KEGG   ENZYME: 1.1.99.42
Entry
EC 1.1.99.42                Enzyme                                 
Name
4-pyridoxic acid dehydrogenase;
mlr6792 (locus name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With unknown physiological acceptors
Sysname
4-pyridoxate:acceptor 5-oxidoreductase
Reaction(IUBMB)
4-pyridoxate + acceptor = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + reduced acceptor [RN:R02993]
Reaction(KEGG)
R02993
Substrate
4-pyridoxate [CPD:C00847];
acceptor [CPD:C00028]
Product
5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate [CPD:C06050];
reduced acceptor [CPD:C00030]
Comment
The enzyme, characterized from the bacteria Pseudomonas sp. MA-1 and Mesorhizobium loti, participates in the degradation of pyridoxine (vitamin B6). It is membrane bound and contains FAD. The enzyme has been assayed in vitro in the presence of the artificial electron acceptor dichloroindophenol (DCPIP).
History
EC 1.1.99.42 created 2018
Pathway
ec00750  Vitamin B6 metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K18611  4-pyridoxate dehydrogenase
Genes
SLIGGTU79_17840
PENPSEEN2583
PCASLOY40_17950
RPJN234_09610
CUHBJN34_35770
BURBcep18194_A4369
PPNODA70_00425
PPNMLV28_05890
PRBX636_01905
PPULRO07_15700
PAPISG18_27430
PVEUC34_08025
PFIBPI93_020865
BAVBAV1907(betA)
BHZACR54_02254(alkJ_2)
BPDZBBN53_10555
AXONH44784_030571
ACHRC2U31_22445
AMIMMIM_c20980(betA3)
PIGEGT29_03170
PACRFXN63_10980
MLOmlr6792
MLNA9174_14040
MCIMesci_2016
MCICA4R28_16595
MAMMesau_02084
MESWA9K65_010520
MESMEJ066_21220
MESPC1M53_04605
MHUAMCHK_0414
MJREB229_14155
MERDEB233_11005
BARHWN72_45755
LNEFZC33_07130
RHZRHPLAN_10160 RHPLAN_17500 RHPLAN_55520
MEYTM49_03780
MMEDMame_00126(betA_1)
AUZSa4125_23890
PSINCAK95_27150
NOHG5V57_22515
RDICMV14_07050
SAMISAMIE_1031420
HTQFRZ44_12430
HADHFRZ61_12490
 » show all
Reference
1  [PMID:6348042]
  Authors
Yagi T, Kishore GM, Snell EE
  Title
The bacterial oxidation of vitamin B6. 4-Pyridoxic acid dehydrogenase: a membrane-bound enzyme from Pseudomonas MA-1.
  Journal
J Biol Chem 258:9419-25 (1983)
Reference
2  [PMID:18216065]
  Authors
Ge F, Yokochi N, Yoshikane Y, Ohnishi K, Yagi T
  Title
Gene identification and characterization of the pyridoxine degradative enzyme 4-pyridoxic acid dehydrogenase from the nitrogen-fixing symbiotic bacterium Mesorhizobium loti MAFF303099.
  Journal
J Biochem 143:603-9 (2008)
DOI:10.1093/jb/mvn010
  Sequence
[mlo:mlr6792]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.99.42
IUBMB Enzyme Nomenclature: 1.1.99.42
ExPASy - ENZYME nomenclature database: 1.1.99.42
BRENDA, the Enzyme Database: 1.1.99.42

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