KEGG   ENZYME: 1.1.1.435
Entry
EC 1.1.1.435                Enzyme                                 
Name
L-fucose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
beta-L-fucopyranose:NADP+ 1-oxidoreductase
Reaction(IUBMB)
beta-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+ [RN:R13105]
Reaction(KEGG)
R13105
Substrate
beta-L-fucopyranose [CPD:C20836];
NADP+ [CPD:C00006]
Product
L-fucono-1,5-lactone [CPD:C18028];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme catalyses the oxidation of beta-L-fucopyranose to L-fucono-1,5-lactone, which is unstable and is rapidly converted to L-fucono-1,4-lactone. The alpha anomer is not recognized. The enzyme can also act on beta-L-galactopyranose and D-arabinose with lower activity. NADP+ is a better cosubstrate than NAD+.
History
EC 1.1.1.435 created 2022
Pathway
ec00051  Fructose and mannose metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K18333  L-fucose dehydrogenase
Genes
CCONAFK62_18615
EAEEAE_05260
EARCCG32946
PGELG71_02970
IZHFEM41_03690
SMARSM39_4975
SMACSMDB11_4718
SMWSMWW4_v1c05980
SPESpro_0642
SRRSerAS9_0578
SRLSOD_c05100(fabG2)
SRYM621_02690
SPLYQ5A_002680(linC_1)
SRSSerAS12_0578
SRASerAS13_0578
SMAFD781_0588
SLQM495_02555
SERFL085_01110
SERSSERRSCBI_02830
SRZAXX16_4521
SERMCLM71_02850
SQUE4343_13445
SFJSAMEA4384070_0669(lvr_1)
SOFNCTC11214_00914(lvr)
SSURATE40_023670
SURIJ0X03_20995
SRHZFO014_06990
SENPKHA73_02725
SNEMNLX84_02870
SNEVOI978_03570
RAHRahaq_4615
RACEJHW33_23670
RAQRahaq2_4620
RAAQ7S_23601
RVCJ9880_22720
RBONQNM34_09895
EAMEGXP68_21935
CARUP0E69_17430
EBIEbC_34960
EGEEM595_p0338
KPIEN5580_19985
PJPLAG73_00450
PORAPT59_18370
PLULFOB45_19505
PDRH681_03975
PFZAV641_17025
PLQAA042_16680
PPSYAOC04_14295
PYMAK972_3693
PGGFX982_03440
PPSHG5J76_20740
PTAENCTC10697_03282(ydaD)
ABERBSR55_03500
WOCBA177_04490
SALNSALB1_1054
VMSLVJ82_03550
AFFH3L97_08430
ACRSLVJ80_02370
CKHLVJ77_06265
RWEKOL96_14840
CUHBJN34_27325
BMABMAA0644
BMLBMA10229_0820
BMNBMA10247_A1782
BMALDM55_4782
BMAEDM78_3207
BMAQDM76_3736
BMAIDM57_12325
BMAFDM51_4360
BMAZBM44_4772
BMABBM45_4960
BPSBPSS0794
BPMBURPS1710b_A2378
BPLBURPS1106A_A1085
BPDBURPS668_A1162
BPSEBDL_4076
BPSMBBQ_5348
BPSUBBN_4248
BPSDBBX_5914
BPZBP1026B_II0872
BPQBPC006_II1109
BPKBBK_3651
BPSHDR55_4547
BPSABBU_5242
BPSOX996_4023
BUTX994_3775
BTEBTH_II1602
BTQBTQ_4889
BTJBTJ_3514
BTZBTL_4362
BTDBTI_5612
BTVBTHA_3594
BTHEBTN_4014
BTHMBTRA_4079
BTHADR62_4049
BTHLBG87_4345
BOKDM82_4915
BOCBG90_5680
BHGI6G56_24010
BUDAQ610_26700
BVIBcep1808_3383
BVEAK36_3378
BURBcep18194_B0623
BCMBcenmc03_5244
BCHBcen2424_5040
BCJBCAM2283
BCENDM39_6870
BCEWDM40_4983
BCEOI35_6174
BAMBamb_4448
BACBamMC406_4968
BMJBMULJ_04919(fabG)
BMUBmul_3598
BMKDM80_4983
BMULNP80_4942
BCTGEM_3407
BCEDDM42_5708
BCEPAPZ15_27700
BDLAK34_3516
BPYRABD05_24170
BCONNL30_01145
BUBBW23_3447
BDFWI26_24100
BLATWK25_27395
BTEIWS51_08435
BSEMWJ12_31305
BPSLWS57_14830
BMECWJ16_29755
BSTGWT74_30135
BSTLBBJ41_25165
BANNJFN94_29260
BARINLX30_25865
BAENL3V59_25925
BGLbglu_1g17980
BGUKS03_2653
BGDbgla_1g19910 bgla_2g00990
BGOBM43_3333 BM43_6849
BUKMYA_3001
BULBW21_5300
BGPBGL_1c19910
BPLAbpln_1g18230
BURKDM992_22840
AKATKWG_18800
AMIMMIM_c09600
RFRRfer_3136
RSBRS694_10700
RHGEXZ61_10370
DLAI6G47_12580
VAPVapar_5322
VPEVarpa_1438
VPDVAPA_2c06620
VAMC4F17_11870
HSEHsero_1047
HSZACP92_05240
HHTF506_01420
HRBHrubri_0846
HEEhmeg3_21070
HHFE2K99_04890
HFRG5S34_05215
CFUCFU_2101(sdr3)
CARELT85_1598
CPRACPter91_1564
MESPC1M53_07795
AAKAA2016_0903
AMIHCO731_01018(linC)
AMISAmn_53260
ANJAMD1_0988
SINOSS05631_c11090
ESJSJ05684_c19530
EAKEKH55_1890
BAPIBBC0122_013290
DEVOH4N61_01085
JAVOXU80_02345
PPHRAPZ00_17325
ACUTMRB58_19645
PLCGRVY76_05230
PYEA6J80_02440
PCONB0A89_08935
PZHCX676_17890
PTPRCA23_c24610
GEHHYN69_09660
TAWEI545_01415
NSMJO391_16695
RHOCQTA57_10480
RBXI3V23_02015
SSANNX02_10175
SAERNEF64_09675
ACRAcry_1855
AMVACMV_20960
GDIGDI2664
GDJGdia_0877
LCKHN018_02395
ACIMGT370_09085
CJECj0485
CJBBN148_0485
CJICJSA_0456
CJSCJS3_0477
CJPA911_02375
CJEJN564_00472
CJEUN565_00521
CJENN755_00520
CJEIN135_00537
CJERH730_03005
CJYQZ67_00496(fabG_2)
CJQUC78_0473(xecE)
CJWPJ18_02415
CJRCJE0535
CJDJJD26997_1449
CJZM635_06785
CFFCFF8240_1065
CFTCFF04554_1052
CFVCFVI03293_1020
CFXCFV97608_1119
CFZCSG_9300
CAMPCFT03427_1045
CFPCR44_05315
CCCG157_06215
CCFYSQ_07415
CCYYSS_02240
CCOIYSU_06425
CCOFVC76_02555(ped)
CCOOATE51_03232(ped)
CISCINS_1511
CUXCUP3940_1290
CGEOCGEO_0774
MHWACT01_03140
PCATPcatena_05880
ATBJ4859_04870
LCALATTO_12990(fabG)
CIICIMIT_11865
CSTACSTAT_07560
CAMGCAMM_07790
CPRPI6I69_03105
CPSPL9H27_08345
AULDCC27_010570
AIGQDX25_10550
AWLP8A24_00420
ACASP7079_00265
AUUCJ184_005290
BLNBlon_2308 Blon_2339
BLONBLIJ_2382 BLIJ_2416
BLLBLJ_0323 BLJ_1835
BLXGS08_01700 GS08_09525
BBVHMPREF9228_0577 HMPREF9228_1822
BBRUBbr_1291 Bbr_1743
BBREB12L_1237 B12L_1673
BBRVB689b_1320 B689b_1771
BBRJB7017_1262 B7017_1937
BBRCB7019_1909
BBRNB2258_1266 B2258_1763
BBRSBS27_1314 BS27_1736
BBRDBBBR_1352 BBBR_1744
BKAAH68_10235
BKSBBKW_1836
BPSCBBPC_1773
BSCABBSC_0457
GVGHMPREF0421_20694
GVHHMPREF9231_0871
GPTK9E43_05750
OBGVerru16b_01340(fabG_3)
SLOMPXH66_18115
PPHTGA004_03645
LCREPla8534_53430(fabG_10)
AAGGETAA8_11660(fabG_3)
FMRFuma_05288(ydaD_2)
LPROPQO03_03205 PQO03_05795
ACAACP_3287
ACMAciX9_3842
GMAAciX8_2947
TSAAciPR4_1795
TRSTerro_2915
TALBFTW19_09845
ORPMOP44_05820
CPICpin_1993
CBAECOR50_21125
CHITFW415_09670
CHIHGWR21_25415
COYHF329_32155
CFILMYF79_09920
CHFKTO58_16870
CHORMKQ68_15630
CSACSIO70_11360
NKONiako_6701
FLASY85_13655
FGGFSB75_09535
ARBA9P82_02005
ARKD6B99_13015
AGIFSB73_14295
ATEEK9M52_13775
ARACE0W69_010530
FLNFLA_0504
PSEGD3H65_02500
PGINFRZ67_19515
PGOFSB84_17590
FLSGLV81_12915
LACSH4075_11695
FLCKJS93_07865
FLVKJS94_02130
HHYHalhy_4138
PHEPhep_2740 Phep_4015
PEPAQ505_01850
PCMAY601_0774
PSTYBFS30_06755
PGSCPT03_17080
PEJFYC62_09475
PEKFFJ24_004975 FFJ24_008310
PROEH9L23_05575 H9L23_10350
PEXIZT61_02665
PMUOLOK61_06575
PRKH9N25_05015
PGJQG516_13340
SHGSph21_0618
SHTKO02_11055
SPHNBV902_22830
SMIZ4412673_01332(fabG_1)
SPSCE2P86_11865
SPHZE3D81_06105
SPHEGFH32_05875
SPDRG6053_06125
SDJNCTC13534_02085(srlD)
STHANCTC11429_00386(fabG_1)
SSPII6J01_18425
SMUII6J00_11405
SSIYJVX97_08410
SFAEMUK51_05475
SBAMSCB77_04160
SCNSolca_1649
MUPA0256_16515
MUCMuYL_3109
MGOTMgSA37_02345(lvr)
MUHHYN43_020430
MGINFRZ54_12050
MGKFSB76_16470
MRUBDEO27_020540
MGOSDIU38_021535
MMABHQ865_21800
MJJPQO05_09110
MSABSNE25_31420
AGDFRZ59_09075 FRZ59_12425
OLIFKG96_26565
SBXCA265_04665 CA265_08605
ALMAO498_13045
ALGOGYM62_03100
SLISlin_0310
SRDSD10_04865
SMONAWR27_16785
SPIRCWM47_12960
SPIKEXU85_25560
SPIBG8759_03360 G8759_11315
STAEHNV11_07595
SRHOHH216_02115
SOQLQ777_07125 LQ777_27520
SFOLH3H32_21960
PSEZHME7025_01464
AANHG9X63_10130
ALENG9X62_10270
RHOZGXP67_13235
DFEDfer_5643
DSNHWI92_10095
DYCNFI80_10845
DFQNFI81_11055
DCNMUK70_13955
LBYLbys_2061
RSIRunsl_0250
RUNDR864_24130
RUPDTQ70_00010
EOLEmtol_1887
EMZMB380_18515
FAEFAES_4384
FIBA6C57_13955
ALSDJ013_18150
MAQALAG90_13300
HYJFHG12_02060
HQIH9L05_00095
HBNGUY19_16655
HMTMTP16_13510
HTBMTX78_20690 MTX78_23820
HSKH4317_06945
HAEIMUN82_11325
HVLMUN86_20630
PKOPKOR_02935
RTIDC20_02260 DC20_21540
ADDHUW48_15470
ASWUHUW51_23170
CLITOQ292_05060
IRORT717_20230
FBTD770_05970
CHKD4L85_15875 D4L85_18570
FUALVD17_12210
REKN6H18_01415 N6H18_16680
RCGN7E81_01910
PRHOPZB74_01150
TPELP0M28_00505
GFOGFO_1703
FJOFjoh_4118
FJGBB050_01492(cpnA_1) BB050_03317(cpnA_3)
FGLEM308_01515 EM308_12725
FCMBIW12_13825
FCRHYN56_05695 HYN56_20460
FNKE1750_15430
FFLHYN86_05075 HYN86_16945
FENJ0383_20910
FPBNLJ00_20395
FBIL0669_05685
FPLUNLG42_17920 NLG42_18520
FHUM0M44_05760 M0M44_19535
FPECQ1W71_14630
ZPRZPR_4360
FBCFB2170_03375
MARMYQ22_01955 YQ22_02030
MARTBTR34_02405
MARBCJ263_04600
CAOCelal_2510
CLYCelly_0417
CLHIX49_01785
CBALM667_00140 M667_09845
CBATM666_00140 M666_09835
COMNPBN93_02115
ZGAZOBELLIA_3474 ZOBELLIA_4684
ZLAQ5W13_00830
POBLPB03_10285
PRNBW723_04175
PHALH9I45_05985
PBATJL193_04255
PCEAJ3359_17655
AHZAPS56_05885
WFUAXE80_03615 AXE80_06975
SALTAO058_08755
AALGAREALGSMS7_01714
FEKC1H87_17900
MARFCJ739_935
AQBD1818_05210
AQDD1816_09345
AQENBT05_07505
EMARD1013_11500
SINHLS482_01715
FLGLV716_14050
SABUMBM09_08965
ZSPMQE36_10205
SAHNJRG66_07450
AESTRBH94_03335
HWSRNZ46_11875
EAOBD94_3584
EMNM876_14995
EENBBD30_08760
ELBVO54_03061(fabG_3)
EMGBBD33_05555
EGOBBD34_07275
EGMAYC65_19755
ELZFCS00_12935
ELTFGE20_09310
ELIZJCR23_12830
CIHATE47_10465
CILEG358_10840
CLACEG342_24645
CTURLNP04_00540
 » show all
Reference
1  [PMID:23214453]
  Authors
Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM
  Title
Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.
  Journal
Biochemistry 52:239-53 (2013)
DOI:10.1021/bi3015554
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.435
IUBMB Enzyme Nomenclature: 1.1.1.435
ExPASy - ENZYME nomenclature database: 1.1.1.435
BRENDA, the Enzyme Database: 1.1.1.435

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