KEGG   ENZYME: 1.1.98.3Help
Entry
EC 1.1.98.3                 Enzyme                                 

Name
decaprenylphospho-beta-D-ribofuranose 2-dehydrogenase;
decaprenylphosphoryl-beta-D-ribofuranose 2'-epimerase;
Rv3790;
DprE1;
decaprenylphospho-beta-D-ribofuranose 2-oxidase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors
BRITE hierarchy
Sysname
trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase
Reaction(IUBMB)
trans,octacis-decaprenylphospho-beta-D-ribofuranose + FAD = trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose + FADH2 [RN:R10112]
Reaction(KEGG)
Substrate
trans,octacis-decaprenylphospho-beta-D-ribofuranose [CPD:C20368];
FAD [CPD:C00016]
Product
trans,octacis-decaprenylphospho-beta-D-erythro-pentofuranosid-2-ulose [CPD:C20369];
FADH2 [CPD:C01352]
Comment
The enzyme, isolated from the bacterium Mycobacterium smegmatis, is involved, along with EC 1.1.1.333, decaprenylphospho-D-erythro-pentofuranosid-2-ulose 2-reductase, in the epimerization of trans,octacis-decaprenylphospho-beta-D-ribofuranose to trans,octacis-decaprenylphospho-beta-D-arabinofuranose, the arabinosyl donor for the biosynthesis of mycobacterial cell wall arabinan polymers.
History
EC 1.1.98.3 created 2012, modified 2014
Orthology
K16653  decaprenylphospho-beta-D-ribofuranose 2-oxidase
Genes
LEZ: GLE_2482
LEM: LEN_4411
DKO: I596_680
VPB: VPBB_0214
VNI: VIBNI_A3471
PAP: PSPA7_6248
PALC: A0T30_03080
RVI: RVIR1_00240
LPH: LPV_2064
LPO: LPO_1840
LPM: LP6_1771
LPF: lpl1758
LPP: lpp1758
LPC: LPC_1235
LPA: lpa_02595
LPE: lp12_1732
LLO: LLO_1125
LFA: LFA_1028
LCD: clem_04035(dprE1_1)
TMC: LMI_1092
MCA: MCA2566
NOC: Noc_1951
NHL: Nhal_2171
NTT: TAO_1201
GAI: IMCC3135_22130(dprE1)
TBN: TBH_C2408
HYB: Q5W_19940
GCA: Galf_2857
SULC: CVO_05140
AMYT: AMYT_0879
SMUL: SMUL_2538
SCL: sce6890
CCRO: CMC5_059830(glcE)
SFU: Sfum_0142
RLG: Rleg_5790
RIR: BN877_p0342(noeH)
BBT: BBta_7179
BRS: S23_01240
RPC: RPC_4213
AZC: AZC_3809(noeH)
MPO: Mpop_1596
BID: Bind_1027
MSL: Msil_2163
BBAR: RHAL1_00360(dprE)
HDI: HDIA_4438(dprE1)
JAN: Jann_2831
OTM: OSB_07410(dprE1)
LAQU: R2C4_10115
CID: P73_1220
RSU: NHU_01788
RHC: RGUI_2703
RID: RIdsm_04469(dprE1)
AHT: ANTHELSMS3_04458(dprE1)
MARU: FIU81_11055(dprE1)
MAGQ: MGMAQ_3649
MGM: Mmc1_1142
BSR: I33_1249
BSO: BSNT_07551(yitY)
BSX: C663_1144
BAMA: RBAU_1077(yitY)
BAMN: BASU_1056(yitY)
BAMT: AJ82_06285
BAMY: V529_10630(yitY)
BPU: BPUM_1040
BPUM: BW16_05950
BPUS: UP12_05555
BACW: QR42_05390
PMW: B2K_21270
PSWU: SY83_18995
BTS: Btus_3156
MTU: Rv3790(dprE1)
MTV: RVBD_3790
MTC: MT3898
MRA: MRA_3830
MTUR: CFBS_4019
MTD: UDA_3790
MTUB: MT7199_3859(dprE1)
MTUE: J114_20240
MTUH: I917_26615
MTUL: TBHG_03728
MTUT: HKBT1_4002
MTUU: HKBT2_4012
MBO: BQ2027_MB3819(dpre1)
MBB: BCG_3852
MBT: JTY_3854
MBX: BCGT_3651
MAF: MAF_38050
MMIC: RN08_4179
MLE: ML0109
MLB: MLBr00109
MPA: MAP_0235c
MAO: MAP4_3636
MAVI: RC58_18075
MAVU: RE97_18110
MAV: MAV_0232
MIT: OCO_02370
MIA: OCU_02430
MID: MIP_00568
MYO: OEM_02480
MIR: OCQ_02370
MLP: MLM_0178
MUL: MUL_4969
MMC: Mmcs_5000
MKM: Mkms_5088
MJL: Mjls_5381
MMI: MMAR_5352
MMM: W7S_01165
MHAD: B586_03115
MSHG: MSG_04854
MVA: Mvan_5627
MGI: Mflv_1178
MPHL: MPHLCCUG_00215(dprE1_1)
MVQ: MYVA_5556
MTHN: 4412656_04392(dprE1_2)
MHAS: MHAS_04506(dprE1_2)
MAB: MAB_0192c
MABB: MASS_0190
MCHE: BB28_00990
MSTE: MSTE_00191
MSAL: DSM43276_00169(dprE1)
MTER: 4434518_04036(dprE1)
ASD: AS9A_0118
CGL: NCgl0187(Cgl0190)
CGB: cg0238
CGU: WA5_0187
CGT: cgR_0269
CGM: cgp_0238
CGJ: AR0_01240
CEF: CE0164
CDI: DIP0162
CDP: CD241_0161(dprE)
CDH: CDB402_0129(dprE)
CDT: CDHC01_0162(dprE)
CDE: CDHC02_0168(dprE)
CDR: CDHC03_0134(dprE)
CDA: CDHC04_0122(dprE)
CDZ: CD31A_0165(dprE)
CDB: CDBH8_0165(dprE)
CDS: CDC7B_0121(dprE)
CDD: CDCE8392_0119(dprE)
CDW: CDPW8_0124(dprE)
CDV: CDVA01_0118(dprE)
CDIP: ERS451417_00129(dprE)
CJK: jk2049
CUR: cu1956
CUA: CU7111_1878(dprE1)
CPL: Cp3995_0106(dprE1)
CPP: CpP54B96_0109(dprE1)
CPZ: CpPAT10_0102(dprE1)
COR: Cp267_0113(dprE1)
COD: Cp106_0105(dprE1)
COS: Cp4202_0102(dprE1)
CPSE: CPTA_00631
CPSU: CPTB_00902
CPSF: CPTC_00564
CRD: CRES_2120(dprE1)
CUL: CULC22_00149(dprE1)
CUC: CULC809_00151(dprE1)
CUN: Cul210932_0152(dprE1)
CUS: CulFRC11_0147(dprE1)
CUQ: Cul210931_0146(dprE1)
CUZ: Cul05146_0152(dprE1)
CUJ: CUL131002_0136c(dprE1)
CVA: CVAR_2925(dprE1)
CTER: A606_00560
COA: DR71_1174
CSX: CSING_00475(dprE1)
CMQ: B840_00775(dprE1)
CKU: UL82_00355(dprE1)
CCJ: UL81_00550(dprE1)
CMV: CMUST_00580(dprE1)
CEI: CEPID_00985(dprE1)
CTED: CTEST_00730(dprE1)
CUT: CUTER_00440(dprE1)
CDX: CDES_01095(dprE1)
CSP: WM42_1261
CPHO: CPHO_00620
CGV: CGLAU_00465(dprE1)
CAQU: CAQU_00425
CAMG: CAMM_01050
CMIN: NCTC10288_02445(dprE1)
CPEG: CPELA_00610(dprE1)
NFA: NFA_1970
NFR: ERS450000_04041(dprE1_2)
RER: RER_02350
ROP: ROP_39530
REQ: REQ_02330
RHB: NY08_3926
RFA: A3L23_02042(dprE1_1)
RHS: A3Q41_01321(dprE1_2)
RHU: A3Q40_03629(dprE1_2)
RRT: 4535765_00240(dprE1_1)
GBR: Gbro_0252
GOR: KTR9_0243
GRU: GCWB2_01070(dprE1)
GOM: D7316_03427(dprE1_1)
TPR: Tpau_4119
SRT: Srot_2816
SCO: SCO4842(SC5G8.10c)
SALB: XNR_3918
SGR: SGR_2699
SGB: WQO_22065
SFA: Sfla_2401
SVE: SVEN_4517
SDV: BN159_3566(dprE1)
SALS: SLNWT_4766
STRP: F750_4397
SFI: SFUL_4635
SLE: sle_28320(sle_28320)
STRD: NI25_14735
SLAU: SLA_4701
SFK: KY5_4944c
SGE: DWG14_03282(dprE1)
SERJ: SGUI_3196
MPH: MLP_13380
MGG: MPLG2_2494(dprE)
TFU: Tfu_2461
NDA: Ndas_0270
NAL: B005_3138
STRR: EKD16_04935(dprE1)
MMAR: MODMU_4725
KRA: Krad_4160
SACC: EYD13_00805(dprE1)
AMD: AMED_0230
AMN: RAM_01165
AMM: AMES_0225
AMZ: B737_0226
AOI: AORI_0235
AJA: AJAP_01220(dprE1)
AMYY: YIM_01230(dprE1)
PDX: Psed_0195
PSEA: WY02_17165
PSEE: FRP1_25600
PSEH: XF36_24965
PAUT: Pdca_01840
ALO: CRK60917
CAI: Caci_5664
TBI: Tbis_0812
AFO: Afer_1740
PMT: PMT_2035
VBL: L21SP4_02259(dprE1)
LBJ: LBJ_1542
LBL: LBL_1766
LBF: LBF_0519
LST: LSS_12287
CPI: Cpin_4051
MUC: MuYL_3236
MGOT: MgSA37_03195(dprE1)
RAI: RA0C_0288
RAR: RIA_0062
RAG: B739_2045
RAE: G148_1549
RAT: M949_0255
CHZ: CHSO_1353
CTAK: 4412677_02567(dprE1)
FBA: FIC_00760
CTS: Ctha_1596
 » show all
Taxonomy
Reference
1  [PMID:22069462]
  Authors
Ribeiro AL, Degiacomi G, Ewann F, Buroni S, Incandela ML, Chiarelli LR, Mori G, Kim J, Contreras-Dominguez M, Park YS, Han SJ, Brodin P, Valentini G, Rizzi M, Riccardi G, Pasca MR
  Title
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis.
  Journal
PLoS One 6:e26675 (2011)
DOI:10.1371/journal.pone.0026675
  Sequence
Reference
2  [PMID:22188377]
  Authors
Trefzer C, Skovierova H, Buroni S, Bobovska A, Nenci S, Molteni E, Pojer F, Pasca MR, Makarov V, Cole ST, Riccardi G, Mikusova K, Johnsson K
  Title
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1.
  Journal
J Am Chem Soc 134:912-5 (2012)
DOI:10.1021/ja211042r
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.98.3
IUBMB Enzyme Nomenclature: 1.1.98.3
ExPASy - ENZYME nomenclature database: 1.1.98.3
BRENDA, the Enzyme Database: 1.1.98.3

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