KEGG   ENZYME: 1.1.7.1
Entry
EC 1.1.7.1                  Enzyme                                 
Name
4-hydroxybenzoyl-CoA reductase;
4-hydroxybenzoyl-CoA reductase (dehydroxylating);
4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase;
benzoyl-CoA:acceptor oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With an iron-sulfur protein as acceptor
Sysname
benzoyl-CoA:oxidized ferredoxin oxidoreductase
Reaction(IUBMB)
benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin [RN:R05316]
Reaction(KEGG)
R05316
Substrate
benzoyl-CoA [CPD:C00512];
oxidized ferredoxin [CPD:C00139];
H2O [CPD:C00001]
Product
4-hydroxybenzoyl-CoA [CPD:C02949];
reduced ferredoxin [CPD:C00138]
Comment
A molybdenum-flavin-iron-sulfur protein that is involved in the anaerobic pathway of phenol metabolism in bacteria. A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor [3].
History
EC 1.1.7.1 created 2000 as EC 1.3.99.20, transferred 2011 to EC 1.3.7.9, transferred 2020 to EC 1.1.7.1
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04107  4-hydroxybenzoyl-CoA reductase subunit gamma
K04108  4-hydroxybenzoyl-CoA reductase subunit alpha
K04109  4-hydroxybenzoyl-CoA reductase subunit beta
Genes
EBAebA3602(hcrB) ebA3603(hcrA) ebA3604(hcrC)
ABREpbN1_21960(hcrB) pbN1_21970(hcrA) pbN1_21980(hcrC)
APETToN1_29630(hcrB) ToN1_29640(hcrA) ToN1_29650(hcrC)
AZAAZKH_0489(hcrB) AZKH_0490(hcrA) AZKH_0491(hcrC)
AZIAzCIB_0406 AzCIB_0407 AzCIB_0408
AZDCDA09_02105(hcrB) CDA09_02110(hcrA) CDA09_02115(hcrC)
TMZTmz1t_0224 Tmz1t_0225 Tmz1t_0226
TCLTchl_2357 Tchl_2358 Tchl_2359
TAKTharo_1513 Tharo_1514 Tharo_1515
DDZDSYM_17590 DSYM_17600 DSYM_17610
RPARPA0670(hbaB) RPA0671(hbaC) RPA0672(hbaD)
RPCRPC_1013 RPC_1014 RPC_1015
RPDRPD_1523 RPD_1524 RPD_1525
RPERPE_0589 RPE_0590 RPE_0591
RPTRpal_0737 Rpal_0738 Rpal_0739
RPXRpdx1_4114 Rpdx1_4115 Rpdx1_4116
MAGamb2019 amb2020 amb2021
MAGXXM1_2739(hcrC) XM1_2740(hcrA) XM1_2741(hcrB)
MAGNWV31_19855 WV31_19860 WV31_19865
FWADCMF_00940
SAIUJ4H86_06065
UAMUABAM_02437
 » show all
Reference
1  [PMID:2753161]
  Authors
Glockler R, Tschech A, Fuchs G.
  Title
Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species.
  Journal
FEBS Lett 251:237-40 (1989)
DOI:10.1016/0014-5793(89)81461-9
Reference
2  [PMID:9683649]
  Authors
Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G.
  Title
Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica.
  Journal
Arch Microbiol 170:120-31 (1998)
DOI:10.1007/s002030050623
Reference
3  [PMID:9490068]
  Authors
Breese K, Fuchs G
  Title
4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins.
  Journal
Eur J Biochem 251:916-23 (1998)
DOI:10.1046/j.1432-1327.1998.2510916.x
  Sequence
Reference
4  [PMID:8477729]
  Authors
Brackmann R, Fuchs G.
  Title
Enzymes of anaerobic metabolism of phenolic compounds. 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species.
  Journal
Eur J Biochem 213:563-71 (1993)
DOI:10.1111/j.1432-1033.1993.tb17795.x
Reference
5  [PMID:9057820]
  Authors
Heider J, Fuchs G.
  Title
Anaerobic metabolism of aromatic compounds.
  Journal
Eur J Biochem 243:577-96 (1997)
DOI:10.1111/j.1432-1033.1997.00577.x
Other DBs
ExplorEnz - The Enzyme Database: 1.1.7.1
IUBMB Enzyme Nomenclature: 1.1.7.1
ExPASy - ENZYME nomenclature database: 1.1.7.1
BRENDA, the Enzyme Database: 1.1.7.1
CAS: 133758-58-4

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