KEGG   ENZYME: 1.1.1.48
Entry
EC 1.1.1.48                 Enzyme                                 
Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
R01094;
(other) R01096 R01097 R08544
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00035  D-galactose 1-dehydrogenase
K22215  galactose dehydrogenase
Genes
XCCXCC0744(dgd)
XCBXC_3491
XCAxcc-b100_3611
XCPXCR_0916
XCVXCV0847
XAXXACM_0792
XACXAC0797(dgd)
XCIXCAW_03785(dgd)
XCTJ151_00922
XCJJ158_00919
XCUJ159_00919
XCNJ169_00918
XCWJ162_00918
XCRJ163_00918
XCMJ164_00918
XCFJ172_00913
XFUXFF4834R_chr08000
XAOXAC29_04060
XOMXOO3586(XOO3586)
XOOXOO3804(dgd)
XOPPXO_04345
XOYAZ54_04880
XORXOC_0862
XOZBE73_20070
XFRBER92_04515
XVEBJD12_16980
XPEBJD13_12735
XHRXJ27_11375
XGABI317_04830
XPHXppCFBP6546_07460(XppCFBP6546P_07460)
XVAC7V42_04440
XANAC801_04115
XARXB05_20920
XCZEBN15_03050
XEUXSP_000805
XHDLMG31886_35330(araA)
XPRMUG10_06025
PSUPsesu_0880
PDDMNQ95_11215
VNIVIBNI_A1286
PORAPT59_06560
PSTPSPTO_4782(gal)
PSBPsyr_4331
PSYRN018_22455
PSPPSPPH_4371(gal)
PSAVPSA3335_23655
PAMGBKM19_025415
PAVLBKM03_25160
PVDCFBP1590_0598(gal)
PCABJGS08_02840
PCOFPOR16_03360
PTREI9H09_20560
PSYIMME58_22220
PFEPSF113_3188
PMANOU5_1017(gal)
PCGAXG94_02455
PMEDE3Z27_13985
PLULFOB45_10870
PBAPSEBR_a2607
PBCCD58_16835
PRHLT40_07475
PKRAYO71_13680
PFKPFAS1_24545
PPSLBJP27_21330
PGGFX982_04466
PVKEPZ47_16995
PEZHWQ56_14755
PBZGN234_01850
PATAJWU58_16555
PZEHU754_012910
PMOEHV782_017180
PTZHU718_017615
PHVHU739_006475
PALVKSS97_16260
PZAHU749_014375
PIEHU724_011570
PGFJ0G10_17775
LALAT746_01710
MTHDA3224_13280
MHYDGTQ55_15345
MCELLPW13_00355
WMAWM2015_1134
CSACsal_1017
HELHELO_2796(araA)
HAKKO116_00851
HAMHALO0848
HHUAR456_09055
HAFC8233_02095
HSRHSBAA_57040
HMDCTT34_07260
HTTHZS52_09060
HCAMI4484_06110
HSXHNO51_05775
HSVHNO53_06465
HTXEKK97_06820
HPROLMS44_19210
HAAA5892_01460
CMAIBFX80_08845
CAMHLCW13_09160
KUSB9G99_10855
KMAB9H00_03950
KUYFY550_04035
PAURFGL86_17675
MARSA8C75_00495
SALNSALB1_2572
TSNW908_05220
THINCRN91_05305
PLGNCTC10937_01992(gal)
BGMCAL15_12825
HSEHsero_2708
HSZACP92_13575
HHTF506_12355
HRBHrubri_2793
HHFE2K99_14415
HFRG5S34_14390
DUGHH213_00205 HH213_15800
DEUDBW_1406
MLOmll0280 mlr4741
MLNA9174_03560 A9174_23670
MCIMesci_0734 Mesci_3619
MOPMesop_0751 Mesop_4628
MAMMesau_00714 Mesau_04253
MAMOA6B35_04175 A6B35_19870
MESWA9K65_003695 A9K65_019490
MESMEJ066_07780 EJ066_24325
MESPC1M53_10555 C1M53_29965
MHUAMCHK_2076 MCHK_5816
MJREB229_03650 EB229_23735
MERDEB233_03705 EB233_20510
MESRFGU64_01240 FGU64_16305
MESOBSQ44_00970 BSQ44_05225
MESMeso_0843 Meso_3587
HOEIMCC20628_02050 IMCC20628_02998
AAKAA2016_0715
AMIHCO731_00808(kduD_1)
PHTBLM14_10615 BLM14_29135
PHYLHB779_23860
RPODE0E05_03020
NIYFQ775_03365 FQ775_08550
ORMHTY61_08730 HTY61_17220
SMESMc00588(gal) SMc00880(fabG2)
SMKSinme_0533 Sinme_0954
SMQSinmeB_0438 SinmeB_0783
SMXSM11_chr0479(fabG2) SM11_chr2506(gal)
SMIBN406_00480 BN406_00892(gal)
SMEGC770_GR4Chr0823 C770_GR4Chr1167
SMELSM2011_c00588(gal) SM2011_c00880(fabG2)
SMERDU99_04260 DU99_06000
SMDSmed_0438 Smed_0768
RHINGR_c04370 NGR_c09060
SFHSFHH103_00504(fabg1) SFHH103_00835(gal)
SFDUSDA257_c05370(bacC1) USDA257_c08790(gal)
SIXBSY16_1689 BSY16_2170
SAMESAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal)
SINOSS05631_c05300 SS05631_c08890
EADOV14_1758 OV14_2179
EAHFA04_02260 FA04_04405
ESJSJ05684_c04240 SJ05684_c08000
EAKEKH55_0435 EKH55_0791
EMXFKV68_04485 FKV68_06230
ATUAtu0705(fabG) Atu1113
ARAArad_1105(fabG1) Arad_1691(gal)
ATAAWN88_23175 AWN88_25140
AGRAGROH133_04267(fabG) AGROH133_05248(gal)
ATFAch5_06290(fabG) Ach5_10290(gal)
AVIAvi_3910
AGCBSY240_2904
AROB0909_07805 B0909_09955
AGTEYD00_01775 EYD00_03870
ALFCFBP5473_09805 CFBP5473_12260
ARUIG6M88_10580 G6M88_12895
AVQHRR99_02380 HRR99_04990
RETRHE_CH00855(fabG1) RHE_CH01458(gal)
RECRHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal)
RELREMIM1_CH00868 REMIM1_CH01471
REPIE4803_CH00866 IE4803_CH01467
REIIE4771_CH00893 IE4771_CH01517
RLERL0917 RL1574
RLTRleg2_0503 Rleg2_1072
RLGRleg_0546 Rleg_1217
RLBRLEG3_12890 RLEG3_16465
RLURLEG12_13890 RLEG12_16705
RTRRTCIAT899_CH04105 RTCIAT899_CH06205
RIRBN877_I0681 BN877_I1100
RPUSCFBP5875_02065 CFBP5875_04285
RHLLPU83_0965(fabG1) LPU83_1415(gal)
RGARGR602_CH00913 RGR602_CH01354
RHNAMJ98_CH00874 AMJ98_CH01506
RPHAAMC79_CH00884 AMC79_CH01485
RHXAMK02_CH00894 AMK02_CH01514
RHVBA939_00440 BA939_12475
RHKKim5_CH00974 Kim5_CH01592
REZAMJ99_CH00874 AMJ99_CH01585
RJGCCGE525_05060 CCGE525_07415
RHRCKA34_07215 CKA34_09320
RGRFZ934_01375 FZ934_03865
RADCO657_02605 CO657_05680
ROYG3A56_05270 G3A56_07555
RIIFFM53_005135 FFM53_008575
RHIDFFM81_013775 FFM81_016715
RBQJ2J99_04525 J2J99_07530
RLNJ0663_13000 J0663_16230
RBANJ2J98_04195 J2J98_07295
RRGJ3P73_05235 J3P73_08825
RLSHB780_29835 HB780_31960
RROSD4A92_05815
NGLRG1141_CH19850 RG1141_CH22060
NGGRG540_CH20660 RG540_CH22940
NEOCYG48_08700
NENNCHU2750_18160 NCHU2750_35760(gal)
RHTNT26_2220 NT26_3705(fabG)
RFVRFYW14_02297 RFYW14_03590
SHZshn_03770 shn_06395
SZOK8M09_03380 K8M09_05385
SOJK6301_02500 K6301_04790
ABAWD5400_07040
PDESFE840_004280
BMEBMEII0355
BMELDK63_2884
BMIBMEA_B0926
BMZBM28_B0912
BMGBM590_B0910
BMWBMNI_II0882
BMEEDK62_2513
BMFBAB2_0293
BMBBruAb2_0292
BMCBAbS19_II02780
BAABAA13334_II00689
BABODK55_2285
BABRDO74_2705
BABTDK49_2946
BABBDK48_2407
BABUDK53_2296
BABSDK51_2874
BABCDO78_2765
BMSBRA0941
BSIBS1330_II0933
BSFBSS2_II0893
BSUIBSSP1_II0890
BSUPBSPT1_II0887
BSUVBSPT2_II0888
BSUCBSSP2_II0898
BMTBSUIS_B0934
BSZDK67_2894
BSVBSVBI22_B0932
BSWIY71_15700
BSGIY72_15650
BOVBOV_A0883
BCSBCAN_B0961(gal)
BSKBCA52141_II1676
BOLBCOUA_II0941
BCARDK60_2632
BCASDA85_14990
BMRBMI_II935
BVLBF3285c2_0471
BRUBFS01_11805
BRJBKD03_01850
OINIAR37_12310
BIOBR141012304_20075
OANOant_1420
OAHDR92_986
OPSA8A54_07840
OCHCES85_1890(gal)
OCRHGK82_08935
OCLGTN27_09245
BJAblr3205(blr3205)
BJUBJ6T_65470
BJPRN69_31735
BRABRADO1814
BBTBBta_2134
BRSS23_47920
AOLS58_57220
BRCBCCGELA001_14415
BRADBF49_1480
BICLMTR13_13405
BROBRAD285_5471
BRKCWS35_13655
BOTCIT37_37500
BRQCIT40_10570
BGQX265_25020
BGZXH91_23130
BSYMCIT39_09610
BBETF8237_04025
BARHWN72_17540
BVZBRAD3257_5483(araA)
BELBE61_28990(gal)
BDGLPJ38_18935
BSEPHAP48_0007390
BQBJ4P68_0028580
BOPAXW83_15045
BVVBHK69_13545
BOFFQV39_05850 FQV39_07840
SNOSnov_0117
STARG3545_22985
LNEFZC33_22290
APRAG3A50_11620
APOLK9D25_15465
MRDMrad2831_1330
METM446_4632
MORMOC_1687
MPHYMCBMB27_00985
METXA3862_24175
MTADM6G65_09095
MOCBB934_26650
MIVC4E04_11380
MICOGDR74_10585
BIDBind_3077
BBARRHAL1_00797(araA)
PHLKKY_220
DEQXM25_21300
DEIC4375_06070
DEAFPZ08_18255
DSALK1X15_00620
DEVOH4N61_00675
MMYRMXMO3_02336 MXMO3_02358
YTIFNA67_02615
MAADAZF01_16590
MLUTJET14_18795
AUAM673_09265
AALAIGS74_17540
AALMLUX29_19605
AUZSa4125_16520(gal)
AUBLXB15_00445
PSFPSE_2806
PPHRAPZ00_12525 APZ00_20900
LAPACP90_05475 ACP90_20260
LABRCHH27_15175
LABPFJ695_08295
LABTFIU93_11110(kduD1) FIU93_26815(araA2)
LAGGB0E33_03985 B0E33_17030
LIZLGH83_12380
ACUTMRB58_08545
CCRCC_0967
CCSCCNA_01018
CAKCaul_3616 Caul_3971
CSECseg_1896 Cseg_3324
CHQAQ619_05210
CFHC1707_10930
CAUFCSW63_18295
CAULKCG34_15460
BRLBZG35_12360
AEXAstex_1898
SITTM1040_3488
RUAD1823_19580
RUTFIU92_19050(kduD3)
JANJann_3834
RDERD1_2866
RLIRLO149_c015750 RLO149_c021980(gal)
RPONG3256_11280
DSHDshi_1243
PGAPGA1_c07370
PGLPGA2_c06870
PGDGal_02755
PHPPhaeoP97_02455
PPICPhaeoP14_00657
PHQD1820_16715
OATOAN307_c48590(gal)
OAROA238_c48520(gal)
OTMOSB_32620(araA)
OCTFTO60_16290
CMARIMCC12053_1223
MALGMALG_02110 MALG_04458
YPACCEW88_14240
YANAYJ57_16180
SULZC1J03_00790 C1J03_06065
SULDB5M07_18740
SPOTG6548_05985
SMEDJNX03_01685 JNX03_16730
SPSESULPSESMR1_02141(xylB)
TOMBWR18_10350
RMMROSMUCSMR3_00498(xylB)
ROKRAK1035_3332
AHTANTHELSMS3_00004 ANTHELSMS3_03457(araA)
SAGUCDO87_14400 CDO87_19375
THAACFI11_06380
OCDFHY55_19130
MARUFIU81_05390(araA1) FIU81_07550(kduD1) FIU81_10735(araA2)
MALUKU6B_19300 KU6B_40840
TGLHFZ77_19080
HATRC74_03105
PALXGQA70_14555
LSALKBK07_02125 KBK07_02860
RSPRSP_1369
RSHRsph17029_0037
RSQRsph17025_0027
RSKRSKD131_2769
CAZTLV780_00130
RBLB6K69_04595 B6K69_06870
PDEPden_4245
PAMIJCM7686_3307
PYEA6J80_10165
PCONB0A89_06250
PZHCX676_01055
PAMNpAMV1p0045(araA)
PARREOJ32_16375 EOJ32_18520
PAAKFIU66_12035
PKDF8A10_05995
PPANESD82_02805
PLIAE4191_18495
PSANHGN31_05895
PMAUCP157_03312(araA_1) CP157_03401(araA_2)
PTPRCA23_c01430
RMBK529_016095
DONBSK21_10855
THWBMG03_12815
TECAKL02_014740
LVSLOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA)
GEHHYN69_13900
GFUKM031_14700
TAWEI545_06570 EI545_13710
SALOEF888_19160
SEDIEBB79_05250
BOOE2K80_13290
LITFPZ52_03870
MONG8E03_05240
PSHQF3W81_19110
POZI0K15_05845
PALWPSAL_020900(araA)
PPAFI8N54_02190 I8N54_16550
CACTHZ995_05760
RBZB9057_15765
FAPGR316_12410
GCEKYE46_03945
NSMJO391_08220 JO391_15130
FAQG5B39_00745
AMAQGO499_03060 GO499_18995
NPPPP1Y_Mpl1273
NREBES08_06875 BES08_21445
NOVTQ38_022505 TQ38_022665
NOTC7W88_19915
NORFA702_20185
NDRHT578_07030
SALSala_0745
SPHKSKP52_01885(araA)
SPHXE5675_04610
SPHUSPPYR_0433(araA)
SPHMG432_06460
STAXMC45_07850
SPHITS85_21120
SSANNX02_07110 NX02_12675
SNJA7E77_05030
SMYBJP26_00310
SPANAWL63_01185 AWL63_05170
SKRBRX40_07015
SPLKAV944_13915
SPHFDM480_08630
SPAUDRN02_007175
SPAPH3Z74_00310
SPIIG7077_07600
SSING7078_02965
SARIH5J25_14685
SSUAFPZ54_00175 FPZ54_02615 FPZ54_13705
SBINSBA_ch1_01370(gal_1) SBA_ch1_35830(gal_2)
SAERNEF64_12275
SJPSJA_C1-05950
SINBSIDU_10715
SYBTZ53_11220 TZ53_22195
SPHBEP837_03127
SPHRBSY17_1053 BSY17_2379
SPHTK426_04590 K426_16895
SHYDCJD35_07410
SYAA6768_01760 A6768_17815
SPYGYGS_C1P1796 YGS_C1P2079
SUFLFIL70_11350 FIL70_17145
SBARH5V43_09110 H5V43_12365
SAMISAMIE_1002330
SPZRG5C33_10840
SPHSETR14_02030 ETR14_18295
POQKZX46_02320 KZX46_06430 KZX46_07780 KZX46_12520
AAYWYH_02192(araA)
ADOA6F68_00759(araA)
CMANA9D14_05810
QCINCF85_08000
POTE2E27_08030
KBAA0U89_02165
RGIRGI145_17595
ROSCTJ15_16445
RMUCFOB66_22030
AZLAZL_e03690(gal)
ALIAZOLI_p50383
ABSAZOBR_p440166
ABQABAZ39_31625
ABFAMK58_27415
ATIAL072_30970
AHUA6A40_14260
AZTTSH58p_21390
AZMDM194_26405
AZZDEW08_21985
AOZHUE56_23235
NAOY958_16055 Y958_28205
NCBC0V82_22765
TMOTMO_a0253
PRZGZH47_16905
NANOG5V58_18475
MFFMFFC18_12940(ped)
 » show all
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J Biol Chem 227:745-57 (1957)
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.48
IUBMB Enzyme Nomenclature: 1.1.1.48
ExPASy - ENZYME nomenclature database: 1.1.1.48
BRENDA, the Enzyme Database: 1.1.1.48
CAS: 9028-54-0

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