ENZYME: 1.1.98.3 Help
Entry
Name
decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase;
decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase;
Rv3790;
DprE1;
decaprenylphospho-beta-D-ribofuranose 2-oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 [RN:
R10112 ]
Reaction(KEGG)
Substrate
trans,octacis-decaprenylphospho-beta-D-ribofuranose [CPD:
C20368 ];
FAD [CPD:
C00016 ]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:
C20369 ];
FADH2 [CPD:
C01352 ]
Comment
The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC
1.1.1.333 , decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.98.3 created 2012, modified 2014
Orthology
K16653 decaprenylphospho-beta-D-ribofuranose 2-oxidase
Genes
LCJ : NCTC11976_01918(dprE1)
LWA : SAMEA4504053_1984(dprE1)
LSS : NCTC12082_01101(dprE1)
GAI : IMCC3135_22130(dprE1)
UPL : DSM104440_03343(dprE1)
YAN : AYJ57_23255 AYJ57_24455
AHT : ANTHELSMS3_04458(dprE1)
BLAS : BSY18_2836 BSY18_2847
SAQT : GJV85_01935 GJV85_06040
MBO : BQ2027_MB3819(dpre1)
MBAI : MB901379_04790(dprE1_2)
MPHL : MPHLCCUG_00215(dprE1_1)
MTHN : 4412656_04392(dprE1_2)
MHAS : MHAS_04506(dprE1_2)
MAUU : NCTC10437_05391(dprE1_2)
MFLV : NCTC10271_00224(dprE1)
MSAL : DSM43276_00169(dprE1)
MTER : 4434518_04036(dprE1)
CDIP : ERS451417_00129(dprE)
CPP : CpP54B96_0109(dprE1)
CUC : CULC809_00151(dprE1)
CUN : Cul210932_0152(dprE1)
CUQ : Cul210931_0146(dprE1)
CUZ : Cul05146_0152(dprE1)
CUJ : CUL131002_0136c(dprE1)
CUS : CulFRC11_0147(dprE1)
CMIN : NCTC10288_02445(dprE1)
CRL : NCTC7448_00917(dprE1)
CCYS : SAMEA4530656_2417(dprE1)
CAUI : CAURIS_00610(dprE1)
CAUS : CAURIC_11115(dprE1)
NFR : ERS450000_04041(dprE1_2)
NBR : O3I_000805 O3I_012165
NNO : NONO_c01590 NONO_c40240
NSR : NS506_00808 NS506_03835
NTP : CRH09_00880 CRH09_21790
NAH : F5544_00925 F5544_19675
NAD : NCTC11293_00941(dprE1_1) NCTC11293_05886(dprE1_3)
NWL : NWFMUON74_01380(dprE1)
NHU : H0264_02055 H0264_21590
NYA : LTV02_07235 LTV02_30720
NSPU : IFM12276_65820(dprE1)
NYU : D7D52_25055 D7D52_26145
REB : XU06_01200 XU06_25320
RHU : A3Q40_03629(dprE1_2)
RRT : 4535765_00240(dprE1_1)
RCR : NCTC10994_02452(dprE1_2)
RHOO : RA302_01260 RA302_25560
RFA : A3L23_02042(dprE1_1)
RHS : A3Q41_01321(dprE1_2)
GOQ : ACH46_01270 ACH46_14840
GOM : D7316_03427(dprE1_1)
DTM : BJL86_0254 BJL86_3234
SLE : sle_28320(sle_28320)
SACG : FDZ84_12700 FDZ84_12705
SACE : GIY23_00735 GIY23_00740
ACTU : Actkin_00164(dprE1)
AQZ : KSP35_00265 KSP35_23730
PSEG : D3H65_28450 D3H65_30560
MGOT : MgSA37_03195(dprE1)
CGLE : NCTC11432_04749(dprE1)
CTAI : NCTC12078_02982(dprE1)
CTAK : 4412677_02567(dprE1)
CSAL : NBC122_02837(dprE1)
CJG : NCTC13459_00142(dprE1)
CANT : NCTC13489_00231(dprE1)
» show all
Taxonomy
Reference
Authors
Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, Chiarelli LR, Mori G, Kim J, Contreras-Dominguez M, Park YS, Han SJ, Brodin P, Valentini G, Rizzi M, Riccardi G, Pasca MR
Title
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis.
Journal
Sequence
Reference
Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.98.3
ExPASy - ENZYME nomenclature database: 1.1.98.3