KEGG ENZYME: 1.1.99.30

ENZYME: 1.1.99.30

Entry

EC 1.1.99.30                Enzyme

Name

2-oxo-acid reductase;
(2R)-hydroxycarboxylate-viologen-oxidoreductase;
HVOR;
2-oxoacid reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors

Sysname

(2R)-hydroxy-carboxylate:acceptor oxidoreductase

Reaction(IUBMB)

a (2R)-hydroxy-carboxylate + acceptor = a 2-oxocarboxylate + reduced acceptor [RN:R07155]

Reaction(KEGG)

R07155

Substrate

(R)-2-hydroxycarboxylate [CPD:C02489];
acceptor [CPD:C00028]

Product

2-oxocarboxylate [CPD:C00161];
reduced acceptor [CPD:C00030]

Comment

Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.

History

EC 1.1.99.30 created 2004

Reference

1 [PMID:8026480]

Authors

Trautwein T, Krauss F, Lottspeich F, Simon H.

Title

The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein.

Journal

Eur J Biochem 222:1025-32 (1994)
DOI:10.1111/j.1432-1033.1994.tb18954.x

Reference

Authors

Neumann S, Simon H.

Title

On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species.

Journal

FEBS Lett 167:29-32 (1985)

Other DBs

ExplorEnz - The Enzyme Database:

1.1.99.30

IUBMB Enzyme Nomenclature:

1.1.99.30

ExPASy - ENZYME nomenclature database:

1.1.99.30

BRENDA, the Enzyme Database:

1.1.99.30

CAS:	115299-99-5

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (8)   

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