KEGG ENZYME: 1.1.3.38

ENZYME: 1.1.3.38

Entry

EC 1.1.3.38                 Enzyme

Name

vanillyl-alcohol oxidase;
4-hydroxy-2-methoxybenzyl alcohol oxidase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

vanillyl alcohol:oxygen oxidoreductase

Reaction(IUBMB)

vanillyl alcohol + O2 = vanillin + H2O2 [RN:R02877]

Reaction(KEGG)

R02877

Substrate

vanillyl alcohol [CPD:C06317];
O2 [CPD:C00007]

Product

vanillin [CPD:C00755];
H2O2 [CPD:C00027]

Comment

Vanillyl-alcohol oxidase from Penicillium simplicissimum contains covalently bound FAD. It converts a wide range of 4-hydroxybenzyl alcohols and 4-hydroxybenzylamines into the corresponding aldehydes. The allyl group of 4-allylphenols is also converted into the -CH=CH-CH2OH group.

History

EC 1.1.3.38 created 1999

Pathway

ec00627

Aminobenzoate degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K20153

vanillyl-alcohol oxidase

Reference

1 [PMID:1396672]

Authors

de Jong E, van Berkel WJ, van der Zwan RP, de Bont JA

Title

Purification and characterization of vanillyl-alcohol oxidase from Penicillium simplicissimum. A novel aromatic alcohol oxidase containing covalently bound FAD.

Journal

Eur J Biochem 208:651-7 (1992)
DOI:10.1111/j.1432-1033.1992.tb17231.x

Sequence

[ag:CAA75722]

Reference

2 [PMID:8529652]

Authors

Fraaije MW, Veeger C, van Berkel WJ.

Title

Substrate specificity of flavin-dependent vanillyl-alcohol oxidase from Penicillium simplicissimum. Evidence for the production of 4-hydroxycinnamyl alcohols from 4-allylphenols.

Journal

Eur J Biochem 234:271-7 (1995)
DOI:10.1111/j.1432-1033.1995.271_c.x

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.38

IUBMB Enzyme Nomenclature:

1.1.3.38

ExPASy - ENZYME nomenclature database:

1.1.3.38

UM-BBD (Biocatalysis/Biodegradation Database):

1.1.3.38

BRENDA, the Enzyme Database:

1.1.3.38

CAS:	143929-24-2

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