KEGG   ENZYME: 1.1.1.87
Entry
EC 1.1.1.87                 Enzyme                                 
Name
homoisocitrate dehydrogenase;
2-hydroxy-3-carboxyadipate dehydrogenase;
3-carboxy-2-hydroxyadipate dehydrogenase;
homoisocitric dehydrogenase;
(-)-1-hydroxy-1,2,4-butanetricarboxylate:NAD+ oxidoreductase (decarboxylating);
3-carboxy-2-hydroxyadipate:NAD+ oxidoreductase (decarboxylating);
HICDH
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate:NAD+ oxidoreductase (decarboxylating)
Reaction(IUBMB)
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate + NAD+ = 2-oxoadipate + CO2 + NADH + H+ [RN:R01934]
Reaction(KEGG)
R01934;
(other) R01936 R04862
Substrate
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate [CPD:C05662];
NAD+ [CPD:C00003]
Product
2-oxoadipate [CPD:C00322];
CO2 [CPD:C00011];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Forms part of the lysine biosynthesis pathway in fungi [3].
History
EC 1.1.1.87 created 1972 (EC 1.1.1.155 created 1976, incorporated 2004)
Pathway
ec00300  Lysine biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K05824  homoisocitrate dehydrogenase
K10978  methanogen homoisocitrate dehydrogenase
Genes
NLU120349269
QSU111984152 111991115
SCEYIL094C(LYS12)
SEUBDI49_2692
SPAOSPAR_I00750
AGOAGOS_ADL214C
ERCEcym_3326
KLAKLLA0_E08339g
KMXKLMA_80130(LYS12)
LTHKLTH0G10384g
VPOKpol_1003p39
ZROZYRO0A01914g
CGRCAGL0G02585g
NCSNCAS_0B06250(NCAS0B06250)
NDINDAI_0B03550(NDAI0B03550)
TPFTPHA_0C03410(TPHA0C03410)
TBLTBLA_0B05940(TBLA0B05940)
TDLTDEL_0G02180(TDEL0G02180)
TGBHG536_0A02300
KAFKAFR_0J01360(KAFR0J01360)
KNGKNAG_0A05420(KNAG0A05420)
ZMKHG535_0D02020
PPAPAS_chr2-2_0168
DHADEHA2C16852g
PICPICST_50442(LYS12)
PGUPGUG_03875 PGUG_03876
SPAASPAPADRAFT_59913
LELLELG_00189
CALCAALFM_CR01400WA(LYS12)
CTPCTRG_00945
COTCORT_0A02990
CDUCD36_26410
CTENCANTEDRAFT_112571
YLIYALI0D10593g
CLUSA9F13_04g01914
CAURCJI97_000756
SLBAWJ20_5129(LYS12)
PKZC5L36_0C04140
BNNFOA43_004130(LYS12)
BBRXBRETT_002820(LYS12)
OPAHPODL_04851
SLUDSCDLUD_002757
NCRNCU02954(lys-7)
NTENEUTE1DRAFT119171(NEUTE1DRAFT_119171)
SMPSMAC_00496
PANPODANSg09901
TTTTHITE_2122134
MTMMYCTH_2295290
CTHRCTHT_0055150
MGRMGG_01566
PPEIPpBr36_01084
TMNUCRPA7_5672
SSCKSPSK_09424
FGRFGSG_01392
FPUFPSE_08564
FVRFVEG_09468
FOXFOXG_11323
TRETRIREDRAFT_23184
TRRM419DRAFT_138813
MAWMAC_01875
MAJMAA_00573
CMTCCM_06018
PLJVFPFJ_08918
VALVDBG_03889
VDAVDAG_01116
CFJCFIO01_06688
CHIGCH63R_06308
SAPOSAPIO_CDS4368
ELAUCREL1_9930
PFYPFICI_15112
SSLSS1G_02537
BFUBCIN_06g02300
MBEMBM_09266
PSCOLY89DRAFT_614007
GLZGLAREA_06943
ANIAN5206.2
AFMAFUA_6G07390
ACTACLA_081560
NFINFIA_053070
AORAO090005001561
ANGANI_1_398134(An15g02490)
AFVAFLA_004390
ALUCAKAW2_60443S(LYS12)
ACHEACHE_11370S(LYS12)
APUUAPUU_41359S(LYS12)
PCSPc18g05890
PDPPDIP_70630
TMFPMAA_057740
TRGTRUGW13939_00840
CIMCIMG_08027
CPWCPC735_020650
UREUREG_02316
PBLPAAG_06387
PBNPADG_01286
ABEARB_06194
TVETRV_01663
AJEHCAG_07785
BGHBDBG_09367
PNOSNOG_01047
PTEPTT_19273
BZECOCCADRAFT_8727
BSCCOCSADRAFT_35926
BORCOCMIDRAFT_8810
AALTCC77DRAFT_1025667
ZTRMYCGRDRAFT_85715
PFJMYCFIDRAFT_201320
FFUCLAFUR5_02121
BCOMBAUCODRAFT_73623
NPAUCRNP2_9220
TMLGSTUM_00011274001
SPOSPAC31G5.04
CNECND03850
CNBCNBD2460
CNGCNAG_01264
CGICGB_D6560C
TMSTREMEDRAFT_37357
TASAA1Q1_01965
TVSTRAVEDRAFT_163469
DSQDICSQDRAFT_103251
PCOPHACADRAFT_249972
SHSSTEHIDRAFT_77028
HIRHETIRDRAFT_311764
PSQPUNSTDRAFT_112210
ADLAURDEDRAFT_110590
FMEFOMMEDRAFT_169234
GTRGLOTRDRAFT_109763
LBCLACBIDRAFT_229977
MRRMoror_17619
MOREE1B28_004546
CCICC1G_00055
SCMSCHCODRAFT_46722
ABPAGABI1DRAFT113649(AGABI1DRAFT_113649)
ABVAGABI2DRAFT191701(AGABI2DRAFT_191701)
PCUBJR316_0004687
CPUTCONPUDRAFT_64839
SLASERLADRAFT_460541
WSEWALSEDRAFT_60334
WICJ056_003089
UMAUMAG_04873
PFPPFL1_04288
MGLMGL_3003
MRTMRET_3610
MSYMMSY001_1272
MLRMELLADRAFT_35949
ACANACA1_255210
NGRNAEGRDRAFT_79802
PFUWKF707C_48470
PCQPcP3B5_09520(hicd)
PMUIG4G71_07730
PDRH681_20765
PKCPKB_4900(leub3)
PSETTHL1_4856
PLALFXN65_23330
PNNKEM63_14200
PPHABVH74_01680
HPEGEAO82_05040
HAESLO767_13135
AQLBXU06_12520
AMAHDLM_3455
AQSDKK66_09785
VOGLCH97_15160
RRSRoseRS_1057
RCARcas_3471
CAUCaur_0331
CHLChy400_0356
CAGCagg_3600
HAUHaur_3304
ATMANT_08240
PSUBPelsub_P2051
LEKhrd7_27880(hicd)
CAPCLDAP_04830
PMETG4Y79_23070
DRADR_1674
DGEDgeo_1458
DDRDeide_09240
DMRDeima_1545
DGODGo_CA1124
DPDDeipe_3811
DSWQR90_06130
DCHSY84_04075
DABAUC44_04755
DPUSU48_06750
DEZDKM44_12070
DWUDVJ83_05910
DFCDFI_05685
DEINDAAJ005_11775
DGADEGR_21420
DPHEHF33_11670
TRATrad_2841
TTHTT_C1012
TTJTTHA1378(TTHA1378)
TTSThthe16_1388
TTLTtJL18_0670
TSCTSC_c20650(icd2)
THCTCCBUS3UF1_6370
TOSTheos_0440
TAQTO73_0559
TPARAV541_03840
TBCA0O31_01242
TANTKNN15_01885
MRBMrub_2738
MREK649_08845
MSVMesil_1337
MTAIMtai_v1c23390
OPROcepr_1387
MHDMarky_1533
SCORJ3U87_19140
MJAMJ_1596
MFEMefer_0957
MVUMetvu_0752
MFSMFS40622_0058
MIFMetin_0287
MJHJH146_0764
MESGMLAUSG7_1557(aksF)
MESAMLASG1_1116(aksF)
MIGMetig_0040
MMPMMP0880(aksF)
MMQMmarC5_0688
MMXMmarC6_1775
MMZMmarC7_0128
MMDGYY_05110
MMAKMMKA1_09750(aksF)
MMAOMMOS7_09540(aksF)
MMADMMJJ_01120(hicd_1)
MAEMaeo_1484
MVNMevan_0040
MVOMvol_0791
MOKMetok_1293
METFCFE53_02585
MTHMTH_184
MMGMTBMA_c06370
MWOMWSIV6_0600(leuB1)
MTEEMTTB_08450
METCMTCT_0151
METEtca_00168(hicd_1)
METZMETMT2_0650
METKFVF72_01360
MTHMFZP57_02855
MSTMsp_0674
METBAW729_04705
MRUmru_1033(aksF)
MSIMsm_0373
MEBAbm4_0999(aksF)
MMILsm9_0644(aksF)
MEYETL18_03130
MOLYLM1_0578
MAROMarbSA_20290
METVK4897_02380
MELMetbo_0581
MEWMSWAN_1784
METHMBMB1_1404(leuB1)
MFCBRM9_0639(aksF)
MFIDSM1535_0612(leuB1)
MCUBMCBB_1645(leuB1)
MSUBBK009_06025
METNBK008_01565
METTCIT01_09740
METOCIT02_10965
MEMEHYG87_10135
MFVMfer_1273
MKAMK1215(leuB_2)
MBAMbar_A0248
MBYMSBRM_2706
MBWMSBRW_0747
MBARMSBR2_2662
MBAKMSBR3_2764
MACMA_3748(leuB)
MMAMM_0642
MMAZMmTuc01_0657
MMJMSMAS_0667
MMACMSMAC_0669
MVCMSVAZ_0686
MEKMSKOL_0664
MLSMSLAZ_2217
METMMSMTP_0734
MEFMSWH1_0829
MEQMSWHS_0888
MSJMSSAC_3556
MSZMSSIH_3098
MSWMSSIT_3155
MTHRMSTHT_2378
MTHEMSTHC_0902
MHORMSHOH_0789
MFZAOB57_003530
MMETMCMEM_2087
MELOJ7W08_09400
MMHMmah_0129
MHAZBHR79_02805
MEVMetev_1314
MZHMzhil_1662
MPYMpsy_2352
MZIHWN40_10585
MHZMetho_0479
MTPMthe_0855
MCJMCON_1920(aksF)
MHIMhar_2394
MHUMhun_1797
MRTJKHC33_05425
MLAMlab_0235
MEMMemar_0637
MBGBN140_3039(leuB3)
MEMAMMAB1_2207(leuB)
MCHKMchiMG62_07670
MPIMpet_2492
MBNMboo_0602
MFOMetfor_2589
MPLMpal_2146
MPDMCP_1963(aksF)
MEZMtc_1557(aksF)
RCIRCIX2644(leuB-2)
PTOPTO0910
MEUZKRP56_01655 KRP56_05915
 » show all
Reference
1  [PMID:4284830]
  Authors
Strassman M, Ceci LN.
  Title
Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid.
  Journal
J Biol Chem 240:4357-61 (1965)
Reference
2  [PMID:4395693]
  Authors
Rowley B, Tucci AF
  Title
Homoisocitric dehydrogenase from yeast.
  Journal
Arch Biochem Biophys 141:499-510 (1970)
DOI:10.1016/0003-9861(70)90167-0
  Sequence
[sce:YIL094C]
Reference
3  [PMID:10714900]
  Authors
Zabriskie TM, Jackson MD.
  Title
Lysine biosynthesis and metabolism in fungi.
  Journal
Nat Prod Rep 17:85-97 (2000)
DOI:10.1039/A801345D
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.87
IUBMB Enzyme Nomenclature: 1.1.1.87
ExPASy - ENZYME nomenclature database: 1.1.1.87
BRENDA, the Enzyme Database: 1.1.1.87
CAS: 9067-90-7

DBGET integrated database retrieval system