Entry
Name
(S)-2-hydroxyglutarate dehydrogenase;
L-2-hydroxyglutarate dehydrogenase;
lhgO (gene name);
ygaF (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
(S)-2-hydroxyglutarate:quinone oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol [RN:
R12217 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacterium Escherichia coli, contains an FAD cofactor that is not covalently attached. It is bound to the cytoplasmic membrane and is coupled to the membrane quinone pool.
History
EC 1.1.5.13 created 2019
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K15736 (S)-2-hydroxyglutarate dehydrogenase
Genes
ECOO : ECRM13514_3498(ygaF)
ECOH : ECRM13516_3364(ygaF)
EDJ : ECDH1ME8569_2576(ygaF)
ECOI : ECOPMV1_02912(lhgO)
SOF : NCTC11214_04023(lhgO_2)
VNA : PN96_16920 PN96_18435
VEJ : VEJY3_16391 VEJY3_18001
VFU : vfu_B00725 vfu_B01319
VPL : SA104470976_03020(lhgO)
PGH : FH974_22690(lhgO) FH974_24100(lhgO)
SCOT : HBA18_05750(lhgO) HBA18_06175(lhgO)
PFUW : KF707C_14040 KF707C_41180
PCQ : PcP3B5_44500(lhgO_1)
PPJ : RK21_01651 RK21_02890
PMOS : O165_009770 O165_014880
PST : PSPTO_A0036 PSPTO_B0042
PPRC : PFLCHA0_c24920(lhgO)
PFN : HZ99_01855 HZ99_03385
PSK : U771_14670 U771_16050
PTRT : HU722_0013685(lhgO)
SALH : HMF8227_01585(lhgO)
HSI : BOX17_04715 BOX17_15115
HAXI : HAALTHF_54290n(ygaF)
HASO : B2G49_06000 B2G49_13005
MRZ : KDW95_00990(lhgO) KDW95_05870(lhgO)
BUZ : AYM40_06965 AYM40_26640
HRB : Hrubri_1108 Hrubri_4254(mgo)
SIX : BSY16_4329 BSY16_4770
RHL : LPU83_pLPU83d1806(lhgO)
SOJ : K6301_23155(lhgO) K6301_24680(lhgO)
SSUM : Q9314_23540(lhgO) Q9314_24455(lhgO)
STAR : G3545_09125(lhgO) G3545_13305(lhgO)
MTUN : MTUNDRAET4_1454(lhgO)
PAEZ : PAE61_00935(lhgO) PAE61_16890(lhgO)
DMA : DMR_02150 DMR_p1_00400
BFD : NCTC4823_03338(lhgO)
HSHI : MUO14_09505(lhgO) MUO14_18655(lhgO)
APAK : AP3564_04965 AP3564_10940
MPHL : MPHLCCUG_02489(lhgO_1)
MAUU : NCTC10437_03163(lhgO_1)
NFR : ERS450000_04239(lhgO)
NAD : NCTC11293_00702(lhgO)
RANT : RHODO2019_13245(lhgO)
SAMB : SAM23877_3573(lhgO)
SLE : sle_37720(sle_37720)
SCLF : BB341_01585 BB341_12890
SPHW : NFX46_13105(lhgO) NFX46_38685(lhgO)
SNQ : CP978_01525 CP978_16485
SNK : CP967_01545 CP967_16000
SGAL : CP966_17220 CP966_31465
SPHV : F9278_22340(lhgO) F9278_41890(lhgO)
SGOB : test1122_14600(lhgO)
SCIR : STRCI_003922(lhgO) STRCI_006987(lhgO)
SXT : KPP03845_104062(lhgO)
LYH : FrondiHNR_03960(lhgO)
PSNI : NIBR502771_08155(lhgO)
DCO : SAMEA4475696_0715(lhgO)
NRO : K8W59_02950(lhgO) K8W59_19985(lhgO)
AGRA : AGRA3207_005999(lhgO)
BSD : BLASA_1396 BLASA_3575
PHH : AFB00_02685 AFB00_12620
BALA : DSM104299_05077(lhgD)
SBAE : DSM104329_05216(lhgD)
SYY : SYNGTS_2994(sll1495)
SYT : SYNGTI_2993(sll1495)
SYS : SYNPCCN_2992(sll1495)
SYQ : SYNPCCP_2992(sll1495)
LET : O77CONTIG1_01355(lhgO)
PSER : ABRG53_0463 ABRG53_2572
GLP : Glo7428_1299 Glo7428_2878
GDU : P0S91_21530(lhgO) P0S91_24495(lhgO)
LCRE : Pla8534_16960(lhgO)
CGLE : NCTC11432_02324(lhgO_1)
CTAK : 4412677_01094(lhgO)
CHRJ : CHRYMOREF3P_1893(lhgD)
PTAN : CRYO30217_01123(lhgD)
HALJ : G9465_00385(lhgO) G9465_23425
HALQ : Hrr1229_007625(lhgO)
» show all
Taxonomy
Reference
Authors
Kalliri E, Mulrooney SB, Hausinger RP
Title
Identification of Escherichia coli YgaF as an L-2-hydroxyglutarate oxidase.
Journal
Sequence
Reference
Authors
Knorr S, Sinn M, Galetskiy D, Williams RM, Wang C, Muller N, Mayans O, Schleheck D, Hartig JS
Title
Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.13
ExPASy - ENZYME nomenclature database: 1.1.5.13