| Entry |
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| Name |
D-galactose 1-dehydrogenase;
D-galactose dehydrogenase;
beta-galactose dehydrogenase (ambiguous);
NAD+-dependent D-galactose dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
D-galactose:NAD+ 1-oxidoreductase
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| Reaction(IUBMB) |
D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+ [RN: R01094]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
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| History |
EC 1.1.1.48 created 1961, modified 2011
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| Pathway |
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| Orthology |
| K00035 | D-galactose 1-dehydrogenase |
| K22215 | galactose dehydrogenase |
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| Genes |
| XPH: | XppCFBP6546_07460(XppCFBP6546P_07460) |
| XHD: | LMG31886_35330(araA) |
| PLG: | NCTC10937_01992(gal) |
| DUG: | HH213_00205 HH213_15800 |
| MLN: | A9174_03560 A9174_23670 |
| MCI: | Mesci_0734 Mesci_3619 |
| MCIC: | A4R28_08495 A4R28_24735 |
| MOP: | Mesop_0751 Mesop_4628 |
| MAM: | Mesau_00714 Mesau_04253 |
| MAMO: | A6B35_04175 A6B35_19870 |
| MESW: | A9K65_003695 A9K65_019490 |
| MESM: | EJ066_07780 EJ066_24325 |
| MESP: | C1M53_10555 C1M53_29965 |
| MHUA: | MCHK_2076 MCHK_5816 |
| MJR: | EB229_03650 EB229_23735 |
| MERD: | EB233_03705 EB233_20510 |
| MESR: | FGU64_01240 FGU64_16305 |
| MOH: | IHQ72_03175 IHQ72_22530 |
| MMEI: | LRP31_03220 LRP31_22355 |
| MESO: | BSQ44_00970 BSQ44_05225 |
| CHEA: | PVE73_00525 PVE73_16980 |
| HOE: | IMCC20628_02050 IMCC20628_02998 |
| AMIH: | CO731_00808(kduD_1) |
| PHT: | BLM14_10615 BLM14_29135 |
| NIY: | FQ775_03365 FQ775_08550 |
| ORM: | HTY61_08730 HTY61_17220 |
| SME: | SMc00588(gal) SMc00880(fabG2) |
| SMK: | Sinme_0533 Sinme_0954 |
| SMQ: | SinmeB_0438 SinmeB_0783 |
| SMX: | SM11_chr0479(fabG2) SM11_chr2506(gal) |
| SMI: | BN406_00480 BN406_00892(gal) |
| SMEG: | C770_GR4Chr0823 C770_GR4Chr1167 |
| SMEL: | SM2011_c00588(gal) SM2011_c00880(fabG2) |
| SMER: | DU99_04260 DU99_06000 |
| RHI: | NGR_c04370 NGR_c09060 |
| SFH: | SFHH103_00504(fabg1) SFHH103_00835(gal) |
| SFD: | USDA257_c05370(bacC1) USDA257_c08790(gal) |
| SIX: | BSY16_1689 BSY16_2170 |
| SAME: | SAMCFNEI73_Ch0860(bacC) SAMCFNEI73_Ch1218(gal) |
| SINO: | SS05631_c05300 SS05631_c08890 |
| ESJ: | SJ05684_c04240 SJ05684_c08000 |
| EAK: | EKH55_0435 EKH55_0791 |
| EMX: | FKV68_04485 FKV68_06230 |
| ENU: | PYH37_003034 PYH37_003394 |
| EGI: | PZN02_000375 PZN02_003970 |
| SKM: | PZL22_004435 PZL22_004775 |
| STEG: | QA637_02145 QA637_03915 |
| EAH: | FA04_02260 FA04_04405 |
| ECAA: | J3R84_02350 J3R84_04350 |
| ENP: | JVX98_16185 JVX98_18195 |
| ATU: | Atu0705(fabG) Atu1113 |
| ATA: | AWN88_23175 AWN88_25140 |
| AGR: | AGROH133_04267(fabG) AGROH133_05248(gal) |
| ATF: | Ach5_06290(fabG) Ach5_10290(gal) |
| AGT: | EYD00_01775 EYD00_03870 |
| ALF: | CFBP5473_09805 CFBP5473_12260 |
| ARUI: | G6M88_10580 G6M88_12895 |
| AVQ: | HRR99_02380 HRR99_04990 |
| ASAL: | CFBP5507_01725 CFBP5507_03695 |
| RIR: | BN877_I0681 BN877_I1100 |
| RPUS: | CFBP5875_02065 CFBP5875_04285 |
| ACUC: | KZ699_02035 KZ699_04185 |
| ALEG: | CFBP4996_01855 CFBP4996_03955 |
| RET: | RHE_CH00855(fabG1) RHE_CH01458(gal) |
| REC: | RHECIAT_CH0000944(fabG1) RHECIAT_CH0001526(gal) |
| REL: | REMIM1_CH00868 REMIM1_CH01471 |
| REP: | IE4803_CH00866 IE4803_CH01467 |
| REI: | IE4771_CH00893 IE4771_CH01517 |
| RLT: | Rleg2_0503 Rleg2_1072 |
| RLB: | RLEG3_12890 RLEG3_16465 |
| RLU: | RLEG12_13890 RLEG12_16705 |
| RTR: | RTCIAT899_CH04105 RTCIAT899_CH06205 |
| RHL: | LPU83_0965(fabG1) LPU83_1415(gal) |
| RGA: | RGR602_CH00913 RGR602_CH01354 |
| RHN: | AMJ98_CH00874 AMJ98_CH01506 |
| RPHA: | AMC79_CH00884 AMC79_CH01485 |
| RHX: | AMK02_CH00894 AMK02_CH01514 |
| RHV: | BA939_00440 BA939_12475 |
| RHK: | Kim5_CH00974 Kim5_CH01592 |
| REZ: | AMJ99_CH00874 AMJ99_CH01585 |
| RJG: | CCGE525_05060 CCGE525_07415 |
| RHR: | CKA34_07215 CKA34_09320 |
| RGR: | FZ934_01375 FZ934_03865 |
| RAD: | CO657_02605 CO657_05680 |
| ROY: | G3A56_05270 G3A56_07555 |
| RII: | FFM53_005135 FFM53_008575 |
| RHID: | FFM81_013775 FFM81_016715 |
| RBQ: | J2J99_04525 J2J99_07530 |
| RLN: | J0663_13000 J0663_16230 |
| RBAN: | J2J98_04195 J2J98_07295 |
| RRG: | J3P73_05235 J3P73_08825 |
| RLS: | HB780_29835 HB780_31960 |
| RAW: | NE851_14520 NE851_17610 |
| RSUL: | N2599_02215 N2599_04580 |
| RLW: | RlegWSM1455_02575 RlegWSM1455_06125 |
| RRHO: | PR018_01830 PR018_04155 |
| RTU: | PR017_01960 PR017_04350 |
| RCT: | PYR68_02530 PYR68_05580 |
| ARA: | Arad_1105(fabG1) Arad_1691(gal) |
| ARO: | B0909_07805 B0909_09955 |
| RBW: | RLCC275e_02645 RLCC275e_06145 |
| NGL: | RG1141_CH19850 RG1141_CH22060 |
| NGG: | RG540_CH20660 RG540_CH22940 |
| NEN: | NCHU2750_18160 NCHU2750_35760(gal) |
| NPM: | QEO92_10670 QEO92_11720 |
| RHT: | NT26_2220 NT26_3705(fabG) |
| RFV: | RFYW14_02297 RFYW14_03590 |
| SZO: | K8M09_03380 K8M09_05385 |
| SOJ: | K6301_02500 K6301_04790 |
| SSUM: | Q9314_04365 Q9314_06780 |
| BOF: | FQV39_05850 FQV39_07840 |
| MMYR: | MXMO3_02336 MXMO3_02358 |
| PPHR: | APZ00_12525 APZ00_20900 |
| LAP: | ACP90_05475 ACP90_20260 |
| LABT: | FIU93_11110(kduD1) FIU93_26815(araA2) |
| LAGG: | B0E33_03985 B0E33_17030 |
| RLI: | RLO149_c015750 RLO149_c021980(gal) |
| MALG: | MALG_02110 MALG_04458 |
| SULZ: | C1J03_00790 C1J03_06065 |
| SMED: | JNX03_01685 JNX03_16730 |
| SPSE: | SULPSESMR1_02141(xylB) |
| RMM: | ROSMUCSMR3_00498(xylB) |
| AHT: | ANTHELSMS3_00004 ANTHELSMS3_03457(araA) |
| SAGU: | CDO87_14400 CDO87_19375 |
| MARU: | FIU81_05390(araA1) FIU81_07550(kduD1) FIU81_10735(araA2) |
| MALU: | KU6B_19300 KU6B_40840 |
| LSAL: | KBK07_02125 KBK07_02860 |
| RBL: | B6K69_04595 B6K69_06870 |
| PARR: | EOJ32_16375 EOJ32_18520 |
| PMAU: | CP157_03312(araA_1) CP157_03401(araA_2) |
| PAEX: | JHW48_00910 JHW48_17205 |
| LVS: | LOKVESSMR4R_02335(xylB) LOKVESSMR4R_03347(araA) |
| TAW: | EI545_06570 EI545_13710 |
| PPAF: | I8N54_02190 I8N54_16550 |
| NSM: | JO391_08220 JO391_15130 |
| AMAQ: | GO499_03060 GO499_18995 |
| PBAE: | P8S53_04310 P8S53_17455 |
| NRE: | BES08_06875 BES08_21445 |
| NOV: | TQ38_022505 TQ38_022665 |
| NHUM: | PQ457_02040 PQ457_20245 |
| SSAN: | NX02_07110 NX02_12675 |
| SPAN: | AWL63_01185 AWL63_05170 |
| SSUA: | FPZ54_00175 FPZ54_02615 FPZ54_13705 |
| SBIN: | SBA_ch1_01370(gal_1) SBA_ch1_35830(gal_2) |
| SMOR: | LHA26_06155 LHA26_11340 |
| SYB: | TZ53_11220 TZ53_22195 |
| SPHR: | BSY17_1053 BSY17_2379 |
| SPHT: | K426_04590 K426_16895 |
| SYA: | A6768_01760 A6768_17815 |
| SPYG: | YGS_C1P1796 YGS_C1P2079 |
| SUFL: | FIL70_11350 FIL70_17145 |
| SBAR: | H5V43_09110 H5V43_12365 |
| SPHS: | ETR14_02030 ETR14_18295 |
| POQ: | KZX46_02320 KZX46_06430 KZX46_07780 KZX46_12520 |
| PMEA: | KTC28_03380 KTC28_04750 KTC28_10375 |
| NAO: | Y958_16055 Y958_28205 |
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| Reference |
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| Authors |
DE LEY J, DOUDOROFF M. |
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| Title |
The metabolism of D-galactose in Pseudomonas saccharophila. |
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| Journal |
J Biol Chem 227:745-57 (1957) |
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| Reference |
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| Authors |
HU AS, CLINE AL. |
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| Title |
THE REGULATION OF SOME SUGAR DEHYDROGENASES IN A PSEUDOMONAD. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.48 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.48 |
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