KEGG ENZYME: 1.1.1.52

ENZYME: 1.1.1.52

Entry

EC 1.1.1.52                 Enzyme

Name

3alpha-hydroxycholanate dehydrogenase (NAD+);
alpha-hydroxy-cholanate dehydrogenase;
lithocholate:NAD+ oxidoreductase;
3alpha-hydroxycholanate dehydrogenase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

lithocholate:NAD+ 3-oxidoreductase

Reaction(IUBMB)

lithocholate + NAD+ = 3-oxo-5beta-cholan-24-oate + NADH + H+ [RN:R04139]

Reaction(KEGG)

R04139

Substrate

lithocholate [CPD:C03990];
NAD+ [CPD:C00003]

Product

3-oxo-5beta-cholan-24-oate [CPD:C03070];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Also acts on other 3alpha-hydroxysteroids with an acidic side-chain. cf. EC 1.1.1.392, 3alpha-hydroxycholanate dehydrogenase (NADP+).

History

EC 1.1.1.52 created 1961, modified 1976, modified 2016

Pathway

ec00121

Secondary bile acid biosynthesis

Orthology

K22604

3alpha-hydroxycholanate dehydrogenase (NAD+)

Genes

SSUN:

H9Q77_04440

HHJ:	NQ487_27535

ELE:

Elen_0690

EYY:	EGYY_08520(FabG)

EGD:	GS424_013575

GPA:

GPA_01510

RTS:	CE91St31_25700

Reference

1 [PMID:14377608]

Authors

HAYAISHI O, SATO Y, JAKOBY WB, STOHLMAN EF.

Title

Reversible enzymatic oxidation of bile acids.

Journal

Arch Biochem 56:554-5 (1955)
DOI:10.1016/0003-9861(55)90278-2

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.52

IUBMB Enzyme Nomenclature:

1.1.1.52

ExPASy - ENZYME nomenclature database:

1.1.1.52

BRENDA, the Enzyme Database:

1.1.1.52

CAS:

9028-57-3

DBGET integrated database retrieval system