KEGG   ENZYME: 1.1.99.2Help
Entry
EC 1.1.99.2                 Enzyme                                 

Name
L-2-hydroxyglutarate dehydrogenase;
alpha-ketoglutarate reductase;
alpha-hydroxyglutarate dehydrogenase;
L-alpha-hydroxyglutarate dehydrogenase;
hydroxyglutaric dehydrogenase;
alpha-hydroxyglutarate oxidoreductase;
L-alpha-hydroxyglutarate:NAD+ 2-oxidoreductase;
alpha-hydroxyglutarate dehydrogenase (NAD+ specific);
(S)-2-hydroxyglutarate:(acceptor) 2-oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(S)-2-hydroxyglutarate:acceptor 2-oxidoreductase
Reaction(IUBMB)
(S)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptor [RN:R00298]
Reaction(KEGG)
Substrate
(S)-2-hydroxyglutarate [CPD:C03196];
acceptor [CPD:C00028]
Product
2-oxoglutarate [CPD:C00026];
reduced acceptor [CPD:C00030]
History
EC 1.1.99.2 created 1961, modified 2013
Pathway
ec00650  Butanoate metabolism
ec01100  Metabolic pathways
Orthology
K00109  2-hydroxyglutarate dehydrogenase
Genes
HSA: 79944(L2HGDH)
PTR: 452898(L2HGDH)
PPS: 100978899(L2HGDH)
GGO: 101139276(L2HGDH)
PON: 100172827(L2HGDH)
NLE: 100600833(L2HGDH)
MCC: 705721(L2HGDH)
MCF: 102137911(L2HGDH)
CSAB: 103228958(L2HGDH)
RRO: 104682749(L2HGDH)
RBB: 108513673(L2HGDH)
CJC: 100410851(L2HGDH)
SBQ: 101047482(L2HGDH)
MMU: 217666(L2hgdh)
RNO: 314196(L2hgdh)
MUN: 110556911(L2hgdh)
CGE: 100768751(L2hgdh)
NGI: 103731511(L2hgdh)
HGL: 101702109(L2hgdh)
OCU: 100343830 100350193(L2HGDH)
TUP: 102480205(L2HGDH)
CFA: 480316(L2HGDH)
AML: 100470952(L2HGDH)
UMR: 103665372(L2HGDH)
ORO: 101385619(L2HGDH)
FCA: 101094353(L2HGDH)
PTG: 102951061(L2HGDH)
AJU: 106981946(L2HGDH)
BTA: 514230(L2HGDH)
BOM: 102277294(L2HGDH)
BIU: 109565017(L2HGDH)
PHD: 102328606(L2HGDH)
CHX: 102190421(L2HGDH)
OAS: 101121015(L2HGDH)
SSC: 100152180(L2HGDH)
CFR: 102520166(L2HGDH)
CDK: 105091405(L2HGDH)
BACU: 103020579(L2HGDH)
LVE: 103075209(L2HGDH)
OOR: 101284995(L2HGDH)
DLE: 111173173(L2HGDH)
ECB: 100066314(L2HGDH)
EPZ: 103545570 103559182(L2HGDH)
EAI: 106828039 106839519(L2HGDH)
MYB: 102238888(L2HGDH)
MYD: 102773864(L2HGDH)
MNA: 107525853(L2HGDH)
HAI: 109375228(L2HGDH)
RSS: 109444343(L2HGDH)
PALE: 102889350(L2HGDH)
LAV: 100657343(L2HGDH)
TMU: 101347817
MDO: 100018728(L2HGDH)
PCW: 110221753(L2HGDH)
OAA: 100084662(L2HGDH)
GGA: 423573(L2HGDH)
MGP: 100540849(L2HGDH)
CJO: 107315524(L2HGDH)
APLA: 101804444(L2HGDH)
ACYG: 106049309(L2HGDH)
TGU: 100220092(L2HGDH)
LSR: 110473477(L2HGDH)
SCAN: 103826825(L2HGDH)
GFR: 102033150(L2HGDH)
FAB: 101808533(L2HGDH)
PHI: 102103991(L2HGDH)
PMAJ: 107206240(L2HGDH)
CCAE: 111929517(L2HGDH) 111945332
CCW: 104695923(L2HGDH)
ETL: 114070306(L2HGDH)
FPG: 101912902(L2HGDH)
FCH: 102056594(L2HGDH)
CLV: 102089678(L2HGDH)
EGZ: 104135009(L2HGDH)
NNI: 104019490(L2HGDH)
ACUN: 113480383(L2HGDH)
AAM: 106497441(L2HGDH)
ASN: 102387436(L2HGDH)
AMJ: 106737189(L2HGDH)
PSS: 102458506(L2HGDH)
CMY: 102946571(L2HGDH)
CPIC: 101935892(L2HGDH)
ACS: 100563174(l2hgdh)
PVT: 110089153(L2HGDH)
PBI: 103059564(L2HGDH)
PMUR: 107296219(L2HGDH) 107300310
GJA: 107122496(L2HGDH) 107122626
XLA: 108698751(l2hgdh.L)
XTR: 100145085(l2hgdh)
NPR: 108795062(L2HGDH)
DRE: 566872(l2hgdh)
SGH: 107553179 107602969(l2hgdh)
CCAR: 109059147
IPU: 108263080(l2hgdh)
PHYP: 113541918(l2hgdh)
AMEX: 103038136(l2hgdh)
EEE: 113577730(l2hgdh)
TRU: 101061325(l2hgdh)
LCO: 104935982(l2hgdh)
NCC: 104958305(l2hgdh)
MZE: 101471313(l2hgdh)
OLA: 101160274(l2hgdh)
XMA: 102234259(l2hgdh)
PRET: 103458314(l2hgdh)
NFU: 107391749(l2hgdh)
KMR: 108237533(l2hgdh)
CSEM: 103380943(l2hgdh)
LCF: 108886702(l2hgdh)
SDU: 111225601(l2hgdh)
HCQ: 109517328(l2hgdh)
BPEC: 110174617(l2hgdh)
MALB: 109973393(l2hgdh)
SASA: 106602521(l2hgdh)
OTW: 112262149(l2hgdh)
SALP: 112074717(l2hgdh)
ELS: 105025540(l2hgdh)
SFM: 108919404(l2hgdh)
PKI: 111840026(l2hgdh)
LCM: 102364974(L2HGDH)
CMK: 103175273(l2hgdh)
CIN: 100184325
SPU: 578357
APLC: 110989722
SKO: 100376601
DME: Dmel_CG10639(L2HGDH)
DER: 6549344
DPE: 6589400
DSI: Dsimw501_GD21794(Dsim_GD21794)
DWI: 6644340
DAZ: 108611749
DHE: 111595763
MDE: 101896371
AAG: 110676307
AME: 410999
BIM: 100749758
BTER: 100651400
SOC: 105200020
MPHA: 105833196
AEC: 105144701
ACEP: 105625974
PBAR: 105427409
HST: 105186316
DQU: 106748629
CFO: 105249825
LHU: 105671500
PGC: 109855448
OBO: 105277467
PCF: 106784231
NVI: 100115746
MDL: 103571533
NVL: 108562516
BMOR: 101745774
PMAC: 106714825
PRAP: 110994004
HAW: 110370685
TNL: 113497247
PXY: 105383252
API: 100161579
DNX: 107173172
AGS: 114122022
ZNE: 110839593
FCD: 110842667
TUT: 107368266
DPTE: 113798662
CEL: CELE_Y45G12B.3(Y45G12B.3)
CBR: CBG06643
BMY: Bm1_52090
TSP: Tsp_09673
PCAN: 112562380
CRG: 105338880
MYI: 110461468
OBI: 106870546
LAK: 106169805
SHX: MS3_09128
EPA: 110250348
ADF: 107331220
PDAM: 113676926
SPIS: 111341504
AQU: 100634553
ATH: AT3G56840
CRB: 17885421
BRP: 103841581
BNA: 106368050
BOE: 106312181
CPAP: 110817154
CIT: 102609019
TCC: 18598621
GRA: 105786167
GAB: 108460382
DZI: 111312149
EGR: 104443589
GMX: 100798359
VRA: 106772172
VAR: 108345625
CCAJ: 109793634
CAM: 101512589
LJA: Lj5g3v0409270.1(Lj5g3v0409270.1)
ADU: 107472023
LANG: 109336445
FVE: 101311454
PPER: 18771102
PMUM: 103339099
PAVI: 110772356
MDM: 103454693
CSV: 101204963
CMO: 103495875
MCHA: 111021786
RCU: 8280365
JCU: 105637120
HBR: 110641410
POP: 7495656
QSU: 112025402
VVI: 100255157
SLY: 101243839
SPEN: 107031969
NTO: 104092698
NAU: 109238833
INI: 109162108
SIND: 105159876
OEU: 111370392
HAN: 110920848
LSV: 111880182
CCAV: 112517920
DCR: 108224905
SOE: 110799881
NNU: 104593510
OSA: 4327565
DOSA: Os01t0809900-01(Os01g0809900)
OBR: 102718692
BDI: 106866221
ATS: 109731554(LOC109731554)
SBI: 8055270
ZMA: 100276389(si605036g08a)
SITA: 106804356
PDA: 103705022
EGU: 105032055
MUS: 103971924
DCT: 110091894
PEQ: 110024641
AOF: 109831714
ATR: 18426140
TCR: 511037.20
 » show all
Taxonomy
Reference
1  [PMID:16746551]
  Authors
Weil-Malherbe H
  Title
The oxidation of l(-)alpha-hydroxyglutaric acid in animal tissues.
  Journal
Biochem J 31:2080-94 (1937)
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.2
IUBMB Enzyme Nomenclature: 1.1.99.2
ExPASy - ENZYME nomenclature database: 1.1.99.2
BRENDA, the Enzyme Database: 1.1.99.2
CAS: 9028-80-2

DBGET integrated database retrieval system