KEGG   ENZYME: 1.1.1.45Help
Entry
EC 1.1.1.45                 Enzyme                                 

Name
L-gulonate 3-dehydrogenase;
L-3-aldonate dehydrogenase;
L-3-aldonic dehydrogenase;
L-gulonic acid dehydrogenase;
L-beta-hydroxyacid dehydrogenase;
L-beta-hydroxy-acid-NAD+-oxidoreductase;
L-3-hydroxyacid dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
L-gulonate:NAD+ 3-oxidoreductase
Reaction(IUBMB)
L-gulonate + NAD+ = 3-dehydro-L-gulonate + NADH + H+ [RN:R02640]
Reaction(KEGG)
Substrate
L-gulonate [CPD:C00800];
NAD+ [CPD:C00003]
Product
3-dehydro-L-gulonate [CPD:C00618];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Also oxidizes other L-3-hydroxyacids.
History
EC 1.1.1.45 created 1961
Pathway
ec00040  Pentose and glucuronate interconversions
ec01100  Metabolic pathways
Orthology
K13247  L-gulonate 3-dehydrogenase
Genes
HSA: 51084(CRYL1)
PTR: 452458(CRYL1)
PPS: 100972837(CRYL1)
GGO: 101150176(CRYL1)
PON: 100171829(CRYL1)
NLE: 100592398(CRYL1)
MCC: 703988(CRYL1)
MCF: 102126962(CRYL1)
CSAB: 103248964(CRYL1)
RRO: 104653941(CRYL1)
RBB: 108519944(CRYL1)
CJC: 100412249(CRYL1)
SBQ: 101053731(CRYL1)
MMU: 68631(Cryl1)
MCAL: 110309524(Cryl1)
MPAH: 110325514(Cryl1)
RNO: 290277(Cryl1)
MUN: 110549743(Cryl1)
CGE: 100763866(Cryl1)
NGI: 103726723(Cryl1)
HGL: 101708457(Cryl1)
CCAN: 109695277(Cryl1)
OCU: 100009108(CRYL1)
TUP: 102481339(CRYL1)
CFA: 486050(CRYL1)
VVP: 112918595(CRYL1)
AML: 100472061(CRYL1)
UMR: 103664279(CRYL1)
UAH: 113251169(CRYL1)
ORO: 101365710(CRYL1)
FCA: 101092816(CRYL1)
PTG: 102950829(CRYL1)
AJU: 106979799(CRYL1)
BTA: 281725(CRYL1)
BOM: 102271200(CRYL1)
BIU: 109567054(CRYL1)
BBUB: 102401582(CRYL1)
PHD: 102332401(CRYL1)
CHX: 102170708(CRYL1)
OAS: 101118708(CRYL1)
SSC: 396914(CRYL1)
CFR: 102509868(CRYL1)
CDK: 105096393(CRYL1)
BACU: 103009238(CRYL1)
LVE: 103070582(CRYL1)
OOR: 101286495(CRYL1)
DLE: 111175144(CRYL1)
ECB: 100054141(CRYL1)
EPZ: 103564931(CRYL1)
EAI: 106828569(CRYL1)
MYB: 102243403(CRYL1)
MYD: 102772105(CRYL1)
MNA: 107529957(CRYL1)
HAI: 109388026(CRYL1)
RSS: 109436831(CRYL1)
DRO: 112323170(CRYL1)
PALE: 102894030(CRYL1)
LAV: 100659835(CRYL1)
TMU: 101345413
MDO: 100023498(CRYL1)
SHR: 100916381 100917581(CRYL1)
PCW: 110195845(CRYL1)
OAA: 100089465(CRYL1)
GGA: 418953(CRYL1)
MGP: 100551040(CRYL1)
CJO: 107308329(CRYL1)
APLA: 101793734(CRYL1)
ACYG: 106040376(CRYL1)
TGU: 100232047(CRYL1)
LSR: 110475660(CRYL1)
SCAN: 103827309(CRYL1)
GFR: 102041430(CRYL1)
FAB: 101817119(CRYL1)
PHI: 102101871(CRYL1)
PMAJ: 107209122(CRYL1)
CCAE: 111923791(CRYL1)
CCW: 104690100(CRYL1)
ETL: 114057805(CRYL1)
FPG: 101922282(CRYL1)
FCH: 102049266(CRYL1)
CLV: 102083838(CRYL1)
EGZ: 104134722(CRYL1)
NNI: 104023102(CRYL1)
ACUN: 113482754(CRYL1)
AAM: 106500417(CRYL1)
ASN: 102385817(CRYL1)
AMJ: 102567690(CRYL1)
PSS: 102463965(CRYL1)
CMY: 102935894(CRYL1)
CPIC: 101933946(CRYL1)
ACS: 100564118(cryl1)
PVT: 110083538(CRYL1)
PBI: 103051802(CRYL1)
PMUR: 107286120(CRYL1)
GJA: 107125996(CRYL1)
XLA: 100036971(cryl1.L) 108709973(cryl1.S)
XTR: 100145620(cryl1)
NPR: 108785578(CRYL1)
DRE: 751596(cryl1)
SRX: 107712274 107724506
SANH: 107658254 107668879
SGH: 107569147(cryl1) 107576390 107597421
CCAR: 109064376 109096347 109096348 109096349
IPU: 100528270(cryl1)
PHYP: 113526091(cryl1)
AMEX: 103023213(cryl1)
EEE: 113588651(cryl1)
TRU: 101068058(cryl1)
TNG: GSTEN00029164G001
LCO: 104934840(cryl1)
NCC: 104945644(cryl1)
MZE: 101465841 112436192 112436206(cryl1)
OLA: 101157739(cryl1)
XMA: 102230923(cryl1)
XCO: 114148696(cryl1)
PRET: 103478202(cryl1)
NFU: 107389625(cryl1)
KMR: 108244181(cryl1)
CSEM: 103391958(cryl1)
LCF: 108897026(cryl1)
SDU: 111218259(cryl1)
HCQ: 109522065(cryl1)
BPEC: 110162057(cryl1)
MALB: 109970945(cryl1)
SASA: 100195418(cryl1)
OTW: 112240524(cryl1)
SALP: 111978533(cryl1)
ELS: 105016416(cryl1)
SFM: 108937705(cryl1)
PKI: 111860704(cryl1)
LCM: 102362253(CRYL1)
CMK: 103186496(cryl1)
BFO: BRAFLDRAFT_116612 BRAFLDRAFT_125244 BRAFLDRAFT_254365 BRAFLDRAFT_88563
CIN: 100176260
SPU: 589657
APLC: 110981494 110981535 110981536
SKO: 100374307
DME: Dmel_CG10131(Had2) Dmel_CG9914(Had1)
DPO: Dpse_GA10097 Dpse_GA23040
DAN: Dana_GF11336 Dana_GF19071
DER: 6548822 6550539
DPE: 6590724 6603093
DSE: Dsec_GM13412 Dsec_GM21560
DSI: Dsimw501_GD11066(Dsim_GD11066) Dsimw501_GD24495(Dsim_GD24495)
DWI: 6639842 6648665
DYA: Dyak_GE11007 Dyak_GE13601
DGR: Dgri_GH12278 Dgri_GH22921
DMO: Dmoj_GI10976 Dmoj_GI18410
DAZ: 108617572 108619199
DNV: 108653241 108656753
DHE: 111592192 111595367
DVI: Dvir_GJ18534 Dvir_GJ21492
MDE: 101888499 101897214
AGA: AgaP_AGAP013544
AAG: 5569895
CQU: CpipJ_CPIJ018047 CpipJ_CPIJ019115
AME: 406119(Cryl1)
BIM: 100742533
BTER: 100650820
SOC: 105195706
MPHA: 105832446
AEC: 105144455
ACEP: 105622538
PBAR: 105431786
HST: 105183285
DQU: 106741081
CFO: 105257467
LHU: 105668733
PGC: 109852151
OBO: 105282065
PCF: 106785654
NVI: 100116345
MDL: 103573914
TCA: 656318
DPA: 109541128
NVL: 108558442
BMOR: 101740023
DPL: KGM_211998
PMAC: 106716619
PRAP: 110996894
HAW: 110375292
TNL: 113502390
PXY: 105383308 105396444
API: 100160442
DNX: 107163082
AGS: 114126889
CLEC: 106668054
PHU: Phum_PHUM424710
ZNE: 110836645
FCD: 110850841
DPX: DAPPUDRAFT_306692
ISC: IscW_ISCW020505 IscW_ISCW024631
TUT: 107361139 107363503 107363504 107371216
DPTE: 113788736 113788737
CEL: CELE_Y71F9B.9(Y71F9B.9)
CBR: CBG04121
NAI: NECAME_01388
LGI: LOTGIDRAFT_189928 LOTGIDRAFT_95422
PCAN: 112555792 112565739 112566077 112566843
CRG: 105330247 105336911
MYI: 110448022 110457594 110457605
OBI: 106873772
LAK: 106152168 106168383
NVE: NEMVE_v1g168735
EPA: 110235936
ADF: 107344229
PDAM: 113664513
SPIS: 111325818
HMG: 100202070
AQU: 100640580
MBR: MONBRDRAFT_2035
SRE: PTSG_04984
 » show all
Taxonomy
Reference
1
  Authors
Dworsky, P. and Hoffmann-Ostenhof, O.
  Title
L-3-Aldonic acid dehydrogenase from Schwanniomyces occidentalis.
  Journal
Acta Biochim Pol 11:269-277 (1964)
Reference
2
  Authors
Smiley, J.D. and Ashwell, G.
  Title
Purification and properties of beta-L-hydroxy acid dehydrogenase. II. Isolation of beta-keto-L-gluconic acid, an intermediate in L-xylulose biosynthesis.
  Journal
J Biol Chem 236:357-364 (1961)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.45
IUBMB Enzyme Nomenclature: 1.1.1.45
ExPASy - ENZYME nomenclature database: 1.1.1.45
BRENDA, the Enzyme Database: 1.1.1.45
CAS: 9028-51-7

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1731)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (259)   
   KEGG MGENES (261)   
   RefGene (1210)   
Protein sequence (45)   
   UniProt (17)   
   SWISS-PROT (7)   
   RefSeq(pep) (19)   
   PDBSTR (2)   
DNA sequence (46)   
   RefSeq(nuc) (29)   
   GenBank (9)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
All databases (1836)   

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