KEGG   ENZYME: 1.1.99.28Help
Entry
EC 1.1.99.28                Enzyme                                 

Name
glucose-fructose oxidoreductase
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
D-glucose:D-fructose oxidoreductase
Reaction(IUBMB)
D-glucose + D-fructose = D-gluconolactone + D-glucitol [RN:R00874]
Reaction(KEGG)
Substrate
D-glucose [CPD:C00031];
D-fructose [CPD:C00095]
Product
D-gluconolactone [CPD:C00198];
D-glucitol [CPD:C00794]
Comment
D-mannose, D-xylose, D-galactose, 2-deoxy-D-glucose and L-arabinose will function as aldose substrates, but with low affinities. The ketose substrate must be in the open-chain form. The apparent affinity for fructose is low, because little of the fructose substrate is in the open-chain form. Xylulose and glycerone (dihydroxyacetone) will replace fructose, but they are poor substrates. The enzyme from Zymomonas mobilis contains tightly bound NADP+.
History
EC 1.1.99.28 created 1999
Orthology
K00118  glucose-fructose oxidoreductase
Genes
MGR: MGG_08115
AFM: AFUA_2G16380
XCC: XCC0815(gfo)
XCB: XC_3415
XCA: xcc-b100_3538(gfo)
XCP: XCR_0995
XCV: XCV0923(gfo)
XAX: XACM_0869(gfo)
XAC: XAC0888(gfo)
XCI: XCAW_03692(gfo)
XOO: XOO3722(gfo)
XOM: XOO3515(XOO3515)
XOP: PXO_04621
XOR: XOC_0940
XAL: XALC_2749
AMAL: I607_15425
AMAE: I876_15725
AMAO: I634_15670
AMAD: I636_15595
AMAI: I635_16235
AMAG: I533_15250
AMAC: MASE_15230
ASP: AOR13_243
CJA: CJA_2424(gfo)
CCR: CC_1225
ZMO: ZMO0689
ZMN: Za10_0578
ZMM: Zmob_0591
ZMB: ZZ6_0591
ZMI: ZCP4_0604
ZMC: A265_00597(gfo)
ZMR: A254_00597(gfo)
KRH: KRH_21840(gfo)
OTE: Oter_0724
RBA: RB3265(gfo)
SRU: SRU_0850(gfo)
SRM: SRM_01033(gfo)
DFE: Dfer_1598
SLI: Slin_2554
FAE: FAES_2065
GFO: GFO_2195(gfo)
ZGA: ZOBELLIA_4647(gfoA)
DTU: Dtur_0639
 » show all
Taxonomy
Reference
1  [PMID:3745122]
  Authors
Zachariou M, Scopes RK.
  Title
Glucose-fructose oxidoreductase, a new enzyme isolated from Zymomonas mobilis that is responsible for sorbitol production.
  Journal
J Bacteriol 167:863-9 (1986)
DOI:10.1128/JB.167.3.863-869.1986
Reference
2  [PMID:3356190]
  Authors
Hardman MJ, Scopes RK.
  Title
The kinetics of glucose-fructose oxidoreductase from Zymomonas mobilis.
  Journal
Eur J Biochem 173:203-9 (1988)
DOI:10.1111/j.1432-1033.1988.tb13985.x
Reference
3  [PMID:1537789]
  Authors
Kanagasundaram V, Scopes RK.
  Title
Cloning, sequence analysis, and expression of the structural gene encoding glucose-fructose oxidoreductase from Zymomonas mobilis.
  Journal
J Bacteriol 174:1439-47 (1992)
DOI:10.1128/JB.174.5.1439-1447.1992
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.28
IUBMB Enzyme Nomenclature: 1.1.99.28
ExPASy - ENZYME nomenclature database: 1.1.99.28
BRENDA, the Enzyme Database: 1.1.99.28
CAS: 94949-35-6

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