KEGG   ENZYME: 1.1.3.46
Entry
EC 1.1.3.46                 Enzyme                                 
Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:R06633]
Reaction(KEGG)
R06633
Substrate
(S)-4-hydroxymandelate [CPD:C03198];
O2 [CPD:C00007]
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:C03590];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16422  4-hydroxymandelate oxidase
Genes
EBIEbC_45010
PAOPat9b_0059
KLNLH22_02000
PANSFCN45_00295
PSUWWQ53_04950
XBAC7S18_07265
PMYPmen_0804
PREPCA10_09820(lldD)
PPSEBN5_0696(glcD3)
PFUWKF707C_9130
PSETTHL1_1034
PALLUYA_03960
POJPtoMrB4_11440
PLALFXN65_04550
PKHJLK41_04285
PWZJ7655_03835
PHFNLY38_04070
PCHEQYM18_11835
AVNAvin_12350(lldD)
AVLAvCA_12350(lldD)
AVDAvCA6_12350(lldD)
ACXAchr_30250(lldD)
EMODM558_00105
EAZJHT90_12855
HAESLO767_01930
PNNKEM63_07345
MSXAU14_05680
KAKKalk_08620
PRWPsycPRwf_1462
PSYYDLE54_06755 DLE54_06980
ATTAMQ28_05560
AEIAOY20_01775
AJORZ95_14500
AHLAHTJS_02455
ASJAsACE_CH00433
AIDCTZ23_02310
ADVDJ533_16435
AWUBEN71_03430
ACUMC9E88_006515
AGUAS4_05470
ADSFPL17_16865
ABERBSR55_17750
ACHICDG60_15615
ASHAG8E00_02820
ATGJ4G44_00650
ABOUACBO_26740
APOTMZO21_10675
SPOLFH971_10065
SKHSTH12_02859(lldD)
SDKKHX94_16705
PTUPTUN_a4088(glcD)
AMACMASE_17490
AMBAMBAS45_17880
AMGAMEC673_17615
AMKAMBLS11_16975
GAGGlaag_2394
PMESFX988_00687
PATPatl_2274
ALKMNKI27_10730
TTUTERTU_2554
ZALAZF00_16215
LFALFA_1216(GLO)
LHALHA_0501
MMAFGCM100_08640
CYQQ91_0345
CZACYCME_2304
CYYCPC19_11350
TXAHQN79_00810
TLHNR989_02675
THISHZT40_14725
TWNL2Y54_11885
GAIIMCC3135_25780(hmo)
HCHHCH_01681
HAHEENC22_22225
HAHHO5O45_17885
HHHCLM76_06065
TOLTOL_2765
MARSA8C75_03950
MRZKDW95_12225
NCUF0U83_13850
GSNYC6258_04793
SINIGT972_11345
SALNSALB1_1045
GPBHDN1F_36910
VFFVITFI_CDS3216
VITADP71_31350
VSTLVJ81_12130
VMSLVJ82_08190
VOGLCH97_08320
AQLBXU06_07955
RMERmet_0839
CGDCR3_3245(glcD)
CPAUEHF44_23235
CCAXKZ686_18395
BGLbglu_2g01780
BGUKS03_3471
BGPBGL_1c27020
BPLAbpln_1g26350
PMEGFNZ07_25555
LTORGQ30_23430
PUTPT7_3646
PUDG9Q38_09430
PUSCKA81_03480
AMIMMIM_c24880
CDNBN940_05041
AFAUZ73_08085
AFQAFA_02405
AAMMFE795_02370
OURCEQ07_08655
OUEI6G29_10405
PIGEGT29_20715
PACRFXN63_21860
RHYRD110_19630
RHOBHTY51_09170
POLBpro_3049
PNAPnap_2560
AJSAjs_0513
ACKC380_14255
ACRABSY15_3965
ACIDCBP33_11150
ACIPCBP36_11075
ACINCBP34_10980
ACISCBP35_07855
ACIOEAG14_07140
ARADKI609_10130
ATEMPQV96_06500
AMONH9L24_02175
VEIVeis_3083
DACDaci_4620
DELDelCs14_2190
DTSBI380_00615
DHKBO996_20975
DLAI6G47_01340
CTTCtCNB1_3045
CTESO987_18710
CKEB5M06_07315
CSERCCO03_11830
COFFOZ74_09250
CAQTKAQ61_14740
CODOLAD35_07210
CTEZCT3_17380
AANTHUK68_11660
CRJQMY55_15020
ADNAlide_0615
ADKAlide2_0580
RTARta_24240
OTKC6570_07945
LIHL63ED372_01067(lldD_1)
HYRBSY239_2087
HYBQ5W_00125
HYLLPB072_15815
HYCE5678_07245
HPSEHPF_09820
HYNF9K07_18330
HTNKI616_14805
HCZG9Q37_19195
DPYBA022_12275
DIHG7047_00230
DAERH9K75_17485
DRGH9K76_18230
DIADtpsy_0529
SIMPC6571_16290
MELMC7H73_03560
MELAC6568_06065
MJELVC68_02580
STHMIS481_00890
SAQAOMP39_00445
RGERGE_43910
KIAG8A07_26140
PKTAT984_17325
PAQAK9V56_022600
SNNEWH46_04875
ATERMW290_15185
JAGGJA_207(GLO5)
MASSCR152_05310
MANCIV454_11370
UNDUNDKW_2976
AONDEH84_01955
TTWLCC91_03490
BBAYA4V04_09650
NSTNstercoris_01156
METRBSY238_10
RBUPG1C_09700
MEUACJ67_12165
SNIVSFSGTM_20120
DSUDsui_1668
AIQAzoinq_10760
OTROTERR_15390(lldD)
DDENKI615_16175
DECHGBK02_13215
QAUKI612_03440
FLEKI610_05585
AZOazo0609(gox)
AOAdqs_0678
AZRCJ010_03930
THUAC731_012105
THAUC4PIVTH_1905(hmo)
THKCCZ27_15025
AZQG3580_15095
ACOMCEW83_18180
ZPAC3497_07680
MLOmll4732
MAMMesau_02928
CHEAPVE73_15290
HOEIMCC20628_00688
PLAPlav_0378
NPMQEO92_06120
NWINwi_0702
TRBHB776_09700
TALZRPMA_16140
BOPAXW83_15230
AZCAZC_1619
SNOSnov_2512
ANCGBB76_07300
APRAG3A50_03145
MLDU0023_03150 U0023_03920
HNIW911_04290
RHZRHPLAN_58200 RHPLAN_67990
YTIFNA67_17300
MPARF7D14_11785
NOHG5V57_17935
AEXAstex_1292
KROBVG79_01849(glcD)
PABYGa0080574_TMP356
SULDB5M07_08410
SPOTG6548_05240
SINLDSM14862_02055(hmo)
SAGUCDO87_26325
LSALKBK07_09835
TRYQF118_14825
PDEPden_4676
PPANESD82_02735
PMEHJWJ88_16220
PSEWJHW44_08180
PALPJHW40_11555
PVERE3U25_03735
PFEOE3U26_19250
PSHQF3W81_12270
HNEHNE_2118
NARSaro_0774
NPNJI59_23605
NREBES08_00445
NOVTQ38_005445
NHUMPQ457_03080
SWISwit_4251
SPANAWL63_11515
SPHAD3Y57_07445
SNAPPQ455_04365
SNOSK8P63_02215
SABIPBT88_12235
SSYSLG_34570
CAENK5X80_04840
RGIRGI145_05600
ROSCTJ15_11790
RMUCFOB66_07430
RMTIAI58_21860
SVCSTVA_32270
ALIAZOLI_p20485
ABSAZOBR_p1110093
ABQABAZ39_15315
ABFAMK58_20855
ATIAL072_18250
AZTTSH58p_26095
AZMDM194_19930
AARED3093_20250
SMUCJL100_019020
SROEJL101_017820
HFLPUV54_13505
PAQIKW060_03495
HTLHPTL_0509
ABUAbu_0725
ABTABED_0676
AELLAELL_0874
ASUIASUIS_0518
ACLOACLO_0849
AVPAVENP_0617
DFIAXF13_09095
DPGDESPIGER_1501
DFLDFE_2112
DMADMR_21260
DCBC3Y92_10185
DGGDGI_1415
DDEDde_0750
DMSE8L03_10940
DSADesal_1465
DHYDESAM_22812
DASDaes_2493
DEJAWY79_15335
PSELGM415_08775 GM415_17505
DSXGD604_14390
DSDGD606_16625
DVLDvul_0528
DVGDeval_2571
DBADbac_1976
DPSDP0843
DPRDespr_0716
DEOCAY53_04955
DOGHP555_00960
DATHRM2_41110
DALKDSCA_14510
DLIdnl_38430
TCMHL41_07275
THETF1847_08305
AGEAA314_00340
AVMJQX13_15815 JQX13_32715
MBDMEBOL_001680
CFUSCYFUS_002912 CYFUS_008761
SCLsce7671
SCUSCE1572_44330
PAUUE8A73_024105
MRMA7982_09601
LLUAKJ09_10055
HOHHoch_0089
GSMMUN87_21740
LADLA14_1588
LAFSD55_1597
LAMLA2_08960
LAILAC30SC_08600
LAYLAB52_07995
LKEWANG_0215
LJEBUE77_00305
CPECPE1878
CPFCPF_2132
CPRCPR_1844
CLJCLJU_c34360
CLSCXIVA_13840(LldD)
CAHCAETHG_1336
CSQCSCA_4771
CACECACET_c16820(lldD)
CCKCcar_17325
CARGRSJ17_08045
CDRKB9W14_21015
CFERD4Z93_04370
HHWNCTC503_02011(lldD)
CALEFDN13_03910
CRSFQB35_00670
SARJHH195_07595 HH195_11630
CCLClocl_0919
RBPB6259_09280
CCECcel_2344
RHEREHE19_004325
RALRumal_2056
FPRFP2_21160
FPAFPR_06650
FPRACG447_04040
DORDesor_5480
DAIDesaci_4587
DMIDesmer_4518
DEDDHBDCA_p1237
DECDCF50_p1303
DCADesca_1949
DRMDred_1257
DRUDesru_2825
DFGB0537_05970
DKUDesku_2803
TFRBR63_01350
HCVFTV88_0031
AWOAwo_c03770
ACAEHYG86_06340
CTHMCFE_0998
EUUADJ67_06690
CCOMI6K69_07045
CSCIHDCHBGLK_02317(hmo)
ACACEYQ97_08425
RGNRGna_01260
MDVC5Q96_08410
AOEClos_1159
GFEGferi_07105
PSORRSJ16_14275
PDCCDIF630_01416 CDIF630_02628
CDCCD196_1125 CD196_2228
CDLCDR20291_1103 CDR20291_2274
PDFCD630DERM_12630 CD630DERM_23870
ROCHF520_09305
PHXKGNDJEFE_01524(hmo)
CSTCLOST_1147
CHYCHY_0269 CHY_1319
ADGAdeg_1075
GEKkuro4_13110
TSHTsac_2535
COBCOB47_2205
CKNCalkro_0254
CCHAELD05_12315
TEPTepRe1_1797
TAETepiRe1_1937
TOCToce_0633
NTHNther_2031
KMEH0A61_01190(hmo)
KPARJL105_01275
MEDMELS_0352
MEGDKB62_02690
PUFUFO1_4337
STEDSPTER_33280(lldD)
AINAcin_0831
AARGAargi30884_12510
ABSIA9CBEGH2_13410
LCGL3BBH23_07350
ERBA4V01_07355
CIUG4D55_06025
ERZER308_09970
NBRO3I_010580
NTPCRH09_30885
NOZDMB37_31330
NAHF5544_09030 F5544_26845
RHBNY08_2291
RPSKJWS13_19495
WHROG579_12455
TPRTpau_3076
TSMASU32_06245
TPULTPB0596_35140
SCOSCO3228(SCE63.05)
SGBWQO_12235
SGRFSGFS_011630
SVLStrvi_5274 Strvi_8790
SHYSHJG_8441
SHOSHJGH_8202
SRCM271_09165 M271_27675 M271_46055
SMALSMALA_0360
SSOII1A49_05315
SBHSBI_01125 SBI_04778
SLVSLIV_21550
SVTSVTN_15860
STREGZL_08686
SLCSL103_26565
STRCAA958_31845
SAMBSAM23877_5651
SRWTUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
STRFASR50_31315
SPAVSpa2297_02910 Spa2297_26640 Spa2297_32980
STRTA8713_31370
SKYD0C37_28255
SALWCP975_03175 CP975_31960 CP975_31975 CP975_34475
SGMGCM10017557_81720
SNRSNOUR_39380 SNOUR_40635
SALUDC74_564
SALLSAZ_03315
SPLULK06_031590
SAUOBV401_05560
SSIAA7J05_00250 A7J05_04110 A7J05_36485
SVUB1H20_11470
SLAUSLA_6885
SALFSMD44_00061(glcD)
STROSTRMOE7_29125
SFKKY5_6264c KY5_6713 KY5_7436c
SRJSRO_7148
SCYAEJ357_01685
SKACP970_03000 CP970_03015 CP970_07080 CP970_09765
SVRCP971_02375 CP971_08180
SFYGFH48_02895 GFH48_36330
SGFHEP81_07478
SBYH7H31_03485
SRIMCP984_06505 CP984_27455 CP984_39205
SFUGCNQ36_25595
STSUB7R87_00115
SCHACP983_01450 CP983_10835
SGXH4W23_38360
SSPBCP982_05960 CP982_06170
STUIGCM10017668_03330
SCYGS1361_20500
SFEUIM697_27410
SCALI6J39_11675
SAUHSU9_002085
SANUK7396_35160
SINEKI385_01580
SDURM4V62_39090
SRUGF0345_27910
SNIGHEK616_29500 HEK616_51640
SENGOJ254_30630
SYUNMOV08_40295
SARGHKX69_01245
SHAUK9S39_10850
SFPQUY26_00115
KSKKSE_65170 KSE_67420
KABB7C62_11140
KAUB6264_28340
KITCFP65_1219
KISHUT16_30910 HUT16_31115 HUT16_31830
STRHGXP74_15535 GXP74_26120 GXP74_29210
ABRYNYE86_02910
RFSC1I64_00520
ROEQ0F99_03120
FRPAX769_15450
AZXN2K95_07325
LMOIVV02_16505
YIMJ5M86_08715
ALXLVQ62_10700
BEIGCM100_14580
XYAET471_17455
CFLCfla_2130
CDONKKR89_10780
CWANKG103_10905
CWNNP075_11210
CXIENP048_10800
SERJSGUI_0332
NCANoca_1980
NDKI601_3731(lldD_2)
NOYEXE57_04390
NOOFE634_08345
NANOG5V58_08260
NAQUENKNEFLB_02043(hmo)
NPSKRR39_10975
NMARHPC71_14175
AERAERYTH_16755
AEZC3E78_17710
AEFGEV26_17485
KFLKfla_6052 Kfla_6167
KQIF1D05_14905 F1D05_15510
KSLOG809_05865 OG809_06465
AGRAAGRA3207_000911
AMAZLUW76_37000
ACTQOG417_28130 OG417_48895
NOABKM31_54210
NOWGBF35_33890
NCXNocox_13260(noc1)
NGNLCN96_07785
MHAIOHB01_12360
FRAFrancci3_2463
FREFranean1_3511
FALFRAAL3814
FRIFraEuI1c_3200
NMLNamu_3188
BSDBLASA_0395(Hao) BLASA_2148(hao2)
MMARMODMU_3504(Hao)
KRAKrad_2981
AMDAMED_0893
AMNRAM_04555
AMMAMES_0890
AMZB737_0891
AOIAORI_1496(glcD)
AJAAJAP_32035
AMYCCU254_03020
AMYBBKN51_41525
AMYYYIM_21185
AORISD37_16615 SD37_33640
AACDLWP59_10735
APRTMUY14_32325
AROONQK81_15405
ARHDVSH64_42030
APRECNX65_20200
AMIAmir_4034 Amir_4598
SSYIEKG83_30070 EKG83_30930
KALKALB_6131
KUTJJ691_47810 JJ691_70340
KPHYAOZ06_37045
ACTIUA75_15340
ACADUA74_14770
ACTAC1701_23445
STPStrop_2478
SAQSare_0496 Sare_2661
MAUMicau_3468
MILML5_4923
MICBMicB006_2522 MicB006_2968
MTUACSH63_07705 CSH63_12375
MICHFJK98_14210 FJK98_16505
MTEMGCE86_13310
MCABHXZ27_13965 HXZ27_18275
MSAGGCM10017556_53930
VMAVAB18032_22225 VAB18032_24785
VERHUT12_12305
MENOJiend_01340
MCHLPVK74_07585 PVK74_09870
MFEUH1D33_22920
MHAWRMN56_24530
ASEACPL_2186
ACTNL083_5468 L083_7109
AFSAFR_01595 AFR_37575
ACTSACWT_2064
ACTRAsp14428_12750 Asp14428_15790
ACTLL3i22_034060
ASICQ0Z83_023880
AOUACTOB_006465
PFLAPflav_007660
PSUUPsuf_064700 Psuf_086480
ATLAthai_14010 Athai_22660
ASERAsera_47800 Asera_52290
PRYPrubr_36980 Prubr_65040
CATICS0771_77030
DVCDvina_13750 Dvina_17890 Dvina_20420 Dvina_38790
DFUDfulv_12390
DAURDaura_12875 Daura_31180
DMATDmats_13285 Dmats_33750
NHYJQS43_15560
CCAZCOUCH_38130
CAICaci_3265 Caci_4107
SNASnas_1502
BTPD805_1170
JTLM6D93_03240
ABAIIMCC26256_11496
RXYRxyl_2999
BALADSM104299_02682(hmo)
PARNNBH00_16110 NBH00_19215
SBAEDSM104329_02733(hmo_2)
TALUJDY09_01785
CEPCri9333_3045
HHGXM38_038450(hmo)
PSERABRG53_a068 ABRG53_a072
CYTcce_1717
CYJCyan7822_5209
TERTery_2398
MPROBJP34_25760
MICMic7113_4887
ANAall0170
NPUNpun_R5717
NOSNos7107_4571
NOPNos7524_4202
NONNOS3756_46730
NFLCOO91_03705
NOECLI64_13360
NSHGXM_03321
NEDHUN01_27595
AVAAva_1430
ANBANA_C12655
ANNEH233_27075
CSGCylst_0380
RSINB6N60_01287
HBQQI031_09050
CALOCal7507_4047
CALHIJ00_16930
CALNNIES2098_15540
DOUBMF77_03099(hmo)
DFSHGD76_08665
AFLOHEQ12_14100
TOQHCG51_14550
NCNBZZ01_30295
CTHEChro_0042
PLPPle7327_3868
STANSTA3757_22630
HAUHaur_0229 Haur_1871
PBFCFX0092_A1841
KBSEPA93_04875 EPA93_25295 EPA93_37090
KBBccbrp13_18330 ccbrp13_32590
DGEDgeo_2057
DDRDeide_15560
DCHSY84_09605
DABAUC44_00610
DPUSU48_02005
DWUDVJ83_02750
DFCDFI_08470
DEINDAAJ005_04280
DGADEGR_01180
DAHDAETH_27050
DAQUM8445_06105
TRATrad_2342
TNRThena_1632
TACITDSAC_1603
VBHCMV30_13800
OBTOPIT5_09870
LUOHHL09_02440
LAMBKBB96_19135
TIMGMBLW1_07500
TPITREPR_3177
TRIDYE50_00095
SSMSpirs_1471
TAZTREAZ_3083
BPOBP951000_1638
BPJB2904_orf2334
BPIPBPP43_07045
BPWWESB_0467
BHPBHAMNSH16_10970
ABASACPOL_6814
SUSAcid_1641 Acid_1779 Acid_7243
ABACLuPra_01597(lldD_1) LuPra_02070(lldD_2)
SCORJ3U87_21565
FVAFV113G1_10750
FGOC4N16_05810 C4N16_06435
FNFBSQ88_05685
IPOIlyop_0744
AMOAnamo_1914
GAUGAU_0248
GPHGEMMAAP_10810 GEMMAAP_16695
GGRHKW67_03885
GBAJ421_0641 J421_1218
PMZHMPREF0659_A6324
PFUSADJ77_07250
PJECRM71_07770
PHISJ5A62_00620
PSCJJ4856_12130
SLISlin_1817
SPIKEXU85_15990
SPIBG8759_31000
RUNDR864_23485
TYETHEYE_A0075
 » show all
Reference
1  [PMID:11137816]
  Authors
Hubbard BK, Thomas MG, Walsh CT
  Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
  Journal
Chem Biol 7:931-42 (2000)
DOI:10.1016/S1074-5521(00)00043-0
  Sequence
Reference
2  [PMID:12240298]
  Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
  Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
  Journal
Chem Commun (Camb) 1752-3 (2001)
DOI:10.1039/b103548g
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.46
IUBMB Enzyme Nomenclature: 1.1.3.46
ExPASy - ENZYME nomenclature database: 1.1.3.46
BRENDA, the Enzyme Database: 1.1.3.46

DBGET integrated database retrieval system