KEGG   ENZYME: 1.1.1.82
Entry
EC 1.1.1.82                 Enzyme                                 
Name
malate dehydrogenase (NADP+);
NADP+-malic enzyme;
NADP+-malate dehydrogenase;
malic dehydrogenase (nicotinamide adenine dinucleotide phosphate);
malate NADP+ dehydrogenase;
NADP+ malate dehydrogenase;
NADP+-linked malate dehydrogenase;
malate dehydrogenase (NADP+)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-malate:NADP+ oxidoreductase
Reaction(IUBMB)
(S)-malate + NADP+ = oxaloacetate + NADPH + H+ [RN:R00343]
Reaction(KEGG)
R00343
Substrate
(S)-malate [CPD:C00149];
NADP+ [CPD:C00006]
Product
oxaloacetate [CPD:C00036];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Activated by light.
History
EC 1.1.1.82 created 1972
Pathway
ec00620  Pyruvate metabolism
ec00710  Carbon fixation by Calvin cycle
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00051  malate dehydrogenase (NADP+)
Genes
AJM119059285
ATHAT5G58330
ALY9300640
CRB17876624
CSAT104726404 104735427 104761929
EUSEUTSA_v10013555mg
BRP103845258 103851645 103856701
BNA106387162 106388230 106420432 106435080 106435756
BOE106317800 106326990 106335373
RSZ108828026 108842484 108847633
THJ104824214
CPAP110817875
CIT102622984
CICCICLE_v10031559mg
MINC123228376
TCC18586537
GRA105780485
GHI107904294 107943658
GAB108457850
HSYR120217956
DZI111310364
EGR104421754
GMX100305890 100782567
GSJ114372222 114403577
PVU137828593
VRA106772560
VAR108321953
VUN114192784
VUM124824026
CCAJ109805341
APRC113871024
MTR25484827
TPRA123908406
CAM101499870
PSAT127098517
VVO131643825
LJA130718596
ADU107466651
AIP107618478
AHF112711491 112776877
LANG109335149 109346097
PCIN129292881 129312899
QSAO6P43_004974 O6P43_008639
FVE101299807
RCN112174171
PPER18785428
PMUM103331480
PAVI110760803
PDUL117617069
MDM103402801 103408309
MSYL126588000 126628159
PXB103937854 103938371 103951716
ZJU107413281
MNT21391387
CSAV115706014
CSV101211170
CMO103489426
BHJ120081316
MCHA111010262
CMAX111467500
CMOS111449691
CPEP111801663
RCU8271083
MEAN126660106
JCU105648670
HBR110646716
MESC110619296 110623872
POP7479845
PEU105130696
PALZ118060285
PNZ133706032
JRE108983075 109011340
CILL122288086 122301262
CAVE132186174 132188038
QSU111992093
QLO115957569
TWL119988885
VVI100247974
VRI117929166
SLY543805(mdh) 778287(chMDH)
SPEN107004667 107015062
SOT102582818
SSTN125844002 125857508
SDUL129899373
CANN107850239
LBB132615141 132637322
NTA107769200 107776723(chMDH) 107778629
NSY104222455
NTO104105470
NAU109209080 109216464
INI109190597
ITR116023156
SIND105179602
OEU111384921
EGT105963464
SSPL121761461 121763643 121791094
SMIL131006293
SHIS125217479
APAN127251305
HAN110872415 110894838
ECAD122600620
LSV111911144
CCAV112524411
DCR108210185
CSIN114321212 114322741
RVL131318959
AEW130760030 130760721
BVG104884197
SOE110802517
CQI110698354 110726180
ATRI130818176
MOF131165452
NNU104587331 104604574
MING122074587 122081181
TSS122651918 122655837
OSA4346332(P0543D10.7)
OBR102709764
OGL127781530
BDI100837587
ATS109767185
TDC119293070 119298570 119329390 119336111
TAES123054367 123097218 123101856 123154897 123159028 123165753
TUA125529370
LPER127315407
LRD124662766 124668670
SBI110436993 8057802
ZMA542374
MFLO136469665 136477066 136498930 136498931
SITA101754520 101775740
SVS117842197 117859844
PVIR120679202 120713117
PHAI112896482
PDA103705497
EGU105055621
MUS103973387
ZOF121984705
DCT110099942
PEQ110020784
AOF109850210
MSIN131225677
ACAK137949628
NCOL116252083 116265856
ATR18432968
SMOSELMODRAFT_175392 SELMODRAFT_270710
PPP112278796 112291394
CRECHLRE_09g410700v5
VCNVOLCADRAFT_76573
MNGMNEG_0778
CSLCOCSUDRAFT_36224
CVRCHLNCDRAFT_29326
OLUOSTLU_42336
OTAOT_ostta08g00930
BPGBathy04g00930
MISMICPUN_104869(NADP-MDH)
MPPMICPUCDRAFT_57848(NADP-MDH)
 » show all
Reference
1  [PMID:5689906]
  Authors
Connelly JL, Danner DJ, Bowden JA.
  Title
Branched chain alpha-keto acid metabolism. I. Isolation, purification, and partial characterization of bovine liver alpha-ketoisocaproic:alpha-keto-beta-methylvaleric acid dehydrogenase.
  Journal
J Biol Chem 243:1198-203 (1968)
Reference
2  [PMID:4397919]
  Authors
Johnson HS.
  Title
NADP-malate dehydrogenase: photoactivation in leaves of plants with Calvin cycle photosynthesis.
  Journal
Biochem Biophys Res Commun 43:703-9 (1971)
DOI:10.1016/0006-291X(71)90672-3
Reference
3  [PMID:4395182]
  Authors
Johnson HS, Hatch MD.
  Title
Properties and regulation of leaf nicotinamide-adenine dinucleotide phosphate-malate dehydrogenase and 'malic' enzyme in plants with the C4-dicarboxylic acid pathway of photosynthesis.
  Journal
Biochem J 119:273-80 (1970)
DOI:10.1042/bj1190273
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.82
IUBMB Enzyme Nomenclature: 1.1.1.82
ExPASy - ENZYME nomenclature database: 1.1.1.82
BRENDA, the Enzyme Database: 1.1.1.82
CAS: 37250-19-4

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