KEGG   ENZYME: 1.1.5.14
Entry
EC 1.1.5.14                 Enzyme                                 
Name
fructose 5-dehydrogenase;
fructose 5-dehydrogenase (acceptor);
D-fructose dehydrogenase;
D-fructose:(acceptor) 5-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With a quinone or similar compound as acceptor
Sysname
D-fructose:ubiquinone 5-oxidoreductase
Reaction(IUBMB)
D-fructose + a ubiquinone = 5-dehydro-D-fructose + a ubiquinol [RN:R00873]
Reaction(KEGG)
R00873
Substrate
D-fructose [CPD:C00095];
ubiquinone [CPD:C00399]
Product
5-dehydro-D-fructose [CPD:C00273];
ubiquinol [CPD:C00390]
Comment
The enzyme, characterized from the bacterium Gluconobacter japonicus, is a heterotrimer composed of an FAD-containing large subunit, a small subunit, and a heme c-containing subunit, which is responsible for anchoring the complex to the cytoplasmic membrane and for transferring the electrons to ubiquinone.
History
EC 1.1.5.14 created 1972 as EC 1.1.99.11, transferred 2021 to EC 1.1.5.14
Orthology
K23273  fructose 5-dehydrogenase large subunit
K23274  fructose 5-dehydrogenase small subunit
Genes
EBTEBL_c19790 EBL_c19800
PGELG71_13885 LG71_13890 LG71_17050
IZHFEM41_17380
YENYE1084 YE1370 YE1370A
YEPYE105_C3005
YEYY11_43061
YEWCH47_500 CH47_788 CH47_789
YETCH48_525
YEFFORC2_1099
YEEYE5303_08371
YALAT01_3556
YFRAW19_276
YKRCH54_1388
YAKACZ76_03685
YCAF0T03_05885
YMOHRD69_19690
SMACSMDB11_3267(kdgB) SMDB11_3268(kdgA)
SMWSMWW4_v1c39930 SMWW4_v1c39940
SPESpro_1808 Spro_1809 Spro_2087 Spro_2334
SRRSerAS9_4061 SerAS9_4062
SRLSOD_c38180 SOD_c38190
SRYM621_20605 M621_20610
SPLYQ5A_020435(fdhS) Q5A_020440(fdhL)
SRSSerAS12_4062 SerAS12_4063
SRASerAS13_4062 SerAS13_4063
SMAFD781_1914
SLQM495_08375 M495_08380 M495_11640
SERFL085_08635 L085_08640
SERSSERRSCBI_20175 SERRSCBI_20180
SFWWN53_24840
SRZAXX16_3215
SERMCLM71_09490
SQUE4343_04525 E4343_05770 E4343_07140 E4343_07145
SFJSAMEA4384070_2147 SAMEA4384070_4002 SAMEA4384070_4003
SSURATE40_016660 ATE40_016665
SURIJ0X03_03155 J0X03_03160
SRHZFO014_00050
RAHRahaq_1024 Rahaq_1317 Rahaq_1318 Rahaq_2267
RACEJHW33_01090 JHW33_01095 JHW33_05495 JHW33_21830
RAQRahaq2_1093 Rahaq2_1394 Rahaq2_1395
RAAQ7S_04890 Q7S_06340 Q7S_06345 Q7S_11465
ROXBV494_01950 BV494_01955 BV494_05655 BV494_23010
RVCJ9880_12950 J9880_14405 J9880_14410 J9880_18575
GQUAWC35_21130
EAMEGXP68_07005 GXP68_07010 GXP68_15400
RBADH2866_01120 H2866_01125 H2866_07370 H2866_07380 H2866_20145
SODSant_P0053
EAMEAMY_1954
EAYEAM_1911
EBIEbC_03940 EbC_05310 EbC_22440 EbC_39160 EbC_39170
ERWIGN242_19160
PAMPANA_4104
PLFPANA5342_p10260
PAJPAJ_p0186
PAQPAGR_p191
PAOPat9b_4395 Pat9b_4433 Pat9b_4449 Pat9b_5524 Pat9b_5525 Pat9b_5527 Pat9b_5590 Pat9b_5591 Pat9b_5677
PSTWDSJ_26125
PALHB1H58_10380 B1H58_10390 B1H58_10395
PANSFCN45_11165
TCIA7K98_02865 A7K98_07340 A7K98_07345 A7K98_09130 A7K98_09475 A7K98_09485 A7K98_11435 A7K98_17885 A7K98_17890 A7K98_20770
TPTYNCTC11468_01473 NCTC11468_01474 NCTC11468_01898 NCTC11468_03836
OPODSM2777_00405
PFQQQ39_17160
SLMBIZ42_00395 BIZ42_00400
STEMCLM74_11435 CLM74_11440
SINCDAIF1_22210(fdhL_2) DAIF1_22220(fdhS)
LCICINQ41_06195
FAUFraau_0212 Fraau_0764 Fraau_0765 Fraau_0943 Fraau_1850 Fraau_3045 Fraau_3047
RHDR2APBS1_0085
RTHLRK53_00345
DJAHY57_14015 HY57_14020
LPYFIV34_11175
PCQPcP3B5_04820(fdhS)
PMUIG4G71_00920
PFVPsefu_4342 Psefu_4343
PFOPfl01_4264
PDRH681_01530
PKCPKB_0364
PFZAV641_07355 AV641_13010
PPSYAOC04_04060 AOC04_09670
PYMAK972_0888
PGYAWU82_25300
PEZHWQ56_09240 HWQ56_15425 HWQ56_18395 HWQ56_18400
PBZGN234_19240
PVWHU752_031590
AVNAvin_26990
AVLAvCA_26990
AVDAvCA6_26990
ACXAchr_21950
MBAHHYN46_11630 HYN46_15405
MCELLPW13_15995
HAFC8233_01725
ZPLZBT109_1076
CMAIBFX80_08470
CAMHLCW13_09295
RSORSc0770
RSLRPSI07_2571
RSMCMR15_30128
RSEF504_789
RSYRSUY_09880(fdhS)
RPIRpic_0718
RPFRpic12D_0788
RMNTK49_08525
RINACS15_0870
RPUCDC45_03980
RSGJK151_18250
CUHBJN34_30870
BMABMAA1246
BMVBMASAVP1_0217
BMLBMA10229_0490
BMNBMA10247_A1082
BMALDM55_4270
BMAEDM78_3900
BMAQDM76_3222
BMAIDM57_10780
BMAFDM51_4907
BMAZBM44_4233
BMABBM45_3356
BPSBPSS0975
BPMBURPS1710b_A2588
BPLBURPS1106A_A1348
BPDBURPS668_A1433
BPSEBDL_4270
BPSMBBQ_5158
BPSUBBN_4438
BPSDBBX_6111
BPZBP1026B_II1070
BPQBPC006_II1359
BPKBBK_3458
BPSHDR55_4357
BPSABBU_5053
BPSOX996_4215
BUTX994_6144
BTEBTH_II1416
BTQBTQ_4703
BTJBTJ_5645
BTZBTL_4186
BTDBTI_5796
BTVBTHA_3773
BTHEBTN_3507
BTHMBTRA_4258
BTHADR62_3579
BTHLBG87_4160
BOKDM82_5142
BOCBG90_5452
BUUWS70_22330
BSAVWS86_23605 WS86_30500 WS86_30505
BVIBcep1808_5085
BVEAK36_3807
BURBcep18194_B1292 Bcep18194_C6550 Bcep18194_C7345 Bcep18194_C7346
BCNBcen_3757 Bcen_3814
BCHBcen2424_4554 Bcen2424_4611
BCMBcenmc03_5693 Bcenmc03_5750
BCJBCAM1736 BCAM1791
BCENDM39_6099
BCEWDM40_4561
BCEOI35_5606 I35_5670
BAMBamb_3979
BACBamMC406_4443
BMJBMULJ_04411
BMUBmul_4093
BMKDM80_5402
BMULNP80_4517
BCTGEM_3832 GEM_3833 GEM_3904
BCEDDM42_6158 DM42_6213
BCEPAPZ15_30350 APZ15_37005 APZ15_37010
BDLAK34_3867
BPYRABD05_27240
BCONNL30_03465
BUBBW23_5383
BDFWI26_21790
BLATWK25_25245
BTEIWS51_06250
BSEMWJ12_28610
BPSLWS57_05325
BMECWJ16_27435
BSTGWT74_27745
BSTLBBJ41_21965 BBJ41_22100 BBJ41_35270 BBJ41_35275
BANNJFN94_26690 JFN94_27735 JFN94_27740
BUKMYA_4129
BULBW21_5481
BUDAQ610_25790
BUMAXG89_20170
BUIAX768_23080
BURKDM992_31945
BGEBC1002_5232
BPYBphyt_6819
BUZAYM40_22285
BFNOI25_5275 OI25_7038
BCAIK788_0000991
PSPWBJG93_20895
PARABTO02_20370
PARBCJU94_29360
PHSC2L64_31770
PTERC2L65_28500
PCJCUJ87_21805
PTSCUJ90_30360
PMEGFNZ07_06295
PTROG5S35_27845
PGISI6I06_17395 I6I06_18605
PACPFAZ97_22135
PEWKZJ38_36075
BRHRBRH_02762
CABASBC2_56530(fdhS)
BUOBRPE64_ACDS21190
BHOD560_0920 D560_0921
BHMD558_0903 D558_0904
BHZACR54_03675(fdhS) ACR54_03676(fdhL_3)
ACHRC2U31_02190 C2U31_02195
PACRFXN63_15905 FXN63_15910 FXN63_21925
PARKLSG25_01240
ACIPCBP36_00065
ACISCBP35_18885
AANTHUK68_20845 HUK68_20850
DIHG7047_28835
HARHEAR2556
JAZYQ44_06770 YQ44_06775 YQ44_10830
JALBZG29_16765 BZG29_21090 BZG29_21095
JSVCNX70_17115 CNX70_21260 CNX70_21265
JASFJQ89_06200 FJQ89_10900 FJQ89_10905
JLVG3257_17470 G3257_21745 G3257_21750
HSEHsero_1670 Hsero_3757 Hsero_3758
HSZACP92_08295 ACP92_18730 ACP92_18735
HHTF506_13235 F506_13240
HEEhmeg3_10765 hmeg3_10770
HHFE2K99_08410 E2K99_19120 E2K99_19125
CFUCFU_4429
CARELT85_0233 LT85_4990
CPRACPter91_5511
GLCJQN73_08715
MIUABE85_19520
RGUA4W93_28050
XYKGT347_01105 GT347_06735 GT347_06740 GT347_26675 GT347_26680
ARAArad_12195 Arad_12196 Arad_4479 Arad_4480
ATFAch5_47670
RLSHB780_24340 HB780_24345
NGGRG540_PA11760
NENNCHU2750_09940 NCHU2750_09950 NCHU2750_41590 NCHU2750_50620
BIDBind_3800 Bind_3801
MEYTM49_09285
KVLKVU_PB0007
KVUEIO_3192
KROBVG79_p1000118
YANAYJ57_19055
SINLDSM14862_01721
TECAKL02_004825
ZMOZMO0786 ZMO1285 ZMO1286
ZMNZa10_0057 Za10_0058 Za10_0496
ZMMZmob_0059 Zmob_0060 Zmob_0505
ZMBZZ6_0062 ZZ6_0063 ZZ6_0507
ZMIZCP4_0057 ZCP4_0058 ZCP4_0518
ZMCA265_00057 A265_00058 A265_00512
ZMRA254_00057 A254_00058 A254_00512
ZMPZymop_0043 Zymop_0044 Zymop_0464
NOVTQ38_017790 TQ38_017795
SPHAD3Y57_01455
GOXGOX2095 GOX2097
GOHB932_3024 B932_3025
GOYGLS_c05080 GLS_c05090 GLS_c22040 GLS_c22050
GALA0U94_04560 A0U94_04565 A0U94_10060 A0U94_10070 A0U94_14555
GTIFXF46_12475
GSPIGS75_00805 IGS75_07905 IGS75_07910 IGS75_13950 IGS75_14605
GDIGDI0858 GDI0859
GDJGdia_1160 Gdia_1161
GXYGLX_11570 GLX_11580
GXLH845_2331 H845_2332 H845_3393 H845_3394
KNAB0W47_11030 B0W47_11035
KEUS101446_01623 S101446_01624
KSCCD178_01736(fdhS) CD178_01737(fdhL) CD178_03402(fdhS) CD178_03403(fdhL)
KREGWK63_11675 GWK63_11680
APTAPA01_22370 APA01_22380
APWAPA42C_22370 APA42C_22380
APFAPA03_22370 APA03_22380
APUAPA07_22370 APA07_22380
APGAPA12_22370 APA12_22380
APQAPA22_22370 APA22_22380
APXAPA26_22370 APA26_22380
APZAPA32_22370 APA32_22380
APKAPA386B_1096 APA386B_1097
ASZASN_3343 ASN_3344
ASVWG31_11325 WG31_11330
APERA0U91_10565 A0U91_10570
APOMCPF11_09430 CPF11_09435
ATOCIW82_14730 CIW82_14735
AASCA4S02_00565
ACETDS739_10975 DS739_10980
AOTAcetOri_orf02197 AcetOri_orf02198
AOYEOV40_010620 EOV40_010625
ACEKFLP30_12765 FLP30_12770
ABGAsbog_00352
KBAA0U89_05215 A0U89_05220
NCHA0U93_06980 A0U93_06985
NTND5366_04375 D5366_04385 D5366_10360 D5366_10365
SSAME3D00_03660 E3D00_03670 E3D00_06395 E3D00_06400
BOMBGT348_00915
KHAIFJ82_10575 IFJ82_10580 IFJ82_11290 IFJ82_11295
 » show all
Reference
1  [PMID:6059959]
  Authors
Yamada Y, Aida K, Uemura T.
  Title
Enzymatic studies on the oxidation of sugar and sugar alcohol. I. Purification and properties of particle-bound fructose dehydrogenase.
  Journal
J Biochem (Tokyo) 61:636-46 (1967)
DOI:10.1093/oxfordjournals.jbchem.a128594
Reference
2
  Authors
Ameyama, M. and Adachi, O.
  Title
D-Fructose dehydrogenase from Gluconobacter industrius, membrane-bound.
  Journal
Methods Enzymol 89:154-159 (1982)
Reference
3  [PMID:4053391]
  Authors
Nakashima K, Takei H, Adachi O, Shinagawa E, Ameyama M.
  Title
Determination of seminal fructose using D-fructose dehydrogenase.
  Journal
Clin Chim Acta 151:307-10 (1985)
DOI:10.1016/0009-8981(85)90094-4
Reference
4  [PMID:23275508]
  Authors
Kawai S, Goda-Tsutsumi M, Yakushi T, Kano K, Matsushita K
  Title
Heterologous overexpression and characterization of a flavoprotein-cytochrome c complex fructose dehydrogenase of Gluconobacter japonicus NBRC3260.
  Journal
Appl Environ Microbiol 79:1654-60 (2013)
DOI:10.1128/AEM.03152-12
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.5.14
IUBMB Enzyme Nomenclature: 1.1.5.14
ExPASy - ENZYME nomenclature database: 1.1.5.14
BRENDA, the Enzyme Database: 1.1.5.14
CAS: 37250-85-4

DBGET integrated database retrieval system