Entry
Name
(R)-2-hydroxyglutarate---pyruvate transhydrogenase;
DLD3 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
BRITE hierarchy
Sysname
(R)-2-hydroxyglutarate:pyruvate oxidoreductase [(R)-lactate-forming]
Reaction(IUBMB)
(R)-2-hydroxyglutarate + pyruvate = 2-oxoglutarate + (R)-lactate [RN:
R11593 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized in the yeast Saccharomyces cerevisiae, also functions as EC
1.1.2.4 , D-lactate dehydrogenase (cytochrome), and is active with oxaloacetate as electron acceptor forming (R)-malate.
History
EC 1.1.99.40 created 2017
Pathway
Orthology
K21618 (R)-2-hydroxyglutarate---pyruvate transhydrogenase
Genes
SCE : YDL178W(DLD2) YEL071W(DLD3)
SEUB : DI49_0901 DI49_5679
SPAO : SPAR_D00650 SPAR_E00030
CGR : 2889585(GVI51_J06149)
NCS : NCAS_0E03520(NCAS0E03520) NCAS_0H00160(NCAS0H00160)
NDI : NDAI_0A03060(NDAI0A03060) NDAI_0H04030(NDAI0H04030)
TPF : TPHA_0A03280(TPHA0A03280)
TBL : TBLA_0F01970(TBLA0F01970)
TGB : HG536_0C05350 HG536_0G04870
TDL : TDEL_0A08020(TDEL0A08020) TDEL_0E05730(TDEL0E05730) TDEL_0H01580(TDEL0H01580)
KAF : KAFR_0L01170(KAFR0L01170)
KNG : KNAG_0B02950(KNAG0B02950)
ZMK : HG535_0C06490 HG535_0G01630
LBG : 92207494(LODBEIA_P22980)
CAL : CAALFM_C303040WA(AIP2)
YLI : 2909313(YALI2_C00112g)
NTE : NEUTE1DRAFT146088(NEUTE1DRAFT_146088)
SMP : 90947621(SMAC4_02202)
TATV : 90959529(TrAtP1_004570)
TASP : 90966426(TrAFT101_003987)
MBRN : 26238479(G6M90_00g014890)
PLJ : 28887755(PLICBS_002988)
PTKZ : JDV02_000856(DLD2_2)
CDET : 87937722(CDEST_01219)
CPW : 9695228(D8B26_006327)
PTRR : 6347812(PtrM4_127580)
ADAC : 96083637(ACET3X_003315)
CNG : CNAG_02664 CNAG_03676
CGI : CGB_B5760W CGB_K2470C
CDEU : CNBG_0079 CNBG_3125
CDEP : 91090398(L203_106190)
KMG : 30167388(I203_103053)
KNE : 92177724(IAR55_000464) 92181969(IAR55_004711)
CCAC : CcaHIS019_0209500(DLD2)
TVS : TRAVEDRAFT_159410 TRAVEDRAFT_16748
ABP : AGABI1DRAFT110375(AGABI1DRAFT_110375)
ABV : AGABI2DRAFT60921(AGABI2DRAFT_60921)
SCM : SCHCO_02609927(SCHCODRAFT_02609927)
SLA : SERLADRAFT_358276 SERLADRAFT_456132
» show all
Taxonomy
Reference
Authors
Becker-Kettern J, Paczia N, Conrotte JF, Kay DP, Guignard C, Jung PP, Linster CL
Title
Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 1.1.99.40