KEGG   ENZYME: 1.1.1.61
Entry
EC 1.1.1.61                 Enzyme                                 
Name
4-hydroxybutyrate dehydrogenase;
gamma-hydroxybutyrate dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
4-hydroxybutanoate:NAD+ oxidoreductase
Reaction(IUBMB)
4-hydroxybutanoate + NAD+ = succinate semialdehyde + NADH + H+ [RN:R01644]
Reaction(KEGG)
R01644
Substrate
4-hydroxybutanoate [CPD:C00989];
NAD+ [CPD:C00003]
Product
succinate semialdehyde [CPD:C00232];
NADH [CPD:C00004];
H+ [CPD:C00080]
History
EC 1.1.1.61 created 1965
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K00043  4-hydroxybutyrate dehydrogenase
K08318  4-hydroxybutyrate dehydrogenase / sulfolactaldehyde 3-reductase
K18120  4-hydroxybutyrate dehydrogenase
Genes
ECOb3882(yihU)
ECJJW3853(yihU)
ECDECDH10B_4072(yihU)
EBWBWG_3552(yihU)
ECOKECMDS42_3321(yihU)
ECEZ5420(yihU)
ECSECs_4805(yihU)
ECFECH74115_5329
ETWECSP_4938(yihU)
ELXCDCO157_4544
EOIECO111_4702(yihU)
EOJECO26_4708(yihU)
EOHECO103_4289(yihU)
ESLO3K_24495
ESOO3O_00840
ESMO3M_24415
ECKEC55989_4353
ECGE2348C_4180
EOKG2583_4683(yihU)
ELRECO55CA74_22435
ELHETEC_4152
ECWEcE24377A_4405
EUNUMNK88_4715
ECPECP_4088
ENAECNA114_3975(yihU)
ECOSEC958_4354(yihU)
ECVAPECO1_2588
ECOAAPECO78_00150
ECXEcHS_A4104
ECMEcSMS35_4267
ECYECSE_4165
ECRECIAI1_4082(yihU)
ECQECED1_4582(yihU)
EUMECUMN_4409(yihU)
ECTECIAI39_3118(yihU)
EOCCE10_4546(yihU)
EBRECB_03767(yihU)
EBLECD_03767(yihU)
EBEB21_03716(yihU)
EBDECBD_4145
ECIUTI89_C4463(yihU)
EIHECOK1_4346
ECZECS88_4324
ECCc4826(yihU)
ELOEC042_4256
ELNNRG857_19350
ESEECSF_3733
ECLEcolC_4139
EKOEKO11_4480
EKFKO11_03195(yihU)
EABECABU_c43810
EDHEcDH1_4104
EDJECDH1ME8569_3753(yihU)
ELUUM146_19610
ELWECW_m4186(yihU)
ELLWFL_20395(yihU)
ELCi14_4419(yihU)
ELDi02_4419(yihU)
ELPP12B_c3997
ELFLF82_610
ECOLLY180_20115
ECOIECOPMV1_04237(garR_4)
ECOJP423_21510
EMAC1192_16095
ESZFEM44_09220(yihU)
STYSTY3855(yihU)
STTt3598(yihU)
SEXSTBHUCCB_37870
SENTTY21A_18195
STMSTM4023(yihU)
SEOSTM14_4836(yihU)
SEVSTMMW_39871
SEYSL1344_3969(yihU)
SEMSTMDT12_C41660
SEJSTMUK_4006(yihU)
SEBSTM474_4200(yihU)
SEFUMN798_4360(yihU)
SETUSTU288_20245
SETCCFSAN001921_20325
SENRSTMDT2_38831(yihU)
SENDDT104_40301(yihU)
SENICY43_21025
SEENSE451236_00795
SPTSPA3864(yihU)
SEKSSPA3594
SPQSPAB_04982
SEISPC_4126(yihU)
SECSCH_3913(yihU)
SEHSeHA_C4346
SHBSU5_0119
SENHCFSAN002069_11975
SEEHSEEH1578_06140
SEESNSL254_A4300
SENNSN31241_47150
SEWSeSA_A4233
SEASeAg_B4255
SENSQ786_19720
SEDSeD_A4411
SEGSG3402(yihU)
SELSPUL_3649(yihU)
SEGASPUCDC_3635(yihU)
SETSEN3811(yihU)
SENAAU38_19695
SENOAU37_19710
SENVAU39_19730
SENQAU40_22020
SENLIY59_20190
SENJCFSAN001992_13600
SEECCFSAN002050_02990
SEEBSEEB0189_022240
SEEPI137_17525
SENBBN855_40890
SENEIA1_19550
SENCSEET0819_03940
SESSARI_03643
SBGSBG_3540(yihU)
SBZA464_4064
SBVN643_17755
SALZEOS98_22210
SFLSF3954(yihU)
SFXS3792(yihU)
SFVSFV_3617(yihU)
SFESFxv_4308(yihU)
SFNSFy_5649
SFSSFyv_5712
SFTNCTC1_04280(yihU)
SSNSSON_4048(yihU)
SBOSBO_3887(yihU)
SHQA0259_00965
ENCECL_05103
ECLGEC036_44050
ECLEECNIH2_23255
ECLNECNIH4_22495
ECLIECNIH5_21760
ECLXLI66_22510
ECLYLI62_24595
ECLZLI64_21625
ECLOENC_00300
EHMAB284_04510
EXFBFV63_21885
ECLAECNIH3_21835
ECLCECR091_21765
EAUDI57_18815
EKBBFV64_23245
ENOECENHK_21935
EECEcWSU1_04480(yihU)
ELGBH714_14860
ECANCWI88_22490
ERNBFV67_21865
ECLSLI67_024265
ECHGFY206_24275(yihU)
EASEntas_4393
LNICWR52_12850
EBGFAI37_07030(yihU)
ENDA4308_06885
ENZG0034_22840(yihU)
ENSHWQ15_07830(yihU)
ENKLOC22_10415(yihU)
EHUD5067_0023105(yihU)
EMORL6Y89_22015(yihU)
ESAESA_04058
CSKES15_0037
CSZCSSP291_18805
CSJCSK29544_00987
CCONAFK62_19810
CSIP262_05706
CMJAFK66_000210
CUIAFK65_19600
CMWAFK63_18745
CTUCTU_41740(yihU)
KLWDA718_29160
KARLGL98_24785(yihU)
KGRJJJ10_27435(yihU)
CROROD_38791
CKOCKO_03131
CFDCFNIH1_06955
CBRAA6J81_16395
CWECO701_21335
CYOCD187_23365
CPOTFOB25_10635(yihU)
CFQC2U38_25190
CSEDJY391_21700(yihU)
CAMAF384_21000
CAFAL524_03835
CIFAL515_02035
CFARCI104_24475
CIRC2U53_10580
CIEAN232_03630
CPARCUC49_19980
CTELGBC03_05230(yihU)
CITZE4Z61_16335(yihU)
CARSE1B03_01740(yihU)
ESCEntcl_1241
LAXAPT61_00220
LEIC2U54_04485
LEEDVA44_23385
LERGNG29_22755(yihU)
LEAGNG26_22095(yihU)
LPNUKQ929_20900(yihU)
LAZA8A57_21395
BAGEBADSM9389_41410
AHNNCTC12129_04955(garR_2)
ASUBNLZ15_21985(yihU)
KINAB182_24960
YALAT01_41
SFWWN53_01445
SFGAV650_24195
SFOZ042_05670
RAHRahaq_4078
RACEJHW33_14720(yihU)
RAQRahaq2_4181
RAAQ7S_20720
RVCJ9880_05845(yihU)
PAMPANA_3497(yihU)
PLFPANA5342_0554(yihU)
PAJPAJ_2726(yihU)
PAQPAGR_g0536
PSTWDSJ_21395
MTHIC7M52_01008(yihU)
HPARAL518_02780
PRAGEKN56_14665
LRINCTC12151_00811(Hgd)
BSUNA4G13_00755
VSIMTO69_14805(yihU)
VSHBSZ05_23595
VSRVspart_03220(hgd)
VGIMID13_22250(yihU)
PMKMDS_0271
PPFPput_2157
PPGPputGB1_3155
PPBPPUBIRD1_3027
PPIYSA_00253
PPXT1E_2653(dhaT)
PPUTL483_10705
PPUNPP4_31900(gbd)
PORAPT59_05510
PVRPverR02_11545
PLULFOB45_03485
PPSLBJP27_20245
PSILPMA3_16430
PALLUYA_00985
MSRAU15_05055
AEIAOY20_11465
SROSBBH56_04580
CSACsal_1756
HELHELO_1042
HAKKO116_02309
HALOBWR19_00250 BWR19_04415
HTTHZS52_00870 HZS52_09090
AXEP40_19220
THINCRN91_08445
RSORSc1771(gbd1) RSp0986(gbd2)
RSCRCFBP_11780
RSLRPSI07_1814 RPSI07_mp0978
RSNRSPO_c01807(gbd1) RSPO_m01535(gbd2)
RSMCMR15_11780 CMR15_mp20069
RSEF504_1618 F504_4216
RSYRSUY_19640(dhaT_1) RSUY_45330(dhaT_2)
RPIRpic_1435
RPFRpic12D_1476
RPJN234_07690 N234_11110 N234_25710
RMNTK49_11475
RINACS15_1682
RPUCDC45_09125 CDC45_22570
RSGJK151_12230 JK151_19010
REHH16_A1553(gbd)
CNCCNE_1c15720(gbd1) CNE_2c21420(dhaT)
CUHBJN34_07770 BJN34_35670 BJN34_36185
REUReut_A1418
CTIRALTA_A1479(gbd1) RALTA_A1654
CBWRR42_m2218
CGDCR3_1469(gbd)
CCUPBKK81_11130
CUPBKK80_11385
CUUBKK79_01450
COXE0W60_17505 E0W60_19295 E0W60_28535
BMABMA0905
BMVBMASAVP1_A1435
BMLBMA10229_A0445
BMNBMA10247_0717
BMALDM55_2122
BMAEDM78_2160
BMAQDM76_2097
BMAIDM57_2961
BMAFDM51_660
BMAZBM44_2344
BMABBM45_1909
BPSBPSL2002
BPMBURPS1710b_1823(gbd1)
BPLBURPS1106A_1668
BPDBURPS668_1646
BPRGBP346_A1691
BPSEBDL_538
BPSMBBQ_1873
BPSUBBN_1999
BPSDBBX_2477
BPZBP1026B_I1971
BPQBPC006_I1715
BPKBBK_48
BPSHDR55_3113
BPSABBU_708
BPSOX996_2727
BUTX994_1181
BTEBTH_I2655
BTQBTQ_1369
BTJBTJ_1083
BTZBTL_2324
BTDBTI_2398
BTVBTHA_2523
BTHEBTN_2444
BTHMBTRA_2604
BTHADR62_2589
BTHLBG87_2548
BOKDM82_940
BOCBG90_3662
BUUWS70_10220
BSAVWS86_10980
BHGI6G56_09160
BYIBYI23_C013470 BYI23_D009270
BUEBRPE67_CCDS13020 BRPE67_DCDS11290
BULBW21_2365
BUDAQ610_11175
BUMAXG89_00640 AXG89_13410
BUIAX768_07270 AX768_10380
BXEBxe_A1316
BXBDR64_3477
BPHBphy_1609
BGEBC1002_2056
BFNOI25_3878
BCAIK788_0004323 K788_0005638
PSPWBJG93_02060
PARABTO02_14775
PARBCJU94_10860
PHSC2L64_05070 C2L64_35875
PTERC2L65_04865 C2L65_18360
PMEGFNZ07_26230
PGISI6I06_00690
PACPFAZ97_29950
PEWKZJ38_07910
PDIOPDMSB3_2375.1(yihU) PDMSB3_3115
PPKU875_19915
PPNODA70_12605
PPNMLV28_18090
PRBX636_14260
PPULRO07_03920
PSPUNA29_15990
PVEUC34_12605
POXMB84_16990
PTXABW99_06350
CABASBC2_25090(dhaT_1)
BUOBRPE64_DCDS02300 BRPE64_DCDS08060
BPARBN117_1237(gbd)
BPABPP2084(gbd)
BBHBN112_1980(gbd) BN112_4333
BBRBB1480(gbd) BB4070
BBMBN115_1435(gbd) BN115_3759
BBXBBS798_1441(gbd) BBS798_3863
BBROBAU06_13910
BFZBAU07_12355
BGMCAL15_12665
AXYAXYL_01396
AISBUW96_16295 BUW96_19440
ASWCVS48_11670
ADYHLG70_04255
AKATKWG_00120
ODIODI_R3947
PACRFXN63_01020 FXN63_12020
PARKLSG25_09570
RSBRS694_10575
RHYRD110_09325 RD110_14010
RHFEUB48_10405
POLBpro_2526
PNAPnap_1943
POSDT070_16925
POOF7R28_13660
AAVAave_3418
AJSAjs_1711
AAAAcav_1813
ACKC380_00980 C380_10655
ACRABSY15_1622 BSY15_3223
ACIDCBP33_08840
ACIPCBP36_00930 CBP36_11490
ACINCBP34_08425
ACISCBP35_07440 CBP35_18025
ACIOEAG14_09075
AANTHUK68_04545
ARADKI609_11230 KI609_19130
DACDaci_3383
DELDelCs14_3386
DTSBI380_02590
DHKBO996_15510
DLAI6G47_06755
VAPVapar_2864
VPEVarpa_3110
VPDVAPA_1c26910
VAAAX767_19875
VBOCKY39_17110
VAMC4F17_04985
CTTCtCNB1_1590 CtCNB1_3095
CTESO987_09340
CKEB5M06_12990
CSERCCO03_12395
CAQTKAQ61_08105
CODOLAD35_04455
ADNAlide_0276
ADKAlide2_0223
RTARta_19890
OTKC6570_11685
OTDJ1M35_09920
LIML103DPR2_01788(dhaT_2)
LIHL63ED372_01374(dhaT)
HYRBSY239_1702
HYBQ5W_09540
HYLLPB072_10990
HYCE5678_05855
HPSEHPF_11925(mdh2)
HYNF9K07_12760 F9K07_14800
HTNKI616_03440 KI616_13470
DPYBA022_03250
DIHG7047_09480 G7047_12135
DAERH9K75_01440 H9K75_23190
DRGH9K76_12430
DIADtpsy_1993
SIMPC6571_16485
MELMC7H73_08270
CBAASRAA_1594
CBABSMCB_1500
STHMIS481_09110
PBHAAW51_2848
KIAG8A07_14125
MPTMpe_A1798
METPC1M51_18570
JAJEKL02_00520
HSEHsero_0146(gbd)
HSZACP92_00725
HHTF506_21500
HRBHrubri_0160(gbd)
HEEhmeg3_22690
HHFE2K99_00985
HFRG5S34_00730
GLCJQN73_16525
RGERGE_26150
RBNRBXJA2T_08555
RDPRD2015_3162
PKTAT984_08415
MIUABE85_10710
AONDEH84_09325
XYKGT347_24120
TTWLCC91_05905
URUDSM104443_03117(dhaT_2)
ACOMCEW83_15610
DWDDSCW_05760
MXAMXAN_5629
MSDMYSTI_06220
MYMA176_001289
MFBMFUL124B02_32800
CCXCOCOR_06119(dhaT)
MFULILAB_35625
MMASMYMAC_005424
SURSTAUR_6309
AGEAA314_08031
AVMJQX13_28060
MBDMEBOL_001286
CFUSCYFUS_007849
MESMeso_4502
NKIKW403_03175
PMOBHG718_08235
ATAAWN88_00520
AVIAvi_6101
ARUIG6M88_17825
RPUSCFBP5875_23470
RHTNT26_p10281
RFVRFYW14_00857 RFYW14_03906
KAIK32_18230
BRSS23_32850
RBKE0H22_05370
BOPAXW83_17025
BOSBSY19_3748
BVVBHK69_26655
BOIBLM15_10485
BOFFQV39_27025
BAPIBBC0122_006250
SNOSnov_3495
STARG3545_21755
METM446_3465
MNOMnod_0063
MAQUMaq22A_1p34110(eutG) Maq22A_c07255(eutG)
MEEDA075_08275
MTEADK419_06010
MINDmvi_51370
CHELAL346_05120 AL346_06850 AL346_16010
CDQBOQ54_00090
PHLKKY_2679
AUAM673_00870
AALAIGS74_10630
AALMLUX29_11645
BRND1F64_18695
PSINCAK95_05960 CAK95_11375
RBMTEF_16385 TEF_19965
PSFPSE_2341(garR)
PPHRAPZ00_11925 APZ00_16710
LAPACP90_24770
LABTFIU93_02600(dhaT1)
LAGGB0E33_08230
PHRC6569_16040 C6569_18140
PSTGE8M01_11950
TSVDSM104635_00837(gbsB)
KVLKVU_0808(gbd)
CIDP73_4768
RIDRIdsm_01292(hgd_4)
SAGUCDO87_05835
TMDKUV46_07845
PALXGQA70_22910
PYEA6J80_20645
PPRUFDP22_20395
HDHG5B40_10300
HNEHNE_0174(gbd)
CBOTATE48_05940
HBCAEM38_02135
NOVTQ38_027345
NOTC7W88_20575
NOGGKE62_14000
SPKCKC8_02205
SPHBEP837_03228
SAMISAMIE_1033770
LCKHN018_18095
SRFLHU95_09535
SHUMSTHU_13550 STHU_22030
SVCSTVA_09960 STVA_25540(garR)
STELSTAQ_13280(gbd) STAQ_18190
ABSAZOBR_p340215
AOZHUE56_26230
SKTIGS68_09080
SMUCJL100_018310
SROEJL101_017015
HTQFRZ44_48020(yihU)
HADHFRZ61_10700 FRZ61_45740
PARHI5S86_18645
LNGBSQ50_05330
CACCA_C1574
CAESMB_G1599(4hbD)
CAYCEA_G1589
CPECPE0539
CPFCPF_0518
CPRCPR_0507
CBECbei_4933
CBZCbs_4933
CKLCKL_3014(4hbD)
CKRCKR_2662
CLJCLJU_c38930(4hbD)
CSRCspa_c29410
CPASClopa_4032 Clopa_4274
CPATCLPA_c06290 CLPA_c39010
CPAECPAST_c06290 CPAST_c39010
CAHCAETHG_1741
CSQCSCA_3619
CBUTATN24_07925
CTYKCTK_C07610(4hbD)
CEUA7L45_11955
CDRKB9W14_01605
CDYF3K33_25345
CFERD4Z93_11460
CLOSDMR38_19405
CRWCROST_026690
CFBCLFE_025340
CAUNCLAUR_004280
CRSFQB35_09320
CPRFK7H06_04710
FPLAA4U99_06825 A4U99_13645 A4U99_15805 A4U99_16840
RUJE5Z56_10345
OBJEIO64_02860
CEWEKH84_04070
LACYA4V08_31370
ARFAR1Y2_2848
ACACEYQ97_04065
DLOK5I24_15100
WHJH9Q79_06935 H9Q79_10125
CDFCD630_23380(4hbD)
PDCCDIF630_02577(gbd)
CDCCD196_2181(abfH)
CDLCDR20291_2227(abfH)
PDFCD630DERM_23380(4hbD)
ROCHF520_04655
PHXKGNDJEFE_01613(mdh)
TEMJW646_08030
TGCL0P85_00495
TFRBR63_10040
AWOAwo_c17320
AWICHL1_001593
CMIUB1H56_01420
AMIJEQM06_05015
AMICAmi3637_13480
SPOAEQM13_06730 EQM13_09885
MEDMELS_0336
MMAXLCQ47_08935
SRISELR_pSRC102430
ERLAOC36_08265
AARGAargi30884_11180
ABSIA9CBEGH2_12320
CIUG4D55_07405
EBMSG0102_24860(4hbD)
ERBA4V01_08655
LMOIVV02_02230
NALB005_2696 B005_3092
SESPBN6_54060
BDEBDP_2141(adh2)
BDNBBDE_2011
BTPD805_1109
GVGHMPREF0421_21009
GVAHMPREF0424_0561
GVHHMPREF9231_0570
GPTK9E43_01150
MBFBHV42_01460
IPAIsop_0941
SACISinac_0778
PBORBSF38_02758(adhB)
AGVOJF2_08320(dhaT_1)
TRMJO41_12040
TRZGWP43_07800
TMEDDWB79_09460
FNTHMPREF0405_01108
FNFBSQ88_08650
IPOIlyop_2598
CPORBED41_04035
PGIPG_0689(4hbD)
PGNPGN_0724
PGTPGTDC60_1814(4hbD)
PAHPoras_0444
PCRENCTC12858_01804(adhB)
PCAGNCTC12856_01247(eutG)
PENDLA319_00250
PSOECE91St14_12640
TFOBFO_1487
OSPOdosp_2059
BUYD8S85_11135
BVIRI6J59_04660
 » show all
Reference
1  [PMID:14427301]
  Authors
NIRENBERG MW, JAKOBY WB.
  Title
Enzymatic utilization of gamma-hydroxybutyric acid.
  Journal
J Biol Chem 235:954-60 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.61
IUBMB Enzyme Nomenclature: 1.1.1.61
ExPASy - ENZYME nomenclature database: 1.1.1.61
BRENDA, the Enzyme Database: 1.1.1.61
CAS: 9028-60-8

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