Entry |
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Name |
hydroxymethylglutaryl-CoA reductase;
beta-hydroxy-beta-methylglutaryl coenzyme A reductase (ambiguous);
beta-hydroxy-beta-methylglutaryl CoA-reductase (ambiguous);
3-hydroxy-3-methylglutaryl coenzyme A reductase (ambiguous);
hydroxymethylglutaryl coenzyme A reductase (ambiguous)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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Sysname |
(R)-mevalonate:NAD+ oxidoreductase (CoA-acylating)
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Reaction(IUBMB) |
(R)-mevalonate + CoA + 2 NAD+ = 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ [RN: R02081]
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Reaction(KEGG) |
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Substrate |
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Product |
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History |
EC 1.1.1.88 created 1972, modified 2002
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Pathway |
ec00900 | Terpenoid backbone biosynthesis |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K00054 | hydroxymethylglutaryl-CoA reductase |
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Genes |
PTAE: | NCTC10697_02276(mvaA) |
LFA: | LFA_1198(hmgA) LFA_2262(mvaA) |
LLG: | 44548918_02234(mvaA) |
LJR: | NCTC11533_02313(mvaA) |
LCJ: | NCTC11976_02826(mvaA) |
LWA: | SAMEA4504053_2305(mvaA_1) SAMEA4504053_2440(mvaA_2) |
LSS: | NCTC12082_01446(mvaA) |
LADL: | NCTC12735_01483(mvaA) |
HAAH: | HALA3H3_510030(hmgA) |
ALCA: | ASALC70_02192(mvaA_2) |
AXX: | ERS451415_03082(mvaA) |
MAQU: | Maq22A_c21635(hmg1) |
SPSE: | SULPSESMR1_00707(mvaA) |
LALG: | LentiSH36_02213(mvaA) |
PPRU: | FDP22_15890 FDP22_19260 |
MSD: | MYSTI_05245 MYSTI_05505 |
MFB: | MFUL124B02_01470 MFUL124B02_11615 MFUL124B02_14135 MFUL124B02_28770 MFUL124B02_30010 |
MYX: | QEG98_27240 QEG98_34385 |
MLAN: | JY572_00400 JY572_39745 |
AGE: | AA314_01868 AA314_03811 |
AVM: | JQX13_22175 JQX13_33160 |
MBD: | MEBOL_004335 MEBOL_005713 |
PAUU: | E8A73_032560 E8A73_039820 |
SAMY: | DB32_000804 DB32_006294 |
BSED: | DN745_02575 DN745_02590 |
VIL: | CFK37_04990 CFK37_10080 |
VNE: | CFK40_00660 CFK40_05840 |
LAO: | AOX59_08350 AOX59_12535 |
LEX: | Len3610_12185 Len3610_16815 |
SUX: | SAEMRSA15_24480(mvaA) |
SUF: | SARLGA251_23200(mvaA) |
SAUT: | SAI1T1_2018940(mvaA) |
SAUJ: | SAI2T2_1018950(mvaA) |
SAUK: | SAI3T3_1018940(mvaA) |
SAUQ: | SAI4T8_1018950(mvaA) |
SPIC: | SAMEA4384060_0646(mvaA) |
SSH: | NCTC13712_02499(mvaA) |
SSIM: | SAMEA4384339_2347(mvaA) |
GMO: | NCTC11323_00064(mvaA) |
GHA: | NCTC10459_01687(mvaA) |
STG: | MGAS15252_0711(mvaS1) |
STX: | MGAS1882_0707(mvaS1) |
SNV: | SPNINV200_15480(mvaA) |
SPNG: | HMPREF1038_01706(mvaA) |
SPNE: | SPN034156_06050(mvaA) |
SPNU: | SPN034183_15150(mvaA) |
SPNM: | SPN994038_15040(mvaA) |
SPNO: | SPN994039_15050(mvaA) |
SMC: | SmuNN2025_1085(mvaA) |
SGG: | SGGBAA2069_c12510(mvaA) |
STRG: | SRT_11520(mvaA) SRT_11530(mvaA) |
SVB: | NCTC12167_00608(mvaA) |
SMEN: | SAMEA4412692_1229(mvaA) |
SFER: | NCTC12278_01037(mvaA) |
SCAI: | NCTC12191_01809(mvaA) |
SPSU: | NCTC13786_02079(mvaA) |
SPOC: | NCTC10925_01058(mvaA) |
SAUP: | NCTC3168_01009(mvaA) |
SURN: | NCTC13766_00981(mvaA) |
SVF: | NCTC3166_01739(mvaA) |
SMIE: | NCTC11169_00165(mvaA) |
LPW: | LpgJCM5343_13710(mvaA) |
LOR: | AYI71_00910 AYI71_08400 |
ECEC: | NCTC12421_01572(atoB) |
AHK: | NCTC10172_00895(mvaA) |
RPSK: | JWS13_01220 JWS13_15810 |
MHOT: | PU630_13685 PU630_15770 |
BAFH: | BafHLJ01_0755(mvaA) |
FOK: | KK2020170_04050(mvaA) |
PHG: | KCTC32516_01348(mvaA) |
AALG: | AREALGSMS7_00744(mvaA) |
KOS: | KORDIASMS9_00482(mvaA) |
KAN: | IMCC3317_23820(mvaA) |
SPON: | HME9304_01002(mvaA) |
CGLE: | NCTC11432_02579(mvaA) |
CTAI: | NCTC12078_01185(mvaA) |
CTAK: | 4412677_02320(mvaA) |
CJG: | NCTC13459_02490(mvaA) |
CANT: | NCTC13489_02506(mvaA) |
PTAN: | CRYO30217_02152(mvaA) |
TVO: | TVG1221182(TVG1221182) |
BARC: | AOA65_0748 AOA65_0762(hmgA) |
LOKI: | Lokiarch_22660(mvaA) |
» show all
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Reference |
1 |
Authors |
Fimognari GM, Rodwell VW. |
Title |
Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA). |
Journal |
Biochemistry 4:2086-2090 (1965) |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.1.1.88 |
ExPASy - ENZYME nomenclature database: | 1.1.1.88 |
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