KEGG   ENZYME: 1.1.99.28
Entry
EC 1.1.99.28                Enzyme                                 
Name
glucose-fructose oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
D-glucose:D-fructose oxidoreductase
Reaction(IUBMB)
D-glucose + D-fructose = D-gluconolactone + D-glucitol [RN:R00874]
Reaction(KEGG)
R00874
Substrate
D-glucose [CPD:C00031];
D-fructose [CPD:C00095]
Product
D-gluconolactone [CPD:C00198];
D-glucitol [CPD:C00794]
Comment
D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+.
History
EC 1.1.99.28 created 1999
Orthology
K00118  glucose-fructose oxidoreductase
Genes
XCCXCC0815(gfo)
XCBXC_3415
XCAxcc-b100_3538(gfo)
XCPXCR_0995
XCVXCV0923(gfo)
XAXXACM_0869(gfo)
XACXAC0888(gfo)
XCIXCAW_03692(gfo)
XCTJ151_01015
XCJJ158_01012
XCUJ159_01012
XCNJ169_01011
XCWJ162_01011
XCRJ163_01011
XCMJ164_01011
XCFJ172_01006
XFUXFF4834R_chr08940
XAOXAC29_04520
XOMXOO3515(XOO3515)
XOOXOO3722(gfo)
XOPPXO_04621
XOYAZ54_05280
XORXOC_0940
XOZBE73_19695
XALXALC_2749
XSASB85_08640
XTNFD63_03505
XFRBER92_04815
XVEBJD12_17355
XPEBJD13_12355
XPHXppCFBP6546_07070(XppCFBP6546P_07070)
XVAC7V42_04805
XANAC801_04490
XHYFZ025_04985
XCZEBN15_03405
XEUXSP_000874
XHDLMG31886_34530(gfo)
XPRMUG10_05635
PSUPsesu_0603
PSUWWQ53_11880
PMEXH4W19_17515
PDDMNQ95_10395
TCNH9L16_08825
AMCMADE_1016150
AMHI633_16820
AMAAamad1_16280
AMALI607_15425
AMAEI876_15725
AMAOI634_15670
AMADI636_15595
AMAII635_16235
AMAGI533_15250
AMACMASE_15230
AMBAMBAS45_15740
AMGAMEC673_15610
AMKAMBLS11_15060
ALTambt_01340
ASPAOR13_243
ASQAVL57_17255
AAWAVL56_16140
ALEAV939_16195
ALZAV940_15950
APELCA267_007875
CJACJA_2424(gfo)
CEGD0C16_01970
TTUTERTU_4571
GILNHM04_16710
MKEOOT55_14135
URUDSM104443_00507(gfo_1)
UPLDSM104440_01440(gfo)
CCRCC_1225
ZMOZMO0689
ZMNZa10_0578
ZMMZmob_0591
ZMBZZ6_0591
ZMIZCP4_0604
ZMCA265_00597(gfo)
ZMRA254_00597(gfo)
ZMPZymop_0543
SDHH9L15_07475
SMORLHA26_01770
SQONMP03_03215
SRADLLW23_09185
PARZDTQ13_08765
BREYMNR06_16580
CXEFOB82_09060
KRHKRH_21840(gfo)
KODHBK84_11780
NPUNpun_R3642
OTEOter_0724
LUOHHL09_12855
LCREPla8534_00460(iolG_1) Pla8534_25270(iolG_10)
GPNPan110_50000
MRIMal4_32450(iolG_11)
SDYNMal52_39150
PLONPla110_07500
GMSSOIL9_11520
TIMGMBLW1_29200
ULIETAA1_28570(iolG_6)
GRWFTO74_13740
EDAGWR55_06740
ADINH7849_07885
PFERIRI77_17140
AOKA3BBH6_15940
ACOUA5CBH24_06470
MCOSGM418_15645
SRUSRU_0850(gfo)
SRMSRM_01033(gfo)
NKONiako_4178
FLCKJS93_11465
HHYHalhy_3652
CMRCycma_2931
EVIEchvi_2803
SLISlin_2554
SPIBG8759_29440
STAEHNV11_15655
SRHOHH216_15675
RHOZGXP67_15140
DFEDfer_1598
DSNHWI92_04575 HWI92_10050
DYCNFI80_02285
RSIRunsl_5400
EOLEmtol_3209
FAEFAES_2065
MAQALAG90_12020
ADDHUW48_24185
ASWUHUW51_08180
RBIRB2501_15414
ZGAZOBELLIA_4647(gfoA)
MRSMurru_3045
MUTGVT53_07130
MAQILDL77_17840
CAGGHYG79_17645
SINHLS482_21250
ASAGFGM00_06510
FLGLV716_17135
FLBLV704_18960
DTHDICTH_0475
DTUDtur_0639
 » show all
Reference
1  [PMID:3745122]
  Authors
Zachariou M, Scopes RK.
  Title
Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production.
  Journal
J Bacteriol 167:863-9 (1986)
DOI:10.1128/JB.167.3.863-869.1986
Reference
2  [PMID:3356190]
  Authors
Hardman MJ, Scopes RK.
  Title
The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis.
  Journal
Eur J Biochem 173:203-9 (1988)
DOI:10.1111/j.1432-1033.1988.tb13985.x
Reference
3  [PMID:1537789]
  Authors
Kanagasundaram V, Scopes RK
  Title
Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis.
  Journal
J Bacteriol 174:1439-47 (1992)
DOI:10.1128/JB.174.5.1439-1447.1992
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.28
IUBMB Enzyme Nomenclature: 1.1.99.28
ExPASy - ENZYME nomenclature database: 1.1.99.28
BRENDA, the Enzyme Database: 1.1.99.28
CAS: 94949-35-6

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