KEGG   ENZYME: 1.1.1.45
Entry
EC 1.1.1.45                 Enzyme                                 

Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
R02640
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K13247  L-gulonate 3-dehydrogenase
Genes
HSA: 51084(CRYL1)
PTR: 452458(CRYL1)
PPS: 100972837(CRYL1)
GGO: 101150176(CRYL1)
PON: 100171829(CRYL1)
NLE: 100592398(CRYL1)
MCC: 703988(CRYL1)
MCF: 102126962(CRYL1)
CSAB: 103248964(CRYL1)
RRO: 104653941(CRYL1)
RBB: 108519944(CRYL1)
CJC: 100412249(CRYL1)
MMU: 68631(Cryl1)
MCAL: 110309524(Cryl1)
MPAH: 110325514(Cryl1)
RNO: 290277(Cryl1)
MUN: 110549743(Cryl1)
CGE: 100763866(Cryl1)
NGI: 103726723(Cryl1)
HGL: 101708457(Cryl1)
CCAN: 109695277(Cryl1)
OCU: 100009108(CRYL1)
TUP: 102481339(CRYL1)
CFA: 486050(CRYL1)
VVP: 112918595(CRYL1)
AML: 100472061(CRYL1)
UMR: 103664279(CRYL1)
UAH: 113251169(CRYL1)
ORO: 101365710(CRYL1)
ELK: 111159885
FCA: 101092816(CRYL1)
PTG: 102950829(CRYL1)
PPAD: 109266190(CRYL1)
AJU: 106979799(CRYL1)
BTA: 281725(CRYL1)
BOM: 102271200(CRYL1)
BIU: 109567054(CRYL1)
BBUB: 102401582(CRYL1)
CHX: 102170708(CRYL1)
OAS: 101118708(CRYL1)
SSC: 396914(CRYL1)
CFR: 102509868(CRYL1)
CDK: 105096393(CRYL1)
BACU: 103009238(CRYL1)
LVE: 103070582(CRYL1)
OOR: 101286495(CRYL1)
DLE: 111175144(CRYL1)
PCAD: 102986755(CRYL1)
ECB: 100054141(CRYL1)
EPZ: 103564931(CRYL1)
EAI: 106828569(CRYL1)
MYB: 102243403(CRYL1)
MYD: 102772105(CRYL1)
MNA: 107529957(CRYL1)
HAI: 109388026(CRYL1)
DRO: 112323170(CRYL1)
PALE: 102894030(CRYL1)
RAY: 107497671(CRYL1)
MJV: 108405961(CRYL1)
LAV: 100659835(CRYL1)
TMU: 101345413
MDO: 100023498(CRYL1)
SHR: 100917581(CRYL1)
PCW: 110195845(CRYL1)
OAA: 100089465(CRYL1)
GGA: 418953(CRYL1)
MGP: 100551040
CJO: 107308329(CRYL1)
NMEL: 110389386(CRYL1)
APLA: 101793734(CRYL1)
ACYG: 106040376(CRYL1)
TGU: 100232047(CRYL1)
LSR: 110475660(CRYL1)
SCAN: 103827309(CRYL1)
GFR: 102041430(CRYL1)
FAB: 101817119(CRYL1)
PHI: 102101871(CRYL1)
PMAJ: 107209122(CRYL1)
CCAE: 111923791(CRYL1)
CCW: 104690100(CRYL1)
ETL: 114057805(CRYL1)
FPG: 101922282(CRYL1)
FCH: 102049266(CRYL1)
CLV: 102083838(CRYL1)
EGZ: 104134722(CRYL1)
NNI: 104023102(CRYL1)
ACUN: 113482754(CRYL1)
PADL: 103920202(CRYL1)
AAM: 106500417(CRYL1)
ASN: 102385817(CRYL1)
AMJ: 102567690(CRYL1)
PSS: 102463965(CRYL1)
CMY: 102935894(CRYL1)
CPIC: 101933946(CRYL1)
ACS: 100564118(cryl1)
PVT: 110083538(CRYL1)
PBI: 103051802(CRYL1)
PMUR: 107286120(CRYL1)
TSR: 106551499(CRYL1)
PMUA: 114595713(CRYL1)
GJA: 107125996(CRYL1)
XLA: 100036971(cryl1.L) 108709973(cryl1.S)
XTR: 100145620(cryl1)
NPR: 108785578(CRYL1)
DRE: 751596(cryl1)
SRX: 107712274 107724506
SANH: 107658254 107668879
SGH: 107569147(cryl1) 107597421
CCAR: 109064376 109096349
IPU: 100528270(cryl1)
PHYP: 113526091(cryl1)
AMEX: 103023213(cryl1)
EEE: 113588651(cryl1)
TRU: 101068058(cryl1)
TNG: GSTEN00029164G001
LCO: 104934840(cryl1)
NCC: 104945644(cryl1)
MZE: 101465841 112436192 112436206(cryl1)
ONL: 100691411(cryl1)
OLA: 101157739(cryl1)
XMA: 102230923(cryl1)
XCO: 114148696(cryl1)
PRET: 103478202(cryl1)
CVG: 107087357(cryl1)
NFU: 107389625(cryl1)
KMR: 108244181(cryl1)
ALIM: 106524932(cryl1)
AOCE: 111581663(cryl1)
CSEM: 103391958(cryl1)
POV: 109637940(cryl1)
LCF: 108897026(cryl1)
SDU: 111218259(cryl1)
SLAL: 111652885(cryl1)
HCQ: 109522065(cryl1)
BPEC: 110162057(cryl1)
MALB: 109970945(cryl1)
SASA: 100195418(cryl1)
OTW: 112240524(cryl1)
SALP: 111978533(cryl1)
ELS: 105016416(cryl1)
SFM: 108937705(cryl1)
PKI: 111860704(cryl1)
LCM: 102362253(CRYL1)
CMK: 103186496(cryl1)
RTP: 109930659(cryl1)
BFO: 118422602
CIN: 100176260
SPU: 115928294 577306 589657
APLC: 110981494 110981535 110981536
SKO: 100374307
DME: Dmel_CG10131(Had2) Dmel_CG9914(Had1)
DER: 6548822 6550539
DSE: 6609182 6617912
DSI: Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
DYA: Dyak_GE11007 Dyak_GE13601
DAN: 6494200 6501835
DSR: 110180150 110191959
DPO: Dpse_GA10097 Dpse_GA23040
DPE: 6590724 6603093
DMN: 108158253 108159363 117190757
DWI: 6639842 6648665
DGR: Dgri_GH12278 Dgri_GH22921
DMO: Dmoj_GI10976 Dmoj_GI18410
DAZ: 108617572 108619199
DNV: 108653241 108656753
DHE: 111592192 111595367
DVI: 6626866 6636728
MDE: 101888499 101897214
LCQ: 111679870 111686013
AGA: AgaP_AGAP013544
AAG: 5569895
AALB: 109399229
CQU: CpipJ_CPIJ018047 CpipJ_CPIJ019115
AME: 406119(Cryl1)
BIM: 100742533
BTER: 100650820
CCAL: 108626681 108629961
OBB: 114882990 114883008
SOC: 105195706
MPHA: 105832446
AEC: 105144455
ACEP: 105622538
PBAR: 105431786
VEM: 105561636 105570417
HST: 105183285
DQU: 106741081
CFO: 105257467
LHU: 105668733
PGC: 109852151
OBO: 105282065
PCF: 106785654
NVI: 100116345
CSOL: 105360276
MDL: 103573914
TCA: 656318
DPA: 109541128
ATD: 109601505
NVL: 108558442
BMOR: 101740023
BMAN: 114241018
DPL: KGM_211998
PMAC: 106716619
PRAP: 110996894
HAW: 110375292
TNL: 113502390
PXY: 105383308 105396444
API: 100160442
DNX: 107163082
AGS: 114126889
RMD: 113556888
BTAB: 109030675
CLEC: 106668054
PHU: Phum_PHUM424710
ZNE: 110836645
FCD: 110850841
DPX: DAPPUDRAFT_306692
PVM: 113820593
ISC: IscW_ISCW024631
TUT: 107361139 107363503 107363504 107371216
DPTE: 113788736 113788737
CSCU: 111638201
PTEP: 107448274 107452836 107454307
CEL: CELE_Y71F9B.9(Y71F9B.9)
CBR: CBG04121
NAI: NECAME_01388
LGI: LOTGIDRAFT_189928 LOTGIDRAFT_95422
PCAN: 112555792 112565739 112566843
CRG: 105330247 105336911
MYI: 110448022 110457594 110457605
OBI: 106873772
LAK: 106152168 106168383
NVE: 5510436
EPA: 110235936
ADF: 107344229
AMIL: 114975193
PDAM: 113664513
SPIS: 111325818
DGT: 114534577
HMG: 100202070
AQU: 100640580
MBR: MONBRDRAFT_2035
SRE: PTSG_04984
PGE: LG71_09120
GAI: IMCC3135_17145(lcdH_2)
HEL: HELO_3286
HAK: KO116_02208
HHU: AR456_19820
HCO: LOKO_03375(lcdH_2)
HALO: BWR19_14340
HHH: CLM76_02790
KUY: FY550_00490
MARS: A8C75_06675
SALN: SALB1_1674
BCEN: DM39_5776
BMK: DM80_5147
BPSL: WS57_04025
BSTG: WT74_30360
BYI: BYI23_B015300 BYI23_C007800
BUE: BRPE67_BCDS02340 BRPE67_CCDS03430
BUQ: AC233_10455
BUM: AXG89_13400
BUI: AX768_07260
BPX: BUPH_04942 BUPH_06489
PARA: BTO02_09540 BTO02_24230 BTO02_32650
PGP: CUJ91_10810
CABA: SBC2_54200(lcdH_1)
BUO: BRPE64_BCDS11720 BRPE64_CCDS01850
BPC: BPTD_1889
BPER: BN118_0916
BPET: B1917_1709
BPEU: Q425_14610
BBH: BN112_1773
BBM: BN115_1644
BBX: BBS798_1643
BPT: Bpet3360
BBRO: BAU06_03200 BAU06_15475
BFZ: BAU07_10930 BAU07_24460
BOH: AKI39_14855 AKI39_21555
BOJ: CBF45_08895
BOZ: DBV39_12625
AXY: AXYL_04862
AXO: NH44784_060221
AXN: AX27061_4268
AXX: ERS451415_04289(paaH_4)
ADT: APT56_19640
AIS: BUW96_13300
ASW: CVS48_14150
ACHR: C2U31_16275
ACHB: DVB37_20335
PUT: PT7_0383
PUS: CKA81_08315
AMIM: MIM_c40310
CDN: BN940_06781
ODI: ODI_R0637
PACR: FXN63_19430
KGY: EHF36_09020
VEI: Veis_4703
HHT: F506_08860
HRB: Hrubri_3455
HEE: hmeg3_17675
HFR: G5S34_18910
XYK: GT347_06140 GT347_19045
MLN: A9174_21020
MCI: Mesci_5299
MOP: Mesop_4014
MESO: BSQ44_20585
MESW: A9K65_021555 A9K65_028980
MJR: EB229_20785
MERD: EB233_18125
AMIH: CO731_01963(lcdH_1)
PHT: BLM14_28735
NIY: FQ775_13525
BOP: AXW83_21945
BOS: BSY19_1277
BVV: BHK69_29370
BOI: BLM15_25010
BOF: FQV39_05910
VGO: GJW-30_1_04255(lcdH_4)
XAU: Xaut_0427
SNO: Snov_4081
LNE: FZC33_04150
ANC: GBB76_15935
APRA: G3A50_13320
MRD: Mrad2831_2898
MET: M446_4642
MNO: Mnod_3695
MOR: MOC_3265
MAQU: Maq22A_c19930(fadB)
MPHY: MCBMB27_02339
MEE: DA075_22515
METX: A3862_17305
MMES: MMSR116_00105
MTEA: DK419_16225
MOC: BB934_42640
RHJ: HZY79_03885
MAAD: AZF01_12450
MMED: Mame_01642(lcdH_2)
NOH: G5V57_15960
RLI: RLO149_c043210
PAMI: JCM7686_pAMI4p135
PARO: CUV01_01410
KVL: KVU_1278
KVU: EIO_1812
RSU: NHU_04219
RHM: B5V46_17805
LABP: FJ695_16130
YAN: AYJ57_24165
TPRO: Ga0080559_TMP3737
AHT: ANTHELSMS3_02315
SAGU: CDO87_26375
THAA: CFI11_06200
PSEB: EOK75_03875
MALU: KU6B_45020
SPHI: TS85_23200
SPHJ: BSL82_11010
PALG: HFP57_02055 HFP57_15870
AMV: ACMV_31100
RGI: RGI145_00840
ROS: CTJ15_17465
RMUC: FOB66_21065
HTQ: FRZ44_36840 FRZ44_43320
HADH: FRZ61_35880 FRZ61_41220
PHR: C6569_05050
PSTG: E8M01_28880
CGS: C624_15115
CGG: C629_15125
CAMG: CAMM_07750
MLV: CVS47_02464(lcdH_1)
SALA: ESZ53_10390
 » show all
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim Pol 11:269-277 (1964)
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J Biol Chem 236:357-364 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7

  All links  
Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3719)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (432)   
   KEGG MGENES (2076)   
   RefGene (1210)   
Protein sequence (49)   
   UniProt (22)   
   SWISS-PROT (7)   
   RefSeq(pep) (18)   
   PDBSTR (2)   
DNA sequence (36)   
   RefSeq(nuc) (19)   
   GenBank (9)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (7)   
   InterPro (7)   
All databases (3825)   

Download RDF
DBGET integrated database retrieval system