KEGG ENZYME: 1.1.3.50

ENZYME: 1.1.3.50

Entry

EC 1.1.3.50                 Enzyme

Name

C-glycoside oxidase;
carA (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor

Sysname

carminate:oxygen 3'-oxidoreductase (H2O2-forming)

Reaction(IUBMB)

carminate + O2 = 3'-dehydrocarminate + H2O2 [RN:R13033]

Reaction(KEGG)

R13033

Substrate

carminate [CPD:C11254];
O2 [CPD:C00007]

Product

3'-dehydrocarminate [CPD:C22530];
H2O2 [CPD:C00027]

Comment

A flavoprotein (FAD). This bacterial enzyme participates in degradation of certain C-glucosides by catalysing the oxidation of the hydroxyl group at position 3 of the glycose moiety. The enzyme was found active with assorted C-glycosides, such as carminate, mangiferin, and C6-glycosylated flavonoids, but not with D-glucose or C8-glycosylated flavonoids.

History

EC 1.1.3.50 created 2022

Orthology

K26081

C-glycoside oxidase

Genes

KPU:

KP1_4211

KPP:

A79E_1147

KVA:

Kvar_1112

PGE:	LG71_16560

EBU:	CUC76_21520

PSV:	PVLB_10685

RHR:	CKA34_30340

RGR:	FZ934_22500

RHIB:

I8E17_28410

DEQ:	XM25_08810

DEVO:

H4N61_15795

DEVD:

GHV40_13610

YTI:	FNA67_12540

YPAC:

CEW88_18040

PPAF:

I8N54_00955

PALJ:

LZC94_02020

PGIN:

FRZ67_05820

RUP:	DTQ70_10705

RLO:	GQ464_000175

MYW:	BVC93_14035

MYJ:	BCA37_28715

MTY:	MTOK_13270

SALB:

XNR_0576

SGRF:

SGFS_021720

SLE:	sle_61010(sle_61010)

SLS:	SLINC_7117

SNR:	SNOUR_10170

SGE:	DWG14_01487(livQ_1)

SAQU:

EJC51_43800

SCHA:

CP983_04300

SCIR:

STRCI_007286

SLON:

LGI35_00400

SCOA:

QU709_05110

KBU:	Q4V64_46695

STRK:

R2B38_48165

KCH:	O1G21_27235

MTS:	MTES_1722 MTES_1751

MIX:	AB663_001885

MIH:	BJP65_09690 BJP65_09805

MLV:	CVS47_00305(betA) CVS47_02096 CVS47_02117(livQ)

MBIN:

LXM64_11185

MTEC:

OAU46_01260 OAU46_01375

MRG:	SM116_17740 SM116_17830

MINV:

T9R20_15585 T9R20_15670 T9R20_15740

MICE:

EHF32_01745

MHOT:

PU630_14240 PU630_14345

MBET:

N8K70_04975 N8K70_16330

MICM:

CHE218_22380 CHE218_22630 CHE218_31180

MALP:

QSU92_07165 QSU92_10730 QSU92_10855

MPRL:

AB0870_16560 AB0870_16685

RATH:

GSU68_00615

FSB:	GCM10025867_10980

CPHY:

B5808_02875 B5808_02985

HEH:	L3i23_11070

SUBT:

KPL76_00415

NAEI:

GCM126_00250 GCM126_00270 GCM126_03530 GCM126_03680 GCM126_36360 GCM126_36380

AOG:	LH407_10870

ARR:	ARUE_c17720 ARUE_c17930

PANY:

ACPFL9_02915 ACPFL9_03020

ACH:

Achl_3529

APN:	Asphe3_01690 Asphe3_01860

PSNI:

NIBR502771_04420 NIBR502771_04490

PSLS:

KTR40_00630 KTR40_00730

PSNB:

NIBR502770_18635 NIBR502770_18705

GNC:	QQS42_01205 QQS42_01250

TEH:	GKE56_07365 GKE56_07385

NCG:	KGD84_08635

AWS:	ACN3XK_13505

MMAR:

MODMU_2738 MODMU_2760

AMD:

AMED_5392

AMN:

RAM_27490

AMM:

AMES_5327

AMZ:

B737_5327

ATHM:

L1857_14360

ACOR:

LCL61_40675

ABAR:

AMYBAR_003756 AMYBAR_003767

PSDS:

K1T35_20685

ACTA:

C1701_00785

ACAU:

ACOJVX_10780

ACTE:

ACTI_64480

DAH:	DAETH_35570

DSC:	ABOD76_01680

» show all

Reference

1 [PMID:34583991]

Authors

Kumano T, Hori S, Watanabe S, Terashita Y, Yu HY, Hashimoto Y, Senda T, Senda M, Kobayashi M.

Title

FAD-dependent C-glycoside-metabolizing enzymes in microorganisms: Screening, characterization, and crystal structure analysis.

Journal

Proc Natl Acad Sci U S A 118:e2106580118 (2021)
DOI:10.1073/pnas.2106580118

Sequence

[ag:BBE36490]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.3.50

IUBMB Enzyme Nomenclature:

1.1.3.50

ExPASy - ENZYME nomenclature database:

1.1.3.50

BRENDA, the Enzyme Database:

1.1.3.50

All links

Gene (23)   
   MGENES (23)   
Protein sequence (6)   
   UniProt (3)   
   SWISS-PROT (3)   
All databases (29)   

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