KEGG   ENZYME: 1.1.3.49
Entry
EC 1.1.3.49                 Enzyme                                 

Name
(R)-mandelonitrile oxidase;
ChuaMOX (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
(R)-mandelonitrile:oxygen oxidoreductase
Reaction(IUBMB)
(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2 [RN:R11380]
Reaction(KEGG)
R11380
Substrate
(R)-mandelonitrile [CPD:C00561];
O2 [CPD:C00007]
Product
benzoyl cyanide [CPD:C21329];
H2O2 [CPD:C00027]
Comment
Contains FAD. The enzyme, characterized from the millipede Chamberlinius hualienensis, is segregated from its substrate, which is contained in special sacs. The sacs are ruptured during defensive behavior, allowing the enzyme and substrate to mix in special reaction chambers leading to production of the defensive chemical benzoyl cyanide.
History
EC 1.1.3.49 created 2016
Orthology
K21270  (R)-mandelonitrile oxidase
Reference
1  [PMID:27265180]
  Authors
Ishida Y, Kuwahara Y, Dadashipour M, Ina A, Yamaguchi T, Morita M, Ichiki Y, Asano Y
  Title
A sacrificial millipede altruistically protects its swarm using a drone blood enzyme, mandelonitrile oxidase.
  Journal
Sci Rep 6:26998 (2016)
DOI:10.1038/srep26998
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.49
IUBMB Enzyme Nomenclature: 1.1.3.49
ExPASy - ENZYME nomenclature database: 1.1.3.49
BRENDA, the Enzyme Database: 1.1.3.49

DBGET integrated database retrieval system