KEGG ENZYME: 1.1.1.45

ENZYME: 1.1.1.45

Entry

EC 1.1.1.45 Enzyme

Name

L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-gulonate:NAD+ 3-oxidoreductase

Reaction(IUBMB)

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]

Reaction(KEGG)

R02640

Substrate

L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]

Product

3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also oxidizes other L-3-hydroxyacids.

History

EC 1.1.1.45 created 1961

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K13247

L-gulonate 3-dehydrogenase

Genes

HSA:	51084(CRYL1)

PTR:	452458(CRYL1)

PPS:	100972837(CRYL1)

GGO:	101150176(CRYL1)

PON:	100171829(CRYL1)

NLE:	100592398(CRYL1)

MCC:	703988(CRYL1)

MCF:	102126962(CRYL1)

CSAB:

103248964(CRYL1)

RRO:	104653941(CRYL1)

RBB:	108519944(CRYL1)

CJC:	100412249(CRYL1)

SBQ:	101053731(CRYL1)

MMU:	68631(Cryl1)

RNO:	290277(Cryl1)

CGE:	100763866(Cryl1)

NGI:	103726723(Cryl1)

HGL:	101708457(Cryl1)

CCAN:

109695277(Cryl1)

OCU:	100009108(CRYL1)

TUP:	102481339(CRYL1)

CFA:	486050(CRYL1)

AML:	100472061(CRYL1)

UMR:	103664279(CRYL1)

ORO:	101365710(CRYL1)

FCA:	101092816(CRYL1)

PTG:	102950829(CRYL1)

AJU:	106979799(CRYL1)

BTA:	281725(CRYL1)

BOM:	102271200(CRYL1)

BIU:	109567054(CRYL1)

PHD:	102332401(CRYL1)

CHX:	102170708(CRYL1)

OAS:	101118708(CRYL1)

SSC:	396914(CRYL1)

CFR:	102509868(CRYL1)

CDK:	105096393(CRYL1)

BACU:

103009238(CRYL1)

LVE:	103070582(CRYL1)

OOR:	101286495(CRYL1)

ECB:	100054141(CRYL1)

EPZ:	103564931(CRYL1)

EAI:	106828569(CRYL1)

MYB:	102243403(CRYL1)

MYD:	102772105(CRYL1)

HAI:	109388026(CRYL1)

RSS:	109436831(CRYL1)

PALE:

102894030(CRYL1)

LAV:	100659835(CRYL1)

TMU:

101345413

MDO:	100023498(CRYL1)

SHR:	100916381 100917581(CRYL1)

OAA:	100089465(CRYL1)

GGA:	418953(CRYL1)

MGP:	100551040(CRYL1)

CJO:	107308329(CRYL1)

APLA:

101793734(CRYL1)

ACYG:

106040376(CRYL1)

TGU:	100232047(CRYL1)

GFR:	102041430(CRYL1)

FAB:	101817119(CRYL1)

PHI:	102101871(CRYL1)

PMAJ:

107209122(CRYL1)

CCAE:

111923791(CRYL1)

CCW:	104690100(CRYL1)

FPG:	101922282(CRYL1)

FCH:	102049266(CRYL1)

CLV:	102083838(CRYL1)

EGZ:	104134722(CRYL1)

AAM:	106500417(CRYL1)

ASN:	102385817(CRYL1)

AMJ:	102567690(CRYL1)

PSS:	102463965(CRYL1)

CMY:	102935894(CRYL1)

CPIC:

101933946(CRYL1)

ACS:	100564118(cryl1)

PVT:	110083538(CRYL1)

PBI:	103051802(CRYL1)

GJA:	107125996(CRYL1)

XLA:	100036971(cryl1.L) 108709973(cryl1.S)

XTR:	100145620(cryl1)

NPR:	108785578(CRYL1)

DRE:	751596(cryl1)

SRX:	107712274 107724506

SANH:

107658254 107668879

SGH:	107569147(cryl1) 107576390 107597421

CCAR:

109064376 109096347 109096348 109096349

IPU:	100528270(cryl1)

AMEX:

103023213(cryl1)

TRU:	101068058(cryl1)

TNG:	GSTEN00029164G001

LCO:	104934840(cryl1)

NCC:	104945644(cryl1)

MZE:	101465841 112436192 112436206(cryl1)

OLA:	101157739(cryl1)

XMA:	102230923(cryl1)

PRET:

103478202(cryl1)

NFU:	107389625(cryl1)

KMR:	108244181(cryl1)

CSEM:

103391958(cryl1)

LCF:	108897026(cryl1)

SDU:	111218259(cryl1)

HCQ:	109522065(cryl1)

BPEC:

110162057(cryl1)

MALB:

109970945(cryl1)

SASA:

100195418(cryl1)

OTW:	112240524(cryl1)

ELS:	105016416(cryl1)

SFM:	108937705(cryl1)

LCM:	102362253(CRYL1)

CMK:	103186496(cryl1)

BFO:	BRAFLDRAFT_116612 BRAFLDRAFT_125244 BRAFLDRAFT_254365 BRAFLDRAFT_88563

CIN:

100176260

SPU:

589657

APLC:

110981494 110981535 110981536

SKO:

100374307

DME:	Dmel_CG10131(CG10131) Dmel_CG9914(CG9914)

DPO:	Dpse_GA10097 Dpse_GA23040

DAN:	Dana_GF11336 Dana_GF19071

DER:	6548822 6550539

DPE:	6590724 6603093

DSE:	Dsec_GM13412 Dsec_GM21560

DSI:	Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)

DWI:	6639842 6648665

DYA:	Dyak_GE11007 Dyak_GE13601

DGR:	Dgri_GH12278 Dgri_GH22921

DMO:	Dmoj_GI10976 Dmoj_GI18410

DVI:	Dvir_GJ18534 Dvir_GJ21492

MDE:	101888499 101897214

AGA:	AgaP_AGAP013544

AAG:

5569895

CQU:	CpipJ_CPIJ018047 CpipJ_CPIJ019115

AME:	406119(Cryl1)

BIM:

BTER:

SOC:

AEC:

ACEP:

PBAR:

HST:

DQU:

CFO:

LHU:

PGC:

PCF:

NVI:

MDL:

TCA:

DPA:

NVL:

BMOR:

DPL:	KGM_211998

PMAC:

106716619

PRAP:

110996894

HAW:

110375292

PXY:	105383308 105396444

API:

100160442

DNX:

107163082

CLEC:

106668054

PHU:	Phum_PHUM424710

ZNE:

110836645

FCD:

110850841

DPX:	DAPPUDRAFT_306692

ISC:	IscW_ISCW020505 IscW_ISCW024631

TUT:	107361139 107363503 107363504 107371216

CEL:	CELE_Y71F9B.9(Y71F9B.9)

CBR:

CBG04121

NAI:	NECAME_01388

LGI:	LOTGIDRAFT_189928 LOTGIDRAFT_95422

CRG:	105330247 105336911

MYI:	110448022 110457594 110457605

OBI:

106873772

LAK:	106152168 106168383

NVE:	NEMVE_v1g168735

EPA:

ADF:

HMG:

AQU:

MBR:	MONBRDRAFT_2035

SRE:	PTSG_04984

» show all

Reference

Authors

Dworsky, P. and Hoffmann-Ostenhof, O.

Title

L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.

Journal

Acta Biochim Pol 11:269-277 (1964)

Reference

Authors

Smiley, J.D. and Ashwell, G.

Title

Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.

Journal

J Biol Chem 236:357-364 (1961)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.45

IUBMB Enzyme Nomenclature:

1.1.1.45

ExPASy - ENZYME nomenclature database:

1.1.1.45

BRENDA, the Enzyme Database:

1.1.1.45

CAS:

9028-51-7

DBGET integrated database retrieval system