   
   KEGG REACTION (1)   
Gene (83)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (82)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
All databases (97)   

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