KEGG ENZYME: 1.1.1.48

ENZYME: 1.1.1.48

Entry

EC 1.1.1.48 Enzyme

Name

D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

D-galactose:NAD+ 1-oxidoreductase

Reaction(IUBMB)

D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]

Reaction(KEGG)

R01094;
(other) R01096 R01097 R08544

Substrate

D-galactose [CPD:C00124];
NAD+ [CPD:C00003]

Product

D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.

History

EC 1.1.1.48 created 1961, modified 2011

Pathway

ec00052

Galactose metabolism

ec01100

Metabolic pathways

Orthology

K00035

D-galactose 1-dehydrogenase

K22215

galactose dehydrogenase

Genes

XCC:	XCC0744(dgd)

XCB:

XC_3491

XCA:	xcc-b100_3611

XCP:

XCR_0916

XCV:

XCV0847

XAX:

XACM_0792

XAC:	XAC0797(dgd)

XCI:	XCAW_03785(dgd)

XCT:	J151_00922

XCJ:	J158_00919

XCU:	J159_00919

XCN:	J169_00918

XCW:	J162_00918

XCR:	J163_00918

XCM:	J164_00918

XCF:	J172_00913

XFU:	XFF4834R_chr08000

XAO:	XAC29_04060

XOO:	XOO3804(dgd)

XOM:	XOO3586(XOO3586)

XOP:

PXO_04345

XOY:	AZ54_04880

XOR:

XOC_0862

XOZ:	BE73_20070

XFR:	BER92_04515

XGA:	BI317_04830

XVE:	BJD12_16980

XPE:	BJD13_12735

XHR:	XJ27_11375

XPH:	XppCFBP6546_07460(XppCFBP6546P_07460)

XVA:	C7V42_04440

PSU:	Psesu_0880

POR:	APT59_06560

PST:	PSPTO_4782(gal)

PSB:

Psyr_4331

PSP:	PSPPH_4371(gal)

PCG:	AXG94_02455

PRH:	LT40_07475

PFK:	PFAS1_24545

PPSL:

BJP27_21330

MTHD:

A3224_13280

WMA:	WM2015_1134

CSA:

Csal_1017

HEL:	HELO_2796(araA)

HAK:	KO116_00851

HAM:

HALO0848

HHU:	AR456_09055

HAF:	C8233_02095

HAA:	A5892_01460

CMAI:

BFX80_08845

KUS:	B9G99_10855

MARS:

A8C75_00495

SALN:

SALB1_2572

TSN:	W908_05220

THIN:

CRN91_05305

BGM:	CAL15_12825

HSE:	Hsero_2708

HSZ:	ACP92_13575

HHT:	F506_12355

HRB:	Hrubri_2793

HHF:	E2K99_14415

DEU:

DBW_1406

MLO:	mll0280 mlr4741

MLN:	A9174_03560 A9174_23670

MCI:	Mesci_0734 Mesci_3619

MOP:	Mesop_0751 Mesop_4628

MAM:	Mesau_00714 Mesau_04253

MAMO:

A6B35_04175 A6B35_19870

MESO:

BSQ44_00970 BSQ44_05225

MESW:

A9K65_003695 A9K65_019490

MESM:

EJ066_07780 EJ066_24325

MESP:

C1M53_10555 C1M53_29965

MES:	Meso_0843 Meso_3587

HOE:	IMCC20628_02050 IMCC20628_02998

AAK:	AA2016_0715

AMIH:

CO731_00808(kduD_1)

PHT:	BLM14_10615 BLM14_29135

RPOD:

E0E05_03020

SME:	SMc00588(gal) SMc00880

SMK:	Sinme_0533 Sinme_0954

SMQ:	SinmeB_0438 SinmeB_0783

SMX:	SM11_chr0479(fabG2) SM11_chr2506(gal)

SMI:	BN406_00480 BN406_00892(gal)

SMEG:

C770_GR4Chr0823 C770_GR4Chr1167

SMEL:

SM2011_c00588(gal) SM2011_c00880(fabG2)

SMER:

DU99_04260 DU99_06000

SMD:	Smed_0438 Smed_0768

RHI:	NGR_c04370 NGR_c09060

SFH:	SFHH103_00504(fabg1) SFHH103_00835(gal)

SFD:	USDA257_c05370(bacC1) USDA257_c08790(gal)

SIX:	BSY16_1689 BSY16_2170

SAME:

SAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal)

SINO:

SS05631_c05300 SS05631_c08890

EAD:	OV14_1758 OV14_2179

EAH:	FA04_02260 FA04_04405

ESJ:	SJ05684_c04240 SJ05684_c08000

ATU:	Atu0705(fabG) Atu1113

ARA:	Arad_1105(fabG1) Arad_1691(gal)

ATF:	Ach5_06290(fabG) Ach5_10290(gal)

ATA:	AWN88_23175 AWN88_25140

AVI:

Avi_3910

AGR:	AGROH133_04267(fabG) AGROH133_05248(gal)

AGC:	BSY240_2904

ARO:	B0909_07805 B0909_09955

AGT:	EYD00_01775 EYD00_03870

RET:	RHE_CH00855(fabG1) RHE_CH01458(gal)

REC:	RHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal)

REL:	REMIM1_CH00868 REMIM1_CH01471

REP:	IE4803_CH00866 IE4803_CH01467

REI:	IE4771_CH00893 IE4771_CH01517

RLE:	RL0917 RL1574

RLT:	Rleg2_0503 Rleg2_1072

RLG:	Rleg_0546 Rleg_1217

RLB:	RLEG3_12890 RLEG3_16465

RLU:	RLEG12_13890 RLEG12_16705

RTR:	RTCIAT899_CH04105 RTCIAT899_CH06205

RIR:	BN877_I0681 BN877_I1100

RHL:	LPU83_0965(fabG1) LPU83_1415(gal)

RGA:	RGR602_CH00913 RGR602_CH01354

RHN:	AMJ98_CH00874 AMJ98_CH01506

RPHA:

AMC79_CH00884 AMC79_CH01485

RHT:	NT26_2220 NT26_3705(fabG)

RHX:	AMK02_CH00894 AMK02_CH01514

RHV:	BA939_00440 BA939_12475

RHK:	Kim5_CH00974 Kim5_CH01592

REZ:	AMJ99_CH00874 AMJ99_CH01585

RJG:	CCGE525_05060 CCGE525_07415

NGL:	RG1141_CH19850 RG1141_CH22060

NGG:	RG540_CH20660 RG540_CH22940

NEO:	CYG48_08700

NEN:	NCHU2750_18160 NCHU2750_35760(gal)

SHZ:	shn_03770 shn_06395

BME:

BMEII0355

BMEL:

DK63_2884

BMI:	BMEA_B0926

BMZ:	BM28_B0912

BMG:	BM590_B0910

BMW:	BMNI_II0882

BMEE:

DK62_2513

BMF:

BAB2_0293

BMB:	BruAb2_0292

BMC:	BAbS19_II02780

BAA:	BAA13334_II00689

BABO:

BABR:

BABT:

BABB:

BABU:

BABS:

BABC:

BMS:

BSI:	BS1330_II0933

BSF:	BSS2_II0893

BSUI:

BSUP:

BSUV:

BSUC:

BMT:	BSUIS_B0934

BSZ:

DK67_2894

BSV:	BSVBI22_B0932

BSW:	IY71_15700

BSG:	IY72_15650

BOV:

BOV_A0883

BCS:	BCAN_B0961(gal)

BSK:	BCA52141_II1676

BOL:	BCOUA_II0941

BCAR:

DK60_2632

BCAS:

DA85_14990

BMR:

BMI_II935

BVL:	BF3285c2_0471

BRU:	BFS01_11805

OAN:

Oant_1420

OAH:

DR92_986

OPS:	A8A54_07840

OCH:	CES85_1890(gal)

BJA:

blr3205

BJU:	BJ6T_65470

BJP:	RN69_31735

BRA:

BBT:

BRS:

AOL:

BRC:	BCCGELA001_14415

BRAD:

BF49_1480

BIC:	LMTR13_13405

BRO:	BRAD285_5471

BRK:	CWS35_13655

BOT:	CIT37_37500

BRQ:	CIT40_10570

BGQ:	X265_25020

BOP:	AXW83_15045

BVV:	BHK69_13545

SNO:

Snov_0117

MRD:	Mrad2831_1330

MET:

MOR:

MPHY:

METX:

MOC:	BB934_26650

MIV:	C4E04_11380

BID:

Bind_3077

PHL:

KKY_220

DEQ:	XM25_21300

DEI:	C4375_06070

MMYR:

MXMO3_02336 MXMO3_02358

MAAD:

AZF01_16590

AUA:	M673_09265

CCR:

CC_0967

CCS:	CCNA_01018

CAK:	Caul_3616 Caul_3971

CSE:	Cseg_1896 Cseg_3324

CHQ:	AQ619_05210

CFH:	C1707_10930

CAUF:

CSW63_18295

BRL:	BZG35_12360

AEX:	Astex_1898

SIT:	TM1040_3488

RUA:	D1823_19580

RMB:	K529_016095

RSP:

RSP_1369

RSH:	Rsph17029_0037

RSQ:	Rsph17025_0027

RSK:	RSKD131_2769

RBL:	B6K69_04595 B6K69_06870

JAN:

Jann_3834

RDE:

RD1_2866

RLI:	RLO149_c015750 RLO149_c021980(gal)

PDE:

Pden_4245

PAMI:

JCM7686_3307

PYE:	A6J80_10165

PCON:

B0A89_06250

PZH:	CX676_01055

PAMN:

pAMV1p0045(araA)

DSH:

Dshi_1243

PSF:

PSE_2806

PGA:	PGA1_c07370

PGL:	PGA2_c06870

PGD:

Gal_02755

PHP:	PhaeoP97_02455

PPIC:

PhaeoP14_00657

PHQ:	D1820_16715

OAT:	OAN307_c48590(gal)

OAR:	OA238_c48520(gal)

OTM:	OSB_32620(araA)

PTP:	RCA23_c01430

CMAR:

IMCC12053_1223

MALG:

MALG_02110 MALG_04458

PPHR:

APZ00_12525 APZ00_20900

HAT:	RC74_03105

LAP:	ACP90_05475 ACP90_20260

LAGG:

B0E33_03985 B0E33_17030

LABR:

CHH27_15175

YAN:	AYJ57_16180

YPAC:

CEW88_14240

SPSE:

SULPSESMR1_02141(xylB)

SULZ:

C1J03_00790 C1J03_06065

SULD:

B5M07_18740

DON:	BSK21_10855

TOM:	BWR18_10350

THW:	BMG03_12815

RMM:	ROSMUCSMR3_00498(xylB)

ROK:	RAK1035_3332

LVS:	LOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA)

AHT:	ANTHELSMS3_00004 ANTHELSMS3_03457(araA)

SAGU:

CDO87_14400 CDO87_19375

THAA:

CFI11_06380

GEH:	HYN69_13900

TAW:	EI545_06570 EI545_13710

SALO:

EF888_14205 EF888_19160

SEDI:

EBB79_05250

BOO:	E2K80_13290

RBZ:	B9057_15765

NPP:	PP1Y_Mpl1273

NRE:	BES08_06875 BES08_21445

NOV:	TQ38_022505 TQ38_022665

NOT:	C7W88_19915

SAL:

Sala_0745

SPHK:

SKP52_01885(araA)

SPHU:

SPPYR_0433(araA)

SPHM:

G432_06460

STAX:

MC45_07850

SPHI:

TS85_21120

SSAN:

NX02_07110 NX02_12675

SNJ:	A7E77_05030

SMY:	BJP26_00310

SPAN:

AWL63_01185 AWL63_05170

SKR:	BRX40_07015

SPLK:

AV944_13915

SPHF:

DM480_08630

SJP:	SJA_C1-05950

SYB:	TZ53_11220 TZ53_22195

SPHB:

EP837_03127

SPHR:

BSY17_1053 BSY17_2379

SINB:

SIDU_10715

SPHT:

K426_04590 K426_16895

SHYD:

CJD35_07410

SYA:	A6768_01760 A6768_17815

SPYG:

YGS_C1P1796 YGS_C1P2079

SPHS:

ETR14_02030 ETR14_18295

AAY:	WYH_02192(araA)

ADO:	A6F68_00759(araA)

CMAN:

A9D14_05810

KBA:	A0U89_02165

RGI:	RGI145_17595

ROS:	CTJ15_16445

AZL:	AZL_e03690(gal)

ALI:	AZOLI_p50383

ABS:	AZOBR_p440166

ABQ:	ABAZ39_31625

ABF:	AMK58_27415

ATI:	AL072_30970

AHU:	A6A40_14260

AZT:	TSH58p_21390

AZM:	DM194_26405

AZZ:	DEW08_21985

TMO:

TMO_a0253

NAO:	Y958_16055 Y958_28205

NCB:	C0V82_22765

ABAW:

D5400_07040

» show all

Reference

1 [PMID:13462997]

Authors

DE LEY J, DOUDOROFF M.

Title

The metabolism of D-galactose in Pseudomonas saccharophila.

Journal

J Biol Chem 227:745-57 (1957)

Reference

2 [PMID:14251301]

Authors

HU AS, CLINE AL.

Title

THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.

Journal

Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.48

IUBMB Enzyme Nomenclature:

1.1.1.48

ExPASy - ENZYME nomenclature database:

1.1.1.48

BRENDA, the Enzyme Database:

1.1.1.48

CAS:

9028-54-0

DBGET integrated database retrieval system