KEGG   ENZYME: 1.1.1.429
Entry
EC 1.1.1.429                Enzyme                                 
Name
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase;
bbsCD (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA:NAD+ oxidoreductase
Reaction(IUBMB)
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD+ = (S)-2-benzoylsuccinyl-CoA + NADH + H+ [RN:R05575]
Reaction(KEGG)
R05575
Substrate
(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA [CPD:C09819];
NAD+ [CPD:C00003]
Product
(S)-2-benzoylsuccinyl-CoA [CPD:C09820];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway. It is specific for NAD+.
History
EC 1.1.1.429 created 2022
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07547  (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsC subunit
K07548  (2S)-[(R)-hydroxy(phenyl)methyl]-succinyl-CoA dehydrogenase BbsD subunit
Genes
EBAc2A313(bbsD) c2A314(bbsC)
APETToN1_01580(bbsD) ToN1_01590(bbsC)
AZIAzCIB_4523 AzCIB_4524
AZDCDA09_07430 CDA09_07435 CDA09_21980 CDA09_21985
TCLTchl_1387 Tchl_1388
TAKTharo_3087 Tharo_3088
BOWNWE53_20565
MTEZHPT29_011595
PAQTE8L99_17100
NHUMPQ457_16550
NNVQNH39_14995
BHUILOK74_00295
ARHDVSH64_18540
DACTKZZ52_17960
 » show all
Reference
1  [PMID:34601806]
  Authors
von Horsten S, Lippert ML, Geisselbrecht Y, Schuhle K, Schall I, Essen LO, Heider J.
  Title
Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation.
  Journal
FEBS J 289:1023-1042 (2022)
DOI:10.1111/febs.16216
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.429
IUBMB Enzyme Nomenclature: 1.1.1.429
ExPASy - ENZYME nomenclature database: 1.1.1.429
BRENDA, the Enzyme Database: 1.1.1.429

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