KEGG   ENZYME: 1.1.98.5
Entry
EC 1.1.98.5                 Enzyme                                 
Name
secondary-alcohol dehydrogenase (coenzyme-F420);
F420-dependent alcohol dehydrogenase;
secondary alcohol:F420 oxidoreductase;
F420-dependent secondary alcohol dehydrogenase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With other, known, physiological acceptors
Sysname
secondary-alcohol:coenzyme F420 oxidoreductase
Reaction(IUBMB)
R-CHOH-R' + oxidized coenzyme F420 = R-CO-R' + reduced coenzyme F420 [RN:R10574]
Reaction(KEGG)
R10574
Substrate
R-CHOH-R' [CPD:C01612];
oxidized coenzyme F420 [CPD:C00876]
Product
R-CO-R' [CPD:C01450];
reduced coenzyme F420 [CPD:C01080]
Comment
The enzyme isolated from the methanogenic archaea Methanogenium liminatans catalyses the reversible oxidation of various secondary and cyclic alcohols to the corresponding ketones.
History
EC 1.1.98.5 created 2013
Orthology
K21835  secondary-alcohol dehydrogenase (coenzyme-F420)
Genes
MRTJKHC33_06890
MEMMemar_0783
MBGBN140_2377
MEMAMMAB1_3164(fgd)
MCHKMchiMG62_09070(fgd)
MPIMpet_1623
MEZMtc_2316(fgd-2)
HAADMW046_02020
HAKZJ0X25_00185
Reference
1  [PMID:1879431]
  Authors
Bleicher K, Winter J
  Title
Purification and properties of F420- and NADP(+)-dependent alcohol dehydrogenases of Methanogenium liminatans and Methanobacterium palustre, specific for secondary alcohols.
  Journal
Eur J Biochem 200:43-51 (1991)
DOI:10.1111/j.1432-1033.1991.tb21046.x
Reference
2  [PMID:15016352]
  Authors
Aufhammer SW, Warkentin E, Berk H, Shima S, Thauer RK, Ermler U
  Title
Coenzyme binding in F420-dependent secondary alcohol dehydrogenase, a member of the bacterial luciferase family.
  Journal
Structure 12:361-70 (2004)
DOI:10.1016/j.str.2004.02.010
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.98.5
IUBMB Enzyme Nomenclature: 1.1.98.5
ExPASy - ENZYME nomenclature database: 1.1.98.5
BRENDA, the Enzyme Database: 1.1.98.5

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