KEGG   ENZYME: 1.1.1.48Help
Entry
EC 1.1.1.48                 Enzyme                                 

Name
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
D-galactose:NAD+ 1-oxidoreductase
Reaction(IUBMB)
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN:R01094]
Reaction(KEGG)
Substrate
D-galactose [CPD:C00124];
NAD+ [CPD:C00003]
Product
D-galactono-1,4-lactone [CPD:C03383];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
History
EC 1.1.1.48 created 1961, modified 2011
Pathway
ec00052  Galactose metabolism
ec01100  Metabolic pathways
Orthology
K00035  D-galactose 1-dehydrogenase
K22215  galactose dehydrogenase
Genes
XCC: XCC0744(dgd)
XCB: XC_3491
XCA: xcc-b100_3611
XCP: XCR_0916
XCV: XCV0847
XAX: XACM_0792
XAC: XAC0797(dgd)
XCI: XCAW_03785(dgd)
XCT: J151_00922
XCJ: J158_00919
XCU: J159_00919
XCN: J169_00918
XCW: J162_00918
XCR: J163_00918
XCM: J164_00918
XCF: J172_00913
XFU: XFF4834R_chr08000
XAO: XAC29_04060
XOO: XOO3804(dgd)
XOM: XOO3586(XOO3586)
XOP: PXO_04345
XOY: AZ54_04880
XOR: XOC_0862
XOZ: BE73_20070
XFR: BER92_04515
XGA: BI317_04830
XVE: BJD12_16980
XPE: BJD13_12735
XHR: XJ27_11375
XPH: XppCFBP6546_07460(XppCFBP6546P_07460)
XVA: C7V42_04440
XAN: AC801_04115
XAR: XB05_20920
PSU: Psesu_0880
POR: APT59_06560
PST: PSPTO_4782(gal)
PSB: Psyr_4331
PSYR: N018_22455
PSP: PSPPH_4371(gal)
PAMG: BKM19_025415
PAVL: BKM03_25160
PFE: PSF113_3188
PMAN: OU5_1017(gal)
PCG: AXG94_02455
PBA: PSEBR_a2607
PBC: CD58_16835
PRH: LT40_07475
PKR: AYO71_13680
PFK: PFAS1_24545
PPSL: BJP27_21330
MTHD: A3224_13280
WMA: WM2015_1134
CSA: Csal_1017
HEL: HELO_2796(araA)
HAK: KO116_00851
HAM: HALO0848
HHU: AR456_09055
HAF: C8233_02095
HSR: HSBAA_57040
HAA: A5892_01460
CMAI: BFX80_08845
KUS: B9G99_10855
KMA: B9H00_03950
KUY: FY550_04035
PAUR: FGL86_17675
MARS: A8C75_00495
SALN: SALB1_2572
TSN: W908_05220
THIN: CRN91_05305
PLG: NCTC10937_01992(gal)
BGM: CAL15_12825
HSE: Hsero_2708
HSZ: ACP92_13575
HHT: F506_12355
HRB: Hrubri_2793
HHF: E2K99_14415
DEU: DBW_1406
MLO: mll0280 mlr4741
MLN: A9174_03560 A9174_23670
MCI: Mesci_0734 Mesci_3619
MOP: Mesop_0751 Mesop_4628
MAM: Mesau_00714 Mesau_04253
MAMO: A6B35_04175 A6B35_19870
MESO: BSQ44_00970 BSQ44_05225
MESW: A9K65_003695 A9K65_019490
MESM: EJ066_07780 EJ066_24325
MESP: C1M53_10555 C1M53_29965
MES: Meso_0843 Meso_3587
HOE: IMCC20628_02050 IMCC20628_02998
AAK: AA2016_0715
AMIH: CO731_00808(kduD_1)
PHT: BLM14_10615 BLM14_29135
RPOD: E0E05_03020
SME: SMc00588(gal) SMc00880
SMK: Sinme_0533 Sinme_0954
SMQ: SinmeB_0438 SinmeB_0783
SMX: SM11_chr0479(fabG2) SM11_chr2506(gal)
SMI: BN406_00480 BN406_00892(gal)
SMEG: C770_GR4Chr0823 C770_GR4Chr1167
SMEL: SM2011_c00588(gal) SM2011_c00880(fabG2)
SMER: DU99_04260 DU99_06000
SMD: Smed_0438 Smed_0768
RHI: NGR_c04370 NGR_c09060
SFH: SFHH103_00504(fabg1) SFHH103_00835(gal)
SFD: USDA257_c05370(bacC1) USDA257_c08790(gal)
SIX: BSY16_1689 BSY16_2170
SAME: SAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal)
SINO: SS05631_c05300 SS05631_c08890
EAD: OV14_1758 OV14_2179
EAH: FA04_02260 FA04_04405
ESJ: SJ05684_c04240 SJ05684_c08000
EAK: EKH55_0435 EKH55_0791
ATU: Atu0705(fabG) Atu1113
ARA: Arad_1105(fabG1) Arad_1691(gal)
ATF: Ach5_06290(fabG) Ach5_10290(gal)
ATA: AWN88_23175 AWN88_25140
AVI: Avi_3910
AGR: AGROH133_04267(fabG) AGROH133_05248(gal)
AGC: BSY240_2904
ARO: B0909_07805 B0909_09955
AGT: EYD00_01775 EYD00_03870
ALF: CFBP5473_09805 CFBP5473_12260
RET: RHE_CH00855(fabG1) RHE_CH01458(gal)
REC: RHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal)
REL: REMIM1_CH00868 REMIM1_CH01471
REP: IE4803_CH00866 IE4803_CH01467
REI: IE4771_CH00893 IE4771_CH01517
RLE: RL0917 RL1574
RLT: Rleg2_0503 Rleg2_1072
RLG: Rleg_0546 Rleg_1217
RLB: RLEG3_12890 RLEG3_16465
RLU: RLEG12_13890 RLEG12_16705
RTR: RTCIAT899_CH04105 RTCIAT899_CH06205
RIR: BN877_I0681 BN877_I1100
RHL: LPU83_0965(fabG1) LPU83_1415(gal)
RGA: RGR602_CH00913 RGR602_CH01354
RHN: AMJ98_CH00874 AMJ98_CH01506
RPHA: AMC79_CH00884 AMC79_CH01485
RHT: NT26_2220 NT26_3705(fabG)
RHX: AMK02_CH00894 AMK02_CH01514
RHV: BA939_00440 BA939_12475
RHK: Kim5_CH00974 Kim5_CH01592
REZ: AMJ99_CH00874 AMJ99_CH01585
RJG: CCGE525_05060 CCGE525_07415
RHR: CKA34_07215 CKA34_09320
RGR: FZ934_01375 FZ934_03865
NGL: RG1141_CH19850 RG1141_CH22060
NGG: RG540_CH20660 RG540_CH22940
NEO: CYG48_08700
NEN: NCHU2750_18160 NCHU2750_35760(gal)
SHZ: shn_03770 shn_06395
ABAW: D5400_07040
BME: BMEII0355
BMEL: DK63_2884
BMI: BMEA_B0926
BMZ: BM28_B0912
BMG: BM590_B0910
BMW: BMNI_II0882
BMEE: DK62_2513
BMF: BAB2_0293
BMB: BruAb2_0292
BMC: BAbS19_II02780
BAA: BAA13334_II00689
BABO: DK55_2285
BABR: DO74_2705
BABT: DK49_2946
BABB: DK48_2407
BABU: DK53_2296
BABS: DK51_2874
BABC: DO78_2765
BMS: BRA0941
BSI: BS1330_II0933
BSF: BSS2_II0893
BSUI: BSSP1_II0890
BSUP: BSPT1_II0887
BSUV: BSPT2_II0888
BSUC: BSSP2_II0898
BMT: BSUIS_B0934
BSZ: DK67_2894
BSV: BSVBI22_B0932
BSW: IY71_15700
BSG: IY72_15650
BOV: BOV_A0883
BCS: BCAN_B0961(gal)
BSK: BCA52141_II1676
BOL: BCOUA_II0941
BCAR: DK60_2632
BCAS: DA85_14990
BMR: BMI_II935
BVL: BF3285c2_0471
BRU: BFS01_11805
BRJ: BKD03_01850
OAN: Oant_1420
OAH: DR92_986
OPS: A8A54_07840
OCH: CES85_1890(gal)
BJA: blr3205
BJU: BJ6T_65470
BJP: RN69_31735
BRA: BRADO1814
BBT: BBta_2134
BRS: S23_47920
AOL: S58_57220
BRC: BCCGELA001_14415
BRAD: BF49_1480
BIC: LMTR13_13405
BRO: BRAD285_5471
BRK: CWS35_13655
BOT: CIT37_37500
BRQ: CIT40_10570
BGQ: X265_25020
BGZ: XH91_23130
BSYM: CIT39_09610
BBET: F8237_04025
BOP: AXW83_15045
BVV: BHK69_13545
BOF: FQV39_05850 FQV39_07840
SNO: Snov_0117
LNE: FZC33_22290
MRD: Mrad2831_1330
MET: M446_4632
MOR: MOC_1687
MPHY: MCBMB27_00985
METX: A3862_24175
MOC: BB934_26650
MIV: C4E04_11380
MICO: GDR74_10585
BID: Bind_3077
BBAR: RHAL1_00797(araA)
PHL: KKY_220
DEQ: XM25_21300
DEI: C4375_06070
DEA: FPZ08_18255
MMYR: MXMO3_02336 MXMO3_02358
YTI: FNA67_02615
MAAD: AZF01_16590
AUA: M673_09265
CCR: CC_0967
CCS: CCNA_01018
CAK: Caul_3616 Caul_3971
CSE: Cseg_1896 Cseg_3324
CHQ: AQ619_05210
CFH: C1707_10930
CAUF: CSW63_18295
BRL: BZG35_12360
AEX: Astex_1898
SIT: TM1040_3488
RUA: D1823_19580
RUT: FIU92_19050(kduD3)
RMB: K529_016095
RSP: RSP_1369
RSH: Rsph17029_0037
RSQ: Rsph17025_0027
RSK: RSKD131_2769
RBL: B6K69_04595 B6K69_06870
JAN: Jann_3834
RDE: RD1_2866
RLI: RLO149_c015750 RLO149_c021980(gal)
PDE: Pden_4245
PAMI: JCM7686_3307
PYE: A6J80_10165
PCON: B0A89_06250
PZH: CX676_01055
PAMN: pAMV1p0045(araA)
PARR: EOJ32_16375 EOJ32_18520
PKD: F8A10_05995
DSH: Dshi_1243
PSF: PSE_2806
PGA: PGA1_c07370
PGL: PGA2_c06870
PGD: Gal_02755
PHP: PhaeoP97_02455
PPIC: PhaeoP14_00657
PHQ: D1820_16715
OAT: OAN307_c48590(gal)
OAR: OA238_c48520(gal)
OTM: OSB_32620(araA)
OCT: FTO60_16290
PTP: RCA23_c01430
CMAR: IMCC12053_1223
MALG: MALG_02110 MALG_04458
PPHR: APZ00_12525 APZ00_20900
HAT: RC74_03105
LAP: ACP90_05475 ACP90_20260
LAGG: B0E33_03985 B0E33_17030
LABR: CHH27_15175
LABP: FJ695_08295
LABT: FIU93_11110(kduD1) FIU93_26815(araA2)
YAN: AYJ57_16180
YPAC: CEW88_14240
SPSE: SULPSESMR1_02141(xylB)
SULZ: C1J03_00790 C1J03_06065
SULD: B5M07_18740
DON: BSK21_10855
TOM: BWR18_10350
THW: BMG03_12815
RMM: ROSMUCSMR3_00498(xylB)
ROK: RAK1035_3332
LVS: LOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA)
AHT: ANTHELSMS3_00004 ANTHELSMS3_03457(araA)
SAGU: CDO87_14400 CDO87_19375
THAA: CFI11_06380
GEH: HYN69_13900
TAW: EI545_06570 EI545_13710
SALO: EF888_14205 EF888_19160
SEDI: EBB79_05250
BOO: E2K80_13290
LIT: FPZ52_03870
OCD: FHY55_19130
MARU: FIU81_05390(araA1) FIU81_07550(kduD1) FIU81_10735(araA2)
RBZ: B9057_15765
NPP: PP1Y_Mpl1273
NRE: BES08_06875 BES08_21445
NOV: TQ38_022505 TQ38_022665
NOT: C7W88_19915
NOR: FA702_20185
SAL: Sala_0745
SPHK: SKP52_01885(araA)
SPHX: E5675_04610
SPHU: SPPYR_0433(araA)
SPHM: G432_06460
STAX: MC45_07850
SPHI: TS85_21120
SSAN: NX02_07110 NX02_12675
SNJ: A7E77_05030
SMY: BJP26_00310
SPAN: AWL63_01185 AWL63_05170
SKR: BRX40_07015
SPLK: AV944_13915
SPHF: DM480_08630
SPAU: DRN02_007175
SJP: SJA_C1-05950
SYB: TZ53_11220 TZ53_22195
SPHB: EP837_03127
SPHR: BSY17_1053 BSY17_2379
SINB: SIDU_10715
SPHT: K426_04590 K426_16895
SHYD: CJD35_07410
SYA: A6768_01760 A6768_17815
SPYG: YGS_C1P1796 YGS_C1P2079
SUFL: FIL70_11350 FIL70_17145
SPHS: ETR14_02030 ETR14_18295
AAY: WYH_02192(araA)
ADO: A6F68_00759(araA)
CMAN: A9D14_05810
POT: E2E27_08030
KBA: A0U89_02165
RGI: RGI145_17595
ROS: CTJ15_16445
RMUC: FOB66_22030
AZL: AZL_e03690(gal)
ALI: AZOLI_p50383
ABS: AZOBR_p440166
ABQ: ABAZ39_31625
ABF: AMK58_27415
ATI: AL072_30970
AHU: A6A40_14260
AZT: TSH58p_21390
AZM: DM194_26405
AZZ: DEW08_21985
TMO: TMO_a0253
NAO: Y958_16055 Y958_28205
NCB: C0V82_22765
MFF: MFFC18_12940(ped)
 » show all
Taxonomy
Reference
1  [PMID:13462997]
  Authors
DE LEY J, DOUDOROFF M.
  Title
The metabolism of D-galactose in Pseudomonas saccharophila.
  Journal
J Biol Chem 227:745-57 (1957)
Reference
2  [PMID:14251301]
  Authors
HU AS, CLINE AL.
  Title
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD.
  Journal
Biochim Biophys Acta 93:237-45 (1964)
DOI:10.1016/0304-4165(64)90371-X
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.48
IUBMB Enzyme Nomenclature: 1.1.1.48
ExPASy - ENZYME nomenclature database: 1.1.1.48
BRENDA, the Enzyme Database: 1.1.1.48
CAS: 9028-54-0

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (6)   
   KEGG REACTION (4)   
   KEGG RCLASS (2)   
Gene (2032)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (465)   
   KEGG MGENES (1267)   
   RefGene (298)   
Protein sequence (229)   
   UniProt (219)   
   SWISS-PROT (4)   
   RefSeq(pep) (5)   
   PDBSTR (1)   
DNA sequence (218)   
   RefSeq(nuc) (5)   
   GenBank (108)   
   EMBL (105)   
3D Structure (1)   
   PDB (1)   
All databases (2498)   

Download RDF
DBGET integrated database retrieval system