KEGG   ENZYME: 1.1.1.48Help
Entry
EC 1.1.1.48                 Enzyme                                 

Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00035  D-galactose 1-dehydrogenase
K22215  galactose dehydrogenase
Genes
XCC: XCC0744(dgd)
XCB: XC_3491
XCA: xcc-b100_3611
XCP: XCR_0916
XCV: XCV0847
XAX: XACM_0792
XAC: XAC0797(dgd)
XCI: XCAW_03785(dgd)
XCT: J151_00922
XCJ: J158_00919
XCU: J159_00919
XCN: J169_00918
XCW: J162_00918
XCR: J163_00918
XCM: J164_00918
XCF: J172_00913
XFU: XFF4834R_chr08000
XAO: XAC29_04060
XOO: XOO3804(dgd)
XOM: XOO3586(XOO3586)
XOP: PXO_04345
XOY: AZ54_04880
XOR: XOC_0862
XOZ: BE73_20070
XFR: BER92_04515
XGA: BI317_04830
XVE: BJD12_16980
XPE: BJD13_12735
XHR: XJ27_11375
XPH: XppCFBP6546_07460(XppCFBP6546P_07460)
XVA: C7V42_04440
PSU: Psesu_0880
POR: APT59_06560
PST: PSPTO_4782(gal)
PSB: Psyr_4331
PSP: PSPPH_4371(gal)
PCG: AXG94_02455
PRH: LT40_07475
PFK: PFAS1_24545
PPSL: BJP27_21330
MTHD: A3224_13280
WMA: WM2015_1134
CSA: Csal_1017
HEL: HELO_2796(araA)
HAK: KO116_00851
HAM: HALO0848
HHU: AR456_09055
HAF: C8233_02095
HAA: A5892_01460
CMAI: BFX80_08845
KUS: B9G99_10855
MARS: A8C75_00495
SALN: SALB1_2572
TSN: W908_05220
BGM: CAL15_12825
HSE: Hsero_2708
HSZ: ACP92_13575
HHT: F506_12355
HRB: Hrubri_2793
DEU: DBW_1406
MLO: mll0280 mlr4741
MLN: A9174_03560 A9174_23670
MCI: Mesci_0734 Mesci_3619
MOP: Mesop_0751 Mesop_4628
MAM: Mesau_00714 Mesau_04253
MAMO: A6B35_04175 A6B35_19870
MESO: BSQ44_00970 BSQ44_05225
MESW: A9K65_003695 A9K65_019490
MES: Meso_0843 Meso_3587
HOE: IMCC20628_02050 IMCC20628_02998
AAK: AA2016_0715
AMIH: CO731_00808(kduD_1)
PHT: BLM14_10615 BLM14_29135
SME: SMc00588(gal) SMc00880
SMK: Sinme_0533 Sinme_0954
SMQ: SinmeB_0438 SinmeB_0783
SMX: SM11_chr0479(fabG2) SM11_chr2506(gal)
SMI: BN406_00480 BN406_00892(gal)
SMEG: C770_GR4Chr0823 C770_GR4Chr1167
SMEL: SM2011_c00588(gal) SM2011_c00880(fabG2)
SMER: DU99_04260 DU99_06000
SMD: Smed_0438 Smed_0768
RHI: NGR_c04370 NGR_c09060
SFH: SFHH103_00504(fabg1) SFHH103_00835(gal)
SFD: USDA257_c05370(bacC1) USDA257_c08790(gal)
SIX: BSY16_1689 BSY16_2170
SAME: SAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal)
SINO: SS05631_c05300 SS05631_c08890
EAD: OV14_1758 OV14_2179
EAH: FA04_02260 FA04_04405
ESJ: SJ05684_c04240 SJ05684_c08000
ATU: Atu0705(fabG) Atu1113
ARA: Arad_1105(fabG1) Arad_1691(gal)
ATF: Ach5_06290(fabG) Ach5_10290(gal)
ATA: AWN88_23175 AWN88_25140
AVI: Avi_3910
AGR: AGROH133_04267(fabG) AGROH133_05248(gal)
AGC: BSY240_2904
ARO: B0909_07805 B0909_09955
RET: RHE_CH00855(fabG1) RHE_CH01458(gal)
REC: RHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal)
REL: REMIM1_CH00868 REMIM1_CH01471
REP: IE4803_CH00866 IE4803_CH01467
REI: IE4771_CH00893 IE4771_CH01517
RLE: RL0917 RL1574
RLT: Rleg2_0503 Rleg2_1072
RLG: Rleg_0546 Rleg_1217
RLB: RLEG3_12890 RLEG3_16465
RLU: RLEG12_13890 RLEG12_16705
RTR: RTCIAT899_CH04105 RTCIAT899_CH06205
RIR: BN877_I0681 BN877_I1100
RHL: LPU83_0965(fabG1) LPU83_1415(gal)
RGA: RGR602_CH00913 RGR602_CH01354
RHN: AMJ98_CH00874 AMJ98_CH01506
RPHA: AMC79_CH00884 AMC79_CH01485
RHT: NT26_2220 NT26_3705(fabG)
RHX: AMK02_CH00894 AMK02_CH01514
RHV: BA939_00440 BA939_12475
RHK: Kim5_CH00974 Kim5_CH01592
REZ: AMJ99_CH00874 AMJ99_CH01585
NGL: RG1141_CH19850 RG1141_CH22060
NGG: RG540_CH20660 RG540_CH22940
NEO: CYG48_08700
NEN: NCHU2750_18160 NCHU2750_35760(gal)
SHZ: shn_03770 shn_06395
BME: BMEII0355
BMEL: DK63_2884
BMI: BMEA_B0926
BMZ: BM28_B0912
BMG: BM590_B0910
BMW: BMNI_II0882
BMEE: DK62_2513
BMF: BAB2_0293
BMB: BruAb2_0292
BMC: BAbS19_II02780
BAA: BAA13334_II00689
BABO: DK55_2285
BABR: DO74_2705
BABT: DK49_2946
BABB: DK48_2407
BABU: DK53_2296
BABS: DK51_2874
BABC: DO78_2765
BMS: BRA0941
BSI: BS1330_II0933
BSF: BSS2_II0893
BSUI: BSSP1_II0890
BSUP: BSPT1_II0887
BSUV: BSPT2_II0888
BSUC: BSSP2_II0898
BMT: BSUIS_B0934
BSZ: DK67_2894
BSV: BSVBI22_B0932
BSW: IY71_15700
BSG: IY72_15650
BOV: BOV_A0883
BCS: BCAN_B0961(gal)
BSK: BCA52141_II1676
BOL: BCOUA_II0941
BCAR: DK60_2632
BCAS: DA85_14990
BMR: BMI_II935
BVL: BF3285c2_0471
BRU: BFS01_11805
OAN: Oant_1420
OAH: DR92_986
OPS: A8A54_07840
OCH: CES85_1890(gal)
BJA: blr3205
BJU: BJ6T_65470
BJP: RN69_31735
BRA: BRADO1814
BBT: BBta_2134
BRS: S23_47920
AOL: S58_57220
BRC: BCCGELA001_14415
BRAD: BF49_1480
BIC: LMTR13_13405
BRO: BRAD285_5471
BRK: CWS35_13655
BOT: CIT37_37500
BRQ: CIT40_10570
BOP: AXW83_15045
BVV: BHK69_13545
SNO: Snov_0117
MRD: Mrad2831_1330
MET: M446_4632
MOR: MOC_1687
MPHY: MCBMB27_00985
METX: A3862_24175
MOC: BB934_26650
MIV: C4E04_11380
BID: Bind_3077
PHL: KKY_220
DEQ: XM25_21300
DEI: C4375_06070
MMYR: MXMO3_02336 MXMO3_02358
MAAD: AZF01_16590
AUA: M673_09265
CCR: CC_0967
CCS: CCNA_01018
CAK: Caul_3616 Caul_3971
CSE: Cseg_1896 Cseg_3324
CHQ: AQ619_05210
CFH: C1707_10930
BRL: BZG35_12360
AEX: Astex_1898
SIT: TM1040_3488
RUA: D1823_19580
RMB: K529_016095
RSP: RSP_1369
RSH: Rsph17029_0037
RSQ: Rsph17025_0027
RSK: RSKD131_2769
RBL: B6K69_04595 B6K69_06870
JAN: Jann_3834
RDE: RD1_2866
RLI: RLO149_c015750 RLO149_c021980(gal)
PDE: Pden_4245
PAMI: JCM7686_3307
PYE: A6J80_10165
PCON: B0A89_06250
PZH: CX676_01055
PAMN: pAMV1p0045(araA)
DSH: Dshi_1243
PSF: PSE_2806
PGA: PGA1_c07370
PGL: PGA2_c06870
PGD: Gal_02755
PHP: PhaeoP97_02455
PPIC: PhaeoP14_00657
PHQ: D1820_16715
OAT: OAN307_c48590(gal)
OAR: OA238_c48520(gal)
OTM: OSB_32620(araA)
PTP: RCA23_c01430
CMAR: IMCC12053_1223
MALG: MALG_02110 MALG_04458
PPHR: APZ00_12525 APZ00_20900
HAT: RC74_03105
LAP: ACP90_05475 ACP90_20260
LAGG: B0E33_03985 B0E33_17030
LABR: CHH27_15175
YAN: AYJ57_16180
YPAC: CEW88_14240
SPSE: SULPSESMR1_02141(xylB)
SULZ: C1J03_00790 C1J03_06065
SULD: B5M07_18740
DON: BSK21_10855
TOM: BWR18_10350
THW: BMG03_12815
RMM: ROSMUCSMR3_00498(xylB)
ROK: RAK1035_3332
LVS: LOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA)
AHT: ANTHELSMS3_00004 ANTHELSMS3_03457(araA)
SAGU: CDO87_14400 CDO87_19375
GEH: HYN69_13900
RBZ: B9057_15765
NPP: PP1Y_Mpl1273
NRE: BES08_06875 BES08_21445
NOV: TQ38_022505 TQ38_022665
NOT: C7W88_19915
SAL: Sala_0745
SPHK: SKP52_01885(araA)
SPHU: SPPYR_0433(araA)
SPHM: G432_06460
STAX: MC45_07850
SPHI: TS85_21120
SSAN: NX02_07110 NX02_12675
SNJ: A7E77_05030
SMY: BJP26_00310
SPAN: AWL63_01185 AWL63_05170
SKR: BRX40_07015
SPLK: AV944_13915
SPHF: DM480_08630
SJP: SJA_C1-05950
SYB: TZ53_11220 TZ53_22195
SPHB: EP837_03127
SPHR: BSY17_1053 BSY17_2379
SINB: SIDU_10715
SPHT: K426_04590 K426_16895
SHYD: CJD35_07410
SYA: A6768_01760 A6768_17815
AAY: WYH_02192(araA)
ADO: A6F68_00759(araA)
CMAN: A9D14_05810
KBA: A0U89_02165
RGI: RGI145_17595
ROS: CTJ15_16445
AZL: AZL_e03690(gal)
ALI: AZOLI_p50383
ABS: AZOBR_p440166
ABQ: ABAZ39_31625
ABF: AMK58_27415
ATI: AL072_30970
AHU: A6A40_14260
AZT: TSH58p_21390
AZM: DM194_26405
TMO: TMO_a0253
NAO: Y958_16055 Y958_28205
NCB: C0V82_22765
 » show all
Taxonomy
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J Biol Chem 227:745-57 (1957)
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.48
IUBMB Enzyme Nomenclature: 1.1.1.48
ExPASy - ENZYME nomenclature database: 1.1.1.48
BRENDA, the Enzyme Database: 1.1.1.48
CAS: 9028-54-0

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (6)   
   KEGG REACTION (4)   
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Gene (1925)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (383)   
   KEGG MGENES (1242)   
   RefGene (298)   
Protein sequence (255)   
   UniProt (195)   
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DNA sequence (368)   
   RefSeq(nuc) (159)   
   GenBank (106)   
   EMBL (103)   
3D Structure (1)   
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All databases (2567)   

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