KEGG ENZYME: 1.1.1.45

ENZYME: 1.1.1.45

Entry

EC 1.1.1.45 Enzyme

Name

L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

L-gulonate:NAD+ 3-oxidoreductase

Reaction(IUBMB)

L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]

Reaction(KEGG)

R02640

Substrate

L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]

Product

3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also oxidizes other L-3-hydroxyacids.

History

EC 1.1.1.45 created 1961

Pathway

ec00040

Pentose and glucuronate interconversions

ec01100

Metabolic pathways

Orthology

K13247

L-gulonate 3-dehydrogenase

Genes

HSA:	51084(CRYL1)

PTR:	452458(CRYL1)

PPS:	100972837(CRYL1)

GGO:	101150176(CRYL1)

PON:	100171829(CRYL1)

NLE:	100592398(CRYL1)

MCC:	703988(CRYL1)

MCF:	102126962(CRYL1)

CSAB:

103248964(CRYL1)

CATY:

105591942(CRYL1)

PANU:

101001860(CRYL1)

RRO:	104653941(CRYL1)

RBB:	108519944(CRYL1)

TFN:	117063326(CRYL1)

PTEH:

111525293(CRYL1)

CJC:	100412249(CRYL1)

MMUR:

105878855(CRYL1)

MMU:	68631(Cryl1)

MCAL:

110309524(Cryl1)

MPAH:

110325514(Cryl1)

RNO:	290277(Cryl1)

MCOC:

116084687(Cryl1)

MUN:	110549743(Cryl1)

CGE:	100763866(Cryl1)

PLEU:

114693857(Cryl1)

NGI:	103726723(Cryl1)

HGL:	101708457(Cryl1)

CCAN:

109695277(Cryl1)

OCU:	100009108(CRYL1)

TUP:	102481339(CRYL1)

CFA:	486050(CRYL1)

VVP:	112918595(CRYL1)

VLG:	121496631(CRYL1)

AML:	100472061(CRYL1)

UMR:	103664279(CRYL1)

UAH:	113251169(CRYL1)

ORO:	101365710(CRYL1)

ELK:

111159885

MPUF:

101676898(CRYL1)

EJU:	114212937(CRYL1)

MLX:	118009602(CRYL1)

FCA:	101092816(CRYL1)

PTG:	102950829(CRYL1)

PPAD:

109266190(CRYL1)

AJU:	106979799(CRYL1)

HHV:	120226076(CRYL1)

BTA:	281725(CRYL1)

BOM:	102271200(CRYL1)

BIU:	109567054(CRYL1)

BBUB:

102401582(CRYL1)

CHX:	102170708(CRYL1)

OAS:	101118708(CRYL1)

ODA:	120882971(CRYL1)

SSC:	396914(CRYL1)

CFR:	102509868(CRYL1)

CBAI:

105066281(CRYL1)

CDK:	105096393(CRYL1)

BACU:

103009238(CRYL1)

LVE:	103070582(CRYL1)

OOR:	101286495(CRYL1)

DLE:	111175144(CRYL1)

PCAD:

102986755(CRYL1)

ECB:	100054141(CRYL1)

EPZ:	103564931(CRYL1)

EAI:	106828569(CRYL1)

MYB:	102243403(CRYL1)

MYD:	102772105(CRYL1)

MMYO:

118650826(CRYL1)

MNA:	107529957(CRYL1)

HAI:	109388026(CRYL1)

DRO:	112323170(CRYL1)

SHON:

118980601(CRYL1)

AJM:	119042440(CRYL1)

MMF:	118623484(CRYL1)

PALE:

102894030(CRYL1)

PGIG:

120602838(CRYL1)

RAY:	107497671(CRYL1)

MJV:	108405961(CRYL1)

TOD:	119258928(CRYL1)

LAV:	100659835(CRYL1)

TMU:

101345413

MDO:	100023498(CRYL1)

SHR:	100917581(CRYL1)

PCW:	110195845(CRYL1)

OAA:	100089465(CRYL1)

GGA:	418953(CRYL1)

PCOC:

116244280(CRYL1)

MGP:

100551040

CJO:	107308329(CRYL1)

NMEL:

110389386(CRYL1)

APLA:

101793734(CRYL1)

ACYG:

106040376(CRYL1)

TGU:	100232047(CRYL1)

LSR:	110475660(CRYL1)

SCAN:

103827309(CRYL1)

PMOA:

120506684(CRYL1)

GFR:	102041430(CRYL1)

FAB:	101817119(CRYL1)

PHI:	102101871(CRYL1)

PMAJ:

107209122(CRYL1)

CCAE:

111923791(CRYL1)

CCW:	104690100(CRYL1)

ETL:	114057805(CRYL1)

FPG:	101922282(CRYL1)

FCH:	102049266(CRYL1)

CLV:	102083838(CRYL1)

EGZ:	104134722(CRYL1)

NNI:	104023102(CRYL1)

ACUN:

113482754(CRYL1)

PADL:

103920202(CRYL1)

AAM:	106500417(CRYL1)

ASN:	102385817(CRYL1)

AMJ:	102567690(CRYL1)

CPOO:

109306668(CRYL1)

GGN:	109302917(CRYL1)

PSS:	102463965(CRYL1)

CMY:	102935894(CRYL1)

CPIC:

101933946(CRYL1)

TST:	117871124(CRYL1)

CABI:

116816440(CRYL1)

ACS:	100564118(cryl1)

PVT:	110083538(CRYL1)

PBI:	103051802(CRYL1)

PMUR:

107286120(CRYL1)

TSR:	106551499(CRYL1)

PGUT:

117661337(CRYL1)

PMUA:

114595713(CRYL1)

ZVI:	118085139(CRYL1)

GJA:	107125996(CRYL1)

XLA:	100036971(cryl1.L) 108709973(cryl1.S)

XTR:	100145620(cryl1)

NPR:	108785578(CRYL1)

DRE:	751596(cryl1)

SRX:	107712274 107724506

SANH:

107658254 107668879

SGH:	107569147(cryl1) 107597421

CCAR:

109064376 109096349

CAUA:

113053392 113071898 113108802

IPU:	100528270(cryl1)

PHYP:

113526091(cryl1)

AMEX:

103023213(cryl1)

EEE:	113588651(cryl1)

TRU:	101068058(cryl1)

TNG:	GSTEN00029164G001

LCO:	104934840(cryl1)

NCC:	104945644(cryl1)

CGOB:

115026817(cryl1)

ELY:	117248914(cryl1)

PLEP:

121948948(cryl1)

SLUC:

116062300(cryl1)

ECRA:

117953287(cryl1)

PFLV:

114564208(cryl1)

GAT:	120833953(cryl1)

MSAM:

119904472(cryl1)

CUD:	121522650(cryl1)

MZE:	101465841 112436192 112436206(cryl1)

ONL:	100691411(cryl1)

OAU:	116332577(cryl1)

OLA:	101157739(cryl1)

OML:	112155251(cryl1)

XMA:	102230923(cryl1)

XCO:	114148696(cryl1)

XHE:	116723531(cryl1)

PRET:

103478202(cryl1)

CVG:	107087357(cryl1)

CTUL:

119772901(cryl1)

NFU:	107389625(cryl1)

KMR:	108244181(cryl1)

ALIM:

106524932(cryl1)

AOCE:

111581663(cryl1)

CSEM:

103391958(cryl1)

POV:	109637940(cryl1)

LCF:	108897026(cryl1)

SDU:	111218259(cryl1)

SLAL:

111652885(cryl1)

XGL:	120801727(cryl1)

HCQ:	109522065(cryl1)

BPEC:

110162057(cryl1)

MALB:

109970945(cryl1)

SASA:

100195418(cryl1)

OTW:	112240524(cryl1)

OMY:	110520403(cryl1)

SALP:

111978533(cryl1)

SNH:	120058412(cryl1)

ELS:	105016416(cryl1)

SFM:	108937705(cryl1)

PKI:	111860704(cryl1)

AANG:

118214554(cryl1) 118223981

LOC:	102684363(cryl1)

PSPA:

121320467(cryl1) 121327669

ARUT:

117406054(cryl1) 117406863

LCM:	102362253(CRYL1)

CMK:	103186496(cryl1)

RTP:	109930659(cryl1)

BFO:

BBEL:

CIN:

SCLV:

SPU:	115928294 577306 589657

APLC:

110981494 110981535 110981536

SKO:

100374307

DME:	Dmel_CG10131(Had2) Dmel_CG9914(Had1)

DER:	6548822 6550539

DSE:	6609182 6617912

DSI:	Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)

DYA:	Dyak_GE11007 Dyak_GE13601

DAN:	6494200 6501835

DSR:	110180150 110191959

DPO:	Dpse_GA10097 Dpse_GA23040

DPE:	6590724 6603093

DMN:	108158253 108159363 117190757

DWI:	6639842 6648665

DGR:	6565348 6568938

DMO:	Dmoj_GI10976 Dmoj_GI18410

DAZ:	108617572 108619199

DNV:	108653241 108656753

DHE:	111592192 111595367

DVI:	6626866 6636728

CCAT:

101453450 101456276 101456789

MDE:	101888499 101897214

LCQ:	111679870 111686013

AGA:	AgaP_AGAP013544

ACOZ:

AARA:

AAG:

AALB:

CQU:	CpipJ_CPIJ018047 CpipJ_CPIJ019115

CPII:

120422649 120431521

AME:	406119(Cryl1)

ACER:

BIM:

BBIF:

BTER:

CCAL:

OBB:	114882990 114883008

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:	105561636 105570417

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

CCIN:

TCA:

DPA:

ATD:

AGB:	108906080 108906095

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_211998

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

PXY:	105383308 105396444

API:

DNX:

AGS:

RMD:

BTAB:

DCI:	103512794 103524139

CLEC:

106668054

HHAL:

106682907

NLU:	111048337 120355770

PHU:	Phum_PHUM424710

ZNE:

110836645

CSEC:

111870196

FCD:

110850841

DPX:	DAPPUDRAFT_306692

DMK:

PVM:

HAME:

HAZT:

EAF:

ISC:	IscW_ISCW024631

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:	107361139 107363503 107363504 107371216

DPTE:

113788736 113788737

CSCU:

111638201

PTEP:

107448274 107452836 122273100

SDM:

118202986

CEL:	CELE_Y71F9B.9(Y71F9B.9)

CBR:

CBG04121

NAI:	NECAME_01388

LGI:	LOTGIDRAFT_189928 LOTGIDRAFT_95422

PCAN:

112555792 112565739 112566843

BGT:	106064558 106073430

GAE:	121369917 121370830 121370832 121372140 121372142 121372193

CRG:	105330247 105336911

MYI:	110448022 110457594 110457605

PMAX:

117326996 117326998 117341359

OBI:

106873772

LAK:	106152168 106168383

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

MBR:	MONBRDRAFT_2035

SRE:	PTSG_04984

PGE:	LG71_09120

GAI:	IMCC3135_17145(lcdH_2)

HEL:

HELO_3286

HAK:	KO116_02208

HHU:	AR456_19820

HCO:	LOKO_03375(lcdH_2)

HALO:

BWR19_14340

HHH:	CLM76_02790

HCAM:

I4484_05150 I4484_12400

KUY:	FY550_00490

MARS:

SALN:

BCEN:

BMK:

BPSL:

BSTG:

BYI:	BYI23_B015300 BYI23_C007800

BUE:	BRPE67_BCDS02340 BRPE67_CCDS03430

BUQ:	AC233_10455

BUM:	AXG89_13400

BUI:	AX768_07260

BPX:	BUPH_04942 BUPH_06489

PARA:

BTO02_09540 BTO02_24230 BTO02_32650

PGP:	CUJ91_10810

PACP:

FAZ97_21260

PACS:

FAZ98_17445

CABA:

SBC2_54200(lcdH_1)

BUO:	BRPE64_BCDS11720 BRPE64_CCDS01850

BPC:

BPER:

BPET:

BPEU:

BBH:	BN112_1773

BBM:	BN115_1644

BBX:	BBS798_1643

BPT:

Bpet3360

BBRO:

BAU06_03200 BAU06_15475

BFZ:	BAU07_10930 BAU07_24460

BOH:	AKI39_14855 AKI39_21555

BOJ:	CBF45_08895

BOZ:	DBV39_12625

AXY:	AXYL_04862

AXO:	NH44784_060221

AXN:	AX27061_4268

AXX:	ERS451415_04289(paaH_4)

ADT:	APT56_19640

AIS:	BUW96_13300

ASW:	CVS48_14150

ACHR:

C2U31_16275

ACHB:

DVB37_20335

PUT:

PT7_0383

PUS:	CKA81_08315

AMIM:

MIM_c40310

CDN:	BN940_06781

ODI:

ODI_R0637

PACR:

FXN63_19430

KGY:	EHF36_09020

AANT:

HUK68_10725

VEI:

Veis_4703

HHT:	F506_08860

HRB:	Hrubri_3455

HEE:	hmeg3_17675

HFR:	G5S34_18910

XYK:	GT347_06140 GT347_19045

MLN:	A9174_21020

MCI:	Mesci_5299

MOP:	Mesop_4014

MESO:

BSQ44_20585

MESW:

A9K65_021555 A9K65_028980

MJR:	EB229_20785

MERD:

EB233_18125

AMIH:

CO731_01963(lcdH_1)

PHT:	BLM14_28735

NIY:	FQ775_13525

KMN:	HW532_07825

VGO:	GJW-30_1_04255(lcdH_4)

BOP:	AXW83_21945

BOS:	BSY19_1277

BVV:	BHK69_29370

BOI:	BLM15_25010

BOF:	FQV39_05910

XAU:

Xaut_0427

SNO:

Snov_4081

LNE:	FZC33_04150

ANC:	GBB76_15935

APRA:

G3A50_13320

MRD:	Mrad2831_2898

MET:

M446_4642

MNO:

Mnod_3695

MOR:

MOC_3265

MAQU:

Maq22A_c19930(fadB)

MPHY:

MCBMB27_02339

MEE:	DA075_22515

METX:

A3862_17305

MMES:

MMSR116_00105

MTEA:

DK419_16225

MOC:	BB934_42640

RHJ:	HZY79_03885

MAAD:

AZF01_12450

MMED:

Mame_01642(lcdH_2)

NOH:	G5V57_15960

LABP:

FJ695_16130

PHR:	C6569_05050

PSTG:

E8M01_28880

RLI:	RLO149_c043210

KVL:

KVU_1278

KVU:

EIO_1812

YAN:	AYJ57_24165

TPRO:

Ga0080559_TMP3737

AHT:	ANTHELSMS3_02315

SAGU:

THAA:

MALU:

PAMI:

PARO:

RSU:

RHM:	B5V46_17805

TEC:	AKL02_003620

PSEB:

EOK75_03875

SPHI:

TS85_23200

SPHJ:

BSL82_11010

PALG:

HFP57_02055 HFP57_15870

AMV:	ACMV_31100

RGI:	RGI145_00840

ROS:	CTJ15_17465

RMUC:

FOB66_21065

SKT:	IGS68_20395 IGS68_24605

HTQ:	FRZ44_36840 FRZ44_43320

HADH:

FRZ61_35880 FRZ61_41220

CGS:	C624_15115

CGG:	C629_15125

CAMG:

CAMM_07750

MLV:	CVS47_02464(lcdH_1)

SALA:

ESZ53_10390

NANO:

G5V58_03890

» show all

Reference

Authors

Dworsky, P. and Hoffmann-Ostenhof, O.

Title

L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.

Journal

Acta Biochim Pol 11:269-277 (1964)

Reference

Authors

Smiley, J.D. and Ashwell, G.

Title

Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.

Journal

J Biol Chem 236:357-364 (1961)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.45

IUBMB Enzyme Nomenclature:

1.1.1.45

ExPASy - ENZYME nomenclature database:

1.1.1.45

BRENDA, the Enzyme Database:

1.1.1.45

CAS:

9028-51-7

DBGET integrated database retrieval system