Entry |
|
Name |
hydroxyacid-oxoacid transhydrogenase;
transhydrogenase, hydroxy acid-oxo acid
|
Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
|
Sysname |
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase
|
Reaction(IUBMB) |
(S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate [RN: R03225]
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Reaction(KEGG) |
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Substrate |
(S)-3-hydroxybutanoate [CPD: C03197];
2-oxoglutarate [CPD: C00026]
|
Product |
acetoacetate [CPD: C00164];
(R)-2-hydroxyglutarate [CPD: C01087]
|
Comment |
4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.
|
History |
EC 1.1.99.24 created 1992
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Orthology |
K11173 | hydroxyacid-oxoacid transhydrogenase |
|
Genes |
TROS: | 130554060(adhfe1) 130561770 |
DSI: | Dsimw501_GD25134(Dsim_GD25134) |
AGA: | AgaP_AGAP006646(HOT_ANOGA) |
AALB: | 109424270 109428710 |
ALAB: | 122711846 122712084 |
ACEP: | 105623996 105625201 |
BTAB: | 109036405 109040019 |
HHAL: | 106679286 106684310 |
PPOI: | 119107893 119108537 |
CEL: | CELE_Y38F1A.6(hphd-1) |
NTE: | NEUTE1DRAFT87713(NEUTE1DRAFT_87713) |
ANG: | ANI_1_430094(An11g03110) |
ABP: | AGABI1DRAFT113486(AGABI1DRAFT_113486) AGABI1DRAFT61606(AGABI1DRAFT_61606) |
ABV: | AGABI2DRAFT191865(AGABI2DRAFT_191865) AGABI2DRAFT229861(AGABI2DRAFT_229861) |
SCM: | SCHCO_02621449(SCHCODRAFT_02621449) |
DDI: | DDB_G0290111(adhfe1) |
GAI: | IMCC3135_33250(mdh_3) |
MSIM: | MSIM_09050 MSIM_50160 |
MBAI: | MB901379_00308(mdh_1) |
MAUU: | NCTC10437_05580(mdh_2) |
PHH: | AFB00_14485 AFB00_27995 |
LOKI: | Lokiarch_22120(mdh_2) |
» show all
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Reference |
|
Authors |
Kaufman EE, Nelson T, Fales HM, Levin DM |
Title |
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria. |
Journal |
J Biol Chem 263:16872-9 (1988) |
Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.99.24 |
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