KEGG   ENZYME: 1.1.99.24
Entry
EC 1.1.99.24                Enzyme                                 
Name
hydroxyacid-oxoacid transhydrogenase;
transhydrogenase, hydroxy acid-oxo acid
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
(S)-3-hydroxybutanoate:2-oxoglutarate oxidoreductase
Reaction(IUBMB)
(S)-3-hydroxybutanoate + 2-oxoglutarate = acetoacetate + (R)-2-hydroxyglutarate [RN:R03225]
Reaction(KEGG)
R03225
Substrate
(S)-3-hydroxybutanoate [CPD:C03197];
2-oxoglutarate [CPD:C00026]
Product
acetoacetate [CPD:C00164];
(R)-2-hydroxyglutarate [CPD:C01087]
Comment
4-Hydroxybutanoate and (R)-2-hydroxyglutarate can also act as donors; 4-oxobutanoate can also act as acceptor.
History
EC 1.1.99.24 created 1992
Orthology
K11173  hydroxyacid-oxoacid transhydrogenase
Genes
HSA137872(ADHFE1)
PTR472781(ADHFE1)
PPS100989227(ADHFE1)
GGO101130649(ADHFE1)
PON100189822(ADHFE1)
NLE100607633(ADHFE1)
MCC703118(ADHFE1)
MCF102139828(ADHFE1)
CSAB103236903(ADHFE1)
CATY105585219(ADHFE1)
PANU100997709(ADHFE1)
TGE112629824(ADHFE1)
RRO104668796(ADHFE1)
RBB108544913(ADHFE1)
TFN117078780(ADHFE1)
PTEH111549237(ADHFE1)
CJC100392867(ADHFE1)
SBQ101033363(ADHFE1)
CSYR103276862(ADHFE1)
MMUR105855911(ADHFE1)
OGA100962084(ADHFE1)
MMU76187(Adhfe1)
MCAL110289036(Adhfe1)
MPAH110338895(Adhfe1)
RNO362474(Adhfe1)
MCOC116088149(Adhfe1)
MUN110564103(Adhfe1)
CGE100764101(Adhfe1)
PLEU114690089(Adhfe1)
NGI103751369(Adhfe1)
HGL101715530(Adhfe1)
CPOC100719015(Adhfe1)
CCAN109683108(Adhfe1)
DORD105999446(Adhfe1)
DSP122096047(Adhfe1)
OCU100344305(ADHFE1)
OPI101531356(ADHFE1)
TUP102492702(ADHFE1)
CFA477899(ADHFE1)
VVP112932418(ADHFE1)
VLG121498944(ADHFE1)
AML100474620(ADHFE1)
UMR103677520(ADHFE1)
UAH113268047(ADHFE1)
UAR123786690(ADHFE1)
ELK111155429
LLV125098411
MPUF101693731(ADHFE1)
ORO101365407(ADHFE1)
EJU114216036(ADHFE1)
ZCA113913240(ADHFE1)
MLX118014884(ADHFE1)
FCA101088980(ADHFE1)
PYU121038173(ADHFE1)
PBG122496022(ADHFE1)
PTG102966071(ADHFE1)
PPAD109269293(ADHFE1)
AJU106979767(ADHFE1)
HHV120241699(ADHFE1)
BTA507711(ADHFE1)
BOM102272942(ADHFE1)
BIU109568623(ADHFE1)
BBUB102404229(ADHFE1)
CHX102171531(ADHFE1)
OAS101113943(ADHFE1)
ODA120878634(ADHFE1)
CCAD122451281(ADHFE1)
SSC100521620(ADHFE1)
CFR102512747(ADHFE1)
CBAI105081454(ADHFE1)
CDK105095646(ADHFE1)
VPC102530626(ADHFE1)
BACU103002395(ADHFE1)
LVE103081097(ADHFE1)
OOR101269318(ADHFE1)
DLE111185580(ADHFE1)
PCAD102989675(ADHFE1)
PSIU116742651(ADHFE1)
ECB100063782(ADHFE1)
EPZ103555251(ADHFE1)
EAI106829414(ADHFE1)
MYB102251413(ADHFE1)
MYD102753736(ADHFE1)
MMYO118670902(ADHFE1)
MLF102420142(ADHFE1)
MNA107532156(ADHFE1)
PKL118718323(ADHFE1)
HAI109376633(ADHFE1)
DRO112315590(ADHFE1)
SHON118995520(ADHFE1)
AJM119051962(ADHFE1)
PDIC114514679(ADHFE1)
PHAS123833053(ADHFE1)
MMF118631557(ADHFE1)
RFQ117034111(ADHFE1)
PALE102888458(ADHFE1)
PGIG120585446(ADHFE1)
PVP105295095
RAY107514812(ADHFE1)
MJV108407685(ADHFE1)
TOD119240988(ADHFE1)
SARA101541141(ADHFE1)
LAV100674318(ADHFE1)
TMU101359091
DNM101430945(ADHFE1)
MDO100029272(ADHFE1)
SHR100918954(ADHFE1)
PCW110219024(ADHFE1)
OAA100080980(ADHFE1)
GGA426446(ADHFE1)
PCOC116236292(ADHFE1)
MGP100542368(ADHFE1)
CJO107310256(ADHFE1)
NMEL110394094(ADHFE1)
APLA101803233(ADHFE1)
ACYG106030646(ADHFE1)
AFUL116486827(ADHFE1)
TGU100222045(ADHFE1)
LSR110484725(ADHFE1)
SCAN103812613(ADHFE1)
PMOA120499249(ADHFE1)
OTC121340181(ADHFE1)
PRUF121356836(ADHFE1)
GFR102041914(ADHFE1)
FAB101812813(ADHFE1)
PHI102114159(ADHFE1)
PMAJ107200386(ADHFE1)
CCAE111924792(ADHFE1)
CCW104692841(ADHFE1)
ETL114062812(ADHFE1)
ZAB102062566(ADHFE1)
FPG101913680(ADHFE1)
FCH102059247(ADHFE1)
CLV102087461(ADHFE1)
EGZ104122034(ADHFE1)
NNI104018499(ADHFE1)
ACUN113476139(ADHFE1)
TALA104361042(ADHFE1)
PADL103926246(ADHFE1)
ACHC115340244(ADHFE1)
AAM106484593(ADHFE1)
AROW112971509(ADHFE1)
NPD112944216(ADHFE1)
DNE112992249(ADHFE1)
ASN102374701(ADHFE1)
AMJ102575665(ADHFE1)
CPOO109319230(ADHFE1)
GGN109298806(ADHFE1)
PSS102449707(ADHFE1)
CMY102942629(ADHFE1)
CPIC101952555(ADHFE1)
CABI116822869(ADHFE1)
MRV120398575(ADHFE1)
ACS100553506(adhfe1)
PVT110089189(ADHFE1)
SUND121928547(ADHFE1)
PBI103048754(ADHFE1)
PMUR107295111(ADHFE1)
TSR106544722 106544726
PGUT117672855(ADHFE1)
VKO123027582(ADHFE1)
PMUA114600549(ADHFE1)
ZVI118090228(ADHFE1)
GJA107108521(ADHFE1)
XLA100158357(adhfe1.S)
XTR394891(adhfe1)
NPR108785185(ADHFE1)
RTEM120941084(ADHFE1)
BBUF121001730(ADHFE1)
BGAR122938949(ADHFE1)
DRE404618(adhfe1)
SRX107721743(adhfe1)
SANH107690131(adhfe1)
SGH107567008(adhfe1)
CCAR109051729(adhfe1)
CAUA113120578
IPU108280437(adhfe1)
PHYP113543312(adhfe1)
SMEO124402916(adhfe1)
AMEX103028398(adhfe1)
EEE113587316(adhfe1)
TRU101064882(adhfe1)
TNGGSTEN00008613G001
NCC104948694(adhfe1)
CGOB115005723(adhfe1)
ELY117272295(adhfe1)
SLUC116056360(adhfe1)
PFLV114565882(adhfe1)
GAT120816166(adhfe1)
PPUG119209806(adhfe1)
MSAM119902789(adhfe1)
MZE101480322(adhfe1)
ONL100691144(adhfe1)
OAU116316222(adhfe1)
OLA101169732(adhfe1)
OML112144317(adhfe1)
XMA102217742(adhfe1)
XCO114146146(adhfe1)
XHE116722080(adhfe1)
PRET103460479(adhfe1)
PFOR103129932(adhfe1)
PLAI106943120(adhfe1)
PMEI106907566(adhfe1)
GAF122841601(adhfe1)
CVG107092489(adhfe1)
CTUL119778951(adhfe1)
GMU124869311(adhfe1)
NFU107372658
KMR108229212(adhfe1)
ALIM106512190
NWH119414341(adhfe1)
AOCE111588952(adhfe1)
CSEM103398723(adhfe1)
POV109646321
SSEN122774543(adhfe1)
HHIP117777845(adhfe1)
LCF108884927(adhfe1)
SDU111237329(adhfe1)
SLAL111659204(adhfe1)
XGL120800364(adhfe1)
HCQ109518917(adhfe1)
BPEC110170950(adhfe1)
MALB109974851(adhfe1)
SASA106569039(adhfe1)
OTW112260437(adhfe1)
OMY110530275(adhfe1)
OGO124010177(adhfe1)
ONE115114373(adhfe1)
SALP111957017(adhfe1)
SNH120055915(adhfe1)
ELS105010261(adhfe1)
SFM108937617(adhfe1)
PKI111861125(adhfe1)
AANG118233020(adhfe1)
LOC102689194(adhfe1)
PSPA121314335(adhfe1)
ARUT117435383(adhfe1)
LCM102362120(ADHFE1)
CMK103180734(adhfe1)
RTP109934150(adhfe1)
BFO118404056
BBEL109473140
CIN100186144
SCLV120328508
SPU575433
APLC110987984
SKO102800714
DMEDmel_CG3425(T3dh)
DER6548467
DSE6615512
DSIDsimw501_GD25134(Dsim_GD25134)
DYADyak_GE11684
DAN6495868
DSR110177513
DPODpse_GA17444
DPE6593199
DMN108159056
DWI6638286
DGR6559051
DMODmoj_GI18989
DAZ108615594
DNV115564926
DHE111593756
DVI6625796
CCAT101452868
BOD106627825
MDE101898360
SCAC106084871
LCQ111685288
AGAAgaP_AGAP006646(HOT_ANOGA)
ACOZ120961048
AARA120897888
AAG5578877
AALB109424270 109428710
CQUCpipJ_CPIJ005432
CPII120427129
AME100577856 552069
ACER108001486
ALAB122711846 122712084
BIM100746095
BBIF117205219
BVK117243594
BVAN117161375
BTER100643126
BPYO122571582
CCAL108622881
OBB114874672
MGEN117220110
NMEA116426186
CGIG122401584
SOC105196343
MPHA105837435
AEC105145091
ACEP105623996 105625201
PBAR105428988
VEM105569976
HST105187748
DQU106748178
CFO105250598
FEX115234745
LHU105667680 105671603
PGC109863800
OBO105286565
PCF106790130
PFUC122523385
VPS122630039
MDL103577546
AGIF122855303
CCIN107274489
TCA656628
ATD109596297
AGB108916341
LDC111512250
NVL108561553
APLN108738192
OTU111425345
BMOR101738633
BMAN114244912
MSEX115441687
DPLKGM_201485
BANY112052512
PMAC106714366
PPOT106111861
PXU106124293
PRAP110994911
ZCE119829574
HAW110383793
TNL113496320
OFU114352420
PXY105398318
API100169201
DNX107163655
AGS114132502
RMD113552281
BTAB109036405 109040019
DCI103512568
CLEC106665119
HHAL106679286 106684310
NLU111055782
ZNE110835399
CSEC111862230
PVM113808512 113814709
PJA122266555 122266556
HAME121860796
PCLA123764725
PTRU123511922
HAZT108677773
ISCIscW_ISCW021748
DSV119450830
RSAN119384018 119384022
RMP119170779
VDE111249035
VJA111263932
PTEP107451106
SDM118186208
CELCELE_Y38F1A.6(hphd-1)
CBRCBG_02769
NAINECAME_11412
LGILOTGIDRAFT_138069
PCAN112562216
BGT106067138
GAE121378151
HRF124128493
HRJ124288959
CRG105344644
MYI110443496
PMAX117316220
MMER123561227
OBI106876888
OSN115210878
LAK106152707 106152715
NVE5520398 5520498
EPA110247393
ATEN116290005
ADF107328715 107350091
AMIL114976473
PDAM113679623
SPIS111342289
DGT114528591
HMG100201794 101240499
AQU100639220
QSU112013617 112028814
YLIYALI0E15818g
SLBAWJ20_1841(ADH4)
NCRNCU04078
NTENEUTE1DRAFT87713(NEUTE1DRAFT_87713)
SMPSMAC_00662
PANPODANSg3233
TTTTHITE_2063410
MTMMYCTH_2306298
MGRMGG_03824
TMNUCRPA7_7301
SSCKSPSK_05162
FGRFGSG_09245
FPUFPSE_09635
FVRFVEG_03863
FOXFOXG_05996
NHENECHADRAFT_58609
TRETRIREDRAFT_104606
TRRM419DRAFT_33138
MAWMAC_03394
MAJMAA_01994
CMTCCM_00356
PLJVFPFJ_04130
VALVDBG_07926
VDAVDAG_05498
CFJCFIO01_06370
SAPOSAPIO_CDS9364
ELAUCREL1_3396
PFYPFICI_09817
SSLSS1G_13491
BFUBCIN_13g04920
MBEMBM_06376
PSCOLY89DRAFT_713602
GLZGLAREA_10898
ANIAN1868.2
AFMAFUA_2G04520
ACTACLA_090080
NFINFIA_081270
AORAO090003000243
ANGANI_1_430094(An11g03110)
AFVAFLA_001449
ALUCAKAW2_80289S
ACHEACHE_80441S
APUUAPUU_21212A
PCSPc12g10580
PDPPDIP_79990
TMFPMAA_030510
TRGTRUGW13939_05819
CIMCIMG_01242
CPWCPC735_051540
UREUREG_01172
PBLPAAG_08911
PBNPADG_08649
ABEARB_07890
TVETRV_00952
AJEHCAG_09021
BGHBDBG_04336
PNOSNOG_13060
PTEPTT_05756
BZECOCCADRAFT_30954
BSCCOCSADRAFT_37131
BORCOCMIDRAFT_25462
AALTCC77DRAFT_598375
ZTRMYCGRDRAFT_66658
PFJMYCFIDRAFT_55798
BCOMBAUCODRAFT_348772
NPAUCRNP2_6086
TMLGSTUM_00001074001
CNECNA01850
CNBCNBA1780
CGICGB_B2250C
TMSTREMEDRAFT_68204
TASAA1Q1_00294
PPLPOSPLDRAFT_104120
TVSTRAVEDRAFT_69690
DSQDICSQDRAFT_136849
PCOPHACADRAFT_249766
SHSSTEHIDRAFT_147985
HIRHETIRDRAFT_381405
PSQPUNSTDRAFT_100490
ADLAURDEDRAFT_112896
FMEFOMMEDRAFT_147995
GTRGLOTRDRAFT_136160
LBCLACBIDRAFT_311781
MPRMPER_03230
MRRMoror_7341
CCICC1G_00301
SCMSCHCODRAFT_71701
ABPAGABI1DRAFT113486(AGABI1DRAFT_113486) AGABI1DRAFT61606(AGABI1DRAFT_61606)
ABVAGABI2DRAFT191865(AGABI2DRAFT_191865) AGABI2DRAFT229861(AGABI2DRAFT_229861)
CPUTCONPUDRAFT_130475
SLASERLADRAFT_462073
WSEWALSEDRAFT_63809
WICJ056_003424
UMAUMAG_10077
PFPPFL1_04265
PGRPGTG_21040
MLRMELLADRAFT_44184
DDIDDB_G0290111(adhfe1)
DPPDICPUDRAFT_51782
DFADFA_01599(adhfe1)
ACANACA1_385440
PTIPHATRDRAFT_19659
SPARSPRG_14119
GAIIMCC3135_33250(mdh_3)
ZPAC3497_08890
MFBMFUL124B02_17965
CCXCOCOR_05927(mdh1)
AGEAA314_06351
AVMJQX13_45835
MBDMEBOL_007170
CFUSCYFUS_005328
CCROCMC5_051330(adhP)
LLUAKJ09_06364
HOHHoch_2344
DAVDESACE_05675
LNEFZC33_28285
ACRAcry_1420
AMVACMV_14680
AZLAZL_005030(adh)
ALIAZOLI_0355
ABSAZOBR_90018
ABQABAZ39_09465
ABFAMK58_05050
ATIAL072_01880
AHUA6A40_01440
AZTTSH58p_07000
AZMDM194_01105
AZZDEW08_09680
AOZHUE56_21250
MHADB586_11215
MDXBTO20_37150
MSHGMSG_02729
MFJMFLOJ_04560
MSTOMSTO_05900
MSIMMSIM_09050 MSIM_50160
MSAKMSAS_37190
MCOOMCOO_34860
MBAIMB901379_00308(mdh_1)
MSEOMSEO_42420
MMAMK3U93_01645
MVAMvan_5811
MGIMflv_1025
MSPMspyr1_51630
MCBMycch_5187
MVQMYVA_5732
MDUMDUV_44460
MAUUNCTC10437_05580(mdh_2)
MFXMFAL_26470
MIJMINS_06450
MPSCMPSYJ_10370
MPOFMPOR_03950
ROPROP_33480
ROAPd630_LPD07965
SVLStrvi_6073
SRCM271_42075
SMALSMALA_0989
SSOII1A49_08435
STREGZL_00291
SAUOBV401_08740
SRIMCP984_38250
SBATG4Z16_15110
DNIHX89_13960
DAYFV141_13370
LMOIVV02_07925
YIMJ5M86_11070
ICAIntca_2309
ARSADJ73_05035
JTEASJ30_02005
JLIEXU32_13000
JMEEEW87_013050
PEIH9L10_13015
NCANoca_0724
NDKI601_0710(mdh_2)
NOYEXE57_09000
NOOFE634_16835
NSNEXE58_04715
NBEBack2_20960
NANOG5V58_00305
NMESH9L09_12275
NAROCFH99_03810
PSIMKR76_04630
AERAERYTH_03675
AEZC3E78_14950
AEBC6I20_01390
AEFGEV26_15060
MUZH4N58_16630
TCUTcur_0729
NCXNocox_32745(ahlD)
TBITbis_2163
GOBGobs_1823
BSDBLASA_1758(adhfe)
MMARMODMU_2285(adhfe)
SVISvir_08580
SACCEYD13_04695(dhaT)
AMQAMETH_2017
AMYCCU254_23555
PDXPsed_6782
PSEAWY02_11675
PSEEFRP1_01185
PSEHXF36_01910
PSEQAD006_08815
PECQAD017_16645
PHHAFB00_14485 AFB00_27995
PAUTPdca_60260
PBROHOP40_11380
PMADBAY61_06180
SACEGIY23_05775
PSUUPsuf_019100
RXYRxyl_2381
RRDRradSPS_2082
RUBGBA63_04615
CWOCwoe_3630
TROtrd_0194
STISthe_0931 Sthe_2689
DGEDgeo_2520
DGODGo_CA2134
DSWQR90_16295
DPUSU48_04235
DEZDKM44_07150
DWUDVJ83_16570
DEINDAAJ005_17760
DPHEHF33_02430
FMRFuma_05697(mdh_2)
SDYNMal52_24910(mdh_2)
ABACLuPra_02437(mdh_1)
AVEArcve_1676
FAIFAD_0984
IHOIgni_0132
IISEYM_00500
PFMPyrfu_0285
SCASSACC_13960
SIMM1627_0846
SINYN1551_2056
SULEGFS03_05455
SULOGFS33_10755
SACDHS1genome_2192
ASCASAC_0700
ACIASE86_00610
LOKILokiarch_22120(mdh_2)
 » show all
Reference
1  [PMID:3182820]
  Authors
Kaufman EE, Nelson T, Fales HM, Levin DM
  Title
Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria.
  Journal
J Biol Chem 263:16872-9 (1988)
  Sequence
[rno:362474]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.24
IUBMB Enzyme Nomenclature: 1.1.99.24
ExPASy - ENZYME nomenclature database: 1.1.99.24
BRENDA, the Enzyme Database: 1.1.99.24
CAS: 117698-31-4

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