Entry
Name
alcohol dehydrogenase (cytochrome c);
type I quinoprotein alcohol dehydrogenase;
quinoprotein ethanol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a cytochrome as acceptor
BRITE hierarchy
Sysname
alcohol:cytochrome c oxidoreductase
Reaction(IUBMB)
a primary alcohol + 2 ferricytochrome c = an aldehyde + 2 ferrocytochrome c + 2 H+
Reaction(KEGG)
Substrate
primary alcohol [CPD:
C00226 ];
ferricytochrome c [CPD:
C00125 ]
Product
Comment
A periplasmic PQQ-containing quinoprotein. Occurs in Pseudomonas and Rhodopseudomonas. The enzyme from Pseudomonas aeruginosa uses a specific inducible cytochrome c550 as electron acceptor. Acts on a wide range of primary and secondary alcohols, but not methanol. It has a homodimeric structure [contrasting with the heterotetrameric structure of EC
1.1.2.7 , methanol dehydrogenase (cytochrome c)]. It is routinely assayed with phenazine methosulfate as electron acceptor. Activity is stimulated by ammonia or amines. Like all other quinoprotein alcohol dehydrogenases it has an 8-bladed 'propeller' structure, a calcium ion bound to the PQQ in the active site and an unusual disulfide ring structure in close proximity to the PQQ.
History
EC 1.1.2.8 created 1972 as EC 1.1.99.8, modified 1982, part transferred 2010 to EC 1.1.2.8
Pathway
ec00010 Glycolysis / Gluconeogenesis
ec00625 Chloroalkane and chloroalkene degradation
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K00114 alcohol dehydrogenase (cytochrome c)
Genes
GHO : AL542_11380 AL542_17210
PAEB : NCGM1900_4505(exaA)
PRE : PCA10_31340(pedH) PCA10_31390(pedE)
PFUW : KF707C_28750 KF707C_28820
PCQ : PcP3B5_36440(qedA) PcP3B5_36490(exaA)
PMUI : G4G71_16080 G4G71_16105
PNT : G5B91_15945 G5B91_15970
PPU : PP_2674(qedH-I) PP_2679(qedH-II)
PPG : PputGB1_3124 PputGB1_3129
PPB : PPUBIRD1_2997 PPUBIRD1_3002(qedH)
PPX : T1E_2678(exaA) T1E_2683
PPUH : B479_11520 B479_11545
PPUT : L483_10830 L483_10855
PPUN : PP4_31590(pedH) PP4_31640(pedE)
PPUD : DW66_2478 DW66_2483 DW66_4707
PMON : X969_09430 X969_09455
PMOT : X970_09090 X970_09115
PPJ : RK21_00206 RK21_02607 RK21_02613
PALD : LU682_017235(pedH) LU682_017260(exaA)
PFL : PFL_2216(pedE) PFL_2221(pedH)
PPRC : PFLCHA0_c22780(exaA1) PFLCHA0_c22820(exaA2)
PPRO : PPC_2256(pedE) PPC_2261(pedH)
PFE : PSF113_2976 PSF113_2981
PCG : AXG94_01405 AXG94_01430
PVR : PverR02_20155 PverR02_20180
PRX : HRH33_17405 HRH33_17430
PMUD : NCTC8068_03188(exaA1)
PFW : PF1751_v1c34010 PF1751_v1c34060
PFF : PFLUOLIPICF718895 PFLUOLIPICF718920
PBA : PSEBR_a2660 PSEBR_a2665
PBC : CD58_14190 CD58_14215
PSK : U771_20885 U771_20910
PSOS : POS17_2165(pedE) POS17_2170(pedH)
PFK : PFAS1_27375 PFAS1_27400
PSET : THL1_2856 THL1_2863
PSIL : PMA3_15655 PMA3_15680
PALL : UYA_14090 UYA_14125
PUM : HGP31_20510 HGP31_20535
PLAL : FXN65_12380 FXN65_12410
PSEJ : HNQ25_11420 HNQ25_11455
PVK : EPZ47_14140 EPZ47_14170
PBZ : GN234_02080 GN234_02105
PKH : JLK41_15365 JLK41_15395(exaA)
PTY : JWV26_00210 JWV26_00240(exaA)
PTRT : HU722_0010890(exaA)
PANH : HU763_013725(pedH) HU763_013750(exaA)
PASG : KSS96_18475 KSS96_18500(exaA)
PALV : KSS97_15295 KSS97_15320(exaA)
PWZ : J7655_09605(exaA) J7655_09645
PTW : TUM18999_41900 TUM18999_41950(exaA)
PZA : HU749_015395(exaA) HU749_015420
PJU : L1P09_11985(exaA) L1P09_12010(pedH)
PHF : NLY38_14680 NLY38_14710(exaA)
PPHN : HU825_14110 HU825_15605
PCAS : LOY40_14640 LOY40_14665(exaA)
PASI : LG197_16415(exaA) LG197_16440(pedH)
PKM : PZ739_11915(exaA) PZ739_11940(pedH)
PSOA : PSm6_02910 PSm6_02970(exaA)
PTAI : ICN73_21945 ICN73_21970
PKK : QQ992_15230(pedH) QQ992_15255(exaA)
PKJ : Q1W70_24585 Q1W70_24610(exaA)
PSZ : PSTAB_2150 PSTAB_2156
PSR : PSTAA_2293 PSTAA_2299
PSC : A458_09430 A458_09460
PSH : Psest_2054 Psest_2060
PSTU : UIB01_10620 UIB01_10650
PSED : DM292_08025 DM292_08055
PCHL : LLJ08_09905(exaA) LLJ08_09935
PBM : CL52_09455 CL52_09750
PKG : LW136_12665 LW136_12695(exaA)
SDEG : GOM96_01105 GOM96_02595
PZD : KQ248_15520(exaA) KQ248_15550
HPEG : EAO82_12705 EAO82_12720
HARR : HV822_03610 HV822_03635(exaA)
PPHA : BVH74_16695 BVH74_16710
MHC : MARHY3265(exaA) MARHY3268(exaA)
MLQ : ASQ50_07960 ASQ50_07975
MSQ : BKP64_09340 BKP64_17865
MARJ : MARI_32520(qedA) MARI_32550(exaA)
MALL : PBN92_17105 PBN92_17125
MSHE : MAALD49_33590 MAALD49_33620(exaA)
AMAC : MASE_05380 MASE_15465
AMB : AMBAS45_05580 AMBAS45_15905
AMG : AMEC673_05455 AMEC673_15760
ALR : DS731_13535 DS731_19985
SNAN : I6N98_16245 I6N98_16265
MEIN : methR_P2259 methR_P2681
BLEP : AL038_04345 AL038_06915
GAI : IMCC3135_20825(qedA)
MARS : A8C75_10220 A8C75_12620
MGEO : CFI10_09850 CFI10_09875
MSEC : LN244_08365 LN244_08390(exaA)
RPJ : N234_08060 N234_11945
CNC : CNE_1c16910(exaA) CNE_2c10080(quiA)
CBW : RR42_m1093 RR42_m2319
BYI : BYI23_B010140 BYI23_D007680
BUE : BRPE67_BCDS14270 BRPE67_DCDS09590
BGE : BC1002_1266 BC1002_5554
PSPW : BJG93_19660 BJG93_28155 BJG93_32655
PARB : CJU94_14945 CJU94_31280
PHS : C2L64_33215 C2L64_40155
BUO : BRPE64_BCDS02790 BRPE64_DCDS04120
LIMN : HKT17_04220 HKT17_04265
PVAC : HC248_03036(qbdA_2)
HYL : LPB072_00220 LPB072_13725
HPSE : HPF_00420(qbdA) HPF_17540(qedA)
MPT : Mpe_A0341 Mpe_A0363 Mpe_A0473 Mpe_A1591 Mpe_A1595
METP : C1M51_00245 C1M51_00265 C1M51_08185 C1M51_10925 C1M51_11510
ATER : MW290_10915 MW290_12840
METR : BSY238_1339 BSY238_1347 BSY238_1798 BSY238_3265 BSY238_622
APET : ToN1_41090 ToN1_41650
DEY : HYN24_02985 HYN24_10930
AZO : azo2975(exaA3) azo3865(exaA5)
AZA : AZKH_1557 AZKH_3818(exaA) AZKH_p0287
AZI : AzCIB_1049 AzCIB_3863
AZD : CDA09_04765 CDA09_07845 CDA09_18620
AZR : CJ010_18560 CJ010_24320
AZQ : G3580_01005 G3580_01345 G3580_04330 G3580_04350 G3580_07425 G3580_17510
ACOM : CEW83_09560 CEW83_15380
SFD : USDA257_c26010(exaA)
BJU : BJ6T_34810 BJ6T_34960
BJP : RN69_16885 RN69_16955
BRA : BRADO1707 BRADO3897 BRADO5480
BBT : BBta_2017 BBta_3937 BBta_5964
BRS : S23_20730 S23_20880(exaA)
AOL : S58_22280 S58_39380 S58_58330
BRC : BCCGELA001_26665 BCCGELA001_26735 BCCGELA001_29165
BRAD : BF49_5350 BF49_5373
BRO : BRAD285_1583 BRAD285_1753 BRAD285_3477
BRK : CWS35_20345 CWS35_32740 CWS35_36570
BOT : CIT37_23130 CIT37_23200
BRQ : CIT40_23210 CIT40_23275
BGQ : X265_11155 X265_11210
BGZ : XH91_10380 XH91_10440
BSYM : CIT39_22185 CIT39_22270
BARH : WN72_34645 WN72_34715
BVZ : BRAD3257_2926 BRAD3257_2940(qedA)
BEL : BE61_38080 BE61_46450
BDG : LPJ38_32910 LPJ38_32980
BSEP : HAP48_0044200 HAP48_0048365
BQB : J4P68_0003415 J4P68_0007575
BBAN : J4G43_037090 J4G43_037165
BCAN : BcanWSM471_27545 BcanWSM471_27615
BAUT : QA635_14625 QA635_18425
BBRA : QA636_14350 QA636_19035
BGK : IC762_22205 IC762_25825
BPAH : QA639_26435 QA639_30475
BXN : I3J27_27060 I3J27_27130
MRD : Mrad2831_0808 Mrad2831_2409
MAQU : Maq22A_1p30675(gcd) Maq22A_1p32165(gcd) Maq22A_c07235(gcd)
MPHY : MCBMB27_00405 MCBMB27_02028
MEE : DA075_03080 DA075_13210
METX : A3862_18705 A3862_26515
MMES : MMSR116_21850 MMSR116_27025
MTEA : DK419_07305 DK419_22175
MIND : mvi_08360 mvi_16330 mvi_21350(exaA)
BBAR : RHAL1_01345(exaA) RHAL1_03347
HDN : Hden_0340 Hden_0783 Hden_0796
HDT : HYPDE_29643 HYPDE_34983
RHZ : RHPLAN_21510 RHPLAN_21530 RHPLAN_21580 RHPLAN_21650 RHPLAN_34730 RHPLAN_57980 RHPLAN_58260
METG : HT051_05195 HT051_05200 HT051_13770
DEQ : XM25_04430 XM25_08630 XM25_13135 XM25_22055
DEA : FPZ08_20360 FPZ08_20370
YTI : FNA67_03505 FNA67_08265 FNA67_12370 FNA67_16870
KVL : KVU_0203 KVU_1366 KVU_2142 KVU_2159
KVU : EIO_0653 EIO_1909 EIO_2636 EIO_2658
KRO : BVG79_02251 BVG79_p1000164
TPRO : Ga0080559_TMP3900 Ga0080559_TMP989
AHT : ANTHELSMS3_00910(exaA)
RCP : RCAP_rcc01396(exaA1) RCAP_rcc01657(exaA2)
PMAU : CP157_03754(qedA_1) CP157_03864(qedA_2)
GFU : KM031_18165 KM031_18690
SPHR : BSY17_1616 BSY17_4000
SHYD : CJD35_06150 CJD35_12410
SPPH : KFK14_16995 KFK14_22885
POQ : KZX46_11985 KZX46_19530
ACR : Acry_1570 Acry_1741 Acry_2797
AMV : ACMV_16130 ACMV_17860 ACMV_31290
AZL : AZL_a05260 AZL_b04560
ALI : AZOLI_p20241 AZOLI_p20409(exaA)
ABS : AZOBR_180211(exaA) AZOBR_p330074
ABQ : ABAZ39_02360 ABAZ39_29210
ATI : AL072_20095 AL072_27795
AZT : TSH58p_13895 TSH58p_31735
AZZ : DEW08_18930 DEW08_27310
AARE : D3093_06830 D3093_30830
NCB : C0V82_05445 C0V82_05455
SKT : IGS68_14195 IGS68_15465 IGS68_28325
APAI : APAC_0386 APAC_0390
BVJ : I5776_05535 I5776_10820
AFX : JZ786_13650 JZ786_14040
PSEE : FRP1_13300 FRP1_13940
PSEQ : AD006_20980 AD006_21605
PECQ : AD017_00560 AD017_01190
PRY : Prubr_54710 Prubr_54730(exaA)
AAGG : ETAA8_14430(qbdA_1)
SDYN : Mal52_04780(bamB_1)
GRW : FTO74_07605 FTO74_09065 FTO74_09170 FTO74_15310
TSA : AciPR4_0226 AciPR4_0416 AciPR4_2733
TRS : Terro_0082 Terro_0324 Terro_2792 Terro_2859 Terro_3908
TALB : FTW19_08070 FTW19_09105 FTW19_10125 FTW19_13720 FTW19_14405
ABAS : ACPOL_2504 ACPOL_5062
EDA : GWR55_03060 GWR55_06180 GWR55_06250 GWR55_06405 GWR55_07095 GWR55_07590 GWR55_16325 GWR55_18760
EDG : H7846_13420 H7846_17140 H7846_17640
ADIN : H7849_01250 H7849_01255 H7849_11310 H7849_14575
SUS : Acid_0538 Acid_2063 Acid_2112 Acid_3070 Acid_3122 Acid_4577 Acid_5010 Acid_5344 Acid_5413 Acid_6133 Acid_6342
PFER : IRI77_05190 IRI77_11660 IRI77_16055
ABAC : LuPra_00240(qbdA_1) LuPra_00349(qbdA_2) LuPra_02152(qgdA_2) LuPra_04749(qbdA_4)
NPE : Natpe_1527 Natpe_2907
NVR : FEJ81_07890 FEJ81_13575
NAY : HYG81_02700 HYG81_16475
HJT : DVR14_04660 DVR14_17190 DVR14_21320
» show all
Taxonomy
Reference
Authors
Rupp M, Gorisch H
Title
Purification, crystallisation and characterization of quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa.
Journal
Reference
Authors
Toyama H, Fujii A, Matsushita K, Shinagawa E, Ameyama M, Adachi O
Title
Three distinct quinoprotein alcohol dehydrogenases are expressed when Pseudomonas putida is grown on different alcohols.
Journal
Sequence
Reference
Authors
Schobert M, Gorisch H
Title
Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an adjacent acetaldehyde dehydrogenase.
Journal
Sequence
Reference
Authors
Keitel T, Diehl A, Knaute T, Stezowski JJ, Hohne W, Gorisch H
Title
X-ray structure of the quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: basis of substrate specificity.
Journal
Sequence
Reference
Authors
Kay CW, Mennenga B, Gorisch H, Bittl R
Title
Characterisation of the PQQ cofactor radical in quinoprotein ethanol dehydrogenase of Pseudomonas aeruginosa by electron paramagnetic resonance spectroscopy.
Journal
Reference
Authors
Mennenga B, Kay CW, Gorisch H
Title
Quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: the unusual disulfide ring formed by adjacent cysteine residues is essential for efficient electron transfer to cytochrome c550.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.2.8
ExPASy - ENZYME nomenclature database: 1.1.2.8
BRENDA, the Enzyme Database: 1.1.2.8