KEGG   ENZYME: 1.1.1.96
Entry
EC 1.1.1.96                 Enzyme                                 
Name
diiodophenylpyruvate reductase;
aromatic alpha-keto acid;
KAR;
2-oxo acid reductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase
Reaction(IUBMB)
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+ [RN:R03431]
Reaction(KEGG)
R03431
Substrate
3-(3,5-diiodo-4-hydroxyphenyl)lactate [CPD:C04367];
NAD+ [CPD:C00003]
Product
3-(3,5-diiodo-4-hydroxyphenyl)pyruvate [CPD:C01244];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.
History
EC 1.1.1.96 created 1972
Reference
1  [PMID:5935348]
  Authors
Zannoni VG, Weber WW.
  Title
Isolation and properties of aromatic alpha-keto acid reductase.
  Journal
J Biol Chem 241:1340-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.96
IUBMB Enzyme Nomenclature: 1.1.1.96
ExPASy - ENZYME nomenclature database: 1.1.1.96
BRENDA, the Enzyme Database: 1.1.1.96
CAS: 37250-31-0

  All links  
Protein sequence (80)   
   UniProt (62)   
   SWISS-PROT (6)   
   RefSeq(pep) (12)   
DNA sequence (13)   
   RefSeq(nuc) (13)   
Protein domain (8)   
   InterPro (8)   
All databases (101)   

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