KEGG   ENZYME: 1.1.3.50
Entry
EC 1.1.3.50                 Enzyme                                 
Name
C-glycoside oxidase;
carA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
carminate:oxygen 3'-oxidoreductase (H2O2-forming)
Reaction(IUBMB)
carminate + O2 = 3'-dehydrocarminate + H2O2 [RN:R13033]
Reaction(KEGG)
R13033
Substrate
carminate [CPD:C11254];
O2 [CPD:C00007]
Product
3'-dehydrocarminate [CPD:C22530];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). This bacterial enzyme participates in degradation of certain C-glucosides by catalysing the oxidation of the hydroxyl group at position 3 of the glycose moiety. The enzyme was found active with assorted C-glycosides, such as carminate, mangiferin, and C6-glycosylated flavonoids, but not with D-glucose or C8-glycosylated flavonoids.
History
EC 1.1.3.50 created 2022
Orthology
K26081  C-glycoside oxidase
Genes
KPUKP1_4211
KPPA79E_1147
KVAKvar_1112
PGELG71_16560
EBUCUC76_21520
PSVPVLB_10685
RHRCKA34_30340
RGRFZ934_22500
DEQXM25_08810
DEVOH4N61_15795
YTIFNA67_12540
YPACCEW88_18040
PPAFI8N54_00955
MTYMTOK_13270
SALBXNR_0576
SGRFSGFS_021720
SLEsle_61010(sle_61010)
SLSSLINC_7117
SNRSNOUR_10170
SGEDWG14_01487(livQ_1)
SAQUEJC51_43800
SCHACP983_04300
SCIRSTRCI_007286
SLONLGI35_00400
SCOAQU709_05110
MTSMTES_1722 MTES_1751
MIXAB663_001885
MIHBJP65_09690 BJP65_09805
MLVCVS47_00305(betA) CVS47_02096 CVS47_02117(livQ)
MBINLXM64_11185
MTECOAU46_01260 OAU46_01375
MRGSM116_17740 SM116_17830
MINVT9R20_15585 T9R20_15670 T9R20_15740
FSBGCM10025867_10980
CPHYB5808_02875 B5808_02985
HEHL3i23_11070
SUBTKPL76_00415
NAEIGCM126_00250 GCM126_00270 GCM126_03530 GCM126_03680 GCM126_36360 GCM126_36380
AOGLH407_10870
ARRARUE_c17720 ARUE_c17930
ACHAchl_3529
APNAsphe3_01690 Asphe3_01860
PSNINIBR502771_04420 NIBR502771_04490
GNCQQS42_01205 QQS42_01250
TEHGKE56_07365 GKE56_07385
NCGKGD84_08635
MMARMODMU_2738 MODMU_2760
AMDAMED_5392
AMNRAM_27490
AMMAMES_5327
AMZB737_5327
ATHML1857_14360
KBUQ4V64_46695
ACTAC1701_00785
DAHDAETH_35570
PGINFRZ67_05820
RUPDTQ70_10705
 » show all
Reference
1  [PMID:34583991]
  Authors
Kumano T, Hori S, Watanabe S, Terashita Y, Yu HY, Hashimoto Y, Senda T, Senda M, Kobayashi M.
  Title
FAD-dependent C-glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis.
  Journal
Proc Natl Acad Sci U S A 118:e2106580118 (2021)
DOI:10.1073/pnas.2106580118
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.50
IUBMB Enzyme Nomenclature: 1.1.3.50
ExPASy - ENZYME nomenclature database: 1.1.3.50
BRENDA, the Enzyme Database: 1.1.3.50

DBGET integrated database retrieval system