| Entry |
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| Name |
glucose-6-phosphate dehydrogenase (NADP+);
NADP-glucose-6-phosphate dehydrogenase;
Zwischenferment;
D-glucose 6-phosphate dehydrogenase;
glucose 6-phosphate dehydrogenase (NADP);
NADP-dependent glucose 6-phosphate dehydrogenase;
6-phosphoglucose dehydrogenase;
Entner-Doudoroff enzyme;
glucose-6-phosphate 1-dehydrogenase;
G6PDH;
GPD;
glucose-6-phosphate dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
D-glucose-6-phosphate:NADP+ 1-oxidoreductase
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| Reaction(IUBMB) |
D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+ [RN: R00835]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme catalyses a step of the pentose phosphate pathway. The enzyme is specific for NADP+. cf. EC 1.1.1.363, glucose-6-phosphate dehydrogenase [NAD(P)+] and EC 1.1.1.388, glucose-6-phosphate dehydrogenase (NAD+).
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| History |
EC 1.1.1.49 created 1961, modified 2013, modified 2015
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K00036 | glucose-6-phosphate 1-dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Engel HJ, Domschke W, Alberti M, Domagk GF. |
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| Title |
Protein structure and enzymatic activity. II. Purification and properties of a crystalline glucose-6-phosphate dehydrogenase from Candida utilis. |
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| Journal |
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| Reference |
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| Authors |
GLASER L, BROWN DH. |
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| Title |
Purification and properties of d-glucose-6-phosphate dehydrogenase. |
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| Journal |
J Biol Chem 216:67-79 (1955) |
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| Reference |
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| Authors |
JULIAN GR, WOLFE RG, REITHEL FJ. |
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| Title |
The enzymes of mammary gland. II. The preparation of glucose 6-phosphate dehydrogenase. |
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| Journal |
J Biol Chem 236:754-8 (1961) |
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| Reference |
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| Authors |
NOLTMANN EA, GUBLER CJ, KUBY SA. |
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| Title |
Glucose 6-phosphate dehydrogenase (Zwischenferment). I. Isolation of the crystalline enzyme from yeast. |
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| Journal |
J Biol Chem 236:1225-30 (1961) |
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| Reference |
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| Authors |
Miclet E, Stoven V, Michels PA, Opperdoes FR, Lallemand JY, Duffieux F. |
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| Title |
NMR spectroscopic analysis of the first two steps of the pentose-phosphate pathway elucidates the role of 6-phosphogluconolactonase. |
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| Journal |
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| Reference |
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| Authors |
Olavarria K, Valdes D, Cabrera R |
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| Title |
The cofactor preference of glucose-6-phosphate dehydrogenase from Escherichia coli--modeling the physiological production of reduced cofactors. |
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| Journal |
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| Reference |
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| Authors |
Hansen T, Schlichting B, Schonheit P |
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| Title |
Glucose-6-phosphate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: expression of the g6pd gene and characterization of an extremely thermophilic enzyme. |
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| Journal |
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| Reference |
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| Authors |
Ibraheem O, Adewale IO, Afolayan A |
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| Title |
Purification and properties of glucose 6-phosphate dehydrogenase from Aspergillus aculeatus. |
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| Journal |
J Biochem Mol Biol 38:584-90 (2005) |
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| Reference |
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| Authors |
Iyer RB, Wang J, Bachas LG |
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| Title |
Cloning, expression, and characterization of the gsdA gene encoding thermophilic glucose-6-phosphate dehydrogenase from Aquifex aeolicus. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Cho SW, Joshi JG |
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| Title |
Characterization of glucose-6-phosphate dehydrogenase isozymes from human and pig brain. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.1.49 |
| ExPASy - ENZYME nomenclature database: | 1.1.1.49 |
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