Entry |
|
Name |
diiodophenylpyruvate reductase;
aromatic alpha-keto acid;
KAR;
2-oxo acid reductase
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
|
Sysname |
3-(3,5-diiodo-4-hydroxyphenyl)lactate:NAD+ oxidoreductase
|
Reaction(IUBMB) |
3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD+ = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H+ [RN: R03431]
|
Reaction(KEGG) |
|
Substrate |
3-(3,5-diiodo-4-hydroxyphenyl)lactate [CPD: C04367];
NAD+ [CPD: C00003]
|
Product |
|
Comment |
Substrates contain an aromatic ring with a pyruvate side chain. The most active substrates are halogenated derivatives. Compounds with hydroxy or amino groups in the 3 or 5 position are inactive.
|
History |
EC 1.1.1.96 created 1972
|
Reference |
|
Authors |
Zannoni VG, Weber WW. |
Title |
Isolation and properties of aromatic alpha-keto acid reductase. |
Journal |
J Biol Chem 241:1340-4 (1966) |
Other DBs |
ExplorEnz - The Enzyme Database: | 1.1.1.96 |
ExPASy - ENZYME nomenclature database: | 1.1.1.96 |
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