KEGG   ENZYME: 1.1.1.426
Entry
EC 1.1.1.426                Enzyme                                 
Name
UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase;
wbpV (gene name);
wreQ (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
UDP-N-acetyl-alpha-D-quinovosamine:NAD(P)+ 4-dehydrogenase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-quinovosamine + NAD(P)+ = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose + NAD(P)H + H+ [RN:R12556 R12760]
Reaction(KEGG)
R12556 R12760
Substrate
UDP-N-acetyl-alpha-D-quinovosamine [CPD:C22262];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylohex-4-ulose [CPD:C04613];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme participates in the biosynthesis of N-acetyl-alpha-D-quinovosamine, a 6-deoxy sugar that is present in the O antigens of many Gram-negative bacteria, including Pseudomonas aeruginosa serotypes O6 and O10, Rhizobium etli, and Brucella abortus.
History
EC 1.1.1.426 created 2021
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K24310  UDP-N-acetyl-alpha-D-quinovosamine dehydrogenase
Genes
EAUDI57_04625
ELGBH714_10905
ECHGFY206_16200
LNICWR52_20440
EBGFAI37_14525
CLAPNCTC11466_01480
YREHEC60_09865
SFOZ042_21270
EAMEGXP68_11785
DDDDda3937_02273
DZEDd1591_3388
DDCDd586_0671
DZCW909_03540
DSOA4U42_12615
CEDLH89_08795
DFNCVE23_03940
DDQDDI_0527
DAQDAQ1742_00765
DLCO1Q98_08115
DDADd703_3272
LBQCKQ53_08345
LPOPI6N93_13490
PAYPAU_04340(wbfT)
VCHVC_0262
VCFIR04_06215
VCSMS6_0125
VCEVch1786_I2543
VCQEN18_18185
VCJVCD_001360
VCIO3Y_01220
VCOVC0395_A2639(galE-1)
VCRVC395_0291(galE-1)
VCMVCM66_0247(galE-1)
VCLVCLMA_A0228
VCXVAA049_3435
VVMVVMO6_02766
VPKM636_20605
VNIVIBNI_A3635(galE) VIBNI_A3655(galE)
VANVAA_02505
LAGN175_02215
VAUVANGNB10_cI2502c(galE-1)
VSCVSVS12_00392(galE)
VGABSQ33_09785
VQICCZ37_12370
VTAA2985(galE)
VAFD1115_14020
VCCFAZ90_14140
VSRVspart_00189(rmd)
VKABTD91_05410
VSLLTQ54_07620
VPLSA104470976_02473
VCRAIS519_09385
VSYK08M4_27480(rfbB)
VRURND59_05145
VMTQYQ96_12570
PGHFH974_11400
GKDK6Q96_04450
SALYE8E00_04270
ELUXBTN50_0559
POJPtoMrB4_38510
PLALFXN65_09155
PAUPA14_23450(orfM)
PAPPSPA7_1984
PAGPLES_19161
PAFPAM18_1820
PAEBNCGM1900_3151(wbjF)
PSGG655_09080
PAEPPA1S_09625
PAEMU769_09160
PAELT223_09640
PAEUBN889_06734
PAEGAI22_24240
SECHB18_28730
PCQPcP3B5_17440
PMUIG4G71_20900
PNTG5B91_22655
PPAAB7D75_09305
PPUPP_1803(wbpV)
PPFPput_3938
PPGPputGB1_1377
PPWPputW619_1412
PPTPPS_1445
PPBPPUBIRD1_3830(wbpV)
PPIYSA_02157
PPXT1E_3062
PPUHB479_06975
PPUTL483_06570
PPUNPP4_39830(wbpV)
PPUDDW66_1725
PMONX969_05155
PMOTX970_05130
PPJRK21_03590
PMOLCLJ08_05515
PALDLU682_021860
PIXRIN61_18470
PSTPSPTO_1754
PSBPsyr_3638
PSYRN018_07230
PSPPSPPH_3658
PSAVPSA3335_22190
PAMGBKM19_021725
PCIPCH70_40470
PAVLBKM03_20975
PVDCFBP1590__1628(galE)
PCABJGS08_06565
PCOFPOR16_07095
PTREI9H09_07735
PSYIMME58_18715
PASTN015_19225
PLIJKQP88_19065
PFLPFL_4307(wbpV)
PPRCPFLCHA0_c43730
PPROPPC_4409
PFNHZ99_27165
PFOPfl01_4054(wbpV)
PTVAA957_05795
PCGAXG94_23835
POIBOP93_07890
PRXHRH33_09185
PMEDE3Z27_08425
PKRAYO71_22330
PMUDNCTC8068_01782(orfM)
PTOLI7845_08105
PBREQDY63_19870
PFXA7318_07360
PENPSEEN1504(wbpV)
PBAPSEBR_a1569
PPUUPputUW4_01378(galE1)
PSKU771_09375
PCHEY04_21820
PCPJM49_09385
PLQAA042_01810
PRHLT40_09370
PSWLK03_11925
PPVNJ69_11665
PSESPSCI_0338
PSECCCOS191_3868(galE)
PSOSPOS17_4381(wbpV)
PFKPFAS1_20085
PANRA7J50_1818
PSILPMA3_20840
PKEDLD99_20370
PUMHGP31_08970
PGGFX982_00132
PGYAWU82_24295
PSEJHNQ25_14920
PVKEPZ47_08555
PEZHWQ56_26275
PBZGN234_09855
PATAJWU58_08595
PZEHU754_021450
PMOEHV782_020650
PXAKSS93_10520
PSAMHU731_024275
PTZHU718_021810
PSHHHU773_009975
PHVHU739_020860
PPRGHU725_006435
PASGKSS96_08815
PAZEKSS91_07800
PALVKSS97_20635
PCASLOY40_20405
PORYEJA05_07555
PWZJ7655_08325
PTWTUM18999_16800(wbpK)
PIEHU724_020330
PWYHU734_007760
PGFJ0G10_21680
PCAVD3880_13420
PJUL1P09_06310
PPHNHU825_12210
PIZLAB08_R15170
PPEGKUA23_08670
PSIINF676_19295
PSIHLOY51_07495
PFITKJY40_20975
PASILG197_12115
PKMPZ739_06825
PNBNK667_04060
PTAIICN73_13265
PKKQQ992_07000
PKJQ1W70_17950
PHYGJTY93_09025
PHOMKJF94_22220
PCUCPSH97_20165
PTRLOU419_20225
PPAELDL65_19540
PPAOK3169_22125 K3169_25800
PSJYAA098_07570
PSKUKUIN1_36020
PSHSJJN09_17725
PSLPBHQ29_12860
PLISNN484_16630
PLAUI0D68_22030
PFOUOZ911_06630
PKVQYQ93_09150
PSMTMT1_2967
PBAMNUH87_08910
PMYPmen_1874
PTYJWV26_20250
PSCA458_02415
PSJPSJM300_08105
PSHPsest_1823
PSTTCH92_13880
PCHLLLJ08_08120
PKGLW136_14040
PZDKQ248_07520
EMODM558_08115
EAZJHT90_08135
ENTOMTZ49_11635
HPEGEAO82_15820
PPHABVH74_11210
DCEO6P33_11960
PCAMHNE05_10935
PBAUOS670_00945
MAQMaqu_2613
MPQABA45_11725
MLQASQ50_04315
MSQBKP64_02500
MALLPBN92_13080
MANPEHN06_13645
MSANLPB19_15005
MNKRE428_18040
MMEENLK58_06210
PRWPsycPRwf_0229
PSYCDABAL43B_0742(wbpV)
AHLAHTJS_16390
ATGJ4G44_02875
AVIVLF296_18020
ASUEF2A31_15270
SONSO_3173
SBLSbal_2878
SBPSbal223_1484
SBSSbal117_3016
SHFCEQ32_00540
SMAVCFF01_12410
SVMKDH10_000099
SSPAK0I31_07200
IABK5X84_02560
IDPU0358_02830
CPSCPS_0589
COMCMT41_02260
TPSYRGQ13_13840
PTNPTRA_a0442
PLZS4054249_18500
PDJD0907_14735
PCARPC2016_0430
PVBJ5X90_03190
PSAZPA25_04170
PDVFFU37_01015
PSMMPspMM1_04430
GNIGNIT_2484
ALKMNKI27_13680
ASEMNNL22_10165
ALIIQR722_05045
PINPing_3457
MOQHWV03_03060
CELLCBR65_04815
MKEOOT55_04640
MAGAMag101_07595
MIIBTJ40_13435
MICTFIU95_08965(rmd)
MCELLPW13_05620
MICZGL2_38840
MVBMJO52_12080
LLG44548918_01752(galE)
LIBE4T55_12955
LGTE4T54_10170
LADLNCTC12735_01326(galE_2)
LANTTUM19329_13050
TMCLMI_2119(galE)
MCAMCA0612(galE-1)
METUGNH96_15115
MMEOOOT43_16505
MAHMEALZ_0064(galE)
MBUREQU24_00380
MPSYCEK71_06950
MMOBF6R98_17275
MEINmethR_P2164
MESLKKZ03_06345
MECHQ9L42_002975
MEJQ7A_1097
MPINLGT42_012835
MMAFGCM100_08290
MTHAVSX76_05760
CYQQ91_1975
CYYCPC19_02940
TXAHQN79_09370
TSETHMIRHAS_06490
THISHZT40_09485
TUNJ9260_12915
TSBHMY34_14775
TLCRCF98_15685
TSJL3K52_17800
TEETel_08650
RHHE0Z06_09895
TLRThiosp_00693
TFRIThiofri_04171
TWGThiowin_01884
TKMTK90_1543
TVRTVD_05180
NAXHC341_12265
GHLGM160_05015
SEDSAAY24_11305
HCHHCH_02402
HAHEENC22_10915
HAHHO5O45_05970
HHAOQWG60_09130
AXEP40_08165
MMWMmwyl1_0811
MRHIKDW99_03235
MSECLN244_11830
MRZKDW95_11675
NIKF5I99_05225
VCWGJQ55_04165
BACZKFF03_06285
LLPGH975_08620
ENGO2T12_14790
AAJBOQ57_14805
AVRB565_2777
ARIVKYK33_13470
ABESIU367_07045
OCEGU3_12805
OPEPU634_03915
OCMCBP12_00560
ZDFAN401_12695
KGETQ33_1389
GBIPG2T_06260
SLIMSCL_1228
IFOCVFO_0850
DEEHQN60_01760
CHIZHQ393_01440
CHICN8I74_14265
PANIDCO16_01750
PPKU875_24425
PVEUC34_23550
PCOMNTU39_25675
PLGNCTC10937_03977
APESFOC84_13800
BOZDBV39_16120
ODHDHf2319_10165
NARMN7E01_07590
RACRA876_17020
RHYRD110_07060
RHOBHTY51_14325
RMKRAN89_05215
RLHMIZ03_4229
POLBpro_3986
PNAPnap_3482
POSDT070_03455
POOF7R28_05980
PVACHC248_00281(gnu)
VPEVarpa_4679
VAVIG196_04440
HYRBSY239_4257
HYBQ5W_21545
HYLLPB072_07020
HPSEHPF_17910
HYNF9K07_02070
HTNKI616_08645
HCZG9Q37_18330
HYYJNX00_01325
CBABSMCB_0545
HARHEAR1149(galE2)
MMSmma_2256(wcaG)
JAGGJA_944
JAZYQ44_03330
JALBZG29_24250
JASFJQ89_13890 FJQ89_16170
JRIP9875_25345
HSEHsero_0476(galE)
HSZACP92_02375
HRBHrubri_0474(galE)
HFRG5S34_02345
HEWHBDW_04880
UPVEJN92_14305
UNDUNDKW_4619
UNYUNDYM_4598
UCYRF679_11420
GLCJQN73_12425
ACTBRHM62_18495
NEUNE0500
NETNeut_0180
SHDSUTH_03383
TBDTbd_1873
TSWVA613_10330
MFAMfla_1276
MMBMmol_1037
MEHM301_1254
MEPMPQ_0106(wcaG)
MBACBN1209_0948(galE)
MMECFIU01_07075
MPAUZMTM_15350
SLTSlit_2882
GCAGalf_2831
NIMW01_22190
NARCNTG6680_2769(galE)
FKUFGKAn22_23250
SULFCAP31_11770
SNIVSFSGTM_06500
DEYHYN24_10215
DDENKI615_14710
AZOazo3583(wbpV)
AOAdqs_3726
AZAAZKH_3758
AZDCDA09_18355
AZRCJ010_21705
THUAC731_013190
THAUC4PIVTH_1602(galE)
TCLTchl_1203
TAKTharo_3266
THAGCKCBHOJB_03411(gnu_2)
AZQG3580_04705
FMYHO273_12245
APPCAP2UW1_0116
CHEAPVE73_03175
RETRHE_CH02844
RECRHECIAT_CH0002995
RELREMIM1_CH02892
REPIE4803_CH03069
REIIE4771_CH03107
RLERL3304(galE)
RLTRleg2_2591
RLGRleg_2851
RLBRLEG3_24835
RLURLEG12_24065
RTRRTCIAT899_CH18220
RHNAMJ98_CH03010
RPHAAMC79_CH03007
RHXAMK02_CH02941
RHKKim5_CH03057
REZAMJ99_CH03009
RJGCCGE525_21635
RHRCKA34_01515
RADCO657_13135
RIIFFM53_020885
RHIDFFM81_006930
RBQJ2J99_14985
RLNJ0663_01735
RBANJ2J98_14340
RRGJ3P73_16880
RLSHB780_25355
RROSD4A92_23320
RAWNE851_25970
RLWRlegWSM1455_14360
RRHOPR018_17775
RTUPR017_17665
RCTPYR68_12665
ARAArad_4777
RBWRLCC275e_14395
RIFU5G49_002950
RHIZQMO80_004046
RHIBI8E17_16235
SOJK6301_03130
SSUMQ9314_06240 Q9314_28535
BREUFKQ52_02945
SPHQBWQ93_05575
SPFDSPYCA_1464
SPBSL7H23_03805
PMEAKTC28_01450
AZLAZL_022200
ALIAZOLI_2269
ABFAMK58_09230
ATIAL072_07900
AHUA6A40_08880
AZMDM194_08325
AOZHUE56_13590
AZSE6C72_00975
MAGXXM1_0887(galE)
MAGNWV31_13295
MAGamb0038
HJOAY555_02130
TIIDY252_16475
MAGQMGMAQ_3641
THART8K17_04140
MAESGa0123461_1860
GMEGmet_1335
GEMGM21_2588
GEBGM18_1460
GEVGSVR_02930
GBMGbem_1625
GSUBKP001_03105
GSBGSUB_15185
GHCL9S41_13015
DEPAOP6_1863
DPRDespr_3185
DDUGF1_21150
DOLDole_1299
ACPA2cp1_4435
PARHI5S86_07870
MFEUH1D33_30080
LBOLBWT_55650
CRKL3I90_05315 L3I90_05325
DMRDeima_2964
DPDDeipe_0920
DFCDFI_17495
DSCABOD76_07580
RCFPoly24_09550
CPHCpha266_2616
PLTPlut_1844
PPHPpha_0568
PROCPtc2401_00338
 » show all
Reference
1  [PMID:10627048]
  Authors
Belanger M, Burrows LL, Lam JS
  Title
Functional analysis of genes responsible for the synthesis of the B-band O antigen of Pseudomonas aeruginosa serotype O6 lipopolysaccharide.
  Journal
Microbiology 145 ( Pt 12):3505-21 (1999)
DOI:10.1099/00221287-145-12-3505
  Sequence
[pael:T223_09640]
Reference
2  [PMID:14551189]
  Authors
Forsberg LS, Noel KD, Box J, Carlson RW.
  Title
Genetic locus and structural characterization of the biochemical defect in the O-antigenic polysaccharide of the symbiotically deficient Rhizobium etli mutant, CE166. Replacement of N-acetylquinovosamine with its hexosyl-4-ulose precursor.
  Journal
J Biol Chem 278:51347-59 (2003)
DOI:10.1074/jbc.M309016200
  Sequence
Reference
3  [PMID:24817117]
  Authors
Li T, Simonds L, Kovrigin EL, Noel KD.
  Title
In vitro biosynthesis and chemical identification of UDP-N-acetyl-d-quinovosamine (UDP-d-QuiNAc).
  Journal
J Biol Chem 289:18110-20 (2014)
DOI:10.1074/jbc.M114.555862
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.426
IUBMB Enzyme Nomenclature: 1.1.1.426
ExPASy - ENZYME nomenclature database: 1.1.1.426
BRENDA, the Enzyme Database: 1.1.1.426

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