KEGG ENZYME: 1.1.1.45

ENZYME: 1.1.1.45

Entry

EC 1.1.1.45                 Enzyme

Name

L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-gulonate:NAD+ 3-oxidoreductase

Reaction(IUBMB)

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]

Reaction(KEGG)

R02640

Substrate

L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]

Product

3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also oxidizes other L-3-hydroxyacids.

History

EC 1.1.1.45 created 1961

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K13247

L-gulonate 3-dehydrogenase

Genes

HSA:	51084(CRYL1)

PTR:	452458(CRYL1)

PPS:	100972837(CRYL1)

GGO:	101150176(CRYL1)

PON:	100171829(CRYL1)

NLE:	100592398(CRYL1)

MCC:	703988(CRYL1)

MCF:	102126962(CRYL1)

CSAB:

103248964(CRYL1)

CATY:

105591942(CRYL1)

PANU:

101001860(CRYL1)

TGE:	112610999(CRYL1)

RRO:	104653941(CRYL1)

RBB:	108519944(CRYL1)

TFN:	117063326(CRYL1)

PTEH:

111525293(CRYL1)

CJC:	100412249(CRYL1)

CSYR:

103270481(CRYL1)

MMUR:

105878855(CRYL1)

LCAT:

123649492(CRYL1)

OGA:	100952755(CRYL1)

MMU:	68631(Cryl1)

MCAL:

110309524(Cryl1)

MPAH:

110325514(Cryl1)

RNO:	290277(Cryl1)

MCOC:

116084687(Cryl1)

MUN:	110549743(Cryl1)

CGE:	100763866(Cryl1)

MAUA:

101840819(Cryl1)

PLEU:

114693857(Cryl1)

MORG:

121435018(Cryl1)

AAMP:

119800418(Cryl1)

NGI:	103726723(Cryl1)

HGL:	101708457(Cryl1)

CPOC:

100724326(Cryl1)

CCAN:

109695277(Cryl1)

DORD:

105981591(Cryl1)

DSP:	122112582(Cryl1)

NCAR:

124974061 124984686

OCU:	100009108(CRYL1)

OPI:	101517946(CRYL1)

TUP:	102481339(CRYL1)

CFA:	486050(CRYL1)

CLUD:

112669557(CRYL1)

VVP:	112918595(CRYL1)

VLG:	121496631(CRYL1)

AML:	100472061(CRYL1)

UMR:	103664279(CRYL1)

UAH:	113251169(CRYL1)

UAR:	123791990(CRYL1)

ELK:

111159885

LLV:

125096155

MPUF:

101676898(CRYL1)

ORO:	101365710(CRYL1)

EJU:	114212937(CRYL1)

ZCA:	113920010(CRYL1)

MLX:	118009602(CRYL1)

FCA:	101092816(CRYL1)

PYU:	121012709(CRYL1)

PBG:	122480396(CRYL1)

PTG:	102950829(CRYL1)

PPAD:

109266190(CRYL1)

AJU:	106979799(CRYL1)

HHV:	120226076(CRYL1)

BTA:	281725(CRYL1)

BOM:	102271200(CRYL1)

BIU:	109567054(CRYL1)

BBUB:

102401582(CRYL1)

CHX:	102170708(CRYL1)

OAS:	101118708(CRYL1)

ODA:	120882971(CRYL1)

CCAD:

122447415(CRYL1)

SSC:	396914(CRYL1)

CFR:	102509868(CRYL1)

CBAI:

105066281(CRYL1)

CDK:	105096393(CRYL1)

VPC:	102524845(CRYL1)

BACU:

103009238(CRYL1)

LVE:	103070582(CRYL1)

OOR:	101286495(CRYL1)

DLE:	111175144(CRYL1)

PCAD:

102986755(CRYL1)

PSIU:

116742905(CRYL1)

ECB:	100054141(CRYL1)

EPZ:	103564931(CRYL1)

EAI:	106828569(CRYL1)

MYB:	102243403(CRYL1)

MYD:	102772105(CRYL1)

MMYO:

118650826(CRYL1)

MLF:	102433427(CRYL1)

MNA:	107529957(CRYL1)

PKL:	118728704(CRYL1)

HAI:	109388026(CRYL1)

DRO:	112323170(CRYL1)

SHON:

118980601(CRYL1)

AJM:	119042440(CRYL1)

PDIC:

114513187(CRYL1)

PHAS:

123822763(CRYL1)

MMF:	118623484(CRYL1)

RFQ:	117021303(CRYL1)

PALE:

102894030(CRYL1)

PGIG:

120602838(CRYL1)

PVP:	105292144(CRYL1)

RAY:	107497671(CRYL1)

MJV:	108405961(CRYL1)

TOD:	119258928(CRYL1)

SARA:

101558948(CRYL1)

LAV:	100659835(CRYL1)

TMU:

101345413

DNM:	101445681(CRYL1)

MDO:	100023498(CRYL1)

GAS:	123240613(CRYL1)

SHR:	100917581(CRYL1)

PCW:	110195845(CRYL1)

OAA:	100089465(CRYL1)

GGA:	418953(CRYL1)

PCOC:

116244280(CRYL1)

MGP:

100551040

CJO:	107308329(CRYL1)

NMEL:

110389386(CRYL1)

APLA:

101793734(CRYL1)

ACYG:

106040376(CRYL1)

AFUL:

116498931(CRYL1)

TGU:	100232047(CRYL1)

LSR:	110475660(CRYL1)

SCAN:

103827309(CRYL1)

PMOA:

120506684(CRYL1)

OTC:	121342022(CRYL1)

PRUF:

121364257(CRYL1)

GFR:	102041430(CRYL1)

FAB:	101817119(CRYL1)

PHI:	102101871(CRYL1)

PMAJ:

107209122(CRYL1)

CCAE:

111923791(CRYL1)

CCW:	104690100(CRYL1)

CBRC:

103613239(CRYL1)

ETL:	114057805(CRYL1)

ZAB:	102061772(CRYL1)

FPG:	101922282(CRYL1)

FCH:	102049266(CRYL1)

CLV:	102083838(CRYL1)

EGZ:	104134722(CRYL1)

NNI:	104023102(CRYL1)

PLET:

104623628(CRYL1)

PCRI:

104026979(CRYL1)

ACUN:

113482754(CRYL1)

TALA:

104361260(CRYL1)

PADL:

103920202(CRYL1)

ACHC:

115353354(CRYL1)

HALD:

104319372(CRYL1)

CCRI:

104156172(CRYL1)

CSTI:

104563835(CRYL1)

EHS:	104502671(CRYL1)

FGA:	104075928(CRYL1)

LDI:	104344006(CRYL1)

MNB:	103769606(CRYL1)

OHA:	104337317(CRYL1)

AAM:	106500417(CRYL1)

AROW:

112968342(CRYL1)

NPD:	112943768(CRYL1)

DNE:	112990415(CRYL1)

ASN:	102385817(CRYL1)

AMJ:	102567690(CRYL1)

CPOO:

109306668(CRYL1)

GGN:	109302917(CRYL1)

PSS:	102463965(CRYL1)

CMY:	102935894(CRYL1)

CPIC:

101933946(CRYL1)

TST:	117871124(CRYL1)

CABI:

116816440(CRYL1)

MRV:	120399237(CRYL1)

ACS:	100564118(cryl1)

PVT:	110083538(CRYL1)

SUND:

121924941(CRYL1)

PBI:	103051802(CRYL1)

PMUR:

107286120(CRYL1)

TSR:	106551499(CRYL1)

PGUT:

117661337(CRYL1)

VKO:	123029093(CRYL1)

PMUA:

114595713(CRYL1)

ZVI:	118085139(CRYL1)

GJA:	107125996(CRYL1)

STOW:

125430493(CRYL1)

XLA:	100036971(cryl1.L) 108709973(cryl1.S)

XTR:	100145620(cryl1)

NPR:	108785578(CRYL1)

RTEM:

120929241(CRYL1)

BBUF:

120996355(CRYL1)

BGAR:

122930603(CRYL1)

DRE:	751596(cryl1)

SRX:	107712274 107724506

SANH:

107658254 107668879

SGH:	107569147(cryl1) 107597421

CCAR:

109064376 109096349

CAUA:

113053392 113071898 113108802

PPRM:

120467043(cryl1)

MAMB:

125270524(cryl1)

IPU:	100528270(cryl1)

PHYP:

113526091(cryl1)

SMEO:

124380707(cryl1)

TFD:	113654286(cryl1)

AMEX:

103023213(cryl1)

EEE:	113588651(cryl1)

TRU:	101068058(cryl1)

TNG:	GSTEN00029164G001

LCO:	104934840(cryl1)

NCC:	104945644(cryl1)

CGOB:

115026817(cryl1)

ELY:	117248914(cryl1)

EFO:	125900209(cryl1)

PLEP:

121948948(cryl1)

SLUC:

116062300(cryl1)

ECRA:

117953287(cryl1)

PFLV:

114564208(cryl1)

GAT:	120833953(cryl1)

PPUG:

119229346(cryl1)

MSAM:

119904472(cryl1)

CUD:	121522650(cryl1)

ALAT:

119025838(cryl1)

MZE:	101465841 112436192 112436206(cryl1)

ONL:	100691411(cryl1)

OAU:	116332577(cryl1)

OLA:	101157739(cryl1)

OML:	112155251(cryl1)

XMA:	102230923(cryl1)

XCO:	114148696(cryl1)

XHE:	116723531(cryl1)

PRET:

103478202(cryl1)

PFOR:

103156381(cryl1)

PLAI:

106935265(cryl1)

PMEI:

106903604(cryl1)

GAF:	122839853(cryl1)

CVG:	107087357(cryl1)

CTUL:

119772901(cryl1)

GMU:	124871079(cryl1)

NFU:	107389625(cryl1)

KMR:	108244181(cryl1)

ALIM:

106524932(cryl1)

NWH:	119419355(cryl1)

AOCE:

111581663(cryl1)

MCEP:

125017187(cryl1)

CSEM:

103391958(cryl1)

POV:	109637940(cryl1)

SSEN:

122761091(cryl1)

HHIP:

117755164(cryl1)

HSP:	118120347(cryl1)

LCF:	108897026(cryl1)

SDU:	111218259(cryl1)

SLAL:

111652885(cryl1)

XGL:	120801727(cryl1)

HCQ:	109522065(cryl1)

BPEC:

110162057(cryl1)

MALB:

109970945(cryl1)

BSPL:

114847366(cryl1)

SASA:

100195418(cryl1)

OTW:	112240524(cryl1)

OMY:	110520403(cryl1)

OGO:	124044093(cryl1)

ONE:	115112116(cryl1)

SALP:

111978533(cryl1)

SNH:	120058412(cryl1)

CCLU:

121536894 121571699

ELS:	105016416(cryl1)

SFM:	108937705(cryl1)

PKI:	111860704(cryl1)

AANG:

118214554(cryl1) 118223981

LOC:	102684363(cryl1)

PSPA:

121320467(cryl1) 121327669

ARUT:

117406054(cryl1) 117406863

LCM:	102362253(CRYL1)

CMK:	103186496(cryl1)

RTP:	109930659(cryl1)

BFO:

118422602

BBEL:

109488016

CIN:

100176260

SCLV:

120336091

SPU:	115928294 577306 589657

APLC:

110981494 110981535 110981536

SKO:

100374307

DME:	Dmel_CG10131(Had2) Dmel_CG9914(Had1)

DER:	6548822 6550539

DSE:	6609182 6617912

DSI:	Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)

DYA:	Dyak_GE11007 Dyak_GE13601

DAN:	6494200 6501835

DSR:	110180150 110191959

DPO:	4803972 6901728

DPE:	6590724 6603093

DMN:	108158253 108159363 117190757

DWI:	6639842 6648665

DGR:	6565348 6568938

DMO:	Dmoj_GI10976 Dmoj_GI18410

DAZ:	108617572 108619199

DNV:	108653241 108656753

DHE:	111592192 111595367

DVI:	6626866 6636728

CCAT:

101453450 101456276 101456789

BOD:	106622355 106626802

MDE:	101888499 101897214

SCAC:

106086914 106086916 106093808

LCQ:	111679870 111686013

LSQ:	119600618 119605148 119615754

HIS:

119661460

AGA:	AgaP_AGAP013544

ACOZ:

120948141

AARA:

120894717

ASTE:

118510134 118516924

AAG:

5569895

AALB:

109399229

CQU:	CpipJ_CPIJ018047 CpipJ_CPIJ019115

CPII:

120422649 120431521

CNS:

116347304

BCOO:

119080762

AME:	406119(Cryl1)

ACER:

107995494

ALAB:

122710384

BIM:

100742533

BBIF:

117211061

BVK:

117232137

BVAN:

117157796

BTER:

100650820

BPYO:

122573401

CCAL:

108626681 108629961

OBB:	114882990 114883008

MGEN:

117225661

NMEA:

116424552

CGIG:

122395521

SOC:

105195706

MPHA:

105832446

AEC:

105144455

ACEP:

105622538

PBAR:

105431786

VEM:	105561636 105570417

HST:

105183285

DQU:

106741081

CFO:

105257467

FEX:

115235110

LHU:

105668733

PGC:

109852151

OBO:

105282065

PCF:

106785654

PFUC:

122516905

VPS:

122628397

NVI:

100116345

CSOL:

105360276

TPRE:

106659815

MDL:

103573914

CGLO:

123268844

FAS:

105266907

DAM:

107045947

AGIF:

122850047

LHT:

122504281

CCIN:

107265976

TCA:

656318

DPA:

109541128

SOY:

115878469

ATD:

109601505

CSET:

123306830

AGB:	108906080 108906095

LDC:

111509970

NVL:

108558442

APLN:

108736178

PPYR:

116168479

OTU:

111416084

BMOR:

101740023

BMAN:

114241018

MSEX:

115441101

DPL:	KGM_211998

BANY:

112043720

PMAC:

106716619

PPOT:

106100831

PXU:

106125533

PRAP:

110996894

ZCE:

119831471

HAW:

110375292

HZE:

124630756

TNL:

113502390

SLIU:

111349675

OFU:

114360575

PXY:	105383308 105396444

API:

100160442

DNX:

107163082

AGS:

114126889

RMD:

113556888

BTAB:

109030675

DCI:	103512794 103524139

CLEC:

106668054

HHAL:

106682907

NLU:	111048337 120355770

PHU:	Phum_PHUM424710

FOC:	113203906 113211664

TPAL:

117640202 117643446

ZNE:

110836645

CSEC:

111870196

FCD:

110850841

DPX:	DAPPUDRAFT_306692

DMK:

116922972

PVM:

113820593

PJA:

122250216

PCHN:

125046015

HAME:

121868225

PCLA:

123764372

PTRU:

123499754

HAZT:

108673194

EAF:

111704761

PPOI:

119102644 119102645 119103678

ISC:	IscW_ISCW024631

DSV:

119460873

RSAN:

119396684 119396685

RMP:

119174841

VDE:

111248233

VJA:

111271569

TUT:	107361139 107363503 107363504 107371216

DPTE:

113788736 113788737

DFR:	124492816 124496926

CSCU:

111638201

PTEP:

107448274 107452836 122273100

SDM:

118202986

CEL:	CELE_Y71F9B.9(Y71F9B.9)

CBR:

CBG_04121

NAI:	NECAME_01388

LGI:	LOTGIDRAFT_189928 LOTGIDRAFT_95422

PCAN:

112555792 112565739 112566843

BGT:	106064558 106073430

GAE:	121369917 121370830 121370832 121372140 121372142 121372193

HRF:	124147318 124147327 124147345 124147347 124147348 124147351

HRJ:	124282586 124282594 124282598 124282607 124283055

CRG:	105330247 105336911 117690734 117690735 117690897

MYI:	110448022 110457594 110457605

PMAX:

117326996 117326998 117341359

MMER:

123551220 123551221 123551632 123560311

OBI:

106873772

OSN:

115228137

LAK:	106152168 106168383

NVE:

5510436

EPA:

110235936

ATEN:

116303602

ADF:

107344229

AMIL:

114975193

PDAM:

113664513

SPIS:

111325818

DGT:

114534577

XEN:	124441295 124442623

HMG:

100202070

AQU:

100640580

MBR:	MONBRDRAFT_2035

SRE:	PTSG_04984

PGE:	LG71_09120

GAI:	IMCC3135_17145(lcdH_2)

HEL:

HELO_3286

HAK:	KO116_02208

HHU:	AR456_19820

HCO:	LOKO_03375(lcdH_2)

HALO:

BWR19_14340

HHH:	CLM76_02790

HCAM:

I4484_05150 I4484_12400

HSX:	HNO51_12115

HPRO:

LMS44_09520

KUY:	FY550_00490

MARS:

A8C75_06675

SALN:

SALB1_1674

BCEN:

DM39_5776

BMK:

DM80_5147

BPSL:

WS57_04025

BSTG:

WT74_30360

BYI:	BYI23_B015300 BYI23_C007800

BUE:	BRPE67_BCDS02340 BRPE67_CCDS03430

BUQ:	AC233_10455

BUM:	AXG89_13400

BUI:	AX768_07260

BPX:	BUPH_04942 BUPH_06489

PARA:

BTO02_09540 BTO02_24230 BTO02_32650

PGP:	CUJ91_10810

PACP:

FAZ97_21260

PACS:

FAZ98_17445

PEW:	KZJ38_13715 KZJ38_25985 KZJ38_35540

CABA:

SBC2_54200(lcdH_1)

BUO:	BRPE64_BCDS11720 BRPE64_CCDS01850

BPC:

BPTD_1889

BPER:

BN118_0916

BPET:

B1917_1709

BPEU:

Q425_14610

BBH:	BN112_1773

BBM:	BN115_1644

BBX:	BBS798_1643

BPT:

Bpet3360

BBRO:

BAU06_03200 BAU06_15475

BFZ:	BAU07_10930 BAU07_24460

BOH:	AKI39_14855 AKI39_21555

BOJ:	CBF45_08895

AXY:	AXYL_04862

AXO:	NH44784_060221

AXN:	AX27061_4268

AXX:	ERS451415_04289(paaH_4)

ADT:	APT56_19640

AIS:	BUW96_13300

ASW:	CVS48_14150

ACHR:

C2U31_16275

ACHB:

DVB37_20335

ADY:	HLG70_29295

PUT:

PT7_0383

PUS:	CKA81_08315

AMIM:

MIM_c40310

CDN:	BN940_06781

ODI:

ODI_R0637

BOZ:	DBV39_12625

PACR:

FXN63_19430

KGY:	EHF36_09020

AANT:

HUK68_10725

VEI:

Veis_4703

HHT:	F506_08860

HRB:	Hrubri_3455

HEE:	hmeg3_17675

HFR:	G5S34_18910

XYK:	GT347_06140 GT347_19045

MLN:	A9174_21020

MCI:	Mesci_5299

MOP:	Mesop_4014

MESW:

A9K65_021555 A9K65_028980

MJR:	EB229_20785

MERD:

EB233_18125

MESO:

BSQ44_20585

AMIH:

CO731_01963(lcdH_1)

PHT:	BLM14_28735

NIY:	FQ775_13525

KMN:	HW532_07825

VGO:	GJW-30_1_04255(lcdH_4)

BOP:	AXW83_21945

BOS:	BSY19_1277

BVV:	BHK69_29370

BOI:	BLM15_25010

BOF:	FQV39_05910

XAU:

Xaut_0427

SNO:

Snov_4081

LNE:	FZC33_04150

ANC:	GBB76_15935

APRA:

G3A50_13320

MRD:	Mrad2831_2898

MET:

M446_4642

MNO:

Mnod_3695

MOR:

MOC_3265

MAQU:

Maq22A_c19930(fadB)

MPHY:

MCBMB27_02339

MEE:	DA075_22515

METX:

A3862_17305

MMES:

MMSR116_00105

MTEA:

DK419_16225

MOC:	BB934_42640

RHJ:	HZY79_03885

MAAD:

AZF01_12450

MMED:

Mame_01642(lcdH_2)

NOH:	G5V57_15960

LABP:

FJ695_16130

PHR:	C6569_05050

PSTG:

E8M01_28880

RLI:	RLO149_c043210

KVL:

KVU_1278

KVU:

EIO_1812

YAN:	AYJ57_24165

TPRO:

Ga0080559_TMP3737

AHT:	ANTHELSMS3_02315

SAGU:

CDO87_26375

THAA:

CFI11_06200

MALU:

KU6B_45020

PAMI:

JCM7686_pAMI4p135

PARO:

CUV01_01410

RSU:

NHU_04219

RHM:	B5V46_17805

TEC:	AKL02_003620

PSEB:

EOK75_03875

SPHI:

TS85_23200

SPHJ:

BSL82_11010

PALG:

HFP57_02055 HFP57_15870

AMV:	ACMV_31100

RGI:	RGI145_00840

ROS:	CTJ15_17465

RMUC:

FOB66_21065

SKT:	IGS68_20395 IGS68_24605

HTQ:	FRZ44_36840 FRZ44_43320

HADH:

FRZ61_35880 FRZ61_41220

CGS:	C624_15115

CGG:	C629_15125

CAMG:

CAMM_07750

MLV:	CVS47_02464(lcdH_1)

SALA:

ESZ53_10390

NANO:

G5V58_03890

» show all

Reference

Authors

Dworsky, P. and Hoffmann-Ostenhof, O.

Title

L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.

Journal

Acta Biochim Pol 11:269-277 (1964)

Reference

Authors

Smiley, J.D. and Ashwell, G.

Title

Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.

Journal

J Biol Chem 236:357-364 (1961)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.45

IUBMB Enzyme Nomenclature:

1.1.1.45

ExPASy - ENZYME nomenclature database:

1.1.1.45

BRENDA, the Enzyme Database:

1.1.1.45

CAS:

9028-51-7

DBGET integrated database retrieval system