Acting on the CH-OH group of donors;
With unknown physiological acceptors
a (2R)-hydroxy-carboxylate + acceptor = a 2-oxo-carboxylate + reduced acceptor [RN:
reduced acceptor [CPD:
Contains [4Fe-4S] and a mononucleotide molybdenum (pyranopterin) cofactor. Has broad substrate specificity, with 2-oxo-monocarboxylates and 2-oxo-dicarboxylates acting as substrates. Branching in a substrate at the C-3 position results in loss of activity. The enzyme from Proteus sp. is inactivated by oxygen.
EC 188.8.131.52 created 2004
Trautwein T, Krauss F, Lottspeich F, Simon H.
The (2R)-hydroxycarboxylate-viologen-oxidoreductase from Proteus vulgaris is a molybdenum-containing iron-sulphur protein.
Neumann, S. and Simon, H.
On a non-pyridine nucleotide-dependent 2-oxoacid reductase of broad specificity from two Proteus species.
FEBS Lett 167:29-32 (1985)
ExPASy - ENZYME nomenclature database: 184.108.40.206