| Entry |
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| Name |
soluble quinoprotein glucose dehydrogenase;
soluble glucose dehydrogenase;
sGDH;
glucose dehydrogenase (PQQ-dependent)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
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| Sysname |
D-glucose:acceptor oxidoreductase
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| Reaction(IUBMB) |
D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor [RN: R10411]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
D-glucono-1,5-lactone [CPD: C00198];
reduced acceptor [CPD: C00030]
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| Comment |
Soluble periplasmic enzyme containing PQQ as prosthetic group, bound to a calcium ion. Electron acceptor is not known. It is assayed with Wurster's Blue or phenazine methosulfate. It has negligible sequence or structure similarity to other quinoproteins. It catalyses an exceptionally high rate of oxidation of a wide range of aldose sugars, including D-glucose, galactose, arabinose and xylose, and also the disaccharides lactose, cellobiose and maltose. It has been described only in Acinetobacter calcoaceticus.
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| History |
EC 1.1.99.35 created 2010
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| Reference |
1 |
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| Authors |
Geiger, O. and Gorisch, H. |
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| Title |
Crystalline quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus. |
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| Journal |
Biochemistry 25:6043-6048 (1986) |
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| Reference |
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| Authors |
Dokter P, Frank J, Duine JA |
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| Title |
Purification and characterization of quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus L.M.D. 79.41. |
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| Journal |
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| Reference |
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| Authors |
Cleton-Jansen AM, Goosen N, Wenzel TJ, van de Putte P |
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| Title |
Cloning of the gene encoding quinoprotein glucose dehydrogenase from Acinetobacter calcoaceticus: evidence for the presence of a second enzyme. |
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| Journal |
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| Reference |
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| Authors |
Matsushita K, Shinagawa E, Adachi O, Ameyama M |
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| Title |
Quinoprotein D-glucose dehydrogenase of the Acinetobacter calcoaceticus respiratory chain: membrane-bound and soluble forms are different molecular species. |
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| Journal |
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| Reference |
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| Authors |
Oubrie A, Dijkstra BW |
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| Title |
Structural requirements of pyrroloquinoline quinone dependent enzymatic reactions. |
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| Journal |
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| Reference |
6 |
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| Authors |
Matsushita, K., Toyama, H., Ameyama, M., Adachi, O., Dewanti, A. and Duine, J.A. |
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| Title |
Soluble and membrane-bound quinoprotein D-glucose dehydrogenases of the Acinetobacter calcoaceticus : the binding process of PQQ to the apoenzymes. |
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| Journal |
Biosci Biotechnol Biochem 59:1548-1555 (1995) |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.99.35 |
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