Entry
Name
UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase;
wbpV (gene name);
wreQ (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-quinovosamine:NAD(P)+ 4-dehydrogenase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-quinovosamine + NAD(P)+ = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NAD(P)H + H+ [RN:
R12556 R12760 ]
Reaction(KEGG)
Substrate
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose [CPD:
C04613 ];
NADH [CPD:
C00004 ];
NADPH [CPD:
C00005 ];
H+ [CPD:
C00080 ]
Comment
The enzyme participates in the biosynthesis of N-acetyl-alpha-D-quinovosamine, a 6-deoxy sugar that is present in the O antigens of many Gram-negative bacteria, including Pseudomonas aeruginosa serotypes O6 and O10, Rhizobium etli, and Brucella abortus.
History
EC 1.1.1.426 created 2021
Pathway
ec00541 O-Antigen nucleotide sugar biosynthesis
Orthology
K24310 UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase
Genes
VCO : VC0395_A2639(galE-1)
VNI : VIBNI_A3635(galE) VIBNI_A3655(galE)
VAU : VANGNB10_cI2502c(galE-1)
PAEB : NCGM1900_3151(wbjF)
PVD : CFBP1590__1628(galE)
PMUD : NCTC8068_01782(orfM)
PPUU : PputUW4_01378(galE1)
PTW : TUM18999_16800(wbpK)
PPAO : K3169_22125 K3169_25800
PSYC : DABAL43B_0742(wbpV)
LLG : 44548918_01752(galE)
LADL : NCTC12735_01326(galE_2)
JAS : FJQ89_13890 FJQ89_16170
THAG : CKCBHOJB_03411(gnu_2)
SSUM : Q9314_06240 Q9314_28535
CRK : L3I90_05315 L3I90_05325
» show all
Taxonomy
Reference
Authors
Belanger M, Burrows LL, Lam JS
Title
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
Journal
Sequence
Reference
Authors
Forsberg LS, Noel KD, Box J, Carlson RW.
Title
Genetic locus and structural characterization of the biochemical defect in the O-antigenic polysaccharide of the symbiotically deficient Rhizobium etli mutant, CE166. Replacement of N-acetylquinovosamine with its hexosyl-4-ulose precursor.
Journal
Sequence
Reference
Authors
Li T, Simonds L, Kovrigin EL, Noel KD.
Title
In vitro biosynthesis and chemical identification of UDP-N-acetyl-d-quinovosamine (UDP-d-QuiNAc).
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.1.426