KEGG   ENZYME: 1.1.1.50
Entry
EC 1.1.1.50                 Enzyme                                 
Name
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)
Reaction(IUBMB)
a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]
Reaction(KEGG)
Substrate
3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).
History
EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013
Pathway
ec00120  Primary bile acid biosynthesis
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K00037  3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Genes
HSA1109(AKR1C4)
PTR450274(AKR1C4)
PPS100987989(AKR1C4)
GGO101148343
PON100434557(AKR1C4)
NLE100605385
MCC711440 722490(AKR1C4)
MCF102116844 102117205(AKR1C4)
CSAB103237814
CATY105597444 105597447
PANU101022938
TGE112631314
RRO104674748
RBB108521035
TFN117082119 117082359
CJC100405255 100405615(AKR1C4)
SBQ101041915
LCAT123623042
OGA100940488
ECB100057251
EPZ103540777
EAI106827243
LAV100660861
DNM101426998
XLA108712557(akr1c4.S)
XTR496490(akr1c4)
NPR108799292
RTEM120932842
BBUF121003666
BGAR122926607
 » show all
Reference
1  [PMID:14406805]
  Authors
JARABAK J, TALALAY P.
  Title
Stereospecificity of hydrogen transfer by pyridine nucleotide-linked hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 235:2147-51 (1960)
Reference
2  [PMID:13405910]
  Authors
KOCHAKIAN CD, CARROLL BR, UHRI B.
  Title
Comparisons of the oxidation of C19-hydroxysteroids by guinea pig liver homogenates.
  Journal
J Biol Chem 224:811-8 (1957)
Reference
3  [PMID:13295221]
  Authors
MARCUS PI, TALALAY P.
  Title
Induction and purification of alpha- and beta-hydroxysteroid dehydrogenases.
  Journal
J Biol Chem 218:661-74 (1956)
Reference
4  [PMID:3479982]
  Authors
Penning TM, Sharp RB
  Title
Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.50
IUBMB Enzyme Nomenclature: 1.1.1.50
ExPASy - ENZYME nomenclature database: 1.1.1.50
BRENDA, the Enzyme Database: 1.1.1.50
CAS: 9028-56-2

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