Entry Name 2-deoxy-scyllo-inosamine dehydrogenase (AdoMet-dependent);
Class Oxidoreductases;BRITE hierarchy
Sysname 2-deoxy-scyllo-inosamine:S-adenosyl-L-methionine 1-oxidoreductase
Reaction(IUBMB) 2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine [RN:
R08893 ]
Reaction(KEGG) Substrate 2-deoxy-scyllo-inosamine [CPD:
C17580 ];
S-adenosyl-L-methionine [CPD:
C00019 ]
Product 3-amino-2,3-dideoxy-scyllo-inosose [CPD:
C17581 ];
5'-deoxyadenosine [CPD:
C05198 ];
L-methionine [CPD:
C00073 ]
Comment Involved in the biosynthetic pathway of the aminoglycoside antibiotics of the butirosin family. The enzyme from Bacillus circulans was shown to be a radical S-adenosyl-L-methionine (SAM) enzyme. cf. EC
1.1.1.329 , 2-deoxy-scyllo-inosamine dehydrogenase.
History EC 1.1.99.38 created 2012, modified 2013
Pathway ec00524 Neomycin, kanamycin and gentamicin biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K13549 2-deoxy-scyllo-inosamine dehydrogenase (SAM-dependent)
Reference Authors Yokoyama K, Numakura M, Kudo F, Ohmori D, Eguchi T
Title Characterization and mechanistic study of a radical SAM dehydrogenase in the biosynthesis of butirosin.
Journal Sequence Reference Authors Yokoyama K, Ohmori D, Kudo F, Eguchi T
Title Mechanistic study on the reaction of a radical SAM dehydrogenase BtrN by electron paramagnetic resonance spectroscopy.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 1.1.99.38
