KEGG   ENZYME: 1.1.1.45
Entry
EC 1.1.1.45                 Enzyme                                 
Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
R02640
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K13247  L-gulonate 3-dehydrogenase
Genes
HSA51084(CRYL1)
PTR452458(CRYL1)
PPS100972837(CRYL1)
GGO101150176(CRYL1)
PON100171829(CRYL1)
NLE100592398(CRYL1)
MCC703988(CRYL1)
MCF102126962(CRYL1)
CSAB103248964(CRYL1)
CATY105591942(CRYL1)
PANU101001860(CRYL1)
TGE112610999(CRYL1)
RRO104653941(CRYL1)
RBB108519944(CRYL1)
TFN117063326(CRYL1)
PTEH111525293(CRYL1)
CJC100412249(CRYL1)
CSYR103270481(CRYL1)
MMUR105878855(CRYL1)
LCAT123649492(CRYL1)
OGA100952755(CRYL1)
MMU68631(Cryl1)
MCAL110309524(Cryl1)
MPAH110325514(Cryl1)
RNO290277(Cryl1)
MCOC116084687(Cryl1)
MUN110549743(Cryl1)
CGE100763866(Cryl1)
MAUA101840819(Cryl1)
PLEU114693857(Cryl1)
MORG121435018(Cryl1)
AAMP119800418(Cryl1)
NGI103726723(Cryl1)
HGL101708457(Cryl1)
CPOC100724326(Cryl1)
CCAN109695277(Cryl1)
DORD105981591(Cryl1)
DSP122112582(Cryl1)
NCAR124974061 124984686
OCU100009108(CRYL1)
OPI101517946(CRYL1)
TUP102481339(CRYL1)
CFA486050(CRYL1)
CLUD112669557(CRYL1)
VVP112918595(CRYL1)
VLG121496631(CRYL1)
AML100472061(CRYL1)
UMR103664279(CRYL1)
UAH113251169(CRYL1)
UAR123791990(CRYL1)
ELK111159885
LLV125096155
MPUF101676898(CRYL1)
ORO101365710(CRYL1)
EJU114212937(CRYL1)
ZCA113920010(CRYL1)
MLX118009602(CRYL1)
FCA101092816(CRYL1)
PYU121012709(CRYL1)
PBG122480396(CRYL1)
PTG102950829(CRYL1)
PPAD109266190(CRYL1)
AJU106979799(CRYL1)
HHV120226076(CRYL1)
BTA281725(CRYL1)
BOM102271200(CRYL1)
BIU109567054(CRYL1)
BBUB102401582(CRYL1)
CHX102170708(CRYL1)
OAS101118708(CRYL1)
ODA120882971(CRYL1)
CCAD122447415(CRYL1)
SSC396914(CRYL1)
CFR102509868(CRYL1)
CBAI105066281(CRYL1)
CDK105096393(CRYL1)
VPC102524845(CRYL1)
BACU103009238(CRYL1)
LVE103070582(CRYL1)
OOR101286495(CRYL1)
DLE111175144(CRYL1)
PCAD102986755(CRYL1)
PSIU116742905(CRYL1)
ECB100054141(CRYL1)
EPZ103564931(CRYL1)
EAI106828569(CRYL1)
MYB102243403(CRYL1)
MYD102772105(CRYL1)
MMYO118650826(CRYL1)
MLF102433427(CRYL1)
MNA107529957(CRYL1)
PKL118728704(CRYL1)
HAI109388026(CRYL1)
DRO112323170(CRYL1)
SHON118980601(CRYL1)
AJM119042440(CRYL1)
PDIC114513187(CRYL1)
PHAS123822763(CRYL1)
MMF118623484(CRYL1)
RFQ117021303(CRYL1)
PALE102894030(CRYL1)
PGIG120602838(CRYL1)
PVP105292144(CRYL1)
RAY107497671(CRYL1)
MJV108405961(CRYL1)
TOD119258928(CRYL1)
SARA101558948(CRYL1)
LAV100659835(CRYL1)
TMU101345413
DNM101445681(CRYL1)
MDO100023498(CRYL1)
GAS123240613(CRYL1)
SHR100917581(CRYL1)
PCW110195845(CRYL1)
OAA100089465(CRYL1)
GGA418953(CRYL1)
PCOC116244280(CRYL1)
MGP100551040
CJO107308329(CRYL1)
NMEL110389386(CRYL1)
APLA101793734(CRYL1)
ACYG106040376(CRYL1)
AFUL116498931(CRYL1)
TGU100232047(CRYL1)
LSR110475660(CRYL1)
SCAN103827309(CRYL1)
PMOA120506684(CRYL1)
OTC121342022(CRYL1)
PRUF121364257(CRYL1)
GFR102041430(CRYL1)
FAB101817119(CRYL1)
PHI102101871(CRYL1)
PMAJ107209122(CRYL1)
CCAE111923791(CRYL1)
CCW104690100(CRYL1)
CBRC103613239(CRYL1)
ETL114057805(CRYL1)
ZAB102061772(CRYL1)
FPG101922282(CRYL1)
FCH102049266(CRYL1)
CLV102083838(CRYL1)
EGZ104134722(CRYL1)
NNI104023102(CRYL1)
PLET104623628(CRYL1)
PCRI104026979(CRYL1)
ACUN113482754(CRYL1)
TALA104361260(CRYL1)
PADL103920202(CRYL1)
ACHC115353354(CRYL1)
HALD104319372(CRYL1)
CCRI104156172(CRYL1)
CSTI104563835(CRYL1)
EHS104502671(CRYL1)
FGA104075928(CRYL1)
LDI104344006(CRYL1)
MNB103769606(CRYL1)
OHA104337317(CRYL1)
AAM106500417(CRYL1)
AROW112968342(CRYL1)
NPD112943768(CRYL1)
DNE112990415(CRYL1)
ASN102385817(CRYL1)
AMJ102567690(CRYL1)
CPOO109306668(CRYL1)
GGN109302917(CRYL1)
PSS102463965(CRYL1)
CMY102935894(CRYL1)
CPIC101933946(CRYL1)
TST117871124(CRYL1)
CABI116816440(CRYL1)
MRV120399237(CRYL1)
ACS100564118(cryl1)
PVT110083538(CRYL1)
SUND121924941(CRYL1)
PBI103051802(CRYL1)
PMUR107286120(CRYL1)
TSR106551499(CRYL1)
PGUT117661337(CRYL1)
VKO123029093(CRYL1)
PMUA114595713(CRYL1)
ZVI118085139(CRYL1)
GJA107125996(CRYL1)
STOW125430493(CRYL1)
XLA100036971(cryl1.L) 108709973(cryl1.S)
XTR100145620(cryl1)
NPR108785578(CRYL1)
RTEM120929241(CRYL1)
BBUF120996355(CRYL1)
BGAR122930603(CRYL1)
DRE751596(cryl1)
SRX107712274 107724506
SANH107658254 107668879
SGH107569147(cryl1) 107597421
CCAR109064376 109096349
CAUA113053392 113071898 113108802
PPRM120467043(cryl1)
MAMB125270524(cryl1)
IPU100528270(cryl1)
PHYP113526091(cryl1)
SMEO124380707(cryl1)
TFD113654286(cryl1)
AMEX103023213(cryl1)
EEE113588651(cryl1)
TRU101068058(cryl1)
TNGGSTEN00029164G001
LCO104934840(cryl1)
NCC104945644(cryl1)
CGOB115026817(cryl1)
ELY117248914(cryl1)
EFO125900209(cryl1)
PLEP121948948(cryl1)
SLUC116062300(cryl1)
ECRA117953287(cryl1)
PFLV114564208(cryl1)
GAT120833953(cryl1)
PPUG119229346(cryl1)
MSAM119904472(cryl1)
CUD121522650(cryl1)
ALAT119025838(cryl1)
MZE101465841 112436192 112436206(cryl1)
ONL100691411(cryl1)
OAU116332577(cryl1)
OLA101157739(cryl1)
OML112155251(cryl1)
XMA102230923(cryl1)
XCO114148696(cryl1)
XHE116723531(cryl1)
PRET103478202(cryl1)
PFOR103156381(cryl1)
PLAI106935265(cryl1)
PMEI106903604(cryl1)
GAF122839853(cryl1)
CVG107087357(cryl1)
CTUL119772901(cryl1)
GMU124871079(cryl1)
NFU107389625(cryl1)
KMR108244181(cryl1)
ALIM106524932(cryl1)
NWH119419355(cryl1)
AOCE111581663(cryl1)
MCEP125017187(cryl1)
CSEM103391958(cryl1)
POV109637940(cryl1)
SSEN122761091(cryl1)
HHIP117755164(cryl1)
HSP118120347(cryl1)
LCF108897026(cryl1)
SDU111218259(cryl1)
SLAL111652885(cryl1)
XGL120801727(cryl1)
HCQ109522065(cryl1)
BPEC110162057(cryl1)
MALB109970945(cryl1)
BSPL114847366(cryl1)
SASA100195418(cryl1)
OTW112240524(cryl1)
OMY110520403(cryl1)
OGO124044093(cryl1)
ONE115112116(cryl1)
SALP111978533(cryl1)
SNH120058412(cryl1)
CCLU121536894 121571699
ELS105016416(cryl1)
SFM108937705(cryl1)
PKI111860704(cryl1)
AANG118214554(cryl1) 118223981
LOC102684363(cryl1)
PSPA121320467(cryl1) 121327669
ARUT117406054(cryl1) 117406863
LCM102362253(CRYL1)
CMK103186496(cryl1)
RTP109930659(cryl1)
BFO118422602
BBEL109488016
CIN100176260
SCLV120336091
SPU115928294 577306 589657
APLC110981494 110981535 110981536
SKO100374307
DMEDmel_CG10131(Had2) Dmel_CG9914(Had1)
DER6548822 6550539
DSE6609182 6617912
DSIDsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
DYADyak_GE11007 Dyak_GE13601
DAN6494200 6501835
DSR110180150 110191959
DPO4803972 6901728
DPE6590724 6603093
DMN108158253 108159363 117190757
DWI6639842 6648665
DGR6565348 6568938
DMODmoj_GI10976 Dmoj_GI18410
DAZ108617572 108619199
DNV108653241 108656753
DHE111592192 111595367
DVI6626866 6636728
CCAT101453450 101456276 101456789
BOD106622355 106626802
MDE101888499 101897214
SCAC106086914 106086916 106093808
LCQ111679870 111686013
LSQ119600618 119605148 119615754
HIS119661460
AGAAgaP_AGAP013544
ACOZ120948141
AARA120894717
ASTE118510134 118516924
AAG5569895
AALB109399229
CQUCpipJ_CPIJ018047 CpipJ_CPIJ019115
CPII120422649 120431521
CNS116347304
BCOO119080762
AME406119(Cryl1)
ACER107995494
ALAB122710384
BIM100742533
BBIF117211061
BVK117232137
BVAN117157796
BTER100650820
BPYO122573401
CCAL108626681 108629961
OBB114882990 114883008
MGEN117225661
NMEA116424552
CGIG122395521
SOC105195706
MPHA105832446
AEC105144455
ACEP105622538
PBAR105431786
VEM105561636 105570417
HST105183285
DQU106741081
CFO105257467
FEX115235110
LHU105668733
PGC109852151
OBO105282065
PCF106785654
PFUC122516905
VPS122628397
NVI100116345
CSOL105360276
TPRE106659815
MDL103573914
CGLO123268844
FAS105266907
DAM107045947
AGIF122850047
LHT122504281
CCIN107265976
TCA656318
DPA109541128
SOY115878469
ATD109601505
CSET123306830
AGB108906080 108906095
LDC111509970
NVL108558442
APLN108736178
PPYR116168479
OTU111416084
BMOR101740023
BMAN114241018
MSEX115441101
DPLKGM_211998
BANY112043720
PMAC106716619
PPOT106100831
PXU106125533
PRAP110996894
ZCE119831471
HAW110375292
HZE124630756
TNL113502390
SLIU111349675
OFU114360575
PXY105383308 105396444
API100160442
DNX107163082
AGS114126889
RMD113556888
BTAB109030675
DCI103512794 103524139
CLEC106668054
HHAL106682907
NLU111048337 120355770
PHUPhum_PHUM424710
FOC113203906 113211664
TPAL117640202 117643446
ZNE110836645
CSEC111870196
FCD110850841
DPXDAPPUDRAFT_306692
DMK116922972
PVM113820593
PJA122250216
PCHN125046015
HAME121868225
PCLA123764372
PTRU123499754
HAZT108673194
EAF111704761
PPOI119102644 119102645 119103678
ISCIscW_ISCW024631
DSV119460873
RSAN119396684 119396685
RMP119174841
VDE111248233
VJA111271569
TUT107361139 107363503 107363504 107371216
DPTE113788736 113788737
DFR124492816 124496926
CSCU111638201
PTEP107448274 107452836 122273100
SDM118202986
CELCELE_Y71F9B.9(Y71F9B.9)
CBRCBG_04121
NAINECAME_01388
LGILOTGIDRAFT_189928 LOTGIDRAFT_95422
PCAN112555792 112565739 112566843
BGT106064558 106073430
GAE121369917 121370830 121370832 121372140 121372142 121372193
HRF124147318 124147327 124147345 124147347 124147348 124147351
HRJ124282586 124282594 124282598 124282607 124283055
CRG105330247 105336911 117690734 117690735 117690897
MYI110448022 110457594 110457605
PMAX117326996 117326998 117341359
MMER123551220 123551221 123551632 123560311
OBI106873772
OSN115228137
LAK106152168 106168383
NVE5510436
EPA110235936
ATEN116303602
ADF107344229
AMIL114975193
PDAM113664513
SPIS111325818
DGT114534577
XEN124441295 124442623
HMG100202070
AQU100640580
MBRMONBRDRAFT_2035
SREPTSG_04984
PGELG71_09120
GAIIMCC3135_17145(lcdH_2)
HELHELO_3286
HAKKO116_02208
HHUAR456_19820
HCOLOKO_03375(lcdH_2)
HALOBWR19_14340
HHHCLM76_02790
HCAMI4484_05150 I4484_12400
HSXHNO51_12115
HPROLMS44_09520
KUYFY550_00490
MARSA8C75_06675
SALNSALB1_1674
BCENDM39_5776
BMKDM80_5147
BPSLWS57_04025
BSTGWT74_30360
BYIBYI23_B015300 BYI23_C007800
BUEBRPE67_BCDS02340 BRPE67_CCDS03430
BUQAC233_10455
BUMAXG89_13400
BUIAX768_07260
BPXBUPH_04942 BUPH_06489
PARABTO02_09540 BTO02_24230 BTO02_32650
PGPCUJ91_10810
PACPFAZ97_21260
PACSFAZ98_17445
PEWKZJ38_13715 KZJ38_25985 KZJ38_35540
CABASBC2_54200(lcdH_1)
BUOBRPE64_BCDS11720 BRPE64_CCDS01850
BPCBPTD_1889
BPERBN118_0916
BPETB1917_1709
BPEUQ425_14610
BBHBN112_1773
BBMBN115_1644
BBXBBS798_1643
BPTBpet3360
BBROBAU06_03200 BAU06_15475
BFZBAU07_10930 BAU07_24460
BOHAKI39_14855 AKI39_21555
BOJCBF45_08895
AXYAXYL_04862
AXONH44784_060221
AXNAX27061_4268
AXXERS451415_04289(paaH_4)
ADTAPT56_19640
AISBUW96_13300
ASWCVS48_14150
ACHRC2U31_16275
ACHBDVB37_20335
ADYHLG70_29295
PUTPT7_0383
PUSCKA81_08315
AMIMMIM_c40310
CDNBN940_06781
ODIODI_R0637
BOZDBV39_12625
PACRFXN63_19430
KGYEHF36_09020
AANTHUK68_10725
VEIVeis_4703
HHTF506_08860
HRBHrubri_3455
HEEhmeg3_17675
HFRG5S34_18910
XYKGT347_06140 GT347_19045
MLNA9174_21020
MCIMesci_5299
MOPMesop_4014
MESWA9K65_021555 A9K65_028980
MJREB229_20785
MERDEB233_18125
MESOBSQ44_20585
AMIHCO731_01963(lcdH_1)
PHTBLM14_28735
NIYFQ775_13525
KMNHW532_07825
VGOGJW-30_1_04255(lcdH_4)
BOPAXW83_21945
BOSBSY19_1277
BVVBHK69_29370
BOIBLM15_25010
BOFFQV39_05910
XAUXaut_0427
SNOSnov_4081
LNEFZC33_04150
ANCGBB76_15935
APRAG3A50_13320
MRDMrad2831_2898
METM446_4642
MNOMnod_3695
MORMOC_3265
MAQUMaq22A_c19930(fadB)
MPHYMCBMB27_02339
MEEDA075_22515
METXA3862_17305
MMESMMSR116_00105
MTEADK419_16225
MOCBB934_42640
RHJHZY79_03885
MAADAZF01_12450
MMEDMame_01642(lcdH_2)
NOHG5V57_15960
LABPFJ695_16130
PHRC6569_05050
PSTGE8M01_28880
RLIRLO149_c043210
KVLKVU_1278
KVUEIO_1812
YANAYJ57_24165
TPROGa0080559_TMP3737
AHTANTHELSMS3_02315
SAGUCDO87_26375
THAACFI11_06200
MALUKU6B_45020
PAMIJCM7686_pAMI4p135
PAROCUV01_01410
RSUNHU_04219
RHMB5V46_17805
TECAKL02_003620
PSEBEOK75_03875
SPHITS85_23200
SPHJBSL82_11010
PALGHFP57_02055 HFP57_15870
AMVACMV_31100
RGIRGI145_00840
ROSCTJ15_17465
RMUCFOB66_21065
SKTIGS68_20395 IGS68_24605
HTQFRZ44_36840 FRZ44_43320
HADHFRZ61_35880 FRZ61_41220
CGSC624_15115
CGGC629_15125
CAMGCAMM_07750
MLVCVS47_02464(lcdH_1)
SALAESZ53_10390
NANOG5V58_03890
 » show all
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim Pol 11:269-277 (1964)
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J Biol Chem 236:357-364 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7

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