Entry
Name
4-hydroxymandelate oxidase;
4HmO;
HmO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
(S)-4-hydroxymandelate:oxygen 1-oxidoreductase
Reaction(IUBMB)
(S)-4-hydroxymandelate + O2 = 2-(4-hydroxyphenyl)-2-oxoacetate + H2O2 [RN:
R06633 ]
Reaction(KEGG)
Substrate
Product
2-(4-hydroxyphenyl)-2-oxoacetate [CPD:
C03590 ];
H2O2 [CPD:
C00027 ]
Comment
A flavoprotein (FMN). The enzyme from the bacterium Amycolatopsis orientalis is involved in the biosynthesis of L-(4-hydroxyphenyl)glycine and L-(3,5-dihydroxyphenyl)glycine, two non-proteinogenic amino acids occurring in the vancomycin group of antibiotics.
History
EC 1.1.3.46 created 2014
Pathway
ec01055 Biosynthesis of vancomycin group antibiotics
ec01110 Biosynthesis of secondary metabolites
Orthology
K16422 4-hydroxymandelate oxidase
Genes
PSYY : DLE54_06755 DLE54_06980
PRAE : MN210_09530 MN210_09995
LIH : L63ED372_01067(lldD_1)
MLD : U0023_03150 U0023_03920
RHZ : RHPLAN_58200 RHPLAN_67990
SINL : DSM14862_02055(hmo)
PSEL : GM415_08775 GM415_17505
AVM : JQX13_15815 JQX13_32715
CFUS : CYFUS_002912 CYFUS_008761
SUS : Acid_1641 Acid_1779 Acid_7243
ABAC : LuPra_01597(lldD_1) LuPra_02070(lldD_2)
GPH : GEMMAAP_10810 GEMMAAP_16695
SARJ : HH195_07595 HH195_11630
CSCI : HDCHBGLK_02317(hmo)
PDC : CDIF630_01416 CDIF630_02628
CDC : CD196_1125 CD196_2228
CDL : CDR20291_1103 CDR20291_2274
PDF : CD630DERM_12630 CD630DERM_23870
SSID : SPSIL_041850(lldD_2)
NAH : F5544_09030 F5544_26845
SVL : Strvi_5274 Strvi_8790
SRC : M271_09165 M271_27675 M271_46055
SRW : TUE45_pSRc_0230(TUE45_pSRTUE45c_0230)
SPAV : Spa2297_02910 Spa2297_26640 Spa2297_32980
SALW : CP975_03175 CP975_31960 CP975_31975 CP975_34475
SNR : SNOUR_39380 SNOUR_40635
SSIA : A7J05_00250 A7J05_04110 A7J05_36485
SFK : KY5_6264c KY5_6713 KY5_7436c
SKA : CP970_03000 CP970_03015 CP970_07080 CP970_09765
SVR : CP971_02375 CP971_08180
SFY : GFH48_02895 GFH48_36330
SRIM : CP984_06505 CP984_27455 CP984_39205
SCHA : CP983_01450 CP983_10835
SSPB : CP982_05960 CP982_06170
SNIG : HEK616_29500 HEK616_51640
SLUO : PS467_34835 PS467_36455
SMIB : SMIR_26540 SMIR_40430
STRL : HEP84_04670 HEP84_18385
KIS : HUT16_30910 HUT16_31115 HUT16_31830
STRH : GXP74_15535 GXP74_26120 GXP74_29210
NAQU : ENKNEFLB_02043(hmo)
KQI : F1D05_14905 F1D05_15510
KSL : OG809_05865 OG809_06465
KRI : OX958_05945 OX958_06525
ACTQ : OG417_28130 OG417_48895
BSD : BLASA_0395(Hao) BLASA_2148(hao2)
AORI : SD37_16615 SD37_33640
AMYZ : HUW46_00117(hmo_1) HUW46_07562(hmo_2)
SSYI : EKG83_30070 EKG83_30930
KUT : JJ691_47810 JJ691_70340
MICB : MicB006_2522 MicB006_2968
MTUA : CSH63_07705 CSH63_12375
MICH : FJK98_14210 FJK98_16505
MCAB : HXZ27_13965 HXZ27_18275
VMA : VAB18032_22225 VAB18032_24785
MCHL : PVK74_07585 PVK74_09870
MICF : QQG74_18910 QQG74_20720
ACTN : L083_5468 L083_7109
ACTR : Asp14428_12750 Asp14428_15790
PSUU : Psuf_064700 Psuf_086480
ATL : Athai_14010 Athai_22660
ASER : Asera_47800 Asera_52290
PRY : Prubr_36980 Prubr_65040
DVC : Dvina_13750 Dvina_17890 Dvina_20420 Dvina_38790
DAUR : Daura_12875 Daura_31180
DMAT : Dmats_13285 Dmats_33750
DACT : KZZ52_12620 KZZ52_44775
BALA : DSM104299_02682(hmo)
PBAJ : LRS13_09820 LRS13_17015
PARN : NBH00_16110 NBH00_19215
SBAE : DSM104329_02733(hmo_2)
PSER : ABRG53_a068 ABRG53_a072
KBS : EPA93_04875 EPA93_25295 EPA93_37090
KBB : ccbrp13_18330 ccbrp13_32590
FGO : C4N16_05810 C4N16_06435
» show all
Taxonomy
Reference
Authors
Hubbard BK, Thomas MG, Walsh CT
Title
Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics.
Journal
Sequence
Reference
Authors
Li TL, Choroba OW, Charles EH, Sandercock AM, Williams DH, Spencer JB
Title
Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.46
ExPASy - ENZYME nomenclature database: 1.1.3.46