Acting on the CH-OH group of donors;
With unknown physiological acceptors
(1) (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-16-methoxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor [RN:
(2) (3R)-3-hydroxy-2,3-dihydrotabersonine + acceptor = (3R)-3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine + reduced acceptor [RN:
reduced acceptor [CPD:
This enzyme is involved in the biosynthesis of vindoline and vindorosine in the plant Catharanthus roseus (Madagascar periwinkle). In vivo, it functions in the direction of reduction. It has no activity with 3-epoxylated compounds, which can form spontaneously from its unstable substrates.
EC 22.214.171.124 created 2017
ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
K22323 3-hydroxy-1,2-didehydro-2,3-dihydrotabersonine reductase
Qu Y, Easson ML, Froese J, Simionescu R, Hudlicky T, De Luca V
Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast.
ExPASy - ENZYME nomenclature database: 126.96.36.199