KEGG ENZYME: 1.1.1.50

ENZYME: 1.1.1.50

Entry

EC 1.1.1.50                 Enzyme

Name

3alpha-hydroxysteroid 3-dehydrogenase (Si-specific);
hydroxyprostaglandin dehydrogenase;
3alpha-hydroxysteroid oxidoreductase;
sterognost 3alpha;
3alpha-hydroxysteroid dehydrogenase (B-specific);
3alpha-hydroxysteroid 3-dehydrogenase (B-specific);
3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (B-specific)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

3alpha-hydroxysteroid:NAD(P)+ 3-oxidoreductase (Si-specific)

Reaction(IUBMB)

a 3alpha-hydroxysteroid + NAD(P)+ = a 3-oxosteroid + NAD(P)H + H+ [RN:R10422 R10423]

Reaction(KEGG)

R10422 > R02476 R04309 R04818 R04824 R04829 R04832 R04835 R04837 R04842 R04845;
R10423 > R02477 R04310 R04819 R04825 R04830 R04833 R04836 R04838 R04843 R04846 R08963

Substrate

3alpha-hydroxysteroid [CPD:C03072];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]

Product

3-oxosteroid [CPD:C01876];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

The enzyme acts on androsterone and other 3alpha-hydroxysteroids and on 9-, 11- and 15-hydroxyprostaglandin. Si-specific with respect to NAD+ or NADP+. cf. EC 1.1.1.213, 3alpha-hydroxysteroid 3-dehydrogenase (Re-specific).

History

EC 1.1.1.50 created 1961, modified 1986, modified 1990, modified 2012, modified 2013

Pathway

ec00120

Primary bile acid biosynthesis

ec00140

Steroid hormone biosynthesis

ec01100

Metabolic pathways

Orthology

K00037

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase